EA036698B9 - Моноклональное антитело против lif человека и его применение для лечения рака с высоким уровнем lif - Google Patents

Моноклональное антитело против lif человека и его применение для лечения рака с высоким уровнем lif

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Publication number
EA036698B9
EA036698B9 EA201201373A EA201201373A EA036698B9 EA 036698 B9 EA036698 B9 EA 036698B9 EA 201201373 A EA201201373 A EA 201201373A EA 201201373 A EA201201373 A EA 201201373A EA 036698 B9 EA036698 B9 EA 036698B9
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lif
cancer
subject
fragment
increase
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EA201201373A
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English (en)
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EA201201373A1 (ru
EA036698B1 (ru
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Хоан Сеоане Суарес
Худит Анидо Фольгьера
Андреа Саэс Бордериас
Original Assignee
Фундасио Привада Институт Д'Инвестигасио Онколохика Валь Д'Эброн (Вхио)
Фундасио Привада Институсио Каталана Де Ресерка И Эстудис Аванкатс (Икреа)
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Publication of EA201201373A1 publication Critical patent/EA201201373A1/ru
Publication of EA036698B1 publication Critical patent/EA036698B1/ru
Publication of EA036698B9 publication Critical patent/EA036698B9/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
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    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G01N2333/5415—Leukaemia inhibitory factor [LIF]

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Abstract

Изобретение касается моноклонального антитела или его фрагмента, которое распознает полноразмерный LIF человека, которое продуцируется гибридомной клеточной линией DSM ACC3054, и применения раскрытого антитела или его фрагмента для лечения рака, который характеризуется высоким уровнем LIF или популяцией клеток, экспрессирующих высокие уровни CD 44 и Id1. Изобретение также касается способа in vitro разработки индивидуализированной терапии для пациентов, страдающих заболеваниями, связанными с повышением уровня LIF, способа in vitro отбора пациентов, страдающих раком, связанным с повышением уровня LIF, для лечения таких пациентов с помощью раскрытого антитела или его фрагмента, способа in vitro прогнозирования вероятной продолжительности жизни или вероятности выживания субъектов, страдающих раком, связанным с повышением уровня LIF, и способа in vitro диагностики рака у субъекта или определения предрасположенности субъекта к такому раку или определения стадии или тяжести такого рака у субъекта или мониторинга эффекта терапии, применяемой к субъекту, страдающему таким раком.
EA201201373A 2010-04-05 2011-04-05 Моноклональное антитело против lif человека и его применение для лечения рака с высоким уровнем lif EA036698B9 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10380049A EP2371860A1 (en) 2010-04-05 2010-04-05 Antibody recognising human leukemia inhibitory factor (LIF) and use of anti-LIF antibodies in the treatment of diseases associated with unwanted cell proliferation
PCT/EP2011/055253 WO2011124566A1 (en) 2010-04-05 2011-04-05 Antibody recognizing human leukemia inhibitory factor (lif) and use of anti-lif antibodies in the treatment of diseases associated with unwanted cell proliferation

Publications (3)

Publication Number Publication Date
EA201201373A1 EA201201373A1 (ru) 2013-04-30
EA036698B1 EA036698B1 (ru) 2020-12-09
EA036698B9 true EA036698B9 (ru) 2021-02-25

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ID=42338260

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Application Number Title Priority Date Filing Date
EA202092276A EA202092276A3 (ru) 2010-04-05 2011-04-05 Антитело, распознающее лейкемический ингибиторный фактор (lif) человека, и применение антител против lif при лечении заболеваний, связанных с нежелательной пролиферацией клеток
EA201201373A EA036698B9 (ru) 2010-04-05 2011-04-05 Моноклональное антитело против lif человека и его применение для лечения рака с высоким уровнем lif

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EA202092276A EA202092276A3 (ru) 2010-04-05 2011-04-05 Антитело, распознающее лейкемический ингибиторный фактор (lif) человека, и применение антител против lif при лечении заболеваний, связанных с нежелательной пролиферацией клеток

Country Status (25)

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US (3) US8926956B2 (ru)
EP (3) EP2371860A1 (ru)
JP (2) JP6289906B2 (ru)
KR (5) KR20170125137A (ru)
CN (2) CN103797031A (ru)
AU (1) AU2011237922B2 (ru)
BR (1) BR112012025517B1 (ru)
CA (1) CA2797257A1 (ru)
CY (1) CY1119451T1 (ru)
DK (1) DK2556091T3 (ru)
EA (2) EA202092276A3 (ru)
ES (1) ES2608699T3 (ru)
HK (2) HK1208469A1 (ru)
HR (1) HRP20161736T1 (ru)
HU (1) HUE030578T2 (ru)
IL (3) IL222270A (ru)
LT (1) LT2556091T (ru)
MX (2) MX2012011636A (ru)
PL (1) PL2556091T3 (ru)
PT (1) PT2556091T (ru)
RS (1) RS55539B1 (ru)
SG (1) SG184429A1 (ru)
SI (1) SI2556091T1 (ru)
SM (1) SMT201600468T1 (ru)
WO (1) WO2011124566A1 (ru)

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