EA201190286A1 - Адъювантные композиции, содержащие неионный агент, обеспечивающий изотоничность - Google Patents

Адъювантные композиции, содержащие неионный агент, обеспечивающий изотоничность

Info

Publication number
EA201190286A1
EA201190286A1 EA201190286A EA201190286A EA201190286A1 EA 201190286 A1 EA201190286 A1 EA 201190286A1 EA 201190286 A EA201190286 A EA 201190286A EA 201190286 A EA201190286 A EA 201190286A EA 201190286 A1 EA201190286 A1 EA 201190286A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compositions containing
adjustent
unique agent
providing isotonicity
isotonicity
Prior art date
Application number
EA201190286A
Other languages
English (en)
Other versions
EA024074B1 (ru
Inventor
Вероник Эндерикс
Доминик Ингрид Лемуан
Original Assignee
Глаксосмитклайн Байолоджикалс С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40937237&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201190286(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Глаксосмитклайн Байолоджикалс С.А. filed Critical Глаксосмитклайн Байолоджикалс С.А.
Publication of EA201190286A1 publication Critical patent/EA201190286A1/ru
Publication of EA024074B1 publication Critical patent/EA024074B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Предложены адъювантные и иммуногенные композиции, содержащие агонист TLR-4 и сапонин в липосомальной композиции, и неионный агент, обеспечивающий изотоничность, где концентрация хлорида натрия или ионная сила составляет менее 100 мМ.
EA201190286A 2009-06-10 2010-06-08 Водная адъювантная композиция, содержащая неионный агент, обеспечивающий изотоничность, иммуногенная композиция и набор на её основе и способ приготовления иммуногенной композиции EA024074B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0910046.2A GB0910046D0 (en) 2009-06-10 2009-06-10 Novel compositions
PCT/EP2010/058017 WO2010142685A1 (en) 2009-06-10 2010-06-08 Adjuvant compositions comprising a non-ionic isotonicity agent

Publications (2)

Publication Number Publication Date
EA201190286A1 true EA201190286A1 (ru) 2012-06-29
EA024074B1 EA024074B1 (ru) 2016-08-31

Family

ID=40937237

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201190286A EA024074B1 (ru) 2009-06-10 2010-06-08 Водная адъювантная композиция, содержащая неионный агент, обеспечивающий изотоничность, иммуногенная композиция и набор на её основе и способ приготовления иммуногенной композиции

Country Status (31)

Country Link
US (2) US20120087976A1 (ru)
EP (1) EP2440242B1 (ru)
JP (3) JP5647677B2 (ru)
KR (1) KR101473686B1 (ru)
CN (2) CN104367997B (ru)
AU (1) AU2010257538B2 (ru)
BR (1) BRPI1012890B1 (ru)
CA (1) CA2764421C (ru)
CL (1) CL2011003113A1 (ru)
CO (1) CO6440528A2 (ru)
CY (1) CY1115522T1 (ru)
DK (1) DK2440242T3 (ru)
DO (1) DOP2011000346A (ru)
EA (1) EA024074B1 (ru)
ES (1) ES2494442T3 (ru)
GB (1) GB0910046D0 (ru)
HR (1) HRP20140792T1 (ru)
IL (1) IL216231A0 (ru)
MA (1) MA33412B1 (ru)
MX (1) MX2011013162A (ru)
MY (1) MY159819A (ru)
NZ (1) NZ596503A (ru)
PE (1) PE20120319A1 (ru)
PL (1) PL2440242T3 (ru)
PT (1) PT2440242E (ru)
RS (1) RS53550B1 (ru)
SG (1) SG176638A1 (ru)
SI (1) SI2440242T1 (ru)
SM (1) SMT201400134B (ru)
UA (1) UA104888C2 (ru)
WO (1) WO2010142685A1 (ru)

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ES2575084T3 (es) 2009-06-10 2016-06-24 Chugai Seiyaku Kabushiki Kaisha Compuesto tetracíclico
CN103052386B (zh) 2010-08-20 2016-03-02 中外制药株式会社 含有四环化合物的组合物
CN106822883A (zh) * 2010-12-14 2017-06-13 葛兰素史密丝克莱恩生物有限公司 分枝杆菌抗原组合物
MY170904A (en) 2012-09-25 2019-09-13 Chugai Pharmaceutical Co Ltd Ret inhibitor
AU2015236106A1 (en) * 2014-03-25 2016-10-20 The Government Of The United States Of America As Represented By The Secretary Of The Army Non-toxic adjuvant formulation comprising a monophosphoryl lipid a (MPLA)-containing liposome composition and a saponin
JP6873698B2 (ja) 2014-04-25 2021-05-19 中外製薬株式会社 ４環性化合物の新規結晶
TWI831128B (zh) 2014-04-25 2024-02-01 日商中外製藥股份有限公司 以高用量含有４環性化合物的製劑
TWI803187B (zh) 2014-08-08 2023-05-21 日商中外製藥股份有限公司 包含４環性化合物的非晶質體之固體分散體及製劑
KR102584344B1 (ko) 2015-01-16 2023-09-27 추가이 세이야쿠 가부시키가이샤 병용 의약
CN108778289B (zh) 2015-11-06 2020-11-17 佐剂技术公司 三萜皂苷类似物
US10695424B2 (en) * 2016-12-07 2020-06-30 Glaxosmithkline Biologicals S.A. Method of making a liposome composition
CA3061205A1 (en) 2017-04-25 2018-11-01 Memorial Sloan Kettering Cancer Center Triterpene saponin analogues
BR112019025104A2 (pt) 2017-05-30 2020-06-23 Glaxosmithkline Biologicals S.A. Método de fabricar um sistema de entrega não viral, sistema de entrega não viral, e, composição
SG11202001826YA (en) * 2017-10-16 2020-03-30 Adjuvance Technologies Inc Triterpene saponin analogues
BR112020010790A2 (pt) 2017-12-01 2020-11-10 Glaxosmithkline Biologicals S.A. purificação da saponina
WO2019106191A1 (en) 2017-12-01 2019-06-06 Glaxosmithkline Biologicals Sa Saponin extraction
BR112020025499A2 (pt) 2018-06-29 2021-03-09 Chugai Seiyaku Kabushiki Kaisha Composição farmacêutica que compreende agente básico pouco solúvel
PL3848361T3 (pl) 2018-09-04 2025-07-07 Chugai Seiyaku Kabushiki Kaisha Sposób wytwarzania związku tetracyklicznego
EP3886901A1 (en) * 2018-11-29 2021-10-06 GlaxoSmithKline Biologicals S.A. Methods for manufacturing an adjuvant
WO2020245207A1 (en) * 2019-06-05 2020-12-10 Glaxosmithkline Biologicals Sa Saponin purification
BR112021026775A2 (pt) * 2019-08-05 2022-05-10 Glaxosmithkline Biologicals Sa Processo para preparar uma composição que compreende um polipeptídeo de proteína d
EP4021407A1 (en) 2019-08-30 2022-07-06 GlaxoSmithKline Biologicals S.A. Jet mixing lipid nanoparticle manufacturing process
CN121013730A (zh) * 2023-03-15 2025-11-25 联合免疫股份有限公司 脂质颗粒
TW202600165A (zh) * 2024-02-29 2026-01-01 優億股份有限公司 佐劑組合物、包含該佐劑組合物的藥物組合物以及預防或治療病毒感染、細菌感染、原蟲感染或癌症引起的疾病的方法

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US5776468A (en) * 1993-03-23 1998-07-07 Smithkline Beecham Biologicals (S.A.) Vaccine compositions containing 3-0 deacylated monophosphoryl lipid A
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Also Published As

Publication number Publication date
RS53550B1 (sr) 2015-02-27
CA2764421A1 (en) 2010-12-16
PE20120319A1 (es) 2012-04-16
SMT201400134B (it) 2014-11-10
US20180021417A1 (en) 2018-01-25
EP2440242A1 (en) 2012-04-18
BRPI1012890A2 (en) 2018-02-27
CA2764421C (en) 2016-12-06
AU2010257538B2 (en) 2016-10-20
WO2010142685A1 (en) 2010-12-16
ES2494442T3 (es) 2014-09-15
NZ596503A (en) 2013-08-30
MA33412B1 (fr) 2012-07-03
UA104888C2 (ru) 2014-03-25
DOP2011000346A (es) 2012-01-15
PT2440242E (pt) 2014-08-29
CL2011003113A1 (es) 2012-08-31
IL216231A0 (en) 2012-01-31
JP5647677B2 (ja) 2015-01-07
JP5977789B2 (ja) 2016-08-24
AU2010257538A1 (en) 2011-12-08
PL2440242T3 (pl) 2014-11-28
CN104367997B (zh) 2019-01-22
MX2011013162A (es) 2012-01-30
JP2016193912A (ja) 2016-11-17
JP2015042646A (ja) 2015-03-05
US20120087976A1 (en) 2012-04-12
MY159819A (en) 2017-02-15
HRP20140792T1 (hr) 2014-10-10
CY1115522T1 (el) 2017-01-04
JP2012529464A (ja) 2012-11-22
DK2440242T3 (da) 2014-09-01
JP6261647B2 (ja) 2018-01-17
EA024074B1 (ru) 2016-08-31
CN102458457A (zh) 2012-05-16
GB0910046D0 (en) 2009-07-22
CN102458457B (zh) 2015-05-20
KR101473686B1 (ko) 2014-12-18
EP2440242B1 (en) 2014-06-25
CO6440528A2 (es) 2012-05-15
CN104367997A (zh) 2015-02-25
BRPI1012890B1 (pt) 2022-03-22
SG176638A1 (en) 2012-01-30
SI2440242T1 (sl) 2014-09-30
KR20120031497A (ko) 2012-04-03

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KG MD TJ TM