EA200401053A1 - Оксо-азабициклические соединения - Google Patents

Оксо-азабициклические соединения

Info

Publication number: EA200401053A1
Authority: EA; Eurasian Patent Office
Prior art keywords: denotes; group; description; inclusive; integer
Prior art date: 2002-03-08

Application number

EA200401053A

Other languages

English (en)

Russian (ru)

Inventor

Бернар Годилльер

Энри Жакобелли

Катрин Костлан

Джэк Ли

Вен-Сонг Юе

Original Assignee

Уорнер-Ламберт Компани Ллс

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-08

Filing date

2003-03-06

Publication date

2005-04-28

2003-03-06 Application filed by Уорнер-Ламберт Компани Ллс filed Critical Уорнер-Ламберт Компани Ллс

2005-04-28 Publication of EA200401053A1 publication Critical patent/EA200401053A1/ru

Links

150000001875 compounds Chemical class 0.000 title abstract 4
102000005741 Metalloproteases Human genes 0.000 abstract 1
108010006035 Metalloproteases Proteins 0.000 abstract 1
150000001204 N-oxides Chemical class 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
239000000654 additive Chemical class 0.000 abstract 1
230000000996 additive effect Effects 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
239000011159 matrix material Substances 0.000 abstract 1
229940126601 medicinal product Drugs 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Vascular Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

EA200401053A 2002-03-08 2003-03-06 Оксо-азабициклические соединения EA200401053A1 (ru)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
PCT/EP2002/003240 WO2003076416A1 (fr)	2002-03-08	2002-03-08	Composes oxo azabicycliques
PCT/EP2003/002277 WO2003076417A2 (fr)	2002-03-08	2003-03-06	Composes oxo-azabicycliques

Publications (1)

Publication Number	Publication Date
EA200401053A1 true EA200401053A1 (ru)	2005-04-28

Family

ID=27798761

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EA200401053A EA200401053A1 (ru)	2002-03-08	2003-03-06	Оксо-азабициклические соединения

Country Status (25)

Country	Link
EP (1)	EP1492775A2 (fr)
JP (1)	JP2005526070A (fr)
KR (1)	KR20040095270A (fr)
CN (1)	CN1738806A (fr)
AP (1)	AP2004003125A0 (fr)
AR (1)	AR039562A1 (fr)
AU (2)	AU2002249275A1 (fr)
BR (1)	BR0308280A (fr)
CA (1)	CA2478706A1 (fr)
CO (1)	CO5601020A2 (fr)
EA (1)	EA200401053A1 (fr)
EC (1)	ECSP045278A (fr)
IL (1)	IL163818A0 (fr)
IS (1)	IS7414A (fr)
MA (1)	MA27183A1 (fr)
MX (1)	MXPA04008681A (fr)
NO (1)	NO20044041L (fr)
OA (1)	OA12782A (fr)
PA (1)	PA8568501A1 (fr)
PE (1)	PE20031018A1 (fr)
PL (1)	PL372622A1 (fr)
SV (1)	SV2003001495A (fr)
TN (1)	TNSN04169A1 (fr)
UY (1)	UY27700A1 (fr)
WO (2)	WO2003076416A1 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PA8539501A1 (es)	2001-02-14	2002-09-30	Warner Lambert Co	Compuestos triazolo como inhibidores de mmp
US6962922B2 (en)	2001-10-12	2005-11-08	Warner-Lambert Company Llc	Alkynylated quinazoline compounds
US6894057B2 (en)	2002-03-08	2005-05-17	Warner-Lambert Company	Oxo-azabicyclic compounds
MXPA05001786A (es)	2002-08-13	2005-04-25	Warner Lambert Co	Derivados de azaisoquinolina como inhibidores de la metaloproteinasa de matriz.
AU2003249540A1 (en)	2002-08-13	2004-02-25	Warner-Lambert Company Llc	Fused bicyclic metalloproteinase inhibitors
WO2004014909A1 (fr)	2002-08-13	2004-02-19	Warner-Lambert Company Llc	Derives fusionnes de la tetrahydropyridine inhibiteurs de la metalloprotease matricielle
WO2004014892A1 (fr)	2002-08-13	2004-02-19	Warner-Lambert Company Llc	Derives monocycliques en tant qu'inhibiteurs de metalloproteinases matricielles
JP2006500351A (ja)	2002-08-13	2006-01-05	ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー	マトリックスメタロプロテアーゼ−１３阻害剤としてのピリミジン−２，４−ジオン誘導体
WO2004014923A1 (fr)	2002-08-13	2004-02-19	Warner-Lambert Company Llc	Inhibiteurs de metalloprotease bicycliques condenses avec la pyrimidinone
AU2003250466A1 (en)	2002-08-13	2004-02-25	Warner-Lambert Company Llc	3-isoquinolinone derivatives as matrix metalloproteinase inhiitors
WO2004014384A2 (fr) *	2002-08-13	2004-02-19	Warner-Lambert Company Llc	Composes cycliques contenant des groupes liant le zinc en tant qu'inhibiteurs de metalloprotease de matrice
AU2003253150A1 (en)	2002-08-13	2004-02-25	Warner-Lambert Company Llc	Chromone derivatives as matrix metalloproteinase inhibitors
PA8578101A1 (es)	2002-08-13	2004-05-07	Warner Lambert Co	Derivados de heterobiarilo como inhibidores de metaloproteinasa de la matriz
WO2005016926A1 (fr) *	2003-08-19	2005-02-24	Warner-Lambert Company Llc	Derives de pyrido[3,4-d]pyrimidine utiles comme inhibiteurs de la metalloproteinase-13 de matrice
DE10360835A1 (de) *	2003-12-23	2005-07-21	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Bicyclische Imidazolverbindungen, deren Herstellung und deren Verwendung als Arzneimittel
CN1976907A (zh) *	2004-04-30	2007-06-06	武田药品工业株式会社	杂环酰胺化合物及其作为mmp－13抑制剂的用途
CA2568756A1 (fr) *	2004-06-15	2005-12-29	Astrazeneca Ab	Quinazolones substitues en tant qu'agents anticancereux
CN101522676A (zh)	2006-10-05	2009-09-02	Cv医药有限公司	用作硬脂酰-CoA脱氢酶抑制剂的双环含氮杂环化合物
WO2012052451A1 (fr)	2010-10-18	2012-04-26	Merz Pharma Gmbh & Co. Kgaa	Modulateurs des récepteurs métabotropes au glutamate
CN103524431B (zh) *	2013-09-24	2016-01-13	西安交通大学	3-苄基-4-喹唑啉酮类化合物及其合成方法和应用
JO3512B1 (ar)	2014-03-26	2020-07-05	Astex Therapeutics Ltd	مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
KR102703498B1 (ko)	2015-09-23	2024-09-04	얀센 파마슈티카 엔브이	신규 화합물
CN108137546B (zh)	2015-09-23	2021-07-27	詹森药业有限公司	双杂芳基取代的1,4-苯并二氮杂卓化合物及其用于治疗癌症的用途
FR3046793B1 (fr) *	2016-01-14	2018-01-05	Les Laboratoires Servier	Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU5380398A (en) *	1996-12-17	1998-07-15	E.I. Du Pont De Nemours And Company	Fungicidal quinazolinones
PA8539401A1 (es) *	2001-02-14	2002-10-28	Warner Lambert Co	Quinazolinas como inhibidores de mmp-13
PA8539301A1 (es) *	2001-02-14	2002-09-30	Warner Lambert Co	Inhibidores de la metaloproteinasa de la matriz

2002
- 2002-03-08 AU AU2002249275A patent/AU2002249275A1/en not_active Abandoned
- 2002-03-08 WO PCT/EP2002/003240 patent/WO2003076416A1/fr not_active Ceased
2003
- 2003-03-04 SV SV2003001495A patent/SV2003001495A/es not_active Application Discontinuation
- 2003-03-06 EP EP03708181A patent/EP1492775A2/fr not_active Withdrawn
- 2003-03-06 PE PE2003000218A patent/PE20031018A1/es not_active Application Discontinuation
- 2003-03-06 CA CA002478706A patent/CA2478706A1/fr not_active Abandoned
- 2003-03-06 AP APAP/P/2004/003125A patent/AP2004003125A0/en unknown
- 2003-03-06 AR ARP030100749A patent/AR039562A1/es not_active Application Discontinuation
- 2003-03-06 JP JP2003574636A patent/JP2005526070A/ja not_active Withdrawn
- 2003-03-06 WO PCT/EP2003/002277 patent/WO2003076417A2/fr not_active Ceased
- 2003-03-06 CN CNA038048752A patent/CN1738806A/zh active Pending
- 2003-03-06 EA EA200401053A patent/EA200401053A1/ru unknown
- 2003-03-06 IL IL16381803A patent/IL163818A0/xx unknown
- 2003-03-06 BR BR0308280-6A patent/BR0308280A/pt not_active IP Right Cessation
- 2003-03-06 OA OA1200400234A patent/OA12782A/en unknown
- 2003-03-06 UY UY27700A patent/UY27700A1/es not_active Application Discontinuation
- 2003-03-06 AU AU2003212307A patent/AU2003212307A1/en not_active Abandoned
- 2003-03-06 MX MXPA04008681A patent/MXPA04008681A/es unknown
- 2003-03-06 PA PA20038568501A patent/PA8568501A1/es unknown
- 2003-03-06 KR KR10-2004-7013994A patent/KR20040095270A/ko not_active Ceased
- 2003-03-06 PL PL03372622A patent/PL372622A1/xx not_active Application Discontinuation
2004
- 2004-08-19 IS IS7414A patent/IS7414A/is unknown
- 2004-08-25 CO CO04082792A patent/CO5601020A2/es not_active Application Discontinuation
- 2004-08-31 MA MA27842A patent/MA27183A1/fr unknown
- 2004-09-03 EC EC2004005278A patent/ECSP045278A/es unknown
- 2004-09-03 TN TNP2004000169A patent/TNSN04169A1/fr unknown
- 2004-09-24 NO NO20044041A patent/NO20044041L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
NO20044041L (no)	2004-10-07
TNSN04169A1 (fr)	2007-03-12
WO2003076416A1 (fr)	2003-09-18
ECSP045278A (es)	2004-10-26
MA27183A1 (fr)	2005-01-03
MXPA04008681A (es)	2004-12-06
KR20040095270A (ko)	2004-11-12
PL372622A1 (en)	2005-07-25
OA12782A (en)	2006-07-10
IL163818A0 (en)	2005-12-18
AP2004003125A0 (en)	2004-09-30
IS7414A (is)	2004-08-19
AU2002249275A1 (en)	2003-09-22
EP1492775A2 (fr)	2005-01-05
PE20031018A1 (es)	2004-01-09
AU2003212307A1 (en)	2003-09-22
CN1738806A (zh)	2006-02-22
JP2005526070A (ja)	2005-09-02
BR0308280A (pt)	2004-12-28
AR039562A1 (es)	2005-02-23
UY27700A1 (es)	2003-10-31
PA8568501A1 (es)	2003-12-19
SV2003001495A (es)	2003-11-04
WO2003076417A2 (fr)	2003-09-18
CO5601020A2 (es)	2006-01-31
CA2478706A1 (fr)	2003-09-18
WO2003076417A3 (fr)	2003-11-13

Similar Documents

Publication	Publication Date	Title
PT1299409E (pt)	2005-08-31	Compostos organicos
ECSP045278A (es)	2004-10-26	Compuestos de oxo-azabicíclicos
EA200200417A1 (ru)	2002-10-31	Фармацевтически активные производные сульфонамида
DE59706313D1 (de)	2002-03-21	Acylierte n-hydroxymethyl thalidomid-prodrugs mit immunomodulatorischer wirkung
EA200101077A1 (ru)	2002-04-25	Композиция для профилактики или лечения слабоумия, включающая производное гидроксикоричной кислоты или экстракт растения рода angelicae, содержащий его
PE20040666A1 (es)	2004-09-25	Derivados novedosos de piperidina
EA200000792A2 (ru)	2001-04-23	Новые пиридиновые соединения, способ их получения и содержащие их фармацевтические композиции
BRPI0409105A (pt)	2006-04-25	análogos de quinobenzoxazina substituìdos
EA200100969A1 (ru)	2002-04-25	Новые соединения циклобутендиона, способ их получения и содержащие их фармацевтические композиции
EA200400806A1 (ru)	2004-12-30	Способ получения эхинокандиновых соединений
ES2183492T3 (es)	2003-03-16	Nuevos derivados de nitrono,su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
AR029001A1 (es)	2003-06-04	Derivados de bencil-3,4-metilendioxicinamico y el uso de los mismos para la manufactura de un medicamento
FR2707089B1 (fr)	1995-08-18	Nouveaux dérivés d'acide phosphonique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
UY24697A1 (es)	1997-10-21	Metodos para producir inhibidores de vih-proteasa y productos intermedios para producir inhibidores de vih-proteasa
EA200100597A3 (ru)	2002-04-25	Новые 1,1- и 1,2-дизамещенные циклопропановые соединения, способ их получения и содержащие их фармацевтические композиции
AR043186A1 (es)	2005-07-20	Indozolamidas dotadas de actividad analgesica, metodo de preparacion de las mismas y compuesto farmaceutico que las comprende
EA200101230A1 (ru)	2002-06-27	Новые ингибиторы металлопротеаз, метод их получения и содержащие их фармацевтические композиции
EA199600007A3 (ru)	1996-12-30	Новые трициклические производные, способ их получения, способы получения оптически активных или рацемических колхицина и тиоколхицина, их аналогов или производных с использованием трициклических соединений и промежуточные продукты синтеза
EA200000374A2 (ru)	2000-12-25	Новые соединения 2,3-метаноаминокислоты, способ их получения и содержащие их фармацевтические композиции
EA200101204A1 (ru)	2002-06-27	Новые бициклические соединения аминопиразинона, способ их получения и содержащие их фармацевтические композиции
EA200000598A1 (ru)	2001-02-26	Новые ингибиторы металлопротеазы, способ их получения и содержащие их фармацевтические композиции
MA26921A1 (fr)	2004-12-20	Derives d'acides aminés cycliques utilisables en tant qu'agents pharmaceutiques.
EA200300029A1 (ru)	2003-06-26	Новые соединения карбамат и тиокарбамат подофиллотоксина, способ их получения и содержащие их фармацевтические композиции
EA200401011A1 (ru)	2004-12-30	Новые соединения аминокислоты, способ их получения и фармацевтические композиции, содержащие их
EA200100344A2 (ru)	2001-10-22	Новые циклобутаиндолкарбоксамидные производные, способ их получения и содержащие их фармацевтические композиции