ECSP003363A - DERIVATIVES OF PHENYL AND PIRIDINYL - Google Patents

DERIVATIVES OF PHENYL AND PIRIDINYL

Info

Publication number
ECSP003363A
ECSP003363A ECSP003363A ECSP003363A EC SP003363 A ECSP003363 A EC SP003363A EC SP003363 A ECSP003363 A EC SP003363A EC SP003363 A ECSP003363 A EC SP003363A
Authority
EC
Ecuador
Prior art keywords
hydrogen
lower alkyl
halogen
group
trifluoromethyl
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Guido Galley
Thierry Godel
Walter Hunkeler
Heinz Stadler
Michael Bos
Torsten Hoffmann
Patrick Schnider
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to ECSP003363 priority Critical patent/ECSP003363A/en
Publication of ECSP003363A publication Critical patent/ECSP003363A/en

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención se refiere a compuestos de la fórmula (gráfico), en donde R es hidrógeno, alquilo inferior, alcoxi inferior, halógeno o trifluorometilo; R1 es hidrógeno o halógeno; o R y R1 pueden ser conjuntamente -CH=CH-CH=CH-; R2 es hidrógeno, halógeno, trifluorometilo, alcoxi inferior o ciano; R3 es hidrógeno, alquilo inferior o forma un grupo cicloalquilo; R4 es hidrógeno, -N(R5)2, -N(R5)S(O)2- alquilo inferior, -N(R5)C(O)R5 o una sal amina terciaria ciclica del grupo (gráfico), es independientemente uno de otro, hidrógeno, C3-6 cicloalquilo, bencilo o alquilo inferior; es hidrógeno, hidroxi, alquilo inferior, -N(R5)CO- alquilo inferior, hidroxi-alquilo-inferior, ciano, -CHO o un grupo heterociclico de 5 ó 6 miembros, unido opcionalmente por un grupo alquileno, X es -C(O)N(R5)-, -(CH2)mO-, -(CH2)mN(R5)-, -N(R5)C(O)-, -C(O)O-, ó -N(R5)(CH2)m-; Y es -(CH2)N, -O-, -S-, -SO2-, -C(O)- ó -N(R5)-; Z es -N-, -CH= ó -C(C1)=; n es 0-4; y m es 1 ó 2; y sales derivadas de una adición ácidafarmacéuticamente aceptables. Se ha demostrado que los compuestos de la fórmula I tienen una mayor afinidad por el receptor de NK-1The invention relates to compounds of the formula (graph), wherein R is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl; R1 is hydrogen or halogen; or R and R1 can be together -CH = CH-CH = CH-; R2 is hydrogen, halogen, trifluoromethyl, lower alkoxy or cyano; R3 is hydrogen, lower alkyl or forms a cycloalkyl group; R4 is hydrogen, -N (R5) 2, -N (R5) S (O) 2- lower alkyl, -N (R5) C (O) R5 or a cyclic tertiary amine salt from the group (graph), is independently one on the other, hydrogen, C3-6 cycloalkyl, benzyl or lower alkyl; it is hydrogen, hydroxy, lower alkyl, -N (R5) CO- lower alkyl, hydroxy-lower alkyl, cyano, -CHO or a 5- or 6-membered heterocyclic group, optionally linked by an alkylene group, X is -C ( O) N (R5) -, - (CH2) mO-, - (CH2) mN (R5) -, -N (R5) C (O) -, -C (O) O-, or -N (R5) (CH2) m-; Y is - (CH2) N, -O-, -S-, -SO2-, -C (O) - or -N (R5) -; Z is -N-, -CH = or -C (C1) =; n is 0-4; and m is 1 or 2; and salts derived from a pharmaceutically acceptable acid addition. Compounds of formula I have been shown to have a higher affinity for the NK-1 receptor.

ECSP003363 2000-02-24 2000-02-24 DERIVATIVES OF PHENYL AND PIRIDINYL ECSP003363A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ECSP003363 ECSP003363A (en) 2000-02-24 2000-02-24 DERIVATIVES OF PHENYL AND PIRIDINYL

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ECSP003363 ECSP003363A (en) 2000-02-24 2000-02-24 DERIVATIVES OF PHENYL AND PIRIDINYL

Publications (1)

Publication Number Publication Date
ECSP003363A true ECSP003363A (en) 2000-09-22

Family

ID=42040994

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP003363 ECSP003363A (en) 2000-02-24 2000-02-24 DERIVATIVES OF PHENYL AND PIRIDINYL

Country Status (1)

Country Link
EC (1) ECSP003363A (en)

Similar Documents

Publication Publication Date Title
AR029616A1 (en) COMPOUNDS DERIVED FROM 3-PHENYL-PYRIDINE, ITS USE, A PROCESS TO PREPARE THEM AND MEDICINES CONTAINING THEM
AR029614A1 (en) DERIVATIVES OF 4-PHENYL-PYRIDINE, ITS USE, A PROCESS TO PREPARE THEM, AND MEDICATIONS CONTAINING THEM
CO5140088A1 (en) DERIVATIVES OF FENIL AND PIRIDINIL AMIDA, ITS SYNTHESIS PROCEDURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
ECSP034431A (en) N-OXIDES AS ANTAGONIST PROPHARMS OF THE NK1 RECEIVER OF 4-PHENYL-PYRIDINE DERIVATIVES
TW200510441A (en) Novel compounds
CR9959A (en) PIRAZOL DERIVATIVES
WO2003106428A8 (en) Arylsulphonamide derivatives and use thereof as b1 bradykinin receptor antagonists
SE0101579D0 (en) New compounds
CO4950567A1 (en) PROTEASE INHIBITORS PROTEASE DORS.
CO4810374A1 (en) NEW USE OF COMPOUNDS FOR ANTI-PRURITIC ACTIVITY
YU64901A (en) Biphenyl derivatives
AR034206A1 (en) A PROCEDURE FOR THE PREPARATION OF MESILATES OF PIPERAZINE DERIVATIVES AND SUCH MESILATES
BR0208823A (en) Compound, method of treating disorders that are remedied or alleviated by vasopressin agonist activity in a mammal in need thereof, and pharmaceutical composition
ECSP003363A (en) DERIVATIVES OF PHENYL AND PIRIDINYL
ECSP003362A (en) DERIVATIVES OF 3- PHENYL- PIRIDINE
ECSP003359A (en) DERIVATIVES OF 4- PHENYL PIRIDINE
CO5640050A2 (en) NEW DERIVATIVES OF ANILINA, ITS ELABORATION AND USE AS PHARMACEUTICAL AGENTS
ECSP003381A (en) DERIVATIVES OF BIPHENIL
HRP20080501T3 (en) Beta-lactams for the treatment of cns disorders
TH49778A (en) Phenyl and pyridinyl derivatives
CO5280091A1 (en) PROTEASE INHIBITORS