ATE354648T1 - Verfahren zur herstellung eines virus inaktivierten thrombin präparates - Google Patents

Verfahren zur herstellung eines virus inaktivierten thrombin präparates

Info

Publication number
ATE354648T1
ATE354648T1 AT03738334T AT03738334T ATE354648T1 AT E354648 T1 ATE354648 T1 AT E354648T1 AT 03738334 T AT03738334 T AT 03738334T AT 03738334 T AT03738334 T AT 03738334T AT E354648 T1 ATE354648 T1 AT E354648T1
Authority
AT
Austria
Prior art keywords
virus
producing
thrombin preparation
inactivated thrombin
preparation
Prior art date
Application number
AT03738334T
Other languages
English (en)
Inventor
Caroline Connolly
Christopher Hardway
David Evans
Peter Feldman
Original Assignee
Nhs Blood & Transplant
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nhs Blood & Transplant filed Critical Nhs Blood & Transplant
Application granted granted Critical
Publication of ATE354648T1 publication Critical patent/ATE354648T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/16—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT03738334T 2002-07-10 2003-07-07 Verfahren zur herstellung eines virus inaktivierten thrombin präparates ATE354648T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0216002.6A GB0216002D0 (en) 2002-07-10 2002-07-10 Process and composition

Publications (1)

Publication Number Publication Date
ATE354648T1 true ATE354648T1 (de) 2007-03-15

Family

ID=9940204

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03738334T ATE354648T1 (de) 2002-07-10 2003-07-07 Verfahren zur herstellung eines virus inaktivierten thrombin präparates

Country Status (19)

Country Link
US (1) US8435779B2 (de)
EP (1) EP1520018B1 (de)
JP (1) JP4445386B2 (de)
AT (1) ATE354648T1 (de)
AU (1) AU2003244858B2 (de)
BR (1) BRPI0312522B8 (de)
CA (1) CA2491718C (de)
CY (1) CY1107632T1 (de)
DE (1) DE60311990T2 (de)
EC (1) ECSP055586A (de)
ES (1) ES2282644T3 (de)
GB (1) GB0216002D0 (de)
IL (3) IL165989A0 (de)
MX (1) MXPA05000393A (de)
NO (1) NO20050090L (de)
NZ (1) NZ537502A (de)
PL (1) PL208219B1 (de)
PT (1) PT1520018E (de)
WO (1) WO2004007707A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5112060B2 (ja) * 2004-06-29 2013-01-09 リライアンス ライフ サイエンシーズ プライベイト リミテッド ウイルス安全性生物学的流体の調製のための方法
EP1685852A1 (de) * 2005-02-01 2006-08-02 Fondation pour la Recherche Diagnostique Set von Einwegbeuteln zur Virusinaktivierung von biologischen Fluids
US20060270015A1 (en) * 2005-05-26 2006-11-30 Dan Pawlak Thrombin purification
KR101555058B1 (ko) * 2005-07-29 2015-09-22 애보트 래버러토리즈 게엠베하 살균된 판크레아틴 분말의 제조방법
US11266607B2 (en) 2005-08-15 2022-03-08 AbbVie Pharmaceuticals GmbH Process for the manufacture and use of pancreatin micropellet cores
US9198871B2 (en) 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions
US10072256B2 (en) 2006-05-22 2018-09-11 Abbott Products Gmbh Process for separating and determining the viral load in a pancreatin sample
UA94945C2 (ru) * 2006-05-22 2011-06-25 Солвей Фармасьютикалс Гмбх Способ выделения и определения вирусной нагрузки в образце панкреатина
US7774628B2 (en) * 2006-05-25 2010-08-10 Foundry Networks, Inc. Enabling/disabling power-over-ethernet software subsystem in response to power supply status
AU2009236960A1 (en) 2008-04-16 2009-10-22 The Chemo-Sero-Therapeutic Research Institute Method of producing thrombin-immobilized bioabsorbable sheet preparation
JP5442310B2 (ja) * 2009-04-23 2014-03-12 旭化成メディカル株式会社 トロンビン溶液の調製方法
AU2015252061A1 (en) * 2009-07-31 2015-11-19 Baxalta GmbH Method for Purifying Recombinant ADAMTS13 and Other Proteins and Compositions Thereof
US8945895B2 (en) * 2009-07-31 2015-02-03 Baxter International Inc. Methods of purifying recombinant ADAMTS13 and other proteins and compositions thereof
SE1050124A1 (sv) * 2010-02-08 2011-08-09 Linkoping Biocontrols Ab Stabil lösning
CN102357259A (zh) 2011-07-28 2012-02-22 王珊珊 一种生物蛋白海绵及其制备方法
CN104507955A (zh) * 2012-05-31 2015-04-08 新加坡科技研究局 采用具有多形式官能性的颗粒对免疫球蛋白g制备物的色谱纯化
US9932388B2 (en) 2014-11-13 2018-04-03 Hemarus Therapeutics Limited Chromatographic process for producing high purity fibrinogen and thrombin
CN113754757B (zh) * 2021-07-01 2024-06-14 华兰生物工程股份有限公司 一种人纤维蛋白原的制备方法
CN115947825B (zh) * 2023-01-30 2025-11-28 华兰生物工程重庆有限公司 一种基于层析方法的纤维蛋白原制备工艺

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3336631A1 (de) * 1983-10-08 1985-04-18 Behringwerke Ag, 3550 Marburg Verfahren zur pasteurisierung von plasma oder von konzentraten der blutgerinnungsfaktoren ii, vii, ix und x
DE3843126C3 (de) * 1988-12-22 1994-10-06 Octapharma Ag Verfahren zur Herstellung eines hochreinen Thrombinkonzentrates
IE73210B1 (en) 1990-01-24 1997-05-07 Warner Lambert Co Process for the production of thrombin and high purity thrombin preparation thereby obtained
EP0443724B1 (de) * 1990-02-20 1999-03-17 Baxter International Inc. Gereinigtes, virusfreies menschliches Thrombin
FR2679251B1 (fr) * 1991-07-18 1993-11-12 Nord Assoc Essor Transfusion San Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique.
AT398079B (de) * 1991-11-04 1994-09-26 Immuno Ag Präparation mit thrombinaktivität sowie verfahren zu ihrer herstellung
DE4137996A1 (de) * 1991-11-19 1993-05-27 Behringwerke Ag Verfahren zur herstellung eines virussicheren thrombinkonzentrates
AT397390B (de) * 1992-04-06 1994-03-25 Immuno Ag Verfahren zur spaltung von proteinen
GB9503750D0 (en) * 1995-02-24 1995-04-12 Common Services Agency Thrombin preparation
AT500670A1 (de) * 1999-05-19 2006-02-15 Bio & Bio Licensing Sa Arzneimittel zur lokalen anwendung
US6245548B1 (en) * 2000-03-09 2001-06-12 American National Red Cross Activation of pure prothrombin to thrombin with about 30% to about 40% sodium citrate
DE10012732A1 (de) 2000-03-18 2001-09-20 Aventis Behring Gmbh Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung
IL136552A (en) 2000-06-05 2005-05-17 Omrix Biopharmaceuticals Ltd Method for the inactivation of viruses by a solvent - detergent combination and by nanofiltration
US20030133829A1 (en) * 2001-12-21 2003-07-17 Baxter Healthcare Corporation Process for inactivating pathogens in a biological material

Also Published As

Publication number Publication date
GB0216002D0 (en) 2002-08-21
IL165989A0 (en) 2006-01-15
IL201146A (en) 2011-05-31
DE60311990D1 (de) 2007-04-05
CA2491718C (en) 2013-10-22
JP4445386B2 (ja) 2010-04-07
ES2282644T3 (es) 2007-10-16
EP1520018B1 (de) 2007-02-21
BR0312522A (pt) 2005-04-19
BRPI0312522B1 (pt) 2019-01-02
JP2005532073A (ja) 2005-10-27
US20060134769A1 (en) 2006-06-22
IL165989A (en) 2010-11-30
AU2003244858A1 (en) 2004-02-02
BRPI0312522B8 (pt) 2021-05-25
ECSP055586A (es) 2005-07-06
CY1107632T1 (el) 2013-04-18
CA2491718A1 (en) 2004-01-22
PT1520018E (pt) 2007-04-30
AU2003244858B2 (en) 2008-01-31
NZ537502A (en) 2007-12-21
DE60311990T2 (de) 2007-11-08
MXPA05000393A (es) 2005-07-22
NO20050090L (no) 2005-04-08
WO2004007707A1 (en) 2004-01-22
US8435779B2 (en) 2013-05-07
PL208219B1 (pl) 2011-03-31
PL374747A1 (en) 2005-10-31
EP1520018A1 (de) 2005-04-06

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