ECSP055576A - Uso de derivados de ciclotiocarbamato en el tratamiento de las condiciones relacionadas con hormonas - Google Patents

Uso de derivados de ciclotiocarbamato en el tratamiento de las condiciones relacionadas con hormonas

Info

Publication number
ECSP055576A
ECSP055576A EC2005005576A ECSP055576A ECSP055576A EC SP055576 A ECSP055576 A EC SP055576A EC 2005005576 A EC2005005576 A EC 2005005576A EC SP055576 A ECSP055576 A EC SP055576A EC SP055576 A ECSP055576 A EC SP055576A
Authority
EC
Ecuador
Prior art keywords
formula
administration
cyclotiocarbamate
hormones
derivatives
Prior art date
Application number
EC2005005576A
Other languages
English (en)
Inventor
Andrew Fensome
Gary Grubb
Diane Deborah Harrison
Richarg Craing Winneker
Puwen Zhang
Jeffrey Curtis Kern
Eugene Anthony Terefenko
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ECSP055576A publication Critical patent/ECSP055576A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención proporciona métodos para inducir contracepción, el cual incluye la administración a una fémina de una composición que contiene un compuesto de fórmula I, fórmula II o tautómeros de los mismos, en un régimen el cual involucra la administración de uno o más de un modulador del receptor de estrógenos selectivo, donde la fórmula I es: (I) y donde R1-R5 y Q1 son definidos como se describe aquí. Se describen métodos para proveer terapia de re-emplazo hormonal y para tratar carcinomas, sangramiento disfuncional, leiomiomata uterino y síndrome del ovario poliquístico, los cuales incluyen la administración de un compuesto de fórmula I o fórmula II y un modulador del receptor de estrógenos selectivo.
EC2005005576A 2002-06-25 2005-01-25 Uso de derivados de ciclotiocarbamato en el tratamiento de las condiciones relacionadas con hormonas ECSP055576A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39187102P 2002-06-25 2002-06-25

Publications (1)

Publication Number Publication Date
ECSP055576A true ECSP055576A (es) 2005-04-18

Family

ID=30000766

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2005005576A ECSP055576A (es) 2002-06-25 2005-01-25 Uso de derivados de ciclotiocarbamato en el tratamiento de las condiciones relacionadas con hormonas

Country Status (19)

Country Link
US (1) US7192956B2 (es)
EP (1) EP1515725A4 (es)
JP (1) JP2005535624A (es)
KR (1) KR20050013247A (es)
CN (1) CN1662241A (es)
AR (1) AR040333A1 (es)
AU (1) AU2003247608A1 (es)
BR (1) BR0312024A (es)
CA (1) CA2489847A1 (es)
CO (1) CO5680438A2 (es)
CR (1) CR7611A (es)
EC (1) ECSP055576A (es)
IL (1) IL165396A0 (es)
MX (1) MXPA04012421A (es)
NO (1) NO20045216L (es)
RU (1) RU2005101638A (es)
TW (1) TW200404548A (es)
WO (1) WO2004000801A2 (es)
ZA (1) ZA200410411B (es)

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* Cited by examiner, † Cited by third party
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US6391907B1 (en) * 1999-05-04 2002-05-21 American Home Products Corporation Indoline derivatives
US6509334B1 (en) 1999-05-04 2003-01-21 American Home Products Corporation Cyclocarbamate derivatives as progesterone receptor modulators
US6355648B1 (en) 1999-05-04 2002-03-12 American Home Products Corporation Thio-oxindole derivatives
US6407101B1 (en) 1999-05-04 2002-06-18 American Home Products Corporation Cyanopyrroles
UA73119C2 (en) * 2000-04-19 2005-06-15 American Home Products Corpoir Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors
IL165395A0 (en) * 2002-06-25 2006-01-15 Wyeth Corp Use of thio-oxubdile derivatives in treatment of hormone-related conditions
US20040248989A1 (en) 2003-06-05 2004-12-09 Risto Santti Method for the treatment or prevention of lower urinary tract symptoms
DK1732922T3 (da) * 2004-04-08 2009-01-12 Wyeth Corp Fremgangsmåde til minimering af thioamidurenheder
ATE413398T1 (de) 2004-04-08 2008-11-15 Wyeth Corp Thioamidderivate als progesteronrezeptormodulatoren
ATE396189T1 (de) * 2004-04-27 2008-06-15 Wyeth Corp Cyanopyrrolhaltige cyclische carbamat- und thiocarbamatbiaryle und verfahren zu deren herstellung
SI1778710T1 (sl) * 2004-08-13 2012-05-31 Wyeth Llc Derivati tanaprogeta metaboliti in njihove uporabe
US7399766B2 (en) * 2004-08-18 2008-07-15 Parion Sciences, Inc. Soluble amide & ester pyrazinoylguanidine sodium channel blockers
BRPI0514528A (pt) * 2004-08-20 2008-06-10 Wyeth Corp estrutura de receptores de progesterona
AR056328A1 (es) * 2005-04-28 2007-10-03 Wyeth Corp TANAPROGET MICRONIZADO, COMPOSICIONES Y MÉTODOS PARA SU PREPARACIoN
EP1874743B1 (en) * 2005-04-28 2013-07-17 Wyeth LLC Purified form of tanaproget
DE602006007453D1 (de) 2005-04-28 2009-08-06 Wyeth Corp Zusammensetzungen mit mikronisiertem tanaproget
US20060246128A1 (en) * 2005-04-28 2006-11-02 Wyeth Micronized tanaproget and compositions containing same
MX2007013469A (es) * 2005-04-28 2008-01-22 Wyeth Corp Forma ii polimorfa de tanaproget.
AU2011203520B2 (en) * 2005-04-28 2012-06-14 Wyeth Micronized tanaproget and compostions containing same
AU2011226814B2 (en) * 2005-04-28 2013-06-13 Wyeth Llc Micronized tanaproget, compositions, and methods of preparing the same
CN103989687A (zh) * 2005-06-09 2014-08-20 惠氏公司 含有炔雌醇的tanaproget组合物
JP2010513381A (ja) * 2006-12-22 2010-04-30 エフ．ホフマン−ラ ロシュ アーゲー （３ｒ，４ｒ）−ｎ−（４−クロロフェニル）−１−（２，２−ジフルオロエチル）−ｎ’−［２−フルオロ−４−（２−オキソ−１（２ｈ）−ピリジニル）フェニル］−３，４−ピロリジンジカルボキサミドの製造方法
EA201070715A1 (ru) 2007-12-20 2011-02-28 Тева Вимен'С Хелс, Инк. Режимы дозирования, фармацевтические композиции и упаковки для экстренной контрацепции
DE102008022221A1 (de) * 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2
US20120238533A1 (en) * 2009-09-11 2012-09-20 Bayer Pharma Aktiengesellschaft (Heteroarylmethyl) Thiohydantoins as anticancer drugs
BR112012031464A2 (pt) 2010-06-10 2020-08-04 Aragon Pharmaceuticals, Inc. moduladores do receptor de estrogênio e os seus usos
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US20170014174A1 (en) * 2015-07-17 2017-01-19 Candela Corporation Cryogenic Cylinder

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Also Published As

Publication number Publication date
CO5680438A2 (es) 2006-09-29
EP1515725A4 (en) 2005-09-21
BR0312024A (pt) 2005-03-22
CR7611A (es) 2006-05-30
AU2003247608A1 (en) 2004-01-06
EP1515725A2 (en) 2005-03-23
TW200404548A (en) 2004-04-01
CN1662241A (zh) 2005-08-31
RU2005101638A (ru) 2006-01-20
MXPA04012421A (es) 2005-04-19
WO2004000801A3 (en) 2004-03-25
WO2004000801A2 (en) 2003-12-31
KR20050013247A (ko) 2005-02-03
CA2489847A1 (en) 2003-12-31
IL165396A0 (en) 2006-01-15
NO20045216L (no) 2005-01-24
JP2005535624A (ja) 2005-11-24
US7192956B2 (en) 2007-03-20
US20040006060A1 (en) 2004-01-08
AR040333A1 (es) 2005-03-30
ZA200410411B (en) 2007-06-27

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