ECSP014066A - FORMULACIONES ESTABILIZADAS DE 6-HIDROXI-3-(4-[2-(PIPERIDIN-1-IL)ETOXI] FENOXI)-2-(4-METOXIFENIL) BENZO [b] TIOFENO Y SUS SALES - Google Patents

FORMULACIONES ESTABILIZADAS DE 6-HIDROXI-3-(4-[2-(PIPERIDIN-1-IL)ETOXI] FENOXI)-2-(4-METOXIFENIL) BENZO [b] TIOFENO Y SUS SALES

Info

Publication number: ECSP014066A
Authority: EC; Ecuador
Prior art keywords: piperidin; benzo; salts; metoxifenil; phenoxi
Prior art date: 2000-05-08

Application number

EC2001004066A

Other languages

English (en)

Spanish (es)

Inventor

Kerry John Hartauer

Fadia Najjar Bashore

Michael Dean Minnett

Eugene Clark Rickard

Cheryl Ann Tingle

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-08

Filing date

2001-05-08

Publication date

2002-02-25

2001-05-08 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2002-02-25 Publication of ECSP014066A publication Critical patent/ECSP014066A/es

Links

150000003839 salts Chemical class 0.000 title abstract 3
FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical compound C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 title 1
239000000203 mixture Substances 0.000 title 1
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 abstract 1
PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 abstract 1
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
229960004308 acetylcysteine Drugs 0.000 abstract 1
MCGDSOGUHLTADD-UHFFFAOYSA-N arzoxifene Chemical compound C1=CC(OC)=CC=C1C1=C(OC=2C=CC(OCCN3CCCCC3)=CC=2)C2=CC=C(O)C=C2S1 MCGDSOGUHLTADD-UHFFFAOYSA-N 0.000 abstract 1
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
235000018417 cysteine Nutrition 0.000 abstract 1
238000000354 decomposition reaction Methods 0.000 abstract 1
238000010348 incorporation Methods 0.000 abstract 1
229930182817 methionine Natural products 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000003381 stabilizer Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Reproductive Health (AREA)
Psychiatry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Oil, Petroleum & Natural Gas (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

EC2001004066A 2000-05-08 2001-05-08 FORMULACIONES ESTABILIZADAS DE 6-HIDROXI-3-(4-[2-(PIPERIDIN-1-IL)ETOXI] FENOXI)-2-(4-METOXIFENIL) BENZO [b] TIOFENO Y SUS SALES ECSP014066A (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US20323500P	2000-05-08	2000-05-08

Publications (1)

Publication Number	Publication Date
ECSP014066A true ECSP014066A (es)	2002-02-25

Family

ID=22753086

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EC2001004066A ECSP014066A (es)	2000-05-08	2001-05-08	FORMULACIONES ESTABILIZADAS DE 6-HIDROXI-3-(4-[2-(PIPERIDIN-1-IL)ETOXI] FENOXI)-2-(4-METOXIFENIL) BENZO [b] TIOFENO Y SUS SALES

Country Status (30)

Country	Link
EP (1)	EP1357903B1 (fr)
JP (1)	JP2003535827A (fr)
KR (1)	KR100806992B1 (fr)
CN (1)	CN1283250C (fr)
AR (1)	AR028401A1 (fr)
AT (1)	ATE348605T1 (fr)
AU (2)	AU2001255310C1 (fr)
BR (1)	BR0110620A (fr)
CA (2)	CA2408563A1 (fr)
CZ (1)	CZ20023651A3 (fr)
DE (1)	DE60125416T2 (fr)
DZ (1)	DZ3376A1 (fr)
EA (1)	EA004871B1 (fr)
EC (1)	ECSP014066A (fr)
EG (1)	EG24223A (fr)
ES (1)	ES2276784T3 (fr)
HR (1)	HRP20020883A2 (fr)
HU (1)	HUP0302190A3 (fr)
IL (2)	IL152699A0 (fr)
MX (1)	MXPA02010923A (fr)
NO (1)	NO20025219D0 (fr)
NZ (1)	NZ521393A (fr)
PE (1)	PE20011255A1 (fr)
PL (1)	PL365472A1 (fr)
SK (1)	SK286346B6 (fr)
SV (1)	SV2002000435A (fr)
TW (1)	TWI225787B (fr)
UA (1)	UA77941C2 (fr)
WO (1)	WO2001085147A2 (fr)
ZA (1)	ZA200207651B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6610706B1 (en)	1999-07-29	2003-08-26	Eli Lilly And Company	Crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene hydrochloride
US6653479B1 (en)	1999-07-29	2003-11-25	Eli Lilly And Company	Crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b] thiophene hydrochloride
KR20060090667A (ko) *	2003-09-22	2006-08-14	닛신 쿄린 세이야꾸 가부시끼가이샤	변색 개선된 5-아미노살리실산 고형 제제 및 그의 보존방법
WO2016024369A1 (fr) *	2014-08-13	2016-02-18	テバ製薬株式会社	Composition médicinale pour le traitement du cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SG64896A1 (en) *	1995-02-28	1999-05-25	Lilly Co Eli	Benzothiophene compounds intermediates compositions and methods
ZA982877B (en) *	1997-04-09	1999-10-04	Lilly Co Eli	Treatment of central nervous system disorders with selective estrogen receptor modulators.
ZA200003837B (en) *	1999-07-29	2002-01-28	Lilly Co Eli	A novel chrystalline form of 6-hydroxy-3-(4-[2-)piperidin-1-yl)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene hydrochloride.
AU6335600A (en) *	1999-07-29	2001-02-19	Eli Lilly And Company	A novel crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-metho yphenyl)benzo[b]thiophene hydrochloride
AU6335500A (en) *	1999-07-29	2001-02-19	Eli Lilly And Company	A novel crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-metho yphenyl)benzo[b]thiophene hydrochloride

2001
- 2001-04-30 PL PL01365472A patent/PL365472A1/xx not_active Application Discontinuation
- 2001-04-30 HR HR20020883A patent/HRP20020883A2/hr not_active Application Discontinuation
- 2001-04-30 NZ NZ521393A patent/NZ521393A/en unknown
- 2001-04-30 IL IL15269901A patent/IL152699A0/xx unknown
- 2001-04-30 CZ CZ20023651A patent/CZ20023651A3/cs unknown
- 2001-04-30 MX MXPA02010923A patent/MXPA02010923A/es active IP Right Grant
- 2001-04-30 UA UA2002118788A patent/UA77941C2/uk unknown
- 2001-04-30 HU HU0302190A patent/HUP0302190A3/hu unknown
- 2001-04-30 AT AT01928454T patent/ATE348605T1/de not_active IP Right Cessation
- 2001-04-30 JP JP2001581801A patent/JP2003535827A/ja active Pending
- 2001-04-30 DE DE60125416T patent/DE60125416T2/de not_active Expired - Fee Related
- 2001-04-30 AU AU2001255310A patent/AU2001255310C1/en not_active Ceased
- 2001-04-30 CA CA002408563A patent/CA2408563A1/fr not_active Abandoned
- 2001-04-30 CA CA002691739A patent/CA2691739A1/fr not_active Abandoned
- 2001-04-30 ES ES01928454T patent/ES2276784T3/es not_active Expired - Lifetime
- 2001-04-30 AU AU5531001A patent/AU5531001A/xx active Pending
- 2001-04-30 DZ DZ013376A patent/DZ3376A1/fr active
- 2001-04-30 WO PCT/US2001/011736 patent/WO2001085147A2/fr not_active Ceased
- 2001-04-30 KR KR1020027014923A patent/KR100806992B1/ko not_active Expired - Fee Related
- 2001-04-30 BR BR0110620-1A patent/BR0110620A/pt not_active Application Discontinuation
- 2001-04-30 SK SK1565-2002A patent/SK286346B6/sk not_active IP Right Cessation
- 2001-04-30 EA EA200201186A patent/EA004871B1/ru not_active IP Right Cessation
- 2001-04-30 EP EP01928454A patent/EP1357903B1/fr not_active Expired - Lifetime
- 2001-04-30 CN CNB018091296A patent/CN1283250C/zh not_active Expired - Fee Related
- 2001-05-02 AR ARP010102074A patent/AR028401A1/es unknown
- 2001-05-02 TW TW090110500A patent/TWI225787B/zh not_active IP Right Cessation
- 2001-05-04 PE PE2001000402A patent/PE20011255A1/es not_active Application Discontinuation
- 2001-05-05 EG EG20010461A patent/EG24223A/xx active
- 2001-05-07 SV SV2001000435A patent/SV2002000435A/es not_active Application Discontinuation
- 2001-05-08 EC EC2001004066A patent/ECSP014066A/es unknown
2002
- 2002-09-23 ZA ZA200207651A patent/ZA200207651B/en unknown
- 2002-10-31 NO NO20025219A patent/NO20025219D0/no not_active Application Discontinuation
- 2002-11-07 IL IL152699A patent/IL152699A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
KR20030009477A (ko)	2003-01-29
IL152699A0 (en)	2003-06-24
AR028401A1 (es)	2003-05-07
AU2001255310B8 (en)	2005-03-10
AU2001255310B2 (en)	2005-03-03
CA2408563A1 (fr)	2001-11-15
DE60125416T2 (de)	2007-09-27
HUP0302190A3 (en)	2009-03-30
PL365472A1 (en)	2005-01-10
NZ521393A (en)	2004-08-27
CN1283250C (zh)	2006-11-08
HK1061349A1 (en)	2004-09-17
CA2691739A1 (fr)	2001-11-15
ZA200207651B (en)	2003-12-23
SK15652002A3 (sk)	2003-04-01
WO2001085147A2 (fr)	2001-11-15
CN1545413A (zh)	2004-11-10
EP1357903A2 (fr)	2003-11-05
TWI225787B (en)	2005-01-01
EG24223A (en)	2008-11-10
HRP20020883A2 (en)	2005-02-28
JP2003535827A (ja)	2003-12-02
IL152699A (en)	2009-09-01
PE20011255A1 (es)	2001-12-11
WO2001085147A3 (fr)	2003-08-28
SV2002000435A (es)	2002-10-24
MXPA02010923A (es)	2003-03-27
AU2001255310C1 (en)	2006-03-09
KR100806992B1 (ko)	2008-02-25
ATE348605T1 (de)	2007-01-15
DE60125416D1 (de)	2007-02-01
UA77941C2 (en)	2007-02-15
NO20025219L (no)	2002-10-31
ES2276784T3 (es)	2007-07-01
EA004871B1 (ru)	2004-08-26
NO20025219D0 (no)	2002-10-31
BR0110620A (pt)	2003-04-01
SK286346B6 (en)	2008-07-07
DZ3376A1 (fr)	2001-11-15
AU5531001A (en)	2001-11-20
HUP0302190A2 (hu)	2003-10-28
EA200201186A1 (ru)	2003-08-28
EP1357903B1 (fr)	2006-12-20
CZ20023651A3 (cs)	2003-02-12

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TR28474A (tr)	1996-08-08	Sodyum alkol etoksi gliseril sülfonat iceren, vücut temizleyici yumusak bilesikler.
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NO20040702L (no)	2004-05-19	Kombinerte preparater som inneholder 1,4-benzotiepin-1,1-dioksidderivater og andre aktive substanser og anvendelsen derav
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CO5150215A1 (es)	2002-04-29	Composiciones que tienen estabilidad mejorada
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AU2001285944A1 (en)	2002-03-26	Fungicidal agent containing n-chlorotaurine and use thereof
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