ECSP044984A - Oxidación del c-14 de derivados de la morfina - Google Patents

Oxidación del c-14 de derivados de la morfina

Info

Publication number
ECSP044984A
ECSP044984A EC2004004984A ECSP044984A ECSP044984A EC SP044984 A ECSP044984 A EC SP044984A EC 2004004984 A EC2004004984 A EC 2004004984A EC SP044984 A ECSP044984 A EC SP044984A EC SP044984 A ECSP044984 A EC SP044984A
Authority
EC
Ecuador
Prior art keywords
benzyl
morphine
oxidation
derivatives
oxidant
Prior art date
Application number
EC2004004984A
Other languages
English (en)
Inventor
Joannes Theodorus Maria Linders
Pieter Vrijhof
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of ECSP044984A publication Critical patent/ECSP044984A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente invención se refiere a un proceso para la preparación de un derivado de 14 hidroxinormorfinona de la fórmula IV, que comprende la reacción del compuesto de la fórmula III con un oxidante de cobalto (II) en presencia de una base suave y aire u oxígenocomo co-oxidante; en donde R1 es (1C-7C)alquilo, sustituido opcionalmente por una o más clorinas, por butenilo, vinilo, bencilo, fenilo o naftilo; y R2 es bencilo o bencilo sustituido por uno o más sustituyentes del grupo (1C-6C)alcoxi o bencilo sustituido por uno o más halógenos. El proceso es muy adecuado para la producción de noroximorfona.
EC2004004984A 2001-08-23 2004-02-19 Oxidación del c-14 de derivados de la morfina ECSP044984A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01203187 2001-08-23

Publications (1)

Publication Number Publication Date
ECSP044984A true ECSP044984A (es) 2004-04-28

Family

ID=8180821

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2004004984A ECSP044984A (es) 2001-08-23 2004-02-19 Oxidación del c-14 de derivados de la morfina

Country Status (25)

Country Link
US (1) US7435817B2 (es)
EP (1) EP1421085B1 (es)
JP (1) JP4559730B2 (es)
KR (1) KR100901402B1 (es)
CN (1) CN1271072C (es)
AR (1) AR035289A1 (es)
AT (1) ATE466016T1 (es)
AU (1) AU2002331163B2 (es)
BR (1) BRPI0211899B8 (es)
CA (1) CA2457671C (es)
DE (1) DE60236171D1 (es)
EC (1) ECSP044984A (es)
ES (1) ES2345327T3 (es)
HR (1) HRP20040161A2 (es)
HU (1) HUP0401600A3 (es)
IL (1) IL160193A0 (es)
IS (1) IS7153A (es)
MX (1) MXPA04001647A (es)
NO (1) NO328655B1 (es)
NZ (1) NZ531152A (es)
PE (1) PE20030460A1 (es)
PL (1) PL368732A1 (es)
RU (1) RU2297419C2 (es)
WO (1) WO2003018588A2 (es)
ZA (1) ZA200401016B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006126529A1 (ja) * 2005-05-25 2006-11-30 Shionogi & Co., Ltd. ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体
ES2357216T3 (es) 2005-06-16 2011-04-20 Mallinckrodt, Inc. Una ruta de síntesis de 14-hidroxil-opiáceos a través de 1-halo-tebaína o análogos.
ES2438997T5 (es) * 2007-03-23 2024-09-03 SpecGx LLC Preparación mejorada de oximorfona a partir de oripavina
CN101033228B (zh) * 2007-04-04 2010-05-19 复旦大学 14-羟基-7,8-二氢降吗啡酮的制备方法
CA2684458A1 (en) 2007-04-16 2008-10-30 Mallinckrodt Inc. Novel opiate reduction utilizing catalytic hydrogen transfer reaction
US8252808B2 (en) * 2007-12-17 2012-08-28 Mallinckrodt Llc Process and compounds for the production of (+)opiates
CA2709882A1 (en) 2007-12-17 2009-06-25 Peter X. Wang N-demethylation of n-methyl morphinans
US8461337B2 (en) * 2007-12-17 2013-06-11 Mallinckrodt Llc Sinomenine derivatives and processes for their synthesis
PH12012502083A1 (en) 2010-05-10 2017-07-26 Euro Celtique Sa Manufacturing of active-free granules and tablets comprising the same
EP2568965A1 (en) 2010-05-10 2013-03-20 Euro-Celtique S.A. Combination of active loaded granules with additional actives
US9700508B2 (en) 2010-05-10 2017-07-11 Euro-Celtique S.A. Pharmaceutical compositions comprising hydromorphone and naloxone
EP2580201B1 (en) 2010-06-11 2017-08-02 Rhodes Technologies Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
CA2802294C (en) 2010-06-11 2016-05-10 Rhodes Technologies Process for n-dealkylation of tertiary amines
MX2014002630A (es) 2011-09-08 2014-04-14 Mallinckrodt Llc Produccion de alcaloides sin el aislamiento de compuestos intermediarios.
CA2919602C (en) * 2013-08-02 2018-03-13 Johnson Matthey Public Limited Company Process for the preparation of oxymorphone
WO2015071380A1 (en) 2013-11-13 2015-05-21 Euro-Celtique S.A. Hydromorphone and naloxone for treatment of pain and opioid bowel dysfunction syndrome
CN114621238B (zh) * 2020-12-10 2026-02-03 鲁南制药集团股份有限公司 一种制备纳呋拉啡的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5112975A (en) * 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
IT1199871B (it) 1984-03-27 1989-01-05 Mallinckrodt Inc Procedimento per la preparazione di norossimorfone dalla morfina e composti intermedi per tale procedimento
US4668685A (en) * 1984-07-05 1987-05-26 E.I. Du Pont De Nemours And Company Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists
US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
WO2000066588A1 (en) * 1999-05-05 2000-11-09 The Government Of The United States Of America, Represented By The Secretary, Departmentof Health A Nd Human Services Direct c-14 oxidation of opioids

Also Published As

Publication number Publication date
EP1421085B1 (en) 2010-04-28
MXPA04001647A (es) 2004-05-31
WO2003018588B1 (en) 2004-02-26
KR100901402B1 (ko) 2009-06-05
IS7153A (is) 2004-02-13
RU2004108210A (ru) 2005-04-10
IL160193A0 (en) 2004-07-25
WO2003018588A3 (en) 2003-11-27
RU2297419C2 (ru) 2007-04-20
ATE466016T1 (de) 2010-05-15
CN1271072C (zh) 2006-08-23
WO2003018588A2 (en) 2003-03-06
KR20040027950A (ko) 2004-04-01
US20050038250A1 (en) 2005-02-17
JP2005502670A (ja) 2005-01-27
CN1545517A (zh) 2004-11-10
HUP0401600A3 (en) 2008-05-28
AU2002331163B2 (en) 2008-02-21
BRPI0211899B8 (pt) 2021-05-25
NO328655B1 (no) 2010-04-19
PL368732A1 (en) 2005-04-04
HRP20040161A2 (en) 2004-06-30
NZ531152A (en) 2005-11-25
HUP0401600A2 (hu) 2004-11-29
AR035289A1 (es) 2004-05-05
JP4559730B2 (ja) 2010-10-13
BR0211899B1 (pt) 2014-01-21
DE60236171D1 (de) 2010-06-10
CA2457671C (en) 2011-02-15
EP1421085A2 (en) 2004-05-26
NO20040724L (no) 2004-02-19
ES2345327T3 (es) 2010-09-21
PE20030460A1 (es) 2003-05-15
HK1063803A1 (en) 2005-01-14
ZA200401016B (en) 2004-10-19
CA2457671A1 (en) 2003-03-06
US7435817B2 (en) 2008-10-14
BR0211899A (pt) 2004-09-21

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