PE20090601A1 - Derivados de piridin-il-oxi-piridinas como inhibidores de alk5 - Google Patents

Derivados de piridin-il-oxi-piridinas como inhibidores de alk5

Info

Publication number
PE20090601A1
PE20090601A1 PE2008001368A PE2008001368A PE20090601A1 PE 20090601 A1 PE20090601 A1 PE 20090601A1 PE 2008001368 A PE2008001368 A PE 2008001368A PE 2008001368 A PE2008001368 A PE 2008001368A PE 20090601 A1 PE20090601 A1 PE 20090601A1
Authority
PE
Peru
Prior art keywords
pyridin
cyane
halo
oxy
nitro
Prior art date
Application number
PE2008001368A
Other languages
English (en)
Inventor
Maurice Raymond Verschoyle Finlay
Frederick Woolf Goldberg
Craig Anthony Roberts
Nicola Jane Roberts
David Alan Rudge
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20090601A1 publication Critical patent/PE20090601A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

REFERIDA A UN COMPUESTO DE FORMULA I, DONDE R1 ES H, HALO, NITRO, CIANO, SULFO, ENTRE OTROS; R3 ES HALO, NITRO, CIANO, SULFO, HIDROXI, ENTRE OTROS; R2 ES H, HALO, CIANO, MERCAPTO, ENTRE OTROS; n ES 0-3; A ES ANILLO CARBOCICLICO, HETEROCICLICO SUSTIUIDOS O NO POR HALO, CIANO, NITRO, HIDROXI, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 4-(5,6-DIMETIL-2-PIRIDIN-2-IL-PIRIDIN-3-IL)OXI-N-PIRIDIN-2-IL-PIRIDIN-2-AMINA; N-(2-AMINO-2-OXOETIL)-3-{[4-(2,6-DIMETILPIRIDIN-3-IL)-OXIPIRIDIN-2-IL]AMINO}BENZAMIDA; 4-(2,6-DIMETIL-PIRIDIN-3-IL)OXI-N-{3-[(4-METILSULFONIL-PIPERAZIN-1-IL)METIL]FENIL}PIRIDIN-2-AMINA; ENTRE OTROS.DICHOS COMPUESTOS SON INHIBIDORES DE ALK5 UTILES EN EL TRATAMIENTO DE CANCER
PE2008001368A 2007-08-13 2008-08-13 Derivados de piridin-il-oxi-piridinas como inhibidores de alk5 PE20090601A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95548607P 2007-08-13 2007-08-13

Publications (1)

Publication Number Publication Date
PE20090601A1 true PE20090601A1 (es) 2009-06-12

Family

ID=39864913

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001368A PE20090601A1 (es) 2007-08-13 2008-08-13 Derivados de piridin-il-oxi-piridinas como inhibidores de alk5

Country Status (7)

Country Link
US (1) US20090048269A1 (es)
AR (1) AR067931A1 (es)
CL (1) CL2008002369A1 (es)
PE (1) PE20090601A1 (es)
TW (1) TW200911783A (es)
UY (1) UY31281A1 (es)
WO (1) WO2009022171A1 (es)

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EA019104B1 (ru) 2007-09-21 2014-01-30 Эррей Биофарма Инк. Активаторы глюкокиназы
US8871744B2 (en) 2010-07-21 2014-10-28 B & G Partyers, LLC Compounds and methods for selectively targeting tumor-associated mucins
US8987461B2 (en) 2012-12-06 2015-03-24 Quanticel Pharmaceuticals, Inc. Histone demethylase inhibitors
PL3089971T3 (pl) 2014-01-01 2021-01-25 Medivation Technologies Llc Związki i sposoby ich zastosowania
JO3336B1 (ar) * 2014-10-07 2019-03-13 Lilly Co Eli مركبات أمينو بيريديلوكسي بيرازول
HUE057041T2 (hu) 2015-07-06 2022-04-28 Alkermes Inc Hiszton deacetiláz hetero-halogén gátlói
WO2017007755A1 (en) 2015-07-06 2017-01-12 Rodin Therapeutics, Inc. Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase
US11466003B2 (en) 2016-07-29 2022-10-11 Shanghai Yingli Pharmaceutical Co., Ltd Nitrogenous heterocyclic aromatic compound, preparation method therefor, pharmaceutical composition thereof, and application thereof
HRP20220223T1 (hr) 2017-01-11 2022-04-29 Alkermes, Inc. Biciklički inhibitori histon deacetilaze
US11225475B2 (en) 2017-08-07 2022-01-18 Alkermes, Inc. Substituted pyridines as inhibitors of histone deacetylase
CN110066276B (zh) 2018-01-24 2020-09-18 上海璎黎药业有限公司 芳香杂环化合物、其中间体、制备方法、药物组合物和应用
CN110066277B (zh) 2018-01-24 2021-07-23 上海璎黎药业有限公司 芳香杂环取代烯烃化合物、其制备方法、药物组合物和应用
WO2020103817A1 (zh) * 2018-11-20 2020-05-28 南京圣和药业股份有限公司 TGF-βR1抑制剂及其应用
SG11202103457PA (en) * 2018-12-27 2021-05-28 Nexys Therapeutics Inc (pyridin-2-yl)amine derivatives as tgf-beta r1 (alk5) inhibitors for the treatment of cancer
CA3133964A1 (en) * 2019-03-18 2020-09-24 The Council Of The Queensland Institute Of Medical Research Cardiomyocyte proliferation
KR102816656B1 (ko) * 2019-06-25 2025-06-02 인벤티스바이오 컴퍼니 리미티드 헤테로고리 화합물, 이의 제조방법 및 이의 사용방법
BR112022024071A2 (pt) 2020-05-27 2022-12-20 Axial Therapeutics Inc Compostos moduladores de tlr2, composições farmacêuticas e usos dos mesmos
EP4251613A4 (en) * 2020-11-27 2024-11-20 Allorion Therapeutics Inc. AMINOHETEROARYL KINASE INHIBITORS
TW202329937A (zh) 2021-12-03 2023-08-01 美商英塞特公司 雙環胺ｃｋ１２抑制劑
US12084453B2 (en) 2021-12-10 2024-09-10 Incyte Corporation Bicyclic amines as CDK12 inhibitors
EP4464694A4 (en) * 2022-01-14 2026-04-01 Shanghai Hansoh Biomedical Co Ltd POLYCYCLIC DERIVATIVE CONTAINING PYRIDINE, ITS PREPARATION PROCESS AND ITS USE
US20250206730A1 (en) * 2022-03-22 2025-06-26 Autotelic Bio Inc. Thiazole derivative compound and uses thereof
WO2024151919A1 (en) * 2023-01-13 2024-07-18 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity
US11939294B1 (en) 2023-10-23 2024-03-26 King Faisal University 1-(2-(substituted phenyl)-2-oxoethyl)-3,5-dimethylpyridin-1-ium bromides as antitubercular agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0102673D0 (en) * 2001-02-02 2001-03-21 Glaxo Group Ltd Compounds
ATE497603T1 (de) * 2001-03-02 2011-02-15 Gpc Biotech Ag Drei-hybrid-assaysystem
JP5236499B2 (ja) * 2006-01-27 2013-07-17 アレイ バイオファーマ、インコーポレイテッド グルコキナーゼ活性化剤
AU2007338792B2 (en) * 2006-12-20 2012-05-31 Amgen Inc. Substituted heterocycles and methods of use
US8431713B2 (en) * 2007-01-24 2013-04-30 Array Biopharma, Inc. 2-aminopyridine derivatives as glucokinase activators

Also Published As

Publication number Publication date
US20090048269A1 (en) 2009-02-19
WO2009022171A1 (en) 2009-02-19
UY31281A1 (es) 2009-03-31
CL2008002369A1 (es) 2009-07-17
TW200911783A (en) 2009-03-16
AR067931A1 (es) 2009-10-28

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