BRPI0411366A - derivados de indazolil (indolil) maleimida substituìdos como inibidores de cinase - Google Patents

derivados de indazolil (indolil) maleimida substituìdos como inibidores de cinase

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Publication number
BRPI0411366A
BRPI0411366A BRPI0411366-7A BRPI0411366A BRPI0411366A BR PI0411366 A BRPI0411366 A BR PI0411366A BR PI0411366 A BRPI0411366 A BR PI0411366A BR PI0411366 A BRPI0411366 A BR PI0411366A
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BR
Brazil
Prior art keywords
sub
indazolyl
kinase inhibitors
kinase
indolyl
Prior art date
Application number
BRPI0411366-7A
Other languages
English (en)
Inventor
Han-Cheng Zhang
Bruce E Maryanoff
Hong Ye
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BRPI0411366A publication Critical patent/BRPI0411366A/pt

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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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Abstract

"DERIVADOS DE INDAZOLIL (INDOLIL) MALEIMIDA SUBSTITUìDOS COMO INIBIDORES DE CINASE". A presente invenção refere-se a novos compostos pirrolina substituídos com indazolila de Fórmula (I): R¬ 2¬ é selecionado do grupo consistindo em C~ 1-8~ alquil-Z, C~ 2-8~ alquenil-Z e -C~ 2-8~ alquinil-Z; onde o -C~ 1-8~ alquil-Z, C~ 2-8~ alquenil-Z e -C~ 2-8~ alquinil-Z e Z é um anel heteroarila monocíclico aromático de 5 a 6 membros tendo de 2 a 4 heteroátomos. Estes compostos são úteis como inibidores de cinase ou cinase dual, processo para produção de tais compostos e processos para tratamento ou melhora de um distúrbio mediado por cinase ou cinase dual.
BRPI0411366-7A 2003-06-13 2004-06-01 derivados de indazolil (indolil) maleimida substituìdos como inibidores de cinase BRPI0411366A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47851603P 2003-06-13 2003-06-13
PCT/US2004/017375 WO2005000836A1 (en) 2003-06-13 2004-06-01 Substituted indazolyl(indolyl)maleimide derivatives as kinase inhibitors

Publications (1)

Publication Number Publication Date
BRPI0411366A true BRPI0411366A (pt) 2006-07-25

Family

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BRPI0411366-7A BRPI0411366A (pt) 2003-06-13 2004-06-01 derivados de indazolil (indolil) maleimida substituìdos como inibidores de cinase

Country Status (22)

Country Link
US (1) US7439363B2 (pt)
EP (1) EP1654255B1 (pt)
JP (1) JP2007500748A (pt)
KR (1) KR20060021890A (pt)
CN (1) CN1832940A (pt)
AT (1) ATE406365T1 (pt)
AU (1) AU2004251178A1 (pt)
BR (1) BRPI0411366A (pt)
CA (1) CA2529353A1 (pt)
CO (1) CO5650246A2 (pt)
CR (1) CR8148A (pt)
DE (1) DE602004016174D1 (pt)
EA (1) EA200600032A1 (pt)
EC (1) ECSP056222A (pt)
ES (1) ES2311161T3 (pt)
HR (1) HRP20050991A2 (pt)
IL (1) IL172456A0 (pt)
IS (1) IS8174A (pt)
NO (1) NO20060145L (pt)
RS (1) RS20050915A (pt)
WO (1) WO2005000836A1 (pt)
ZA (1) ZA200600294B (pt)

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EP1513520B1 (en) * 2002-06-05 2008-09-24 Janssen Pharmaceutica N.V. Substituted pyrrolines as kinase inhibitors
JP2005531609A (ja) * 2002-06-05 2005-10-20 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ キナーゼ阻害剤としてのシスインドリル−マレイミド誘導体
US7488826B2 (en) * 2003-03-27 2009-02-10 Janssen Pharmaceutica N.V. Substituted pyrroline kinase inhibitors

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JP2007500748A (ja) 2007-01-18
KR20060021890A (ko) 2006-03-08
EP1654255B1 (en) 2008-08-27
RS20050915A (sr) 2008-04-04
AU2004251178A1 (en) 2005-01-06
ES2311161T3 (es) 2009-02-01
ECSP056222A (es) 2006-04-19
CR8148A (es) 2008-09-10
EP1654255A1 (en) 2006-05-10
US20050004201A1 (en) 2005-01-06
EA200600032A1 (ru) 2006-06-30
ATE406365T1 (de) 2008-09-15
ZA200600294B (en) 2007-04-25
CA2529353A1 (en) 2005-01-06
WO2005000836A1 (en) 2005-01-06
IL172456A0 (en) 2006-04-10
CO5650246A2 (es) 2006-06-30
NO20060145L (no) 2006-03-07
US7439363B2 (en) 2008-10-21
IS8174A (is) 2005-12-09
HRP20050991A2 (en) 2006-09-30
DE602004016174D1 (de) 2008-10-09

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