ECSP034904A - Derivados de índole naftil sustituido como inhibidores del activador plasminogen del inhibidor tipo-1 (pai-1) - Google Patents

Derivados de índole naftil sustituido como inhibidores del activador plasminogen del inhibidor tipo-1 (pai-1)

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Publication number
ECSP034904A
ECSP034904A EC2003004904A ECSP034904A ECSP034904A EC SP034904 A ECSP034904 A EC SP034904A EC 2003004904 A EC2003004904 A EC 2003004904A EC SP034904 A ECSP034904 A EC SP034904A EC SP034904 A ECSP034904 A EC SP034904A
Authority
EC
Ecuador
Prior art keywords
optionally substituted
alkyl
alkanoyl
pai
naftile
Prior art date
Application number
EC2003004904A
Other languages
English (en)
Inventor
Hassan Mahmoud Elokdah
Scott Christian Mayer
Eric Gould Gundersen
David Leroy Crandall
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ECSP034904A publication Critical patent/ECSP034904A/es

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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Urology & Nephrology (AREA)
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Abstract

La presente invención provee PAI-1 inhibiendo compuestos de la Fórmula (I): donde: R1, R2, R3 y R4 son cada H, alquil, alcanoil, halo, OH, aril opcionalmente sustituido con R8, perfluoroalquil, alcoxi, amino, alquilamino, dialquilamino, perfluoroalcoxi; R5 es H, alquil perfluoroalquil, aril opcionalmente sustituido con R8, alcanoil, aroil opcionalmente sustituido con R8, R6 es H, alquil, alquilaril, bencilo opcionalmente sustituido con R8, alcanoil, aroil opcionalmente sustituido con R8, R7 es H, alquil, alquilaril, aril opcionalmente sustituido con R8, n es 0-6 es COOH, o un ácido imitante tales como tetraazole, SO3H, PO3H2, ácido tetrónico, etc., R8 es H, alquil, cicloalquil, alcanoil, halo, OH, perfluoroalquil, alcoxi, amino, alquilamino, dialquilamino, perfluoroalcoxi; o una sal aceptable farmacéuticamente del mismo; así como también composiciones farmacéuticas y métodos de tratamiento usando eso compuestos.
EC2003004904A 2001-06-20 2003-12-17 Derivados de índole naftil sustituido como inhibidores del activador plasminogen del inhibidor tipo-1 (pai-1) ECSP034904A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29965101P 2001-06-20 2001-06-20

Publications (1)

Publication Number Publication Date
ECSP034904A true ECSP034904A (es) 2004-01-28

Family

ID=23155676

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2003004904A ECSP034904A (es) 2001-06-20 2003-12-17 Derivados de índole naftil sustituido como inhibidores del activador plasminogen del inhibidor tipo-1 (pai-1)

Country Status (25)

Country Link
US (4) US6800654B2 (es)
EP (1) EP1397356B1 (es)
JP (1) JP4520144B2 (es)
KR (1) KR20040007744A (es)
CN (1) CN1280288C (es)
AR (1) AR036101A1 (es)
AT (1) ATE431346T1 (es)
AU (1) AU2002316533B2 (es)
BR (1) BR0210504A (es)
CA (1) CA2448798C (es)
CO (1) CO5540286A2 (es)
DE (1) DE60232328D1 (es)
EA (1) EA009696B1 (es)
EC (1) ECSP034904A (es)
ES (1) ES2325733T3 (es)
HU (1) HUP0400233A3 (es)
IL (1) IL159449A0 (es)
MX (1) MXPA03011522A (es)
NO (2) NO326316B1 (es)
NZ (1) NZ530312A (es)
PL (1) PL367525A1 (es)
TW (1) TWI224101B (es)
UA (1) UA78708C2 (es)
WO (1) WO2003000684A1 (es)
ZA (1) ZA200400380B (es)

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US6939886B2 (en) 2005-09-06
JP2004534825A (ja) 2004-11-18
TWI224101B (en) 2004-11-21
US7351730B2 (en) 2008-04-01
BR0210504A (pt) 2004-05-18
NO20035635D0 (no) 2003-12-17
EP1397356B1 (en) 2009-05-13
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UA78708C2 (en) 2007-04-25
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