MA33412B1 - Compositions adjuvantes contenant un agent d'isotonicité non ionique - Google Patents

Compositions adjuvantes contenant un agent d'isotonicité non ionique

Info

Publication number
MA33412B1
MA33412B1 MA34506A MA34506A MA33412B1 MA 33412 B1 MA33412 B1 MA 33412B1 MA 34506 A MA34506 A MA 34506A MA 34506 A MA34506 A MA 34506A MA 33412 B1 MA33412 B1 MA 33412B1
Authority
MA
Morocco
Prior art keywords
isotonicity agent
compositions containing
adjuvant compositions
ionic isotonicity
ionic
Prior art date
Application number
MA34506A
Other languages
Arabic (ar)
English (en)
Inventor
Veronique Henderickx
Dominique Ingrid Lemoine
Original Assignee
Glaxosmithkline Biolog Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40937237&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA33412(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Biolog Sa filed Critical Glaxosmithkline Biolog Sa
Publication of MA33412B1 publication Critical patent/MA33412B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des compositions adjuvantes et immunogènes renfermant un agoniste du TLR-4 et une saponine dans une formulation liposomique et un agent d'isotonicité non ionique, la concentration en chlorure de sodium ou la force ionique étant inférieure à 100 mM.
MA34506A 2009-06-10 2010-06-08 Compositions adjuvantes contenant un agent d'isotonicité non ionique MA33412B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0910046.2A GB0910046D0 (en) 2009-06-10 2009-06-10 Novel compositions
PCT/EP2010/058017 WO2010142685A1 (fr) 2009-06-10 2010-06-08 Compositions adjuvantes contenant un agent d'isotonicité non ionique

Publications (1)

Publication Number Publication Date
MA33412B1 true MA33412B1 (fr) 2012-07-03

Family

ID=40937237

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34506A MA33412B1 (fr) 2009-06-10 2010-06-08 Compositions adjuvantes contenant un agent d'isotonicité non ionique

Country Status (31)

Country Link
US (2) US20120087976A1 (fr)
EP (1) EP2440242B1 (fr)
JP (3) JP5647677B2 (fr)
KR (1) KR101473686B1 (fr)
CN (2) CN104367997B (fr)
AU (1) AU2010257538B2 (fr)
BR (1) BRPI1012890B1 (fr)
CA (1) CA2764421C (fr)
CL (1) CL2011003113A1 (fr)
CO (1) CO6440528A2 (fr)
CY (1) CY1115522T1 (fr)
DK (1) DK2440242T3 (fr)
DO (1) DOP2011000346A (fr)
EA (1) EA024074B1 (fr)
ES (1) ES2494442T3 (fr)
GB (1) GB0910046D0 (fr)
HR (1) HRP20140792T1 (fr)
IL (1) IL216231A0 (fr)
MA (1) MA33412B1 (fr)
MX (1) MX2011013162A (fr)
MY (1) MY159819A (fr)
NZ (1) NZ596503A (fr)
PE (1) PE20120319A1 (fr)
PL (1) PL2440242T3 (fr)
PT (1) PT2440242E (fr)
RS (1) RS53550B1 (fr)
SG (1) SG176638A1 (fr)
SI (1) SI2440242T1 (fr)
SM (1) SMT201400134B (fr)
UA (1) UA104888C2 (fr)
WO (1) WO2010142685A1 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2575084T3 (es) 2009-06-10 2016-06-24 Chugai Seiyaku Kabushiki Kaisha Compuesto tetracíclico
CN103052386B (zh) 2010-08-20 2016-03-02 中外制药株式会社 含有四环化合物的组合物
CN106822883A (zh) * 2010-12-14 2017-06-13 葛兰素史密丝克莱恩生物有限公司 分枝杆菌抗原组合物
MY170904A (en) 2012-09-25 2019-09-13 Chugai Pharmaceutical Co Ltd Ret inhibitor
AU2015236106A1 (en) * 2014-03-25 2016-10-20 The Government Of The United States Of America As Represented By The Secretary Of The Army Non-toxic adjuvant formulation comprising a monophosphoryl lipid a (MPLA)-containing liposome composition and a saponin
JP6873698B2 (ja) 2014-04-25 2021-05-19 中外製薬株式会社 ４環性化合物の新規結晶
TWI831128B (zh) 2014-04-25 2024-02-01 日商中外製藥股份有限公司 以高用量含有４環性化合物的製劑
TWI803187B (zh) 2014-08-08 2023-05-21 日商中外製藥股份有限公司 包含４環性化合物的非晶質體之固體分散體及製劑
KR102584344B1 (ko) 2015-01-16 2023-09-27 추가이 세이야쿠 가부시키가이샤 병용 의약
CN108778289B (zh) 2015-11-06 2020-11-17 佐剂技术公司 三萜皂苷类似物
US10695424B2 (en) * 2016-12-07 2020-06-30 Glaxosmithkline Biologicals S.A. Method of making a liposome composition
CA3061205A1 (fr) 2017-04-25 2018-11-01 Memorial Sloan Kettering Cancer Center Analogues de saponine triterpenique
BR112019025104A2 (pt) 2017-05-30 2020-06-23 Glaxosmithkline Biologicals S.A. Método de fabricar um sistema de entrega não viral, sistema de entrega não viral, e, composição
SG11202001826YA (en) * 2017-10-16 2020-03-30 Adjuvance Technologies Inc Triterpene saponin analogues
BR112020010790A2 (pt) 2017-12-01 2020-11-10 Glaxosmithkline Biologicals S.A. purificação da saponina
WO2019106191A1 (fr) 2017-12-01 2019-06-06 Glaxosmithkline Biologicals Sa Extraction de saponine
BR112020025499A2 (pt) 2018-06-29 2021-03-09 Chugai Seiyaku Kabushiki Kaisha Composição farmacêutica que compreende agente básico pouco solúvel
PL3848361T3 (pl) 2018-09-04 2025-07-07 Chugai Seiyaku Kabushiki Kaisha Sposób wytwarzania związku tetracyklicznego
EP3886901A1 (fr) * 2018-11-29 2021-10-06 GlaxoSmithKline Biologicals S.A. Procédés de fabrication d'un adjuvant
WO2020245207A1 (fr) * 2019-06-05 2020-12-10 Glaxosmithkline Biologicals Sa Purification de saponine
BR112021026775A2 (pt) * 2019-08-05 2022-05-10 Glaxosmithkline Biologicals Sa Processo para preparar uma composição que compreende um polipeptídeo de proteína d
EP4021407A1 (fr) 2019-08-30 2022-07-06 GlaxoSmithKline Biologicals S.A. Procédé de fabrication de nanoparticules lipidiques mélangées par jet
CN121013730A (zh) * 2023-03-15 2025-11-25 联合免疫股份有限公司 脂质颗粒
TW202600165A (zh) * 2024-02-29 2026-01-01 優億股份有限公司 佐劑組合物、包含該佐劑組合物的藥物組合物以及預防或治療病毒感染、細菌感染、原蟲感染或癌症引起的疾病的方法

Family Cites Families (16)

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Publication number Priority date Publication date Assignee Title
US5804381A (en) 1996-10-03 1998-09-08 Cornell Research Foundation Isolated nucleic acid molecule encoding an esophageal cancer associated antigen, the antigen itself, and uses thereof
US5776468A (en) * 1993-03-23 1998-07-07 Smithkline Beecham Biologicals (S.A.) Vaccine compositions containing 3-0 deacylated monophosphoryl lipid A
UA56132C2 (uk) * 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
DE19803453A1 (de) * 1998-01-30 1999-08-12 Boehringer Ingelheim Int Vakzine
CZ298364B6 (cs) 1998-02-05 2007-09-05 Smithkline Beecham Biologicals S. A. Deriváty antigenu asociovaných s nádory z MAGE rodiny a sekvence nukleových kyselin kodující tyto deriváty, jejich použití pro prípravu fúzních proteinu a prostredku pro vakcinaci
NZ508013A (en) * 1998-05-07 2003-08-29 Corixa Corp Adjuvant composition for use with an antigen in a vaccine composition
JP3765232B2 (ja) 2000-11-16 2006-04-12 株式会社ジェイテクト 電動式パワーステアリング装置及びこれに用いる歯車の製造方法
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GB0411411D0 (en) * 2004-05-21 2004-06-23 Glaxosmithkline Biolog Sa Vaccines
WO2006056142A1 (fr) * 2004-11-29 2006-06-01 Changchun Huapu Biotechnology Co., Ltd. Desoxynucleotides cpg a brin unique a utiliser comme adjuvant
PE20110072A1 (es) * 2005-06-27 2011-02-04 Glaxosmithkline Biolog Sa Composicion inmunogenica
TWI457133B (zh) * 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
PT2114993E (pt) 2007-01-15 2012-11-28 Glaxosmithkline Biolog Sa Vacina
ES2398492T3 (es) 2007-01-15 2013-03-19 Glaxosmithkline Biologicals Sa Proteínas de fusión que comprenden los antígenos de rechazo tumoral NY-ESO-1 y LAGE-1
JP5331105B2 (ja) * 2007-05-24 2013-10-30 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 凍結乾燥抗原組成物
GB0910045D0 (en) * 2009-06-10 2009-07-22 Glaxosmithkline Biolog Sa Novel compositions

Also Published As

Publication number Publication date
RS53550B1 (sr) 2015-02-27
CA2764421A1 (fr) 2010-12-16
PE20120319A1 (es) 2012-04-16
SMT201400134B (it) 2014-11-10
US20180021417A1 (en) 2018-01-25
EP2440242A1 (fr) 2012-04-18
BRPI1012890A2 (en) 2018-02-27
CA2764421C (fr) 2016-12-06
AU2010257538B2 (en) 2016-10-20
WO2010142685A1 (fr) 2010-12-16
ES2494442T3 (es) 2014-09-15
NZ596503A (en) 2013-08-30
UA104888C2 (uk) 2014-03-25
DOP2011000346A (es) 2012-01-15
PT2440242E (pt) 2014-08-29
CL2011003113A1 (es) 2012-08-31
IL216231A0 (en) 2012-01-31
JP5647677B2 (ja) 2015-01-07
JP5977789B2 (ja) 2016-08-24
AU2010257538A1 (en) 2011-12-08
PL2440242T3 (pl) 2014-11-28
CN104367997B (zh) 2019-01-22
MX2011013162A (es) 2012-01-30
JP2016193912A (ja) 2016-11-17
JP2015042646A (ja) 2015-03-05
US20120087976A1 (en) 2012-04-12
MY159819A (en) 2017-02-15
HRP20140792T1 (hr) 2014-10-10
CY1115522T1 (el) 2017-01-04
JP2012529464A (ja) 2012-11-22
DK2440242T3 (da) 2014-09-01
JP6261647B2 (ja) 2018-01-17
EA024074B1 (ru) 2016-08-31
EA201190286A1 (ru) 2012-06-29
CN102458457A (zh) 2012-05-16
GB0910046D0 (en) 2009-07-22
CN102458457B (zh) 2015-05-20
KR101473686B1 (ko) 2014-12-18
EP2440242B1 (fr) 2014-06-25
CO6440528A2 (es) 2012-05-15
CN104367997A (zh) 2015-02-25
BRPI1012890B1 (pt) 2022-03-22
SG176638A1 (en) 2012-01-30
SI2440242T1 (sl) 2014-09-30
KR20120031497A (ko) 2012-04-03

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