ECSP055586A - Proceso para producir una preparación de trombina con virus inactivados - Google Patents

Proceso para producir una preparación de trombina con virus inactivados

Info

Publication number
ECSP055586A
ECSP055586A EC2005005586A ECSP055586A ECSP055586A EC SP055586 A ECSP055586 A EC SP055586A EC 2005005586 A EC2005005586 A EC 2005005586A EC SP055586 A ECSP055586 A EC SP055586A EC SP055586 A ECSP055586 A EC SP055586A
Authority
EC
Ecuador
Prior art keywords
thrombin
inactivated viruses
preparation
prothrombin
medium
Prior art date
Application number
EC2005005586A
Other languages
English (en)
Inventor
David Evans
Peter Feldman
Carolina Connolly
Christopher Hardway
Original Assignee
Nat Blood Authority
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nat Blood Authority filed Critical Nat Blood Authority
Publication of ECSP055586A publication Critical patent/ECSP055586A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/16—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención describe un método para la preparación de trombina con virus inactivados que comprende inactivación de virus con solvente y detergente de una solución que comprende protrombina y factor X, cargar la protrombina y el factor X de virus inactivados sobre un medio de intercambio aniónico, lavar el medio para remover los reactivos usados para la inactivación de virus con solvente y detergente y activar la protrombina sobre el medio para formar trombina mediante la adición de iones metálicos, de preferencia iones de calcio. La trombina después se eluye, de preferencia selectivamente desde el medio de intercambio aniónico.
EC2005005586A 2002-07-10 2005-02-02 Proceso para producir una preparación de trombina con virus inactivados ECSP055586A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0216002.6A GB0216002D0 (en) 2002-07-10 2002-07-10 Process and composition

Publications (1)

Publication Number Publication Date
ECSP055586A true ECSP055586A (es) 2005-07-06

Family

ID=9940204

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2005005586A ECSP055586A (es) 2002-07-10 2005-02-02 Proceso para producir una preparación de trombina con virus inactivados

Country Status (19)

Country Link
US (1) US8435779B2 (es)
EP (1) EP1520018B1 (es)
JP (1) JP4445386B2 (es)
AT (1) ATE354648T1 (es)
AU (1) AU2003244858B2 (es)
BR (1) BRPI0312522B8 (es)
CA (1) CA2491718C (es)
CY (1) CY1107632T1 (es)
DE (1) DE60311990T2 (es)
EC (1) ECSP055586A (es)
ES (1) ES2282644T3 (es)
GB (1) GB0216002D0 (es)
IL (3) IL165989A0 (es)
MX (1) MXPA05000393A (es)
NO (1) NO20050090L (es)
NZ (1) NZ537502A (es)
PL (1) PL208219B1 (es)
PT (1) PT1520018E (es)
WO (1) WO2004007707A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2411959C2 (ru) * 2004-06-29 2011-02-20 Релайанс Лайф Сайенсиз Пвт Лтд Способ получения безопасных в вирусном отношении биологических текучих сред
EP1685852A1 (en) * 2005-02-01 2006-08-02 Fondation pour la Recherche Diagnostique Set of disposable bags for viral inactivation of biological fluids
US20060270015A1 (en) * 2005-05-26 2006-11-30 Dan Pawlak Thrombin purification
HUE031042T2 (en) * 2005-07-29 2017-06-28 Abbott Laboratories Gmbh Methods for producing pancreatin powder with low viral content
US9198871B2 (en) 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions
US11266607B2 (en) 2005-08-15 2022-03-08 AbbVie Pharmaceuticals GmbH Process for the manufacture and use of pancreatin micropellet cores
PL2027263T3 (pl) * 2006-05-22 2013-01-31 Abbott Laboratories Gmbh Sposób separacji i określenia wiremii w próbce pankreatyny
US10072256B2 (en) 2006-05-22 2018-09-11 Abbott Products Gmbh Process for separating and determining the viral load in a pancreatin sample
US7774628B2 (en) * 2006-05-25 2010-08-10 Foundry Networks, Inc. Enabling/disabling power-over-ethernet software subsystem in response to power supply status
JP5437236B2 (ja) * 2008-04-16 2014-03-12 一般財団法人化学及血清療法研究所 トロンビン固定化生体吸収性シート製剤の製造方法
JP5442310B2 (ja) * 2009-04-23 2014-03-12 旭化成メディカル株式会社 トロンビン溶液の調製方法
AU2015252061A1 (en) * 2009-07-31 2015-11-19 Baxalta GmbH Method for Purifying Recombinant ADAMTS13 and Other Proteins and Compositions Thereof
US8945895B2 (en) * 2009-07-31 2015-02-03 Baxter International Inc. Methods of purifying recombinant ADAMTS13 and other proteins and compositions thereof
SE1050124A1 (sv) * 2010-02-08 2011-08-09 Linkoping Biocontrols Ab Stabil lösning
CN102357259A (zh) * 2011-07-28 2012-02-22 王珊珊 一种生物蛋白海绵及其制备方法
SG11201407809QA (en) * 2012-05-31 2014-12-30 Agency Science Tech & Res Chromatographic purification of immunoglobulin g preparations with particles having multimodal functionalities
US9932388B2 (en) 2014-11-13 2018-04-03 Hemarus Therapeutics Limited Chromatographic process for producing high purity fibrinogen and thrombin
CN113754757B (zh) * 2021-07-01 2024-06-14 华兰生物工程股份有限公司 一种人纤维蛋白原的制备方法
CN115947825B (zh) * 2023-01-30 2025-11-28 华兰生物工程重庆有限公司 一种基于层析方法的纤维蛋白原制备工艺

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3336631A1 (de) * 1983-10-08 1985-04-18 Behringwerke Ag, 3550 Marburg Verfahren zur pasteurisierung von plasma oder von konzentraten der blutgerinnungsfaktoren ii, vii, ix und x
DE3843126C3 (de) 1988-12-22 1994-10-06 Octapharma Ag Verfahren zur Herstellung eines hochreinen Thrombinkonzentrates
IE73210B1 (en) 1990-01-24 1997-05-07 Warner Lambert Co Process for the production of thrombin and high purity thrombin preparation thereby obtained
ATE177781T1 (de) * 1990-02-20 1999-04-15 Baxter Int Gereinigtes, virusfreies menschliches thrombin
FR2679251B1 (fr) 1991-07-18 1993-11-12 Nord Assoc Essor Transfusion San Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique.
AT398079B (de) 1991-11-04 1994-09-26 Immuno Ag Präparation mit thrombinaktivität sowie verfahren zu ihrer herstellung
DE4137996A1 (de) 1991-11-19 1993-05-27 Behringwerke Ag Verfahren zur herstellung eines virussicheren thrombinkonzentrates
AT397390B (de) 1992-04-06 1994-03-25 Immuno Ag Verfahren zur spaltung von proteinen
GB9503750D0 (en) 1995-02-24 1995-04-12 Common Services Agency Thrombin preparation
AT500670A1 (de) 1999-05-19 2006-02-15 Bio & Bio Licensing Sa Arzneimittel zur lokalen anwendung
US6245548B1 (en) * 2000-03-09 2001-06-12 American National Red Cross Activation of pure prothrombin to thrombin with about 30% to about 40% sodium citrate
DE10012732A1 (de) * 2000-03-18 2001-09-20 Aventis Behring Gmbh Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung
IL136552A (en) 2000-06-05 2005-05-17 Omrix Biopharmaceuticals Ltd Method for the inactivation of viruses by a solvent - detergent combination and by nanofiltration
US20030133829A1 (en) * 2001-12-21 2003-07-17 Baxter Healthcare Corporation Process for inactivating pathogens in a biological material

Also Published As

Publication number Publication date
MXPA05000393A (es) 2005-07-22
EP1520018B1 (en) 2007-02-21
US20060134769A1 (en) 2006-06-22
BRPI0312522B8 (pt) 2021-05-25
JP4445386B2 (ja) 2010-04-07
GB0216002D0 (en) 2002-08-21
IL165989A0 (en) 2006-01-15
IL201146A (en) 2011-05-31
WO2004007707A1 (en) 2004-01-22
BRPI0312522B1 (pt) 2019-01-02
AU2003244858B2 (en) 2008-01-31
PT1520018E (pt) 2007-04-30
BR0312522A (pt) 2005-04-19
DE60311990D1 (de) 2007-04-05
CA2491718A1 (en) 2004-01-22
ATE354648T1 (de) 2007-03-15
NO20050090L (no) 2005-04-08
DE60311990T2 (de) 2007-11-08
CA2491718C (en) 2013-10-22
JP2005532073A (ja) 2005-10-27
IL165989A (en) 2010-11-30
ES2282644T3 (es) 2007-10-16
NZ537502A (en) 2007-12-21
PL374747A1 (en) 2005-10-31
PL208219B1 (pl) 2011-03-31
CY1107632T1 (el) 2013-04-18
EP1520018A1 (en) 2005-04-06
US8435779B2 (en) 2013-05-07
AU2003244858A1 (en) 2004-02-02

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