ECSP045124A - Composiciones polimeras de liberacion controlada de compuestos que promueven el crecimiento oseo - Google Patents

Composiciones polimeras de liberacion controlada de compuestos que promueven el crecimiento oseo

Info

Publication number
ECSP045124A
ECSP045124A EC2004005124A ECSP045124A ECSP045124A EC SP045124 A ECSP045124 A EC SP045124A EC 2004005124 A EC2004005124 A EC 2004005124A EC SP045124 A ECSP045124 A EC SP045124A EC SP045124 A ECSP045124 A EC SP045124A
Authority
EC
Ecuador
Prior art keywords
growth
oseo
promote
compounds
polymer compositions
Prior art date
Application number
EC2004005124A
Other languages
English (en)
Inventor
Francis Dumont
Richard Wilker Korsmeyer
Mei Li
Vishwas Madhav Paralkar
Richard Lee Dunn
Scott Alexander Jeffers
Mingxing Zhou
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ECSP045124A publication Critical patent/ECSP045124A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

La presente invención se refiere a un sistema mejorado para la liberación controlada de un compuesto que promueve el crecimiento óseo y a una composición fluible para su formación. La composición fluible está compuesta de un compuesto que promueve el crecimiento óseo, un polímero termoplástico y un disolvente orgánico. La composición fluible es capaz de formar una matriz de polímero sólida, microporosa, biodegradable y/o bioerosionable. La matriz es útil como implante en pacientes (seres humanos y animales) para suministrar a ciertos tejidos un compuesto que promueve el crecimiento óseo.
EC2004005124A 2001-11-30 2004-05-28 Composiciones polimeras de liberacion controlada de compuestos que promueven el crecimiento oseo ECSP045124A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33725501P 2001-11-30 2001-11-30

Publications (1)

Publication Number Publication Date
ECSP045124A true ECSP045124A (es) 2004-07-23

Family

ID=23319774

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2004005124A ECSP045124A (es) 2001-11-30 2004-05-28 Composiciones polimeras de liberacion controlada de compuestos que promueven el crecimiento oseo

Country Status (35)

Country Link
US (2) US20030104031A1 (es)
EP (1) EP1448166A1 (es)
JP (1) JP4903985B2 (es)
KR (1) KR100629380B1 (es)
CN (1) CN1599598A (es)
AP (1) AP1781A (es)
AR (1) AR037462A1 (es)
AU (2) AU2002347502A1 (es)
BR (1) BR0214610A (es)
CA (1) CA2468703C (es)
DO (1) DOP2002000534A (es)
EA (1) EA011350B1 (es)
EC (1) ECSP045124A (es)
GE (1) GEP20063951B (es)
GT (1) GT200200242A (es)
HR (1) HRP20040486A2 (es)
HU (1) HUP0402135A3 (es)
IL (1) IL161835A0 (es)
IS (1) IS7217A (es)
MA (1) MA27084A1 (es)
MX (1) MXPA04003723A (es)
NO (1) NO20042273L (es)
NZ (1) NZ533115A (es)
OA (1) OA12731A (es)
PA (1) PA8559001A1 (es)
PE (1) PE20030581A1 (es)
PL (1) PL370085A1 (es)
PY (1) PY0229226A (es)
SV (1) SV2004001421A (es)
TN (1) TNSN04096A1 (es)
TW (1) TW200300695A (es)
UA (1) UA76792C2 (es)
WO (1) WO2003045351A1 (es)
YU (1) YU35004A (es)
ZA (1) ZA200402755B (es)

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GB0307011D0 (en) 2003-03-27 2003-04-30 Regentec Ltd Porous matrix
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GB0329654D0 (en) 2003-12-23 2004-01-28 Smith & Nephew Tunable segmented polyacetal
US8123787B2 (en) 2004-10-28 2012-02-28 Ogilvie James W Method of treating scoliosis using a biological implant
US8641738B1 (en) 2004-10-28 2014-02-04 James W. Ogilvie Method of treating scoliosis using a biological implant
CA2619571A1 (en) * 2005-08-18 2007-02-22 Smith & Nephew, Plc High strength devices and composites
CN100443065C (zh) * 2006-01-26 2008-12-17 上海交通大学 用于颌面骨缺损修复的复合体系植入体单元
CA2679365C (en) 2006-11-30 2016-05-03 Smith & Nephew, Inc. Fiber reinforced composite material
EP2142353A1 (en) 2007-04-18 2010-01-13 Smith & Nephew PLC Expansion moulding of shape memory polymers
ATE547129T1 (de) 2007-04-19 2012-03-15 Smith & Nephew Inc Multimodale formgedächtnis-polymere
JP5680957B2 (ja) 2007-04-19 2015-03-04 スミス アンド ネフュー インコーポレーテッドＳｍｉｔｈ ＆ Ｎｅｐｈｅｗ，Ｉｎｃ． グラフト固定
US8062739B2 (en) * 2007-08-31 2011-11-22 Zimmer, Inc. Hydrogels with gradient
US20090181068A1 (en) * 2008-01-14 2009-07-16 Dunn Richard L Low Viscosity Liquid Polymeric Delivery System
EP2172189A1 (en) * 2008-10-01 2010-04-07 Novartis AG Pharmaceutical Compositions
EP2323623B1 (en) 2008-08-12 2016-07-27 Novartis AG Pharmaceutical compositions
US9642658B2 (en) 2008-10-15 2017-05-09 Orthoclip Llc Device and method for delivery of therapeutic agents via internal implants
WO2010045487A1 (en) * 2008-10-15 2010-04-22 Palmetto Biomedical, Inc. Device and method for delivery of therapeutic agents via internal implants
BR112012002341A8 (pt) 2009-08-06 2017-10-10 Koninklijke Philips Electronics Nv Semente radioativa para uso na terapia oncológica e método de terapia oncológica
US20130071403A1 (en) 2011-09-20 2013-03-21 Vical Incorporated Synergistic anti-tumor efficacy using alloantigen combination immunotherapy
CN104189954B (zh) * 2014-09-19 2017-03-29 中国科学院长春应用化学研究所 一种原位固化组织工程支架及其制备方法
RU2571548C1 (ru) * 2014-12-17 2015-12-20 Федеральное государственное бюджетное учреждение науки Институт органической и физической химии им. А.Е. Арбузова Казанского научного центра Российской академии наук Ветеринарное имплантируемое средство пролонгированного действия (варианты)
WO2017084973A1 (en) 2015-11-16 2017-05-26 Evonik Röhm Gmbh Injection solution comprising a non-nucleoside reverse-transcriptase inhibitor and poly(lactide-co-glycolide)
CN109498852B (zh) * 2018-12-29 2022-06-24 广州噢斯荣医药技术有限公司 治疗骨科疾病的生物降解材料及其应用
JP2023500506A (ja) 2019-11-04 2023-01-06 アストラゼネカ・アクチエボラーグ 癌を治療するための組み合わせ療法
EP4255357A1 (en) 2020-12-29 2023-10-11 Sino Medical Sciences Technology Inc. Drug eluting stent
EP4608995A1 (en) 2022-10-24 2025-09-03 Memorial Sloan-Kettering Cancer Center Tumour stratification for responsiveness to an immune checkpoint inhibitor
CN120187419A (zh) 2022-10-24 2025-06-20 癌症研究技术有限公司 通过氧化还原状态调节剂使肿瘤对检查点抑制剂敏感
WO2024150017A1 (en) 2023-01-13 2024-07-18 Akrivia Biomedics Limited Method of profiling diseases
NL2037811B1 (en) 2024-05-29 2025-12-12 Univ Oslo Treatment for Cancer
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Also Published As

Publication number Publication date
US8017144B2 (en) 2011-09-13
GT200200242A (es) 2003-06-25
GEP20063951B (en) 2006-10-25
AU2002347502A1 (en) 2003-06-10
JP4903985B2 (ja) 2012-03-28
CN1599598A (zh) 2005-03-23
MA27084A1 (fr) 2004-12-20
AR037462A1 (es) 2004-11-10
PY0229226A (es) 2004-06-01
IS7217A (is) 2004-04-07
CA2468703A1 (en) 2003-06-05
EA200400608A1 (ru) 2004-10-28
SV2004001421A (es) 2004-05-07
KR20040062977A (ko) 2004-07-09
HUP0402135A2 (hu) 2005-02-28
NO20042273L (no) 2004-07-14
YU35004A (sh) 2006-08-17
AU2009200125B2 (en) 2012-02-02
KR100629380B1 (ko) 2006-09-29
PA8559001A1 (es) 2003-11-12
JP2005515190A (ja) 2005-05-26
BR0214610A (pt) 2004-09-14
EP1448166A1 (en) 2004-08-25
EA011350B1 (ru) 2009-02-27
CA2468703C (en) 2009-12-29
NZ533115A (en) 2005-12-23
IL161835A0 (en) 2005-11-20
WO2003045351A1 (en) 2003-06-05
AP2004003037A0 (en) 2004-06-30
DOP2002000534A (es) 2003-05-31
ZA200402755B (en) 2005-04-08
PL370085A1 (en) 2005-05-16
HUP0402135A3 (en) 2008-04-28
US20030104031A1 (en) 2003-06-05
MXPA04003723A (es) 2005-04-08
UA76792C2 (uk) 2006-09-15
AP1781A (en) 2007-09-27
HRP20040486A2 (en) 2004-10-31
PE20030581A1 (es) 2003-07-08
OA12731A (en) 2006-06-28
TNSN04096A1 (fr) 2006-06-01
AU2009200125A1 (en) 2009-02-05
TW200300695A (en) 2003-06-16
US20090169595A1 (en) 2009-07-02

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