ECSP056222A - Derivados de indazolil(indolil)maleimida sustituidoscomo inhibidores de cinasa - Google Patents

Derivados de indazolil(indolil)maleimida sustituidoscomo inhibidores de cinasa

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Publication number
ECSP056222A
ECSP056222A EC2005006222A ECSP056222A ECSP056222A EC SP056222 A ECSP056222 A EC SP056222A EC 2005006222 A EC2005006222 A EC 2005006222A EC SP056222 A ECSP056222 A EC SP056222A EC SP056222 A ECSP056222 A EC SP056222A
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EC
Ecuador
Prior art keywords
sub
inhibitors
substituted
kinase
indazolil
Prior art date
Application number
EC2005006222A
Other languages
English (en)
Inventor
Han-Cheng Zhang
Bruce E Maryanoff
Hong Ye
Original Assignee
Janssen Pharmaceutica Nv
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Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ECSP056222A publication Critical patent/ECSP056222A/es

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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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Abstract

La presente invención se dirige a compuestos novedosos de compuestos de pirrolina sustituida con indazolilo de fórmula (I): fórmula (I), R2 se selecciona a partir del grupo que consiste de -alquilo de C1-8-Z, -alquenilo de C2-8-Z y -alquinilo de C2-8-Z; en donde el -alquilo de C1-8-Z, -alquenilo de C2-8-Z y -alquinilo de C2-8-Z y Z es un anillo heteroarilo monocíclico aromático de 5 a 6 miembros que tiene de 2 a 4 heteroátomos; estos compuestos son útiles con inhibidores de cinasa o cinasa-dual, métodos para producir dichos compuestos y métodos para tratamiento o mejoría de un trastorno mediado por cinasa o cinasa-dual.
EC2005006222A 2003-06-13 2005-12-13 Derivados de indazolil(indolil)maleimida sustituidoscomo inhibidores de cinasa ECSP056222A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47851603P 2003-06-13 2003-06-13

Publications (1)

Publication Number Publication Date
ECSP056222A true ECSP056222A (es) 2006-04-19

Family

ID=33551833

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2005006222A ECSP056222A (es) 2003-06-13 2005-12-13 Derivados de indazolil(indolil)maleimida sustituidoscomo inhibidores de cinasa

Country Status (22)

Country Link
US (1) US7439363B2 (es)
EP (1) EP1654255B1 (es)
JP (1) JP2007500748A (es)
KR (1) KR20060021890A (es)
CN (1) CN1832940A (es)
AT (1) ATE406365T1 (es)
AU (1) AU2004251178A1 (es)
BR (1) BRPI0411366A (es)
CA (1) CA2529353A1 (es)
CO (1) CO5650246A2 (es)
CR (1) CR8148A (es)
DE (1) DE602004016174D1 (es)
EA (1) EA200600032A1 (es)
EC (1) ECSP056222A (es)
ES (1) ES2311161T3 (es)
HR (1) HRP20050991A2 (es)
IL (1) IL172456A0 (es)
IS (1) IS8174A (es)
NO (1) NO20060145L (es)
RS (1) RS20050915A (es)
WO (1) WO2005000836A1 (es)
ZA (1) ZA200600294B (es)

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EP1513520B1 (en) * 2002-06-05 2008-09-24 Janssen Pharmaceutica N.V. Substituted pyrrolines as kinase inhibitors
JP2005531609A (ja) * 2002-06-05 2005-10-20 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ キナーゼ阻害剤としてのシスインドリル−マレイミド誘導体
US7488826B2 (en) * 2003-03-27 2009-02-10 Janssen Pharmaceutica N.V. Substituted pyrroline kinase inhibitors

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JP2007500748A (ja) 2007-01-18
KR20060021890A (ko) 2006-03-08
EP1654255B1 (en) 2008-08-27
RS20050915A (sr) 2008-04-04
AU2004251178A1 (en) 2005-01-06
ES2311161T3 (es) 2009-02-01
CR8148A (es) 2008-09-10
EP1654255A1 (en) 2006-05-10
US20050004201A1 (en) 2005-01-06
EA200600032A1 (ru) 2006-06-30
ATE406365T1 (de) 2008-09-15
ZA200600294B (en) 2007-04-25
CA2529353A1 (en) 2005-01-06
WO2005000836A1 (en) 2005-01-06
IL172456A0 (en) 2006-04-10
CO5650246A2 (es) 2006-06-30
BRPI0411366A (pt) 2006-07-25
NO20060145L (no) 2006-03-07
US7439363B2 (en) 2008-10-21
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HRP20050991A2 (en) 2006-09-30
DE602004016174D1 (de) 2008-10-09

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