ECSP003362A - DERIVATIVES OF 3- PHENYL- PIRIDINE - Google Patents
DERIVATIVES OF 3- PHENYL- PIRIDINEInfo
- Publication number
- ECSP003362A ECSP003362A ECSP003362A ECSP003362A EC SP003362 A ECSP003362 A EC SP003362A EC SP003362 A ECSP003362 A EC SP003362A EC SP003362 A ECSP003362 A EC SP003362A
- Authority
- EC
- Ecuador
- Prior art keywords
- hydrogen
- lower alkyl
- halogen
- group
- trifluoromethyl
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 150000002431 hydrogen Chemical group 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- 102000002002 Neurokinin-1 Receptors Human genes 0.000 abstract 1
- 108010040718 Neurokinin-1 Receptors Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- -1 cyclic tertiary amine salt Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención se refiere a compuestos de la fórmula (gráfico), en donde R es hidrógeno, alquilo inferior, alcoxi inferior, halógeno o trifluorometilo; R1 es hidrógeno o halógeno; o R y R1 pueden ser conjuntamente -CH=CH-CH=CH-; R2 es hidrógeno, halógeno, trifluorometilo, alcoxi inferior o ciano; R3 es hidrógeno, alquilo inferior o forma un grupo cicloalquilo; R4 es hidrógeno, -N(R5)2, -N(R5)S(O)2- alquilo inferior, -N(R5)C(O)R5 o una sal amina terciaria ciclica del grupo (gráfico), es independientemente uno de otro, hidrógeno, C3-6 cicloalquilo, bencilo o alquilo inferior; es hidrógeno, hidroxi, alquilo inferior, -N(R5)CO- alquilo inferior, hidroxi-alquilo-inferior, ciano, -CHO o un grupo heterociclico de 5 ó 6 miembros, unido opcionalmente por un grupo alquileno, X es -C(O)N(R5)-, -(CH2)mO-, -(CH2)mN(R5)-, -N(R5)C(O)-, ó -n(R5)(CH2)m-; n es 0-4; y m es 1 ó 2; y sales derivadas de una adición ácida farmacéuticamente aceptable. Se ha demostardo que los compuestos anteriuormente mencionados tienen una buena afinidad por el receptor de NK-1The invention relates to compounds of the formula (graph), wherein R is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl; R1 is hydrogen or halogen; or R and R1 can be together -CH = CH-CH = CH-; R2 is hydrogen, halogen, trifluoromethyl, lower alkoxy or cyano; R3 is hydrogen, lower alkyl or forms a cycloalkyl group; R4 is hydrogen, -N (R5) 2, -N (R5) S (O) 2- lower alkyl, -N (R5) C (O) R5 or a cyclic tertiary amine salt from the group (graph), is independently one on the other, hydrogen, C3-6 cycloalkyl, benzyl or lower alkyl; it is hydrogen, hydroxy, lower alkyl, -N (R5) CO- lower alkyl, hydroxy-lower alkyl, cyano, -CHO or a 5- or 6-membered heterocyclic group, optionally linked by an alkylene group, X is -C ( O) N (R5) -, - (CH2) mO-, - (CH2) mN (R5) -, -N (R5) C (O) -, or -n (R5) (CH2) m-; n is 0-4; and m is 1 or 2; and salts derived from a pharmaceutically acceptable acid addition. The compounds mentioned above have been shown to have a good affinity for the NK-1 receptor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003362 ECSP003362A (en) | 2000-02-24 | 2000-02-24 | DERIVATIVES OF 3- PHENYL- PIRIDINE |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003362 ECSP003362A (en) | 2000-02-24 | 2000-02-24 | DERIVATIVES OF 3- PHENYL- PIRIDINE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP003362A true ECSP003362A (en) | 2000-09-22 |
Family
ID=42040993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP003362 ECSP003362A (en) | 2000-02-24 | 2000-02-24 | DERIVATIVES OF 3- PHENYL- PIRIDINE |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP003362A (en) |
-
2000
- 2000-02-24 EC ECSP003362 patent/ECSP003362A/en unknown
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