ECSP066365A - Anilino purinas sustituidas en la posición 6 útiles como inhibidores de rtk - Google Patents

Anilino purinas sustituidas en la posición 6 útiles como inhibidores de rtk

Info

Publication number
ECSP066365A
ECSP066365A EC2006006365A ECSP066365A ECSP066365A EC SP066365 A ECSP066365 A EC SP066365A EC 2006006365 A EC2006006365 A EC 2006006365A EC SP066365 A ECSP066365 A EC SP066365A EC SP066365 A ECSP066365 A EC SP066365A
Authority
EC
Ecuador
Prior art keywords
purinas
anilino
replaced
useful
rtk inhibitors
Prior art date
Application number
EC2006006365A
Other languages
English (en)
Inventor
Nathanael S Gray
Dai Cheng
Qiang Ding
Dong Han
Guobao Zhang
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irm Llc filed Critical Irm Llc
Publication of ECSP066365A publication Critical patent/ECSP066365A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención provee una clase novedosa de compuestos, composiciones farmacéuticas que comprenden a dichos compuestos y métodos para utilizar dichos compuestos para tratar o prevenir enfermedades o trastornos asociados con actividad de cSRC, Lck, FGFR3, Flt3, TrkB, Bmx, y/o PFGFRa cinasa.
EC2006006365A 2003-08-15 2006-02-14 Anilino purinas sustituidas en la posición 6 útiles como inhibidores de rtk ECSP066365A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49540603P 2003-08-15 2003-08-15
US52435703P 2003-11-21 2003-11-21
US56536704P 2004-04-26 2004-04-26

Publications (1)

Publication Number Publication Date
ECSP066365A true ECSP066365A (es) 2006-08-30

Family

ID=34198974

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2006006365A ECSP066365A (es) 2003-08-15 2006-02-14 Anilino purinas sustituidas en la posición 6 útiles como inhibidores de rtk

Country Status (16)

Country Link
US (2) US20050124637A1 (es)
EP (1) EP1656378A4 (es)
JP (1) JP2007502776A (es)
AU (2) AU2004264419B2 (es)
BR (1) BRPI0413563A (es)
CA (1) CA2535620A1 (es)
CO (1) CO5680404A2 (es)
EC (1) ECSP066365A (es)
IL (1) IL173392A0 (es)
IS (1) IS8345A (es)
MA (1) MA27997A1 (es)
MX (1) MXPA06001758A (es)
NO (1) NO20061074L (es)
SG (1) SG145748A1 (es)
TN (1) TNSN06053A1 (es)
WO (1) WO2005016528A2 (es)

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IS8345A (is) 2006-03-09
AU2009201480A1 (en) 2009-05-14
EP1656378A2 (en) 2006-05-17
AU2004264419A1 (en) 2005-02-24
MXPA06001758A (es) 2006-08-11
SG145748A1 (en) 2008-09-29
CA2535620A1 (en) 2005-02-24
NO20061074L (no) 2006-03-06
TNSN06053A1 (en) 2007-10-03
US20050124637A1 (en) 2005-06-09
WO2005016528A3 (en) 2005-05-12
US20110092491A1 (en) 2011-04-21
IL173392A0 (en) 2006-06-11
BRPI0413563A (pt) 2006-10-17
CO5680404A2 (es) 2006-09-29
AU2004264419B2 (en) 2009-01-15
WO2005016528A2 (en) 2005-02-24
JP2007502776A (ja) 2007-02-15
EP1656378A4 (en) 2011-05-11

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