ECSP013867A - Dihidrobenzopiranos substituidos y analogos de los mismos para el tratamiento de desordenes causados por cox-2 - Google Patents

Dihidrobenzopiranos substituidos y analogos de los mismos para el tratamiento de desordenes causados por cox-2

Info

Publication number
ECSP013867A
ECSP013867A EC2001003867A ECSP013867A ECSP013867A EC SP013867 A ECSP013867 A EC SP013867A EC 2001003867 A EC2001003867 A EC 2001003867A EC SP013867 A ECSP013867 A EC SP013867A EC SP013867 A ECSP013867 A EC SP013867A
Authority
EC
Ecuador
Prior art keywords
treatment
dihydrobenzopirans
cox
analogs
substituted
Prior art date
Application number
EC2001003867A
Other languages
English (en)
Inventor
Jeffery Steven Carter
John J Talley
J Rogier Donald Jr
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22635573&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP013867(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of ECSP013867A publication Critical patent/ECSP013867A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

Se describe una clase de dihidrobenzopiranos, dihidrobenzotiopiranos, tetrahidroquinolinas, tetrahidronaftalenos y análogos de los mismos para su uso en eltratamiento de las afecciones mediadas por la ciclooxigenasa-2. Los compuestos de interés parti cular se definen en la fórmula 1 donde X, A1, A2, A3, A4, R, R11, R1 y R2 son como se describe en la memoria descriptiva.
EC2001003867A 2000-01-03 2001-01-03 Dihidrobenzopiranos substituidos y analogos de los mismos para el tratamiento de desordenes causados por cox-2 ECSP013867A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17428100P 2000-01-03 2000-01-03

Publications (1)

Publication Number Publication Date
ECSP013867A true ECSP013867A (es) 2002-09-27

Family

ID=22635573

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2001003867A ECSP013867A (es) 2000-01-03 2001-01-03 Dihidrobenzopiranos substituidos y analogos de los mismos para el tratamiento de desordenes causados por cox-2

Country Status (16)

Country Link
US (2) US6822102B2 (es)
EP (1) EP1274700B1 (es)
JP (1) JP2003519221A (es)
AR (1) AR026784A1 (es)
AT (1) ATE282604T1 (es)
AU (1) AU2584001A (es)
CA (1) CA2395795A1 (es)
DE (1) DE60016047T2 (es)
EC (1) ECSP013867A (es)
ES (1) ES2231301T3 (es)
MX (1) MXPA02006617A (es)
PE (1) PE20010995A1 (es)
PT (1) PT1274700E (es)
TW (1) TWI227234B (es)
WO (1) WO2001049675A1 (es)
ZA (1) ZA200205098B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030100594A1 (en) * 2001-08-10 2003-05-29 Pharmacia Corporation Carbonic anhydrase inhibitor
US7504508B2 (en) 2002-10-04 2009-03-17 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
PL376156A1 (en) 2002-10-04 2005-12-27 Millennium Pharmaceuticals, Inc. Pgd2 receptor antagonists for the treatment of inflammatory diseases
CA2424009A1 (en) 2003-03-28 2004-09-28 Ibm Canada Limited - Ibm Canada Limitee Context-sensitive attributes
GB0407908D0 (en) * 2004-04-07 2004-05-12 Univ York Ionic liquids
TW200603792A (en) * 2004-04-23 2006-02-01 Pharmacia & Upjohn Co Llc Monotherapy for the treatment of psoriasis with cyclooxygenase-2 selective inhibitors
US7122700B2 (en) 2004-07-30 2006-10-17 Xerox Corporation Arylamine processes
WO2006040672A1 (en) * 2004-10-12 2006-04-20 Pharmacia & Upjohn Company Llc Substituted cyclopropyl chromene compounds for use in the treatment and prevention of inflammation related conditions
BRPI0608553A2 (pt) 2005-02-24 2010-01-12 Millennium Pharm Inc antagonistas de receptor de pgd2 para o tratamento de doenças inflamatórias
US7999107B2 (en) 2007-01-31 2011-08-16 Merck Sharp & Dohme Corp. Substituted pyrano[2,3-B]pyridine derivatives as cannabinoid-1 receptor modulators
BR112013000946B1 (pt) 2010-07-14 2020-09-08 Novartis Ag Compostos heterocíclicos agonistas de receptor de ip, seus usos, composição e combinação farmacêuticas
AR089698A1 (es) 2012-01-13 2014-09-10 Novartis Ag Compuestos heterociclicos antagonistas del receptor ip
CN119954759B (zh) * 2025-01-03 2025-10-21 安炎达医药技术(广州)有限公司 一种苯并吡喃类cox-2抑制剂及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100343832B1 (ko) * 1996-08-27 2002-07-20 시오노기세이야쿠가부시키가이샤 크로멘-3-카르복실산 유도체
DE19638484A1 (de) * 1996-09-20 1998-03-26 Basf Ag Hetaroylderivate
US6077850A (en) * 1997-04-21 2000-06-20 G.D. Searle & Co. Substituted benzopyran analogs for the treatment of inflammation
US6034256A (en) * 1997-04-21 2000-03-07 G.D. Searle & Co. Substituted benzopyran derivatives for the treatment of inflammation

Also Published As

Publication number Publication date
ZA200205098B (en) 2004-03-31
CA2395795A1 (en) 2001-07-12
US20050010050A1 (en) 2005-01-13
PT1274700E (pt) 2005-02-28
JP2003519221A (ja) 2003-06-17
TWI227234B (en) 2005-02-01
DE60016047T2 (de) 2005-11-03
AU2584001A (en) 2001-07-16
DE60016047D1 (de) 2004-12-23
PE20010995A1 (es) 2001-09-21
US20030232844A1 (en) 2003-12-18
EP1274700B1 (en) 2004-11-17
US6822102B2 (en) 2004-11-23
AR026784A1 (es) 2003-02-26
WO2001049675A1 (en) 2001-07-12
MXPA02006617A (es) 2004-09-10
EP1274700A1 (en) 2003-01-15
ATE282604T1 (de) 2004-12-15
ES2231301T3 (es) 2005-05-16

Similar Documents

Publication Publication Date Title
ECSP066467A (es) Formas Polimórficas de 3-(4-amino-1-Oxo-1-3 DIhidroisoindol-2-IL)-Piperidin-2,6-Diona
AR026784A1 (es) Dihidrobenzopiranos sustituidos y analogos de los mismos para el tratamiento de afecciones mediadas por cox-2.
CU23094A3 (es) Derivados benzopirano sustituidos para el tratamiento de inflamaciones
HRP20080664A2 (hr) Supstituirani piridinski herbicidi
EA200600621A1 (ru) Производные тетрагидронафталина, способ их получения и их применение в качестве противовоспалительных средств
BR0014352A (pt) Cetoenóis espirocìclicos substituìdos por trifluormetila
UY27427A1 (es) Nuevas dihidro-pteridinonas, procedimientos para su preparación y su utilización como medicamentos
TR200100410T2 (tr) 2-(purin-9-il)-tetrahidrofuran-3,4-diol türevleri.
AR024839A1 (es) Compuesto bi o triciclico sustituido, su uso en la fabricacion de un medicamento y composicion farmaceutica que lo comprende.
AR091405A2 (es) Omega-carboxiaril difenil urea sustituida con fluoro y composiciones farmaceuticas que las contienen
AR010062A1 (es) Nuevos benzamidaldehidos y su utilizacion
CY1113047T1 (el) Νεα κρυσταλλικη και αμορφη μορφη μιας ενωσης τριαζολο (4,5-d) πυριμιδινης
BR0115080A (pt) Derivados de acila e sulfonila de 2-(trans-1,4-diaminocicloexil)-purinas 6,9-dissubstituìdas e o uso destes como agentes antiproliferativos
HRP20080057T3 (en) 9,10-alpha,alpha-oh-taxane analogs and methods for production thereof
PA8527401A1 (es) 7-oxo-piridopirimidinas (ii)
ECSP077306A (es) Derivados de alquiliden-tetrahidronaftaleno, procedimiento para su preparación y su uso como antiinflamatorios
AR028743A1 (es) DERIVADOS DE N-TRIAZOLILMETIL-PIPERAZINA CON ACCIoN ANTAGONISTA DE RECEPTORES DE NEUROQUININA
AR027575A1 (es) Benzoilciclohexenonas substituidas
SE9903290D0 (sv) Novel compounds
DE60017374D1 (de) Antibakterielle mittel
UY26556A1 (es) Compuestos calcilíticos
UY26568A1 (es) Nuevos derivados de amidas heterocíclicas
NO20052994L (no) Nye fosforamidderivater.
ATE399169T1 (de) Imidazopyridinderivate als inhibitoren der induzierbaren no-synthase
BR0104738A (pt) Beta-hidroxialquilamidas, processo para sua produção e seu uso