ECSP055975A - Tinturas de cianina hidrofílicas, reactivas con tiol y conjugados de las mismas con biomoléculas para diagnóstico por fluorescencia - Google Patents

Tinturas de cianina hidrofílicas, reactivas con tiol y conjugados de las mismas con biomoléculas para diagnóstico por fluorescencia

Info

Publication number
ECSP055975A
ECSP055975A EC2005005975A ECSP055975A ECSP055975A EC SP055975 A ECSP055975 A EC SP055975A EC 2005005975 A EC2005005975 A EC 2005005975A EC SP055975 A ECSP055975 A EC SP055975A EC SP055975 A ECSP055975 A EC SP055975A
Authority
EC
Ecuador
Prior art keywords
dyes
biomolecules
conjugates
tiol
hydrophylic
Prior art date
Application number
EC2005005975A
Other languages
English (en)
Inventor
Kai Licha
Christin Perlitz
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2003102787 external-priority patent/DE10302787A1/de
Application filed by Schering Ag filed Critical Schering Ag
Publication of ECSP055975A publication Critical patent/ECSP055975A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C09B23/0025—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being bound through an oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C09B23/005—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being a COOH and/or a functional derivative thereof
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0066—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid)
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/086—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

La presente invención se refiere a nuevas tinturas para fluorescencia de la clase de las tinturas de cianina, especialmente indotricarbocianinas con un máximo de absorción y de fluorescencia en el rango espectral entre 700 y 900nm, un grupo reactivo específico para tiol, y tres, preferiblemente cuatro, grupos sulfonato, para obtener un aumento de la solubilidad en agua así como la producción de tinturas. La presente invención también se refiere a los conjugados de dichas tinturas con biomoléculas y a usos de los mismos.
EC2005005975A 2003-01-24 2005-08-23 Tinturas de cianina hidrofílicas, reactivas con tiol y conjugados de las mismas con biomoléculas para diagnóstico por fluorescencia ECSP055975A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2003102787 DE10302787A1 (de) 2003-01-24 2003-01-24 Hydrophile, Thiol-reaktive Cyaninfarbstoffe und deren Konjugate mit Biomolekülen für die Fluoreszenzdiagnostik
US44319703P 2003-01-29 2003-01-29

Publications (1)

Publication Number Publication Date
ECSP055975A true ECSP055975A (es) 2006-01-16

Family

ID=32773159

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2005005975A ECSP055975A (es) 2003-01-24 2005-08-23 Tinturas de cianina hidrofílicas, reactivas con tiol y conjugados de las mismas con biomoléculas para diagnóstico por fluorescencia

Country Status (17)

Country Link
US (1) US20040260072A1 (es)
EP (1) EP1585791B1 (es)
JP (1) JP2006513293A (es)
KR (1) KR20050103907A (es)
AT (1) ATE409209T1 (es)
AU (1) AU2003292019A1 (es)
BR (1) BR0318028A (es)
CA (1) CA2514131A1 (es)
CR (1) CR7925A (es)
DE (1) DE60323766D1 (es)
EA (1) EA009386B1 (es)
EC (1) ECSP055975A (es)
ES (1) ES2311736T3 (es)
MX (1) MXPA05007668A (es)
NZ (1) NZ541414A (es)
PL (1) PL376459A1 (es)
WO (1) WO2004065491A1 (es)

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US7972789B2 (en) 2005-11-28 2011-07-05 Dako Denmark A/S Dye compounds
WO2007091661A1 (ja) * 2006-02-08 2007-08-16 National Institute Of Advanced Industrial Science And Technology 分子イメージングに適した糖鎖修飾リポソームならびにその利用および製造
US8221721B2 (en) * 2007-02-09 2012-07-17 Visen Medical, Inc. Polycyclo dyes and use thereof
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KR101043407B1 (ko) * 2009-02-19 2011-06-22 한국과학기술연구원 암 표적성이 우수한 단백질 복합체 및 이의 제조방법
JP2011046663A (ja) 2009-08-28 2011-03-10 Fujifilm Corp 近赤外蛍光造影剤
KR101228147B1 (ko) * 2010-08-13 2013-01-31 국립암센터 방사성 동위원소가 표지되고 근적외선 영역의 형광색소 및 가시광선 영역의 색소가 결합된 알부민을 포함하는 감시림프절 표지자
WO2012054749A1 (en) * 2010-10-20 2012-04-26 Li-Cor, Inc. Cyanine dyes and their conjugates
WO2012088007A1 (en) 2010-12-21 2012-06-28 Pierce Biotechnology, Inc. Fluorescent compounds
US8889884B1 (en) 2011-07-14 2014-11-18 Pierce Biotechnology, Inc. Phosphine derivatives of fluorescent compounds
US9249307B2 (en) 2011-08-16 2016-02-02 Pierce Biotechnology, Inc. Benzocyanine compounds
WO2013044156A1 (en) * 2011-09-23 2013-03-28 Li-Cor, Inc. Application of reduced dyes in imaging
EP3338617B1 (en) 2012-01-23 2020-08-19 Washington University Goggle imaging systems and devices
US9751868B2 (en) 2012-02-28 2017-09-05 Pierce Biotechnology, Inc. Benzocyanine compounds
EP2804860B1 (en) 2012-03-02 2016-06-15 Pierce Biotechnology, Inc. Indole derivatives as labeling dye for biomolecule
CA2867144C (en) 2012-03-27 2019-07-02 Ventana Medical Systems, Inc. Signaling conjugates and methods of use
CN104540819B (zh) 2012-08-28 2019-04-19 皮尔斯生物科技有限公司 苯并吡喃鎓化合物
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TWI758784B (zh) 2014-09-12 2022-03-21 美商建南德克公司 抗her2抗體及免疫結合物
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JP6752582B2 (ja) * 2016-02-08 2020-09-09 キヤノン株式会社 光音響イメージング用造影剤
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Also Published As

Publication number Publication date
PL376459A1 (en) 2005-12-27
NZ541414A (en) 2007-12-21
WO2004065491A1 (en) 2004-08-05
US20040260072A1 (en) 2004-12-23
EP1585791A1 (en) 2005-10-19
CR7925A (es) 2006-02-06
AU2003292019A1 (en) 2004-08-13
ES2311736T3 (es) 2009-02-16
BR0318028A (pt) 2005-12-06
CA2514131A1 (en) 2004-08-05
JP2006513293A (ja) 2006-04-20
MXPA05007668A (es) 2005-09-30
KR20050103907A (ko) 2005-11-01
EA009386B1 (ru) 2007-12-28
EP1585791B1 (en) 2008-09-24
EA200501064A1 (ru) 2006-02-24
ATE409209T1 (de) 2008-10-15
DE60323766D1 (de) 2008-11-06

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