NO20050090L - Fremgangsmate for fremstilling av et virus-inaktivert trombinpreparat - Google Patents

Fremgangsmate for fremstilling av et virus-inaktivert trombinpreparat

Info

Publication number
NO20050090L
NO20050090L NO20050090A NO20050090A NO20050090L NO 20050090 L NO20050090 L NO 20050090L NO 20050090 A NO20050090 A NO 20050090A NO 20050090 A NO20050090 A NO 20050090A NO 20050090 L NO20050090 L NO 20050090L
Authority
NO
Norway
Prior art keywords
virus
preparing
thrombin
medium
inactivated
Prior art date
Application number
NO20050090A
Other languages
English (en)
Inventor
David Evans
Peter Feldman
Caroline Connolly
Christopher Hardway
Original Assignee
Nat Blood Authority
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nat Blood Authority filed Critical Nat Blood Authority
Publication of NO20050090L publication Critical patent/NO20050090L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/16—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

2005-04-08 Sammendrag Det beskrives en metode for fremstilling av virus-inaktivert trombin omfattende løsningsmiddel-detergent virus-inaktivering av en løsning omfattende protrombin og faktor X, påføring av det virus-inaktiverte protrombin og faktor X på et anionbyttermedium, vasking av mediet for å fjerne reagensene anvendt for løsningsmiddel-detergent virus-inaktiveringen og aktivering av protrombinet på mediet for å danne trombin ved tilsetning av metallioner, fortrinnsvis kalsium-ioner. Trombinet blir deretter fortrinnsvis selektivt eluert fra anionbyttermediet.
NO20050090A 2002-07-10 2005-01-06 Fremgangsmate for fremstilling av et virus-inaktivert trombinpreparat NO20050090L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0216002.6A GB0216002D0 (en) 2002-07-10 2002-07-10 Process and composition
PCT/GB2003/002942 WO2004007707A1 (en) 2002-07-10 2003-07-07 Process for producing a virus-inactivated thrombin preparation

Publications (1)

Publication Number Publication Date
NO20050090L true NO20050090L (no) 2005-04-08

Family

ID=9940204

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20050090A NO20050090L (no) 2002-07-10 2005-01-06 Fremgangsmate for fremstilling av et virus-inaktivert trombinpreparat

Country Status (19)

Country Link
US (1) US8435779B2 (no)
EP (1) EP1520018B1 (no)
JP (1) JP4445386B2 (no)
AT (1) ATE354648T1 (no)
AU (1) AU2003244858B2 (no)
BR (1) BRPI0312522B8 (no)
CA (1) CA2491718C (no)
CY (1) CY1107632T1 (no)
DE (1) DE60311990T2 (no)
EC (1) ECSP055586A (no)
ES (1) ES2282644T3 (no)
GB (1) GB0216002D0 (no)
IL (3) IL165989A0 (no)
MX (1) MXPA05000393A (no)
NO (1) NO20050090L (no)
NZ (1) NZ537502A (no)
PL (1) PL208219B1 (no)
PT (1) PT1520018E (no)
WO (1) WO2004007707A1 (no)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005265960B8 (en) * 2004-06-29 2012-01-12 Reliance Life Sciences Pvt Ltd Process for improvement of virus-safe biological fluids
EP1685852A1 (en) * 2005-02-01 2006-08-02 Fondation pour la Recherche Diagnostique Set of disposable bags for viral inactivation of biological fluids
US20060270015A1 (en) * 2005-05-26 2006-11-30 Dan Pawlak Thrombin purification
HUE031042T2 (en) 2005-07-29 2017-06-28 Abbott Laboratories Gmbh Methods for producing pancreatin powder with low viral content
US11266607B2 (en) 2005-08-15 2022-03-08 AbbVie Pharmaceuticals GmbH Process for the manufacture and use of pancreatin micropellet cores
US9198871B2 (en) 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions
AU2007253380B2 (en) * 2006-05-22 2013-03-14 Abbott Laboratories Gmbh Process for separating and determining the viral load in a pancreatin sample
US10072256B2 (en) 2006-05-22 2018-09-11 Abbott Products Gmbh Process for separating and determining the viral load in a pancreatin sample
US7774628B2 (en) * 2006-05-25 2010-08-10 Foundry Networks, Inc. Enabling/disabling power-over-ethernet software subsystem in response to power supply status
EP2269594B1 (en) 2008-04-16 2016-03-02 The Chemo-Sero-Therapeutic Research Institute Method of producing thrombin-immobilized bioabsorbable sheet preparation
JP5442310B2 (ja) * 2009-04-23 2014-03-12 旭化成メディカル株式会社 トロンビン溶液の調製方法
US8945895B2 (en) * 2009-07-31 2015-02-03 Baxter International Inc. Methods of purifying recombinant ADAMTS13 and other proteins and compositions thereof
AU2015252061A1 (en) * 2009-07-31 2015-11-19 Baxalta GmbH Method for Purifying Recombinant ADAMTS13 and Other Proteins and Compositions Thereof
SE1050124A1 (sv) * 2010-02-08 2011-08-09 Linkoping Biocontrols Ab Stabil lösning
CN102357259A (zh) 2011-07-28 2012-02-22 王珊珊 一种生物蛋白海绵及其制备方法
WO2013180647A1 (en) * 2012-05-31 2013-12-05 Agency For Science, Technology And Research Chromatographic purification of immunoglobulin g preparations with particles having multimodal functionalities
US9932388B2 (en) 2014-11-13 2018-04-03 Hemarus Therapeutics Limited Chromatographic process for producing high purity fibrinogen and thrombin
CN113754757B (zh) * 2021-07-01 2024-06-14 华兰生物工程股份有限公司 一种人纤维蛋白原的制备方法
CN115947825B (zh) * 2023-01-30 2025-11-28 华兰生物工程重庆有限公司 一种基于层析方法的纤维蛋白原制备工艺

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3336631A1 (de) * 1983-10-08 1985-04-18 Behringwerke Ag, 3550 Marburg Verfahren zur pasteurisierung von plasma oder von konzentraten der blutgerinnungsfaktoren ii, vii, ix und x
DE3843126C3 (de) 1988-12-22 1994-10-06 Octapharma Ag Verfahren zur Herstellung eines hochreinen Thrombinkonzentrates
IE73210B1 (en) * 1990-01-24 1997-05-07 Warner Lambert Co Process for the production of thrombin and high purity thrombin preparation thereby obtained
ES2131504T3 (es) * 1990-02-20 1999-08-01 Baxter Int Trombina humana purificada viricamente segura.
FR2679251B1 (fr) 1991-07-18 1993-11-12 Nord Assoc Essor Transfusion San Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique.
AT398079B (de) 1991-11-04 1994-09-26 Immuno Ag Präparation mit thrombinaktivität sowie verfahren zu ihrer herstellung
DE4137996A1 (de) 1991-11-19 1993-05-27 Behringwerke Ag Verfahren zur herstellung eines virussicheren thrombinkonzentrates
AT397390B (de) 1992-04-06 1994-03-25 Immuno Ag Verfahren zur spaltung von proteinen
GB9503750D0 (en) 1995-02-24 1995-04-12 Common Services Agency Thrombin preparation
AT500670A1 (de) 1999-05-19 2006-02-15 Bio & Bio Licensing Sa Arzneimittel zur lokalen anwendung
US6245548B1 (en) * 2000-03-09 2001-06-12 American National Red Cross Activation of pure prothrombin to thrombin with about 30% to about 40% sodium citrate
DE10012732A1 (de) * 2000-03-18 2001-09-20 Aventis Behring Gmbh Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung
IL136552A (en) 2000-06-05 2005-05-17 Omrix Biopharmaceuticals Ltd Method for the inactivation of viruses by a solvent - detergent combination and by nanofiltration
US20030133829A1 (en) * 2001-12-21 2003-07-17 Baxter Healthcare Corporation Process for inactivating pathogens in a biological material

Also Published As

Publication number Publication date
DE60311990D1 (de) 2007-04-05
PL208219B1 (pl) 2011-03-31
US8435779B2 (en) 2013-05-07
ATE354648T1 (de) 2007-03-15
ES2282644T3 (es) 2007-10-16
PL374747A1 (en) 2005-10-31
MXPA05000393A (es) 2005-07-22
EP1520018B1 (en) 2007-02-21
IL165989A (en) 2010-11-30
PT1520018E (pt) 2007-04-30
IL201146A (en) 2011-05-31
DE60311990T2 (de) 2007-11-08
BR0312522A (pt) 2005-04-19
AU2003244858A1 (en) 2004-02-02
AU2003244858B2 (en) 2008-01-31
CA2491718C (en) 2013-10-22
EP1520018A1 (en) 2005-04-06
CY1107632T1 (el) 2013-04-18
BRPI0312522B8 (pt) 2021-05-25
NZ537502A (en) 2007-12-21
JP4445386B2 (ja) 2010-04-07
GB0216002D0 (en) 2002-08-21
IL165989A0 (en) 2006-01-15
JP2005532073A (ja) 2005-10-27
BRPI0312522B1 (pt) 2019-01-02
CA2491718A1 (en) 2004-01-22
US20060134769A1 (en) 2006-06-22
WO2004007707A1 (en) 2004-01-22
ECSP055586A (es) 2005-07-06

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