EA201401200A1 - Новая композиция альфентанила для лечения острой боли - Google Patents

Новая композиция альфентанила для лечения острой боли

Info

Publication number
EA201401200A1
EA201401200A1 EA201401200A EA201401200A EA201401200A1 EA 201401200 A1 EA201401200 A1 EA 201401200A1 EA 201401200 A EA201401200 A EA 201401200A EA 201401200 A EA201401200 A EA 201401200A EA 201401200 A1 EA201401200 A1 EA 201401200A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alfentanil
treatment
acid
microparticles
acute pain
Prior art date
Application number
EA201401200A
Other languages
English (en)
Other versions
EA028110B1 (ru
Inventor
Андерс Петтерссон
Эмиль Шван
Барбро Йоханссон
Original Assignee
Орексо Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48577134&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201401200(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB1207701.2A external-priority patent/GB201207701D0/en
Priority claimed from GBGB1221130.6A external-priority patent/GB201221130D0/en
Application filed by Орексо Аб filed Critical Орексо Аб
Publication of EA201401200A1 publication Critical patent/EA201401200A1/ru
Publication of EA028110B1 publication Critical patent/EA028110B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Обеспечиваются фармацевтические композиции для лечения боли, например кратковременной боли, где композиции включают смесь, содержащую (a) микрочастицы альфентанила или его фармацевтически пригодной соли, где микрочастицы присутствуют на поверхностях частиц носителя большего размера; (b) водорастворимое слабое основание и (c) соединение, являющееся слабой кислотой, где кислота присутствует в однородной смеси с микрочастицами альфентанила или его соли. Композиция может дополнительно содержать дезинтегрант. Кислота предпочтительно является лимонной кислотой.
EA201401200A 2012-05-02 2013-05-01 Новая композиция альфентанила для лечения острой боли EA028110B1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB1207701.2 2012-05-02
GBGB1207701.2A GB201207701D0 (en) 2012-05-02 2012-05-02 New pharmaceutical composition
GB1221130.6 2012-11-23
GBGB1221130.6A GB201221130D0 (en) 2012-11-23 2012-11-23 New pharmaceutical composition
PCT/GB2013/051131 WO2013164620A1 (en) 2012-05-02 2013-05-01 New alfentanil composition for the treatment of acute pain

Publications (2)

Publication Number Publication Date
EA201401200A1 true EA201401200A1 (ru) 2015-02-27
EA028110B1 EA028110B1 (ru) 2017-10-31

Family

ID=48577134

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201401200A EA028110B1 (ru) 2012-05-02 2013-05-01 Новая композиция альфентанила для лечения острой боли

Country Status (33)

Country Link
US (4) US8815911B2 (ru)
EP (2) EP3150199B1 (ru)
JP (1) JP6275696B2 (ru)
KR (1) KR20150005695A (ru)
CN (1) CN104427978B (ru)
AU (1) AU2013255640B2 (ru)
BR (1) BR112014027213A8 (ru)
CA (1) CA2871805A1 (ru)
CL (1) CL2014002979A1 (ru)
CO (1) CO7170181A2 (ru)
CY (2) CY1118570T1 (ru)
DK (2) DK3150199T3 (ru)
EA (1) EA028110B1 (ru)
ES (2) ES2614757T3 (ru)
HR (2) HRP20161634T1 (ru)
HU (1) HUE031792T2 (ru)
IL (1) IL235272B (ru)
IN (1) IN2014MN02156A (ru)
LT (2) LT3150199T (ru)
ME (1) ME02644B (ru)
MX (1) MX360665B (ru)
NZ (1) NZ701428A (ru)
PE (1) PE20142444A1 (ru)
PH (1) PH12014502407A1 (ru)
PL (2) PL2849730T3 (ru)
PT (2) PT3150199T (ru)
RS (2) RS55489B1 (ru)
SG (1) SG11201407081PA (ru)
SI (2) SI2849730T1 (ru)
SM (3) SMT201700086T1 (ru)
TR (1) TR201815935T4 (ru)
WO (1) WO2013164620A1 (ru)
ZA (1) ZA201407559B (ru)

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JP6210988B2 (ja) 2011-09-19 2017-10-11 オレクソ・アクチエボラゲット オピオイド依存を治療するための新規乱用耐性医薬組成物
EP3150199B1 (en) * 2012-05-02 2018-08-08 Orexo AB New alfentanil composition for the treatment of acute pain
WO2017180659A1 (en) * 2016-04-11 2017-10-19 Arizona Board Of Regents On Behalf Of University Of Arizona Opioid receptor modulators
JP7023054B2 (ja) * 2017-04-05 2022-02-21 東和薬品株式会社 レベチラセタム含有医薬組成物及びその製造方法
CN115047109B (zh) * 2022-06-17 2024-05-31 三明海关综合技术服务中心 一种检测食品中芬太尼类新精神活性物质的方法

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Also Published As

Publication number Publication date
RS57951B1 (sr) 2019-01-31
US9782396B2 (en) 2017-10-10
US20150133501A1 (en) 2015-05-14
PE20142444A1 (es) 2015-01-09
PL2849730T3 (pl) 2017-05-31
EP2849730B1 (en) 2016-11-09
LT2849730T (lt) 2016-12-27
NZ701428A (en) 2016-10-28
WO2013164620A1 (en) 2013-11-07
HRP20181761T1 (hr) 2018-12-28
KR20150005695A (ko) 2015-01-14
JP2015515974A (ja) 2015-06-04
SI3150199T1 (sl) 2018-12-31
BR112014027213A8 (pt) 2018-01-16
US8815911B2 (en) 2014-08-26
PL3150199T3 (pl) 2019-03-29
ES2614757T3 (es) 2017-06-01
SMT201800585T1 (it) 2019-01-11
US20170071927A1 (en) 2017-03-16
BR112014027213A2 (pt) 2017-06-27
ES2694644T3 (es) 2018-12-26
CO7170181A2 (es) 2015-01-28
PH12014502407B1 (en) 2015-01-12
IL235272B (en) 2018-10-31
DK3150199T3 (en) 2018-11-12
HUE031792T2 (en) 2017-07-28
TR201815935T4 (tr) 2018-11-21
IN2014MN02156A (ru) 2015-08-28
EA028110B1 (ru) 2017-10-31
US9345698B2 (en) 2016-05-24
CN104427978B (zh) 2017-03-01
PT3150199T (pt) 2018-11-21
AU2013255640B2 (en) 2017-06-15
US20180214437A1 (en) 2018-08-02
ME02644B (me) 2017-06-20
EP3150199A1 (en) 2017-04-05
HRP20161634T1 (hr) 2017-01-13
US20140005223A1 (en) 2014-01-02
RS55489B1 (sr) 2017-04-28
LT3150199T (lt) 2018-11-12
SMT201700086T1 (it) 2017-03-08
EP3150199B1 (en) 2018-08-08
MX2014013176A (es) 2015-01-19
MX360665B (es) 2018-11-13
PT2849730T (pt) 2017-02-15
CN104427978A (zh) 2015-03-18
CL2014002979A1 (es) 2014-12-05
CY1118570T1 (el) 2017-07-12
SI2849730T1 (sl) 2017-02-28
SMT201700086B (it) 2017-03-08
CY1120820T1 (el) 2019-12-11
SG11201407081PA (en) 2014-11-27
JP6275696B2 (ja) 2018-02-14
EP2849730A1 (en) 2015-03-25
ZA201407559B (en) 2016-05-25
PH12014502407A1 (en) 2015-01-12
DK2849730T3 (en) 2017-02-13
HK1203399A1 (en) 2015-10-30
AU2013255640A1 (en) 2014-11-20
CA2871805A1 (en) 2013-11-07

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