EA201200765A1 - Способ получения полиморфной модификации холиновой соли производного пиримидин-5-илуксусной кислоты - Google Patents

Способ получения полиморфной модификации холиновой соли производного пиримидин-5-илуксусной кислоты

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Publication number
EA201200765A1
EA201200765A1 EA201200765A EA201200765A EA201200765A1 EA 201200765 A1 EA201200765 A1 EA 201200765A1 EA 201200765 A EA201200765 A EA 201200765A EA 201200765 A EA201200765 A EA 201200765A EA 201200765 A1 EA201200765 A1 EA 201200765A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrimidin
iluxic
acid
salt derivative
polymorphic modification
Prior art date
Application number
EA201200765A
Other languages
English (en)
Inventor
Дхилип Кришнамёрти
Хуан-Мануэль Родригес-Дели
Михаэль Шуль
Сяоцзунь Ван
Биншио Ян
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43447007&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201200765(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA201200765A1 publication Critical patent/EA201200765A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

В заявке описан способ получения холиновой соли [4,6-бис(диметиламино)-2-(4-{[4-(трифторметил)бензоил]амино}бензил)пиримидин-5-ил]уксусной кислоты. Предлагаемый в изобретении способ позволяет получать подобную соль в более чистой форме. В заявке описана также более чистая форма холиновой соли [4,6-бис-(диметиламино)-2-(4-{[4-(трифторметил)бензоил]амино}бензил)пиримидин-5-ил]уксусной кислоты.
EA201200765A 2009-11-24 2010-11-19 Способ получения полиморфной модификации холиновой соли производного пиримидин-5-илуксусной кислоты EA201200765A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26387109P 2009-11-24 2009-11-24
PCT/US2010/057312 WO2011066176A1 (en) 2009-11-24 2010-11-19 Process for preparing a polymorph of the choline salt of a pyrimidin-5-yl acetic acid derivative

Publications (1)

Publication Number Publication Date
EA201200765A1 true EA201200765A1 (ru) 2013-02-28

Family

ID=43447007

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201200765A EA201200765A1 (ru) 2009-11-24 2010-11-19 Способ получения полиморфной модификации холиновой соли производного пиримидин-5-илуксусной кислоты

Country Status (16)

Country Link
US (1) US20110294828A1 (ru)
EP (1) EP2504319A1 (ru)
JP (1) JP2013512242A (ru)
KR (1) KR20120101399A (ru)
CN (1) CN102666499A (ru)
AR (1) AR079128A1 (ru)
AU (1) AU2010324980A1 (ru)
BR (1) BR112012012384A2 (ru)
CA (1) CA2781610A1 (ru)
CL (1) CL2012001170A1 (ru)
EA (1) EA201200765A1 (ru)
IL (1) IL218990A0 (ru)
MX (1) MX2012006003A (ru)
PH (1) PH12012500953A1 (ru)
TW (1) TW201200501A (ru)
WO (1) WO2011066176A1 (ru)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4570630A (en) 1983-08-03 1986-02-18 Miles Laboratories, Inc. Medicament inhalation device
EP0211595B1 (en) 1985-07-30 1991-11-13 Glaxo Group Limited Devices for administering medicaments to patients
SE453566B (sv) 1986-03-07 1988-02-15 Draco Ab Anordning vid pulverinhalatorer
SG45171A1 (en) 1990-03-21 1998-01-16 Boehringer Ingelheim Int Atomising devices and methods
DE4318455A1 (de) 1993-06-03 1994-12-08 Boehringer Ingelheim Kg Kapselhalterung
DE19536902A1 (de) 1995-10-04 1997-04-10 Boehringer Ingelheim Int Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung
ES2257616T3 (es) * 2003-04-25 2006-08-01 Actimis Pharmaceuticals, Inc. Derivados del acido pirimidinilacetico utiles para el tratamiento de enfermedades mediadas por crth2.
CA2659189A1 (en) 2006-08-03 2008-02-07 Bromine Compounds Ltd. Method, device and system for water treatment
NZ581856A (en) * 2007-06-21 2011-05-27 Actimis Pharmaceuticals Inc Amine salts of the CRTH2 antagonist {4,6-bis(dimethylamino)-2-(4-(4-(trifluoromethyl)benzamido)benzyl)pyrimidin-5-yl} acetic acid
WO2008156780A1 (en) 2007-06-21 2008-12-24 Actimis Pharmaceuticals, Inc. Particulates of a crth2 antagonist

Also Published As

Publication number Publication date
PH12012500953A1 (en) 2013-01-07
CN102666499A (zh) 2012-09-12
AR079128A1 (es) 2011-12-28
US20110294828A1 (en) 2011-12-01
EP2504319A1 (en) 2012-10-03
WO2011066176A1 (en) 2011-06-03
TW201200501A (en) 2012-01-01
BR112012012384A2 (pt) 2016-03-22
MX2012006003A (es) 2012-06-19
AU2010324980A1 (en) 2012-05-03
KR20120101399A (ko) 2012-09-13
CL2012001170A1 (es) 2012-10-12
JP2013512242A (ja) 2013-04-11
IL218990A0 (en) 2012-06-28
CA2781610A1 (en) 2011-06-03

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