EA201290077A1 - Соединения-801 - Google Patents

Соединения-801

Info

Publication number
EA201290077A1
EA201290077A1 EA201290077A EA201290077A EA201290077A1 EA 201290077 A1 EA201290077 A1 EA 201290077A1 EA 201290077 A EA201290077 A EA 201290077A EA 201290077 A EA201290077 A EA 201290077A EA 201290077 A1 EA201290077 A1 EA 201290077A1
Authority
EA
Eurasian Patent Office
Prior art keywords
preparation
pharmaceutical compositions
connections
archchnh
intermediates
Prior art date
Application number
EA201290077A
Other languages
English (en)
Other versions
EA020566B1 (ru
Inventor
Лилиан Алькараз
Эндрю Бэйли
Николас Киндон
Original Assignee
Астразенека Аб
Пулмаджин Терапеутикс (Синерджи) Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41129405&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201290077(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Астразенека Аб, Пулмаджин Терапеутикс (Синерджи) Лимитед filed Critical Астразенека Аб
Publication of EA201290077A1 publication Critical patent/EA201290077A1/ru
Publication of EA020566B1 publication Critical patent/EA020566B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Спироциклические производные амидов формулы (I), где ArCHCHNH- представляет собой β-адренорецептор-связывающую группу, способ их получения, фармацевтические композиции, содержащие их, способ изготовления таких фармацевтических композиций, их применение в терапии и промежуточные соединения для применения в их получении.
EA201290077A 2009-07-31 2010-07-29 Спироциклические производные амидов EA020566B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0913342.2A GB0913342D0 (en) 2009-07-31 2009-07-31 Compounds - 801
PCT/GB2010/051242 WO2011012896A2 (en) 2009-07-31 2010-07-29 Compounds - 801

Publications (2)

Publication Number Publication Date
EA201290077A1 true EA201290077A1 (ru) 2012-08-30
EA020566B1 EA020566B1 (ru) 2014-12-30

Family

ID=41129405

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201290077A EA020566B1 (ru) 2009-07-31 2010-07-29 Спироциклические производные амидов

Country Status (33)

Country Link
US (2) US8455483B2 (ru)
EP (1) EP2459572B1 (ru)
JP (1) JP5612092B2 (ru)
KR (1) KR101664525B1 (ru)
CN (1) CN102625808B (ru)
AR (1) AR080601A1 (ru)
AU (1) AU2010277384B2 (ru)
BR (1) BR112012008043A2 (ru)
CA (1) CA2768527C (ru)
CL (1) CL2012000263A1 (ru)
CO (1) CO6491034A2 (ru)
CR (1) CR20120054A (ru)
CU (1) CU24103B1 (ru)
DO (1) DOP2012000032A (ru)
EA (1) EA020566B1 (ru)
ES (1) ES2702467T3 (ru)
GB (1) GB0913342D0 (ru)
GT (1) GT201200028A (ru)
HN (1) HN2012000217A (ru)
IL (1) IL217557A (ru)
MX (1) MX2012001232A (ru)
MY (1) MY163117A (ru)
NI (1) NI201200018A (ru)
NZ (1) NZ597589A (ru)
PE (1) PE20121441A1 (ru)
SA (1) SA110310628B1 (ru)
SG (1) SG177634A1 (ru)
TR (1) TR201819140T4 (ru)
TW (1) TWI443103B (ru)
UA (1) UA106887C2 (ru)
UY (1) UY32814A (ru)
WO (1) WO2011012896A2 (ru)
ZA (1) ZA201201473B (ru)

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KR101273200B1 (ko) 2008-02-06 2013-06-17 펄마젠 쎄라퓨틱스 (시너지) 리미티드 화합물
TWI466885B (zh) 2009-07-31 2015-01-01 Japan Tobacco Inc 含氮螺環化合物及其醫藥用途
GB0913342D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab Compounds - 801
GB201021992D0 (en) * 2010-12-23 2011-02-02 Astrazeneca Ab Compound
GB201021979D0 (en) * 2010-12-23 2011-02-02 Astrazeneca Ab New compound
WO2016179349A1 (en) * 2015-05-05 2016-11-10 Northwestern University Cxcr4 chemokine receptor modulators
WO2018059537A1 (zh) * 2016-09-30 2018-04-05 四川海思科制药有限公司 一种二氮杂螺[5.5]十一碳烷衍生物及其用途
JP6963616B2 (ja) 2016-12-14 2021-11-10 ベイジン ショウバイ ファーマシューティカル カンパニー，リミティッド ４級アンモニウム塩構造を有する二官能性化合物
CN110678463B (zh) 2017-06-01 2023-06-06 百时美施贵宝公司 经取代的含氮化合物
EP3682906A1 (en) * 2019-01-17 2020-07-22 Julius-Maximilians-Universität Würzburg Compound targeting norepinephrine transporter

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Also Published As

Publication number Publication date
AR080601A1 (es) 2012-04-25
CU20120021A7 (es) 2012-06-21
MY163117A (en) 2017-08-15
NI201200018A (es) 2012-09-10
ZA201201473B (en) 2012-11-28
EP2459572B1 (en) 2018-09-12
JP2013500958A (ja) 2013-01-10
WO2011012896A2 (en) 2011-02-03
CL2012000263A1 (es) 2012-08-31
EA020566B1 (ru) 2014-12-30
EP2459572A2 (en) 2012-06-06
TWI443103B (zh) 2014-07-01
CO6491034A2 (es) 2012-07-31
US20110053909A1 (en) 2011-03-03
TW201107335A (en) 2011-03-01
UY32814A (es) 2011-02-28
US20130018037A1 (en) 2013-01-17
HN2012000217A (es) 2015-03-09
TR201819140T4 (tr) 2019-01-21
ES2702467T3 (es) 2019-03-01
GB0913342D0 (en) 2009-09-16
KR20120056838A (ko) 2012-06-04
WO2011012896A3 (en) 2011-04-21
MX2012001232A (es) 2012-03-26
CA2768527C (en) 2017-07-11
NZ597589A (en) 2013-12-20
SA110310628B1 (ar) 2014-02-27
BR112012008043A2 (pt) 2020-08-25
JP5612092B2 (ja) 2014-10-22
GT201200028A (es) 2013-09-26
AU2010277384B2 (en) 2014-01-30
CN102625808B (zh) 2014-08-27
KR101664525B1 (ko) 2016-10-11
PE20121441A1 (es) 2012-11-16
CA2768527A1 (en) 2011-02-03
DOP2012000032A (es) 2017-08-15
US8455483B2 (en) 2013-06-04
UA106887C2 (ru) 2014-10-27
IL217557A0 (en) 2012-02-29
CR20120054A (es) 2012-03-26
US8476265B2 (en) 2013-07-02
SG177634A1 (en) 2012-02-28
CN102625808A (zh) 2012-08-01
CU24103B1 (es) 2015-07-30
IL217557A (en) 2015-01-29
HK1171755A1 (en) 2013-04-05
AU2010277384A1 (en) 2012-03-22

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU