EA201190293A1 - Пролекарства триптолида - Google Patents

Пролекарства триптолида

Info

Publication number
EA201190293A1
EA201190293A1 EA201190293A EA201190293A EA201190293A1 EA 201190293 A1 EA201190293 A1 EA 201190293A1 EA 201190293 A EA201190293 A EA 201190293A EA 201190293 A EA201190293 A EA 201190293A EA 201190293 A1 EA201190293 A1 EA 201190293A1
Authority
EA
Eurasian Patent Office
Prior art keywords
formula
compounds
tripolida
spirits
methods
Prior art date
Application number
EA201190293A
Other languages
English (en)
Other versions
EA021135B1 (ru
Inventor
Ингрид Гунда Георг
Сатиш Пракаш Патил
Ашок К. Салуя
Рохит Чугх
Селвин М. Виккерс
Original Assignee
Реджентс Оф Зе Юниверсити Оф Миннесота
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Реджентс Оф Зе Юниверсити Оф Миннесота filed Critical Реджентс Оф Зе Юниверсити Оф Миннесота
Publication of EA201190293A1 publication Critical patent/EA201190293A1/ru
Publication of EA021135B1 publication Critical patent/EA021135B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Согласно настоящему изобретению предложены соединения формулы I:или соль указанных соединений. Согласно настоящему изобретению также предложены фармацевтические композиции, содержащие соединение формулы I, способы получения соединений формулы I, промежуточные соединения, подходящие для получения соединений формулы I, и способы лечения с применением соединений формулы I.
EA201190293A 2009-05-07 2010-05-07 Пролекарства триптолида EA021135B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17624909P 2009-05-07 2009-05-07
PCT/US2010/034117 WO2010129918A1 (en) 2009-05-07 2010-05-07 Triptolide prodrugs

Publications (2)

Publication Number Publication Date
EA201190293A1 true EA201190293A1 (ru) 2012-11-30
EA021135B1 EA021135B1 (ru) 2015-04-30

Family

ID=42244313

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201190293A EA021135B1 (ru) 2009-05-07 2010-05-07 Пролекарства триптолида

Country Status (17)

Country Link
US (1) US8507552B2 (ru)
EP (1) EP2427467B1 (ru)
JP (3) JP6000122B2 (ru)
KR (1) KR101821823B1 (ru)
CN (1) CN102596977B (ru)
AU (1) AU2010245669B2 (ru)
BR (1) BRPI1014802B8 (ru)
CA (2) CA2964631A1 (ru)
DK (1) DK2427467T3 (ru)
EA (1) EA021135B1 (ru)
ES (1) ES2552163T3 (ru)
MX (1) MX2011011776A (ru)
MY (1) MY160392A (ru)
PL (1) PL2427467T3 (ru)
PT (1) PT2427467E (ru)
SG (1) SG175885A1 (ru)
WO (1) WO2010129918A1 (ru)

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US9150600B2 (en) 2009-05-07 2015-10-06 Regents Of The University Of Minnesota Triptolide prodrugs
RS58781B1 (sr) 2012-08-23 2019-06-28 Senestech Inc Kompozicije i postupci za redukciju reproduktivnog kapaciteta ženki pacova
WO2014047783A1 (zh) * 2012-09-25 2014-04-03 鼎泓国际投资（香港）有限公司 含有雷公藤甲素及雷公藤甲素类衍生物和Bcl-2抑制剂的药物组合物及其应用
WO2014167581A2 (en) * 2013-04-01 2014-10-16 Laurus Labs Private Limited An improved process for the preparation of triptolide prodrugs
DK3348276T3 (da) * 2015-09-11 2021-08-09 Ys Ac Co Ltd Cancerbehandlingssammensætning, hvor af anti-CD26-antistof og et andet anticancermiddel er kombineret
CN109942665B (zh) * 2018-04-02 2021-04-06 欣凯医药化工中间体（上海）有限公司 雷公藤内酯醇衍生物及其制备方法和应用
CN110551171B (zh) * 2018-05-31 2021-07-27 欣凯医药化工中间体（上海）有限公司 一种雷公藤内酯醇衍生物的制备方法
KR20210058880A (ko) * 2018-09-13 2021-05-24 미네암리타 테라퓨틱스, 엘엘씨 섬유증, nash, 및 nafld를 치료하기 위한 방법에서 사용을 위한 트립톨리드 및 이의 전구약물
WO2021221179A1 (ja) * 2020-04-28 2021-11-04 国立大学法人高知大学 ヒト膵癌オルガノイドを用いたマウスモデルの樹立
US20230303618A1 (en) 2020-08-21 2023-09-28 Reyoung Corporation Triptolide conjugates and uses thereof
CN115227829B (zh) * 2022-02-22 2023-10-13 成都中医药大学 酸敏感性适配体雷公藤甲素偶联物及应用
WO2024186320A1 (en) 2023-03-09 2024-09-12 Minneamrita Therapeutics Llc Drug combination for treatment of pancreatic cancer
WO2024187139A1 (en) 2023-03-09 2024-09-12 Minneamrita Therapeutics Llc Drug combination for treatment of gastric cancer
AU2024204522B1 (en) 2023-03-09 2024-08-22 Minneamrita Therapeutics Llc Drug combination for treatment of gastric cancer

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US5759550A (en) 1993-05-06 1998-06-02 Pharmagenesis, Inc. Method for suppressing xenograft rejection
US5609991A (en) 1995-02-10 1997-03-11 Morton International, Inc. Photoimageable composition having improved alkaline process resistance and tack-free surface for contact imaging
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US6204257B1 (en) * 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
US6548537B1 (en) * 1998-09-02 2003-04-15 Pharmagenesis, Inc. Triptolide prodrugs having high aqueous solubility
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WO2000048619A1 (en) 1999-02-16 2000-08-24 The Board Of Trustees Of The Leland Stanford Junior University Combined therapy of diterpenoid triepoxides and trail for synergistic killing of tumor cells
AU5368699A (en) 1999-04-16 2000-11-02 Chengdu Diao Pharmaceutical Group Company Limited Derivatives of triptolide, and preparation and uses thereof
US6294546B1 (en) 1999-08-30 2001-09-25 The Broad Of Trustees Of The Leland Stanford Junior University Uses of diterpenoid triepoxides as an anti-proliferative agent
US6620843B2 (en) * 2001-01-19 2003-09-16 Pharmagenesis Anticancer treatment using triptolide prodrugs
US6569893B2 (en) * 2001-03-15 2003-05-27 Pharmagenesis, Inc. Amino acid derivatives of triptolide compounds as immune modulators and anticancer agents
CA2470423C (en) * 2001-12-21 2011-03-15 Guilford Pharmaceuticals, Inc. Process for preparing water-soluble phosphonooxymethyl derivatives of alcohol and phenol
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Also Published As

Publication number Publication date
KR101821823B1 (ko) 2018-01-24
AU2010245669B2 (en) 2015-11-26
CA2760953C (en) 2017-05-30
BRPI1014802A2 (pt) 2016-04-05
MY160392A (en) 2017-03-15
HK1168107A1 (en) 2012-12-21
BRPI1014802B8 (pt) 2021-05-25
EA021135B1 (ru) 2015-04-30
PT2427467E (pt) 2015-11-19
JP2014185181A (ja) 2014-10-02
SG175885A1 (en) 2011-12-29
JP2016065099A (ja) 2016-04-28
EP2427467A1 (en) 2012-03-14
JP6000122B2 (ja) 2016-09-28
CN102596977A (zh) 2012-07-18
WO2010129918A8 (en) 2011-01-20
KR20120015339A (ko) 2012-02-21
JP2012526148A (ja) 2012-10-25
EP2427467B1 (en) 2015-08-05
CA2964631A1 (en) 2010-11-11
US20120238529A1 (en) 2012-09-20
MX2011011776A (es) 2012-08-03
DK2427467T3 (en) 2015-11-09
US8507552B2 (en) 2013-08-13
CN102596977B (zh) 2016-06-29
BRPI1014802B1 (pt) 2020-09-24
CA2760953A1 (en) 2010-11-11
AU2010245669A1 (en) 2011-12-01
PL2427467T3 (pl) 2016-04-29
WO2010129918A1 (en) 2010-11-11
ES2552163T3 (es) 2015-11-26

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