EA201400152A1 - Микроорганизмы, продуцирующие эйкозапентаеновую кислоту, композиции, содержащие жирные кислоты, и способы их получения и применения - Google Patents

Микроорганизмы, продуцирующие эйкозапентаеновую кислоту, композиции, содержащие жирные кислоты, и способы их получения и применения

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EA201400152A1
EA201400152A1 EA201400152A EA201400152A EA201400152A1 EA 201400152 A1 EA201400152 A1 EA 201400152A1 EA 201400152 A EA201400152 A EA 201400152A EA 201400152 A EA201400152 A EA 201400152A EA 201400152 A1 EA201400152 A1 EA 201400152A1
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Prior art keywords
acid
fatty acids
eicopapenna
microorganisms
produce
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EA201400152A
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English (en)
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EA035287B1 (ru
Inventor
Кирк Е. Эпт
Пол Уоррен Беренс
Джон Милтон Хансен
III Джозеф У. Пфайфер
Трейси Линн Шталь
Росс Зиркл
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ДСМ АйПи АССЕТС Б.В.
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Publication of EA201400152A1 publication Critical patent/EA201400152A1/ru
Publication of EA035287B1 publication Critical patent/EA035287B1/ru

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    • C—CHEMISTRY; METALLURGY
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6432—Eicosapentaenoic acids [EPA]
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6434—Docosahexenoic acids [DHA]
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    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/10—General cosmetic use

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Abstract

Изобретение имеет отношение к микробным маслам, содержащим омега-3 полиненасыщенные жирные кислоты, включающие докозагексаеновую кислоту, эйкозапентаеновую кислоту и необязательно докозапентаеновую кислоту, и лекарственным формам, содержащим такие масла.
EA201400152A 2011-07-21 2012-07-20 Микроорганизмы, продуцирующие эйкозапентаеновую кислоту, композиции, содержащие жирные кислоты, и способы их получения и применения EA035287B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161510441P 2011-07-21 2011-07-21
PCT/US2012/047731 WO2013013211A1 (en) 2011-07-21 2012-07-20 Fatty acid compositions

Publications (2)

Publication Number Publication Date
EA201400152A1 true EA201400152A1 (ru) 2014-05-30
EA035287B1 EA035287B1 (ru) 2020-05-25

Family

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Family Applications (1)

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EA201400152A EA035287B1 (ru) 2011-07-21 2012-07-20 Микроорганизмы, продуцирующие эйкозапентаеновую кислоту, композиции, содержащие жирные кислоты, и способы их получения и применения

Country Status (14)

Country Link
US (6) US9222112B2 (ru)
EP (2) EP2734197A4 (ru)
JP (1) JP6208125B2 (ru)
KR (2) KR102149116B1 (ru)
CN (3) CN108771240A (ru)
AU (1) AU2012285806B2 (ru)
BR (2) BR112014001126B1 (ru)
CA (1) CA2842272C (ru)
EA (1) EA035287B1 (ru)
HK (1) HK1198515A1 (ru)
MX (1) MX342216B (ru)
PH (1) PH12014500105A1 (ru)
TW (1) TWI582235B (ru)
WO (1) WO2013013211A1 (ru)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011090493A1 (en) 2010-01-19 2011-07-28 Martek Biosciences Corporation Eicosapentaenoic acid-producing microorganisms, fatty acid compositions, and methods of making and uses thereof
HK1198515A1 (en) 2011-07-21 2015-05-15 Dsm Ip Assets B.V. Fatty acid compositions
KR20150098611A (ko) * 2012-10-23 2015-08-28 디킨 유니버시티 트리글리세라이드를 감소시키기 위한 방법
EP3066183A4 (en) * 2013-11-08 2017-09-27 Omega Protein Corporation Purification of dpa enriched oil
JP2018504887A (ja) * 2014-12-12 2018-02-22 ディーエスエム アイピー アセッツ ビー．ブイ． 水産養殖試料における使用のための試料添加材料
WO2017006918A1 (ja) 2015-07-03 2017-01-12 国立大学法人九州大学 微生物油産生ラビリンチュラ類、微生物油、ならびにそれらの作成方法およびそれらの使用
WO2017055169A1 (en) 2015-10-01 2017-04-06 Dsm Ip Assets B.V. Supplement material for use in pet food
WO2017131188A1 (ja) * 2016-01-28 2017-08-03 日本水産株式会社 高度不飽和脂肪酸を含む油脂の製造方法
FI128587B (en) * 2017-12-22 2020-08-31 Neste Oyj Process for the production of free fatty acids
EP4570889A3 (en) * 2017-12-22 2026-03-04 DSM IP Assets B.V. Oil comprising at least one polyunsaturated fatty acid having at least 20 carbon atoms (lc-pufa)
WO2019185910A2 (en) * 2018-03-29 2019-10-03 Dsm Ip Assets B.V. Novel use of substituted 2h-chromens and their derivatives
BR112020019783A2 (pt) * 2018-03-29 2021-01-05 Dsm Ip Assets B.V. Uso inovador de 2h-cromenos substituídos e seus derivados
EP3586640A1 (en) * 2018-06-21 2020-01-01 Nuseed Pty Ltd Dha enriched polyunsaturated fatty acid compositions
KR102050070B1 (ko) * 2019-03-29 2019-11-28 (주)알피바이오 산화안정성이 있는 유지조성물 및 이를 포함하는 연질캡슐제제
WO2022211017A1 (ja) * 2021-04-01 2022-10-06 花王株式会社 油脂組成物
AU2022328181A1 (en) 2021-08-09 2024-03-21 Kentucky Equine Research, Inc. Compositions and methods for modulating equine fatty acid profiles
US20250017254A1 (en) * 2021-11-24 2025-01-16 Dsm Ip Assets B.V. COMPOSITIONS HAVING HIGH LEVELS OF DPA (n-3) AND METHODS FOR PRODUCING
SE2151489A1 (en) * 2021-12-07 2023-06-08 Mycorena Ab A food product or food ingredient comprising fungi biomass with an increased intracellular fat content
KR102795205B1 (ko) * 2022-01-27 2025-04-10 씨제이제일제당 (주) 냉각 공정을 이용한 오일 회수율이 향상된 바이오오일 추출 방법
BE1031793B1 (nl) 2023-07-11 2025-02-11 Bc Int Consulting Vetsamenstellingen met Omega-3 vetzuurresiduen
WO2025019424A1 (en) * 2023-07-14 2025-01-23 Dsm Ip Assets B.V. Microbial oils having high epa content and methods of making the same

Family Cites Families (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4485173A (en) 1981-01-19 1984-11-27 Cpc International Inc. Preparation of fats and oils
DE3783396T2 (de) 1986-07-08 1993-07-29 Suntory Ltd Verfahren zur herstellung von bishomo-gamma-linolensaeure und eicosapentaensaeure.
US5246841A (en) 1986-12-26 1993-09-21 Sagami Chemical Research Center Microbial process for production of eicosapentaenoic acid
EP0273708B1 (en) 1986-12-26 1994-03-23 Sagami Chemical Research Center Process for production of eicosapentaenoic acid
JP2746371B2 (ja) 1987-12-21 1998-05-06 サントリー株式会社 ビスホモ−γ−リノレン酸及びこれを含有する脂質の製造方法
JP2710344B2 (ja) 1988-07-13 1998-02-10 サントリー株式会社 高度不飽和脂肪酸及びこれを含有する脂質の製造方法
US6451567B1 (en) * 1988-09-07 2002-09-17 Omegatech, Inc. Fermentation process for producing long chain omega-3 fatty acids with euryhaline microorganisms
US5340742A (en) 1988-09-07 1994-08-23 Omegatech Inc. Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids
US5130242A (en) 1988-09-07 1992-07-14 Phycotech, Inc. Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids
US5698244A (en) 1988-09-07 1997-12-16 Omegatech Inc. Method for raising animals having high concentrations of omega-3 highly unsaturated fatty acids
US5340594A (en) 1988-09-07 1994-08-23 Omegatech Inc. Food product having high concentrations of omega-3 highly unsaturated fatty acids
US5244921A (en) 1990-03-21 1993-09-14 Martek Corporation Eicosapentaenoic acids and methods for their production
JPH078215A (ja) 1993-04-30 1995-01-13 Kawasaki Steel Corp ドコサヘキサエン酸含有海洋性微細藻類食品素材およびその製造方法
AU5346296A (en) 1995-04-17 1996-11-07 Japan As Represented By Director-General Of Agency Of Industrial Science And Technology Novel microorganisms capable of producing highly unsaturated fatty acids and process for producing highly unsaturated fa tty acids by using the microorganisms
GB9514649D0 (en) 1995-07-18 1995-09-13 Zeneca Ltd Extraction of triglycerides from microorganisms
ATE328104T1 (de) 1996-03-28 2006-06-15 Dsm Ip Assets Bv Mikrobielles polyungesättigte fettsäure enthaltendes öl und verfahren zur herstellung eines öls aus pasteurisierter und granulierter biomasse
US6255505B1 (en) 1996-03-28 2001-07-03 Gist-Brocades, B.V. Microbial polyunsaturated fatty acid containing oil from pasteurised biomass
US20030143659A1 (en) 1996-03-28 2003-07-31 Hendrik Louis Bijl Process for the preparation of a granular microbial biomass and isolation of a compound thereform
DE69737063T2 (de) 1996-07-23 2007-07-19 Nagase Chemtex Corp. Verfahren zur herstellung von decosahexaensäure und decosapentsäure
JP3792309B2 (ja) * 1996-08-30 2006-07-05 サントリー株式会社 不飽和脂肪酸含有油脂の製造方法
JP4197744B2 (ja) 1996-12-27 2008-12-17 サントリー株式会社 微生物培養用培地、並びに不飽和脂肪酸またはこれを含有する脂質の製造方法
JP2001512029A (ja) 1997-08-01 2001-08-21 マーテック・バイオサイエンスィズ・コーポレーション Ｄｈａ含有栄養組成物およびそれらの製造方法
US6531150B1 (en) 1997-10-30 2003-03-11 Morishita Jintan Co., Ltd. Encapsulated unsaturated fatty acid substance and method for producing the same
JP4175698B2 (ja) 1998-06-19 2008-11-05 サントリー株式会社 新規なトリグリセリド及びそれを含む組成物
US8003772B2 (en) 1999-01-14 2011-08-23 Martek Biosciences Corporation Chimeric PUFA polyketide synthase systems and uses thereof
CA2362515C (en) 1999-03-04 2008-07-15 Suntory Limited Utilization of material containing docosapentaenoic acid
JP4593721B2 (ja) 1999-05-19 2010-12-08 グンゼ株式会社 タッチパネル
US6579714B1 (en) 1999-09-29 2003-06-17 Micro Gaia Co., Ltd. Method of culturing algae capable of producing phototrophic pigments, highly unsaturated fatty acids, or polysaccharides at high concentration
AU2001232786A1 (en) 2000-01-11 2001-07-24 Monsanto Company Process for making an enriched mixture of polyunsaturated fatty acid esters
RU2336307C2 (ru) 2000-01-19 2008-10-20 Мартек Биосайнсис Корпорейшн Способ получения липидов (варианты) и липиды, полученные этим способом
EP2960325B1 (en) 2000-01-28 2017-09-27 DSM IP Assets B.V. Enhanced production of lipids containing polyenoic fatty acids by high density cultures of eukaryotic microbes in fermentors
AU3987601A (en) 2000-02-24 2001-09-03 Thomas Veach Long Process for production of carotenoids, xanthophylls and apo-carotenoids utilizing eukaryotic microorganisms
KR100680906B1 (ko) 2000-03-29 2007-02-08 카운슬 오브 사이언티픽 앤드 인더스트리얼 리서치 트라우스토키트리드 진균에서 다불포화 지방산의 수준을증가시키는 방법
JP3425622B2 (ja) 2000-03-30 2003-07-14 独立行政法人産業技術総合研究所 ラビリンチュラ属菌を用いた高度不飽和脂肪酸含有培養物および高度不飽和脂肪酸含有油脂の製造方法
US6410282B1 (en) 2000-03-30 2002-06-25 Council Of Scientific And Industrial Research Method for enhancing levels of polyunsaturated fatty acids in thraustochytrid fungi
EP1178118A1 (en) 2000-08-02 2002-02-06 Dsm N.V. Isolation of microbial oils
TWI324181B (en) 2001-04-16 2010-05-01 Martek Biosciences Corp Product and process for transformation of thraustochytriales microorganisms
AU2002309856B2 (en) * 2001-05-14 2008-10-23 Dsm Ip Assets B.V. Production and use of a polar lipid-rich fraction containing omega-3 and/or omega-6 highly unsaturated fatty acids from microbes, genetically modified plant seeds and marine organisms
WO2003004667A1 (en) 2001-07-02 2003-01-16 Suntory Limited Process for producing fat comprising triglyceride containing highly unsaturated fatty acid
US20030060509A1 (en) 2001-08-24 2003-03-27 Elswyk Mary Van Products containing highly unsaturated fatty acids for use by women and their children during stages of preconception, pregnancy and lactation/post-partum
DE10151155A1 (de) 2001-10-19 2003-05-08 Nutrinova Gmbh Native PUFA-Triglyceridmischungen mit einem hohen Gehalt an mehrfach ungesättigten Fettsäuren sowie Verfahren zu deren Herstellung und deren Verwendung
US6677470B2 (en) 2001-11-20 2004-01-13 Natural Asa Functional acylglycerides
US7419596B2 (en) * 2001-12-12 2008-09-02 Martek Biosciences Corporation Extraction and winterization of lipids from oilseed and microbial sources
US20040203120A1 (en) 2002-03-22 2004-10-14 Council Of Scientific And Industrial Research Method for enhancing levels of polyunsaturated fatty acids in thraustochytrid protists
WO2003092628A2 (en) 2002-05-03 2003-11-13 Martek Biosciences Corporation High-quality lipids and methods for producing by enzymatic liberation from biomass
MXPA04012915A (es) 2002-06-19 2005-03-31 Dsm Ip Assets Bv Preparacion de aceite microbiano.
US7998712B2 (en) 2002-09-13 2011-08-16 Suntory Holdings Limited Process for production of transesterified oils/fats or triglycerides
AU2003272095B2 (en) 2002-10-11 2010-04-08 Nippon Suisan Kaisha, Ltd. Process for producing microbial fat or oil having lowered unsaponifiable matter content and said fat or oil
RU2235481C2 (ru) 2002-11-20 2004-09-10 Общество с ограниченной ответственностью "Гелла-Фарма" Способ получения биологически активной добавки к пище (варианты)
JP4280158B2 (ja) * 2002-12-27 2009-06-17 富士フイルム株式会社 ドコサヘキサエン酸生産能を有する微生物及びその利用
EP1604255A1 (en) 2003-03-10 2005-12-14 Koninklijke Philips Electronics N.V. Current mirror
MY144341A (en) 2003-03-27 2011-08-29 Suntory Holdings Ltd Lipid-improving agent and composition containing lipid-improving agent
US20050019880A1 (en) 2003-03-31 2005-01-27 Council Of Scientific And Industrial Research Method of enhancing levels of polyunsaturated fatty acids in thraustochytrid protists
US6846942B2 (en) 2003-05-20 2005-01-25 David Rubin Method for preparing pure EPA and pure DHA
JP4441681B2 (ja) 2003-06-27 2010-03-31 奥村遊機株式会社 遊技機
WO2005021735A1 (en) 2003-09-01 2005-03-10 Novozymes A/S Method for increasing yield of biomass of and/or components of biomass from marine microorganisms
JP4733043B2 (ja) 2003-10-02 2011-07-27 マーテック バイオサイエンシーズ コーポレーション 改変された量の塩化物およびカリウムを使用した微細藻類における高レベルのｄｈａの産生法
DE10352838A1 (de) 2003-11-10 2005-07-07 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Verfahren zur Kultivierung von Mikroorganismen der Gattung Thraustochytriales unter Verwendung eines optimierten Niedrigsalzmediums
TWI365716B (en) 2003-12-02 2012-06-11 Suntory Holdings Ltd Oil or fat and oil compositions containing phospholipids and a long-chain polyunsaturated fatty acid supply compound, and food using same
SE0303513D0 (sv) 2003-12-19 2003-12-19 Pronova Biocare As Use of a fatty acid composition comprising at least one of epa and dha or any combinations thereof
KR101167331B1 (ko) 2003-12-30 2012-07-19 디에스엠 아이피 어셋츠 비.브이. 탈기 방법
GB0403247D0 (en) 2004-02-13 2004-03-17 Tillotts Pharma Ag A pharmaceutical composition
DE102004060340A1 (de) 2004-07-16 2006-02-09 Basf Plant Science Gmbh Verfahren zur Erhöhung des Gehalts an mehrfach ungesättigten langkettigen Fettsäuren in transgenen Organismen
DK1776450T3 (da) 2004-08-12 2010-06-21 Nippon Suisan Kaisha Ltd Fremgangsmåde til polyumættet fedtsyreproduktion under anvendelse af hidtil ukendt cellepræservationsteknik
WO2006022356A1 (ja) 2004-08-24 2006-03-02 Suntory Limited ジアシルグリセロールの含量を任意に含んだ微生物油脂の製造法並びに該油脂
JP4624040B2 (ja) 2004-09-06 2011-02-02 日本水産株式会社 菌体培養方法
TWI397582B (zh) 2004-11-04 2013-06-01 Monsanto Technology Llc 油組合物之製備方法
US7550286B2 (en) 2004-11-04 2009-06-23 E. I. Du Pont De Nemours And Company Docosahexaenoic acid producing strains of Yarrowia lipolytica
US8241868B2 (en) 2005-02-08 2012-08-14 Nippon Suisan Kaisha, Ltd. Production of polyunsaturated fatty acids using cell treatment method
JP4849806B2 (ja) * 2005-02-08 2012-01-11 日本水産株式会社 新規な菌体処理方法を用いた高度不飽和脂肪酸の製造方法
ES2626018T3 (es) 2005-06-07 2017-07-21 Dsm Nutritional Products Ag Microorganismos eucariotas para la producción de lípidos y antioxidantes
ZA200800079B (en) * 2005-06-07 2009-03-25 Ocean Nutrition Canada Ltd Eukaryotic microorganisms for producing lipids and antioxidants
AU2006265801B2 (en) 2005-07-01 2011-07-14 Martek Biosciences Corporation Polyunsaturated fatty acid-containing oil product and uses and production thereof
AU2006269807B2 (en) 2005-07-12 2010-11-25 Adelaide Research And Innovation Pty Ltd Chelating agents for micronutrient fertilisers
CN101321477A (zh) * 2005-10-07 2008-12-10 加拿大海洋营养食品有限公司 脂肪酸盐及其制备和使用方法
US20090182050A1 (en) * 2005-10-07 2009-07-16 Ocean Nutrition Canada, Ltd. Salts of Fatty Acids and Methods of Making and Using thereof
CA2639071A1 (en) 2005-12-16 2007-06-21 Avesthagen Limited Docosahexaenoic acid (dha) producing thraustochytrid strain - sc1
US9265745B2 (en) 2005-12-21 2016-02-23 Brudy Technology S.L. Use of DHA, EPA or DHA-derived EPA for treating a pathology associated with cellular oxidative damage
ATE474909T1 (de) 2005-12-29 2010-08-15 Abl Biotechnologies Ltd Neuer schizochytrium-limacinum-stamm, der sich für die produktion von lipiden und extrazellulären polysacchariden eignet, sowie verfahren hierfür
TW200806184A (en) 2006-04-11 2008-02-01 Martek Biosciences Corp Food products comprising long chain polyunsaturated fatty acids and methods for preparing the same
KR100795114B1 (ko) 2006-06-21 2008-01-17 주식회사 우양이엔지 소형 습식 집진기
WO2007149577A2 (en) 2006-06-23 2007-12-27 The Procter & Gamble Company Concentrated and odorless omega 3 fatty acids
CA2656311C (en) 2006-07-05 2016-06-21 Photonz Corporation Limited Ultra pure epa and polar lipids produced in largely heterotrophic culture
WO2008012329A2 (en) 2006-07-28 2008-01-31 V. Mane Fils Seamless capsules containing high amounts of polyunsaturated fatty acids and a flavouring component
CN101981201A (zh) 2006-08-01 2011-02-23 加拿大海洋营养食品有限公司 产油微生物及改良这些微生物的方法
KR100684642B1 (ko) * 2006-09-14 2007-02-22 주식회사 일신웰스 어유 유래 글리세라이드 유지 조성물 및 이의 제조방법
DK2087105T3 (da) 2006-10-30 2015-05-26 Du Pont Delta 17-desaturase og anvendelse heraf ved fremstilling af flerumættede fedtsyrer
US8936923B2 (en) 2006-12-05 2015-01-20 Biomass Research & Refining Pty Ltd Production of biodiesel
JP5101894B2 (ja) 2007-01-15 2012-12-19 サントリーホールディングス株式会社 高度不飽和脂肪酸及びこれを含有する脂質の製造方法
WO2008103753A2 (en) * 2007-02-20 2008-08-28 Martek Biosciences Corporation Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same
US20080234377A1 (en) 2007-03-23 2008-09-25 Martek Biosciences Corporation Polyunsaturated fatty acids for treatment of dementia and pre-dementia-related conditions
EP1992233A1 (en) 2007-05-11 2008-11-19 DSMIP Assets B.V. Stabilized marine oils and process of making them
WO2009002145A1 (en) 2007-06-26 2008-12-31 N.V. Nutricia Lipid composition for improving function of brain functioning
WO2009009040A2 (en) 2007-07-06 2009-01-15 Baum Seth J Fatty acid compositions and methods of use
CN101874117A (zh) 2007-09-12 2010-10-27 马太克生物科学公司 生物油及其制备与应用
US20090099261A1 (en) 2007-09-25 2009-04-16 Isi Brands Inc. Omega-3 mixtures
CA2701130A1 (en) * 2007-10-03 2009-04-09 E.I. Du Pont De Nemours And Company Peroxisome biogenesis factor protein (pex) disruptions for altering the content of polyunsaturated fatty acids and the total lipid content in oleaginous eukaryotic organisms
US20090117253A1 (en) 2007-10-03 2009-05-07 E. I. Du Pont De Nemours And Company Peroxisome biogenesis factor protein (pex) disruptions for altering polyunsaturated fatty acids and total lipid content in oleaginous eukaryotic organisms
US8343753B2 (en) 2007-11-01 2013-01-01 Wake Forest University School Of Medicine Compositions, methods, and kits for polyunsaturated fatty acids from microalgae
DE102008042932A1 (de) 2008-10-17 2010-04-22 Evonik Degussa Gmbh Herstellung und Verwendung von Methionylmethionin als Futtermitteladditiv für Fische und Krustentiere
AU2009319722B2 (en) 2008-11-28 2016-08-04 Corbion Biotech, Inc. Production of tailored oils in heterotrophic microorganisms
US20100178369A1 (en) 2009-01-15 2010-07-15 Nicole Lee Arledge Antioxidant-stabilized concentrated fish oil
EP2883958B1 (en) 2009-02-25 2018-04-11 V.B.Medicare Pvt. Ltd. Improved methods for fermentative production of docosahexaenoic acid
ES2894340T3 (es) 2009-03-09 2022-02-14 Basf As Composiciones que comprenden una mezcla de aceites de ácidos grasos y un tensioactivo, y métodos y usos de las mismas
NZ703725A (en) * 2009-03-19 2017-06-30 Dsm Ip Assets Bv Thraustochytrids, fatty acid compositions, and methods of making and uses thereof
ES2717102T3 (es) * 2009-03-19 2019-06-19 Dsm Ip Assets Bv Moléculas de ácido nucleico de ácido graso poliinsaturado sintasas, y polipéptidos, composiciones y métodos de preparación y usos de los mismos
US8207363B2 (en) 2009-03-19 2012-06-26 Martek Biosciences Corporation Thraustochytrids, fatty acid compositions, and methods of making and uses thereof
US9717703B2 (en) * 2009-10-16 2017-08-01 Glaxosmithkline Llc Emulsion and emulsion preconcentrate compositions comprising omega-3 fatty acids and uses thereof are disclosed
CN103068965A (zh) 2009-12-28 2013-04-24 Dsmip资产公司 在蔗糖上生长的重组破囊壶菌和其组合物、制备方法及用途
EP2519636B8 (en) * 2009-12-28 2017-08-09 DSM IP Assets B.V. Production of hemagglutinin-neuraminidase protein in microalgae
CN101892160B (zh) * 2010-01-06 2012-10-03 吉林省希玛生物科技有限公司 一种海洋真菌裂殖壶菌(Schizochytrium)LX0809及其工业应用
WO2011090493A1 (en) 2010-01-19 2011-07-28 Martek Biosciences Corporation Eicosapentaenoic acid-producing microorganisms, fatty acid compositions, and methods of making and uses thereof
CN103124791B (zh) * 2010-06-01 2016-08-24 帝斯曼知识产权资产管理有限公司 从细胞中提取脂质以及由此获得的产品
HK1198515A1 (en) * 2011-07-21 2015-05-15 Dsm Ip Assets B.V. Fatty acid compositions
CN104011217B (zh) 2011-07-21 2018-09-04 帝斯曼知识产权资产管理有限公司 生产二十碳五烯酸的微生物、脂肪酸组合物及其制作方法与用途

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