EA200802415A1 - Замещенные фенилуксусные кислоты в качестве dp-2-антагонистов - Google Patents

Замещенные фенилуксусные кислоты в качестве dp-2-антагонистов

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Publication number
EA200802415A1
EA200802415A1 EA200802415A EA200802415A EA200802415A1 EA 200802415 A1 EA200802415 A1 EA 200802415A1 EA 200802415 A EA200802415 A EA 200802415A EA 200802415 A EA200802415 A EA 200802415A EA 200802415 A1 EA200802415 A1 EA 200802415A1
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Eurasian Patent Office
Prior art keywords
antagonist
replaced
phenylacetic acids
methods
conditions
Prior art date
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EA200802415A
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English (en)
Inventor
Томас Дадлер
Франсьен Фаруз
Керри Фаулер
Натали Хоторн
Данвен Хуанг
Анжела Джадкинс
Мусон Ким
Джошуа Одинго
Эми Оливер
Марк Рид
Фуцян Руан
Юджин Торсет
Original Assignee
Икос Корпорейшн
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Publication of EA200802415A1 publication Critical patent/EA200802415A1/ru

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Abstract

Изобретение относится к замещенным фенилуксусным производным формулы (I), фармацевтическим композициям, способам их получения и способам, которые являются полезными в лечении и предупреждении нарушений или состояний, чувствительных к модуляции DP-2-рецептора, в частности воспалительных и связанных с иммунитетом нарушений и состояний, таких как астма, аллергический ринит и атопический дерматит.
EA200802415A 2006-06-09 2007-06-08 Замещенные фенилуксусные кислоты в качестве dp-2-антагонистов EA200802415A1 (ru)

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PCT/US2007/070803 WO2007143745A2 (en) 2006-06-09 2007-06-08 Substituted phenyl acetic acids as dp-2 antagonists

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BRPI0817425A2 (pt) * 2007-10-19 2015-06-16 Janssen Pharmaceutica Nv Moduladores de gama-secretase ligados à amida
AU2008312355B2 (en) * 2007-10-19 2013-07-04 Janssen Pharmaceutica, N.V. Carbon linked modulators of y-secretase
US9045445B2 (en) 2010-06-04 2015-06-02 Albany Molecular Research, Inc. Glycine transporter-1 inhibitors, methods of making them, and uses thereof
TW201201805A (en) 2010-07-05 2012-01-16 Actelion Pharmaceuticals Ltd 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators
EP2457900A1 (en) 2010-11-25 2012-05-30 Almirall, S.A. New pyrazole derivatives having CRTh2 antagonistic behaviour
CA2844982A1 (en) 2011-08-15 2013-02-21 Intermune, Inc. Lysophosphatidic acid receptor antagonists
CN104011021B (zh) 2011-12-21 2016-08-24 埃科特莱茵药品有限公司 杂环衍生物及其作为前列腺素d2受体调节剂的用途
US9169270B2 (en) 2012-07-05 2015-10-27 Actelion Pharmaceuticals Ltd. 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators
CN102757339A (zh) * 2012-08-01 2012-10-31 北京联本医药化学技术有限公司 一种改进的4-(2-羧基苄氧基)苯乙酸制备方法
CA2911902A1 (en) 2013-05-07 2014-11-13 The Regents Of The University Of California Radiomitigating pharmaceutical formulations
CN112300120B (zh) * 2019-07-31 2023-04-14 北京四环制药有限公司 一种用于制备巴罗萨韦或其衍生物的化合物及其制备方法和其应用
EP4065112A4 (en) * 2019-11-22 2023-12-27 The Regents of the University of California Taspase1 inhibitors and uses thereof

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ES2257616T3 (es) * 2003-04-25 2006-08-01 Actimis Pharmaceuticals, Inc. Derivados del acido pirimidinilacetico utiles para el tratamiento de enfermedades mediadas por crth2.
SE0302811D0 (sv) * 2003-10-23 2003-10-23 Astrazeneca Ab Novel compounds
AR048523A1 (es) * 2004-04-07 2006-05-03 Kalypsys Inc Compuestos con estructura de aril sulfonamida y sulfonilo como moduladores de ppar y metodos para tratar trastornos metabolicos
JP2008534678A (ja) * 2005-04-04 2008-08-28 アストラゼネカ・アクチエボラーグ 新規ジアザスピロアルカン類およびｃｃｒ８介在疾患の処置のためのそれらの使用
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Publication number Priority date Publication date Assignee Title
US8492437B2 (en) 2006-08-21 2013-07-23 Array Biopharma Inc. 4-substituted phenoxyphenylacetic acid derivatives

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JP2009539880A (ja) 2009-11-19
BRPI0712301A2 (pt) 2012-01-17
MX2008015696A (es) 2009-02-10
AU2007256597A1 (en) 2007-12-13
NO20090138L (no) 2009-03-05
CA2654784A1 (en) 2007-12-13
CN101490024A (zh) 2009-07-22
EP2044044A2 (en) 2009-04-08
WO2007143745A2 (en) 2007-12-13

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