ECSP055736A - Formulaciones precisas derivadas de acido nodulisporico para combatir parasitos - Google Patents
Formulaciones precisas derivadas de acido nodulisporico para combatir parasitosInfo
- Publication number
- ECSP055736A ECSP055736A EC2005005736A ECSP055736A ECSP055736A EC SP055736 A ECSP055736 A EC SP055736A EC 2005005736 A EC2005005736 A EC 2005005736A EC SP055736 A ECSP055736 A EC SP055736A EC SP055736 A ECSP055736 A EC SP055736A
- Authority
- EC
- Ecuador
- Prior art keywords
- birds
- mammals
- nodulisporic acid
- prophylaxis
- formulations derived
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 244000045947 parasite Species 0.000 title abstract 3
- UNCVXXVJJXJZII-QLETUHIQSA-N 1k1cu6363a Chemical compound OC(=O)C(/C)=C/C=C/[C@@](C)([C@@H]1CC2)[C@@H](O)CC[C@]1(C)[C@]1(C)[C@@H]2CC2=C1N1[C@@H](C(=C)C)C(=O)C3=C([C@@H](O)[C@@H]4C(OC(C)(C)C=C44)(C)C)C4=CC2=C31 UNCVXXVJJXJZII-QLETUHIQSA-N 0.000 title 1
- 229930187416 nodulisporic acid Natural products 0.000 title 1
- UNCVXXVJJXJZII-UHFFFAOYSA-N nodulisporic acid A Natural products C1CC2C(C)(C=CC=C(C)C(O)=O)C(O)CCC2(C)C2(C)C1CC1=C2N2C(C(=C)C)C(=O)C3=C(C(O)C4C(OC(C)(C)C=C44)(C)C)C4=CC1=C32 UNCVXXVJJXJZII-UHFFFAOYSA-N 0.000 title 1
- 206010061217 Infestation Diseases 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 238000011321 prophylaxis Methods 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 238000011938 amidation process Methods 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 230000003071 parasitic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A61K9/0017—Non-human animal skin, e.g. pour-on, spot-on
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
- A01N43/38—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Environmental Sciences (AREA)
- Epidemiology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Esta invención proporciona composiciones interalia, precisas para el tratamiento o profilaxis de infestaciones de parásitos en mamíferos o aves que comprenden: (1) por lo menos un derivado de ácido nodulispórico; (2) un vehículo portador líquido aceptable; y (3) opcionalmente, un inhibidor de cristalización. La invención también proporciona un método para el tratamiento de infestaciones parasitarias o para la profilaxis de infestaciones de parásitos en mamíferos o aves que comprende aplicar tópicamente a los mamíferos o aves una cantidad eficaz de una composición de conformidad con la presente invención. Además, esta invención se relaciona a un proceso de amidación para preparar derivados de amida de ácido nodulispórico y a intermediarios formados en este proceso.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41562702P | 2002-10-02 | 2002-10-02 | |
| US10/618,975 US20040077703A1 (en) | 2002-10-02 | 2003-07-14 | Nodulisporic acid derivative spot-on formulations for combating parasites |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP055736A true ECSP055736A (es) | 2005-09-20 |
Family
ID=32073382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2005005736A ECSP055736A (es) | 2002-10-02 | 2005-04-18 | Formulaciones precisas derivadas de acido nodulisporico para combatir parasitos |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20040077703A1 (es) |
| EP (1) | EP1545211B1 (es) |
| JP (1) | JP2006502241A (es) |
| KR (2) | KR20050059235A (es) |
| CN (1) | CN100496244C (es) |
| AP (1) | AP2047A (es) |
| AU (1) | AU2003279002A1 (es) |
| BR (1) | BR0314531A (es) |
| CA (1) | CA2500822C (es) |
| CO (1) | CO5700750A2 (es) |
| CR (2) | CR7810A (es) |
| EA (1) | EA009683B1 (es) |
| EC (1) | ECSP055736A (es) |
| ES (1) | ES2482101T3 (es) |
| GE (1) | GEP20084414B (es) |
| MA (1) | MA27457A1 (es) |
| MX (1) | MXPA05003581A (es) |
| NZ (1) | NZ539227A (es) |
| UA (1) | UA83199C2 (es) |
| WO (1) | WO2004030457A1 (es) |
| ZA (1) | ZA200502904B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9416065B2 (en) * | 2007-02-12 | 2016-08-16 | Archer Daniels Midland Company | Adjuvants and methods of using them |
| US8097266B2 (en) * | 2007-11-26 | 2012-01-17 | Merial Limited | Solvent systems for pour-on formulations for combating parasites |
| EP2875726A1 (fr) | 2013-11-13 | 2015-05-27 | Ceva Animal Health | Nouvelles applications de compositions vétérinaires dans le traitement contre les parasites |
| KR101687973B1 (ko) | 2015-12-08 | 2016-12-21 | 주식회사 씨티씨바이오 | 마이크로필름 코팅을 이용한 동물 사료용 프리믹스 제조방법 |
| WO2019064243A1 (en) * | 2017-09-29 | 2019-04-04 | Victoria Link Limited | HETEROLOGICAL BIOSYNTHESIS OF NODULISPORIC ACID |
| KR102178885B1 (ko) * | 2020-01-17 | 2020-11-13 | 강현준 | 카프릴산을 포함하는 안정한 해충 방제제 및 이의 제조방법 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2753377B1 (fr) * | 1996-09-19 | 1999-09-24 | Rhone Merieux | Nouvelle association parasiticide a base de 1-n-phenylpyra- zoles et de lactones macrocycliques endectocides |
| US6426333B1 (en) * | 1996-09-19 | 2002-07-30 | Merial | Spot-on formulations for combating parasites |
| US3950360A (en) * | 1972-06-08 | 1976-04-13 | Sankyo Company Limited | Antibiotic substances |
| SE434277B (sv) * | 1976-04-19 | 1984-07-16 | Merck & Co Inc | Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis |
| US4199569A (en) * | 1977-10-03 | 1980-04-22 | Merck & Co., Inc. | Selective hydrogenation products of C-076 compounds and derivatives thereof |
| JPS57139012A (en) * | 1981-02-23 | 1982-08-27 | Sankyo Co Ltd | Anthelmintic composition |
| US4427663A (en) * | 1982-03-16 | 1984-01-24 | Merck & Co., Inc. | 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof |
| EP0237482A1 (de) * | 1986-03-06 | 1987-09-16 | Ciba-Geigy Ag | C(29)-Carbonyloxi-milbemycin-Derivate zur Bekämpfung von tier- und pflanzenparasitären Schädlingen |
| DE3785936T2 (de) * | 1986-03-25 | 1993-08-26 | Sankyo Co | Makrolid-derivate, ihre herstellung und ihre verwendung. |
| GB8613914D0 (en) * | 1986-06-07 | 1986-07-09 | Coopers Animal Health | Liquid formulations |
| EP0252879B1 (de) * | 1986-07-02 | 1992-05-06 | Ciba-Geigy Ag | Pestizide |
| US4855317A (en) * | 1987-03-06 | 1989-08-08 | Ciba-Geigy Corporation | Insecticides and parasiticides |
| US4871719A (en) * | 1987-03-24 | 1989-10-03 | Ciba-Geigy Corporation | Composition for controlling parasites in productive livestock |
| EP0319142B1 (en) * | 1987-11-03 | 1994-04-06 | Beecham Group Plc | Intermediates for the preparation of anthelmintic macrolide antibiotics |
| NZ232422A (en) * | 1989-02-16 | 1992-11-25 | Merck & Co Inc | 13-ketal milbemycin derivatives and parasiticides |
| CA2036147A1 (en) * | 1990-06-29 | 1991-12-30 | Hiroki Tomioka | A 1-pyridylimidazole derivative and its production and use |
| GB9205007D0 (en) * | 1992-03-07 | 1992-04-22 | Pfizer Ltd | Antiparasitic agents |
| GB9300883D0 (en) | 1993-01-18 | 1993-03-10 | Pfizer Ltd | Antiparasitic agents |
| DE59408292D1 (de) * | 1993-02-19 | 1999-07-01 | Hoffmann La Roche | Racemisierungsfreie Herstellung von Amiden und Peptiden in Gegenwart katalytischer Mengen einer N-Hydroxy-Verbindung |
| GB9315108D0 (en) * | 1993-07-21 | 1993-09-01 | Pfizer Ltd | Antiparasitic agents |
| US5399582A (en) * | 1993-11-01 | 1995-03-21 | Merck & Co., Inc. | Antiparasitic agents |
| GB9402916D0 (en) * | 1994-02-16 | 1994-04-06 | Pfizer Ltd | Antiparasitic agents |
| JPH0827018A (ja) * | 1994-07-22 | 1996-01-30 | Sanwa Kagaku Kenkyusho Co Ltd | 生理活性ペプチド又は蛋白質を含有する薬剤組成物 |
| AUPM969994A0 (en) * | 1994-11-28 | 1994-12-22 | Virbac S.A. | Equine anthelmintic formulations |
| US5595998A (en) * | 1994-12-15 | 1997-01-21 | Wolin; Ronald L. | Pyrazoloquinolines |
| US5962499A (en) * | 1995-03-20 | 1999-10-05 | Merck & Co., Inc. | Nodulisporic acid derivatives |
| US6221894B1 (en) * | 1995-03-20 | 2001-04-24 | Merck & Co., Inc. | Nodulisporic acid derivatives |
| US5595991A (en) * | 1995-03-20 | 1997-01-21 | Merck & Co., Inc. | Anthelmintic use of nodulisporic acid and analogs thereof |
| ATE435648T1 (de) * | 1995-03-20 | 2009-07-15 | Merck & Co Inc | Derivaten von nodulisporen säure |
| WO1998012196A1 (en) * | 1996-09-19 | 1998-03-26 | Merck & Co., Inc. | Nodulisporic acid derivatives |
| FR2739255B1 (fr) * | 1995-09-29 | 1998-09-04 | Rhone Merieux | Composition antiparasitaire pour le traitement et la protection des animaux de compagnie |
| US6010710A (en) * | 1996-03-29 | 2000-01-04 | Merial | Direct pour-on skin solution for antiparasitic use in cattle and sheep |
| IE80657B1 (en) * | 1996-03-29 | 1998-11-04 | Merial Sas | Insecticidal combination to control mammal fleas in particular fleas on cats and dogs |
| US5885607A (en) * | 1996-03-29 | 1999-03-23 | Rhone Merieux | N-phenylpyrazole-based anti-flea and anti-tick external device for cats and dogs |
| US5834260A (en) * | 1996-08-30 | 1998-11-10 | Merck & Co., Inc. | Antiparasitic agents |
| US6136838A (en) * | 1998-03-19 | 2000-10-24 | Merck & Co., Inc. | Sulfurpentafluorophenylpyrazoles for controlling ectoparasitic infestations |
| JP3510591B2 (ja) * | 1998-03-30 | 2004-03-29 | エルジ ケミカル リミテッド | ポリエトキシル化レチンアミド誘導体およびその製造方法 |
| US6399796B2 (en) * | 2000-03-17 | 2002-06-04 | Roche Vitamins Inc. | Activation of a Diels-Alder reaction of a sterol 5,7-diene |
| US6399786B1 (en) * | 2000-07-14 | 2002-06-04 | Merck & Co., Inc. | Nonacyclic nodulisporic acid derivatives |
| US20040037869A1 (en) * | 2002-08-16 | 2004-02-26 | Douglas Cleverly | Non-animal product containing veterinary formulations |
| US20050234119A1 (en) * | 2004-04-16 | 2005-10-20 | Soll Mark D | Antiparasitical agents and methods for treating, preventing and controlling external parasites in animals |
| US20080003282A1 (en) * | 2005-04-18 | 2008-01-03 | Soll Mark D | Antiparasitical agents and methods for treating, preventing and controlling external parasites in animals |
-
2003
- 2003-07-14 US US10/618,975 patent/US20040077703A1/en not_active Abandoned
- 2003-09-29 UA UAA200504055A patent/UA83199C2/ru unknown
- 2003-09-29 CN CNB038253070A patent/CN100496244C/zh not_active Expired - Fee Related
- 2003-09-29 BR BR0314531-0A patent/BR0314531A/pt not_active Application Discontinuation
- 2003-09-29 WO PCT/US2003/030500 patent/WO2004030457A1/en not_active Ceased
- 2003-09-29 NZ NZ539227A patent/NZ539227A/en not_active IP Right Cessation
- 2003-09-29 GE GEAP20038771A patent/GEP20084414B/en unknown
- 2003-09-29 MX MXPA05003581A patent/MXPA05003581A/es unknown
- 2003-09-29 KR KR1020057005819A patent/KR20050059235A/ko not_active Ceased
- 2003-09-29 ES ES03770513.4T patent/ES2482101T3/es not_active Expired - Lifetime
- 2003-09-29 EA EA200500579A patent/EA009683B1/ru not_active IP Right Cessation
- 2003-09-29 KR KR1020077019588A patent/KR20070099668A/ko not_active Withdrawn
- 2003-09-29 CA CA2500822A patent/CA2500822C/en not_active Expired - Lifetime
- 2003-09-29 JP JP2005500323A patent/JP2006502241A/ja active Pending
- 2003-09-29 EP EP03770513.4A patent/EP1545211B1/en not_active Expired - Lifetime
- 2003-09-29 AP AP2005003289A patent/AP2047A/xx active
- 2003-09-29 AU AU2003279002A patent/AU2003279002A1/en not_active Abandoned
-
2005
- 2005-04-11 ZA ZA200502904A patent/ZA200502904B/en unknown
- 2005-04-18 EC EC2005005736A patent/ECSP055736A/es unknown
- 2005-04-25 MA MA28236A patent/MA27457A1/fr unknown
- 2005-04-28 CR CR7810A patent/CR7810A/es unknown
- 2005-04-28 CO CO05040666A patent/CO5700750A2/es not_active Application Discontinuation
-
2008
- 2008-09-25 CR CR10319A patent/CR10319A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004030457A1 (en) | 2004-04-15 |
| EP1545211A1 (en) | 2005-06-29 |
| CR7810A (es) | 2005-05-25 |
| JP2006502241A (ja) | 2006-01-19 |
| UA83199C2 (ru) | 2008-06-25 |
| MXPA05003581A (es) | 2005-06-17 |
| CA2500822C (en) | 2013-12-24 |
| EA009683B1 (ru) | 2008-02-28 |
| KR20070099668A (ko) | 2007-10-09 |
| US20040077703A1 (en) | 2004-04-22 |
| AP2005003289A0 (en) | 2005-06-30 |
| EA200500579A1 (ru) | 2005-08-25 |
| NZ539227A (en) | 2007-01-26 |
| ZA200502904B (en) | 2005-10-19 |
| CR10319A (es) | 2008-10-21 |
| CN1700859A (zh) | 2005-11-23 |
| GEP20084414B (en) | 2008-07-10 |
| ES2482101T3 (es) | 2014-08-01 |
| EP1545211B1 (en) | 2014-04-30 |
| AU2003279002A1 (en) | 2004-04-23 |
| HK1072348A1 (en) | 2005-08-26 |
| CA2500822A1 (en) | 2004-04-15 |
| BR0314531A (pt) | 2005-08-09 |
| KR20050059235A (ko) | 2005-06-17 |
| MA27457A1 (fr) | 2005-07-01 |
| CN100496244C (zh) | 2009-06-10 |
| AP2047A (en) | 2009-09-18 |
| CO5700750A2 (es) | 2006-11-30 |
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