EA201301183A1 - Гетероциклические соединения в качестве ингибиторов киназ - Google Patents

Гетероциклические соединения в качестве ингибиторов киназ

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EA201301183A1
EA201301183A1 EA201301183A EA201301183A EA201301183A1 EA 201301183 A1 EA201301183 A1 EA 201301183A1 EA 201301183 A EA201301183 A EA 201301183A EA 201301183 A EA201301183 A EA 201301183A EA 201301183 A1 EA201301183 A1 EA 201301183A1
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diseases
kinase
disease
heterocyclic compounds
compounds
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EA201301183A
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EA034193B1 (ru
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Михаэль Альмштеттер
Михаэль Торманн
Андреас Тремль
Роланд Кёстлер
Нассер Йехия
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Оригенис Гмбх
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Publication of EA201301183A1 publication Critical patent/EA201301183A1/ru
Publication of EA034193B1 publication Critical patent/EA034193B1/ru

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Abstract

Изобретение относится к новым соединениям формулы (I)которые способны ингибировать одну или несколько киназ, в особенности SYK (селезеночная тирозинкиназа), LRRK2 (богатая лейцином повторная киназа 2) и/или MYLK (киназа легких цепей миозина), или их мутанты. Соединения находят применение при лечении различных заболеваний. Эти заболевания включают аутоиммунные заболевания, воспалительные заболевания, заболевания костей, заболевания обмена веществ, неврологические и нейродегенеративные заболевания, рак, сердечно-сосудистые заболевания, аллергии, астму, болезнь Альцгеймера, болезнь Паркинсона, нарушения кожи, заболевания глаз, инфекционные заболевания и гормоносвязанные заболевания.
EA201301183A 2011-04-21 2012-04-23 Гетероциклические соединения в качестве ингибиторов киназ EA034193B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161517581P 2011-04-21 2011-04-21
PCT/EP2012/001736 WO2012143143A1 (en) 2011-04-21 2012-04-23 Heterocyclic compounds as kinase inhibitors

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EA201301183A1 true EA201301183A1 (ru) 2014-04-30
EA034193B1 EA034193B1 (ru) 2020-01-15

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US (1) US9499535B2 (ru)
EP (1) EP2699572B1 (ru)
JP (1) JP6278406B2 (ru)
KR (1) KR101649610B1 (ru)
CN (1) CN103717597B (ru)
AP (1) AP2013007252A0 (ru)
AU (1) AU2012244549B2 (ru)
BR (1) BR112013026744B1 (ru)
CA (1) CA2831680C (ru)
CL (1) CL2013003052A1 (ru)
CO (1) CO6831983A2 (ru)
CR (1) CR20130537A (ru)
CU (1) CU20130144A7 (ru)
EA (1) EA034193B1 (ru)
EC (1) ECSP13012984A (ru)
GT (1) GT201300259A (ru)
IL (1) IL228967B (ru)
MA (1) MA35123B1 (ru)
MX (1) MX365784B (ru)
PE (1) PE20140927A1 (ru)
PH (1) PH12013502184A1 (ru)
SG (1) SG194216A1 (ru)
TN (1) TN2013000422A1 (ru)
TW (1) TWI557121B (ru)
WO (1) WO2012143143A1 (ru)

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