ECSP066542A - Derivados de disulfuro, sulfuro, sulfóxido, y sulfota de azúcares cíclicos y sus usos - Google Patents

Derivados de disulfuro, sulfuro, sulfóxido, y sulfota de azúcares cíclicos y sus usos

Info

Publication number: ECSP066542A
Authority: EC; Ecuador
Prior art keywords: derivatives; sulphote; sulphoxide; disulfide; sulfide
Prior art date: 2003-10-03

Application number

EC2006006542A

Other languages

English (en)

Spanish (es)

Inventor

Moliner Jose Repolles

Coy Francisco Pubill

Original Assignee

Lacer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-03

Filing date

2006-05-03

Publication date

2006-10-17

2006-05-03 Application filed by Lacer Sa filed Critical Lacer Sa

2006-10-17 Publication of ECSP066542A publication Critical patent/ECSP066542A/es

Links

ATTZFSUZZUNHBP-UHFFFAOYSA-N Piperonyl sulfoxide Chemical compound CCCCCCCCS(=O)C(C)CC1=CC=C2OCOC2=C1 ATTZFSUZZUNHBP-UHFFFAOYSA-N 0.000 title 1
UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 title 1
150000002019 disulfides Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Biomedical Technology (AREA)
Endocrinology (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Emergency Medicine (AREA)
Biochemistry (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Immunology (AREA)
Toxicology (AREA)
Gynecology & Obstetrics (AREA)
Reproductive Health (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EC2006006542A 2003-10-03 2006-05-03 Derivados de disulfuro, sulfuro, sulfóxido, y sulfota de azúcares cíclicos y sus usos ECSP066542A (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ES200302368A ES2258365B1 (es)	2003-10-03	2003-10-03	Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos.

Publications (1)

Publication Number	Publication Date
ECSP066542A true ECSP066542A (es)	2006-10-17

Family

ID=34451643

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EC2006006542A ECSP066542A (es)	2003-10-03	2006-05-03	Derivados de disulfuro, sulfuro, sulfóxido, y sulfota de azúcares cíclicos y sus usos

Country Status (34)

Country	Link
US (3)	US7521571B2 (pt)
EP (1)	EP1668017B1 (pt)
JP (2)	JP4809769B2 (pt)
KR (1)	KR101141683B1 (pt)
CN (1)	CN1863805B (pt)
AP (1)	AP1976A (pt)
AR (1)	AR045962A1 (pt)
AT (1)	ATE423781T1 (pt)
AU (1)	AU2004281916B2 (pt)
BR (1)	BRPI0415020A (pt)
CA (1)	CA2540500C (pt)
DE (2)	DE602004019666D1 (pt)
DK (1)	DK1668017T3 (pt)
EA (1)	EA008942B1 (pt)
EC (1)	ECSP066542A (pt)
ES (2)	ES2258365B1 (pt)
GB (1)	GB2421241B (pt)
GE (1)	GEP20084490B (pt)
GT (1)	GT200400200A (pt)
HR (1)	HRP20090152T3 (pt)
IL (1)	IL174371A0 (pt)
IS (1)	IS8436A (pt)
MX (1)	MXPA06003610A (pt)
NO (1)	NO20061872L (pt)
NZ (1)	NZ546043A (pt)
PA (1)	PA8614201A1 (pt)
PE (1)	PE20050436A1 (pt)
PL (1)	PL1668017T3 (pt)
PT (1)	PT1668017E (pt)
RS (1)	RS20060241A (pt)
SI (1)	SI1668017T1 (pt)
UY (1)	UY28547A1 (pt)
WO (1)	WO2005037842A1 (pt)
ZA (1)	ZA200603475B (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2258365B1 (es) *	2003-10-03	2007-12-01	Lacer, S.A.	Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos.
EP1941876A1 (en) *	2006-12-28	2008-07-09	Lacer, S.A.	Isosorbide mononitrate derivatives for the treatment of Inflammation and ocular hypertension
ES2332565B1 (es) *	2007-01-23	2010-10-21	Lacer, S.A.	Uso de derivados de mononitrato de dianhidrohexita como agentes antiinflamatorios.
JP2010518171A (ja) *	2007-02-13	2010-05-27	ギリアード・パロ・アルト・インコーポレイテッド	非冠微小血管疾患の処置のためのラノラジンの使用
US20080248112A1 (en) *	2007-02-13	2008-10-09	Brent Blackburn	Use of ranolazine for the treatment of coronary microvascular diseases
US20090111826A1 (en) *	2007-02-13	2009-04-30	Louis Lange	Use of ranolazine for the treatment of cardiovascular diseases
EP2117508A1 (en) *	2007-02-13	2009-11-18	CV Therapeutics Inc.	Intravenous solutions comprising ranolazine
US20080233191A1 (en) *	2007-03-22	2008-09-25	Brent Blackburn	Use of ranolazine for elevated brain-type natriuretic peptide
WO2008150565A2 (en) *	2007-05-31	2008-12-11	Cv Therapeutics, Inc.	Ranolazine for elevated brain-type natriuretic peptide
IE20070934A1 (en)	2007-12-21	2009-06-24	Trinity College Dublin	Efficient aspirin prodrugs
WO2009098113A1 (en) *	2008-02-07	2009-08-13	Nicox S.A.	Nitric oxide donor compounds
EP2149576A1 (en)	2008-07-22	2010-02-03	Lacer, S.A.	Isosorbide Nitrates having vasodilating activity
EP2149577B1 (en) *	2008-07-22	2011-04-27	Lacer, S.A.	New stereospecific method for the preparation of dioxa-bicyclooctane compounds
EP2177216A1 (en) *	2008-10-13	2010-04-21	Lacer, S.A.	Use of dianhydrohexite mononitrate derivatives as healing agents
WO2010055138A1 (en) *	2008-11-14	2010-05-20	Lacer, S.A.	New stereospecific method for the preparation of dioxa-bicyclooctane compounds
EP2199294A1 (en)	2008-12-19	2010-06-23	Lacer, S.A.	New stereospecific method for the preparation of dioxa bicyclooctane nitrate compounds
US20130131161A1 (en) *	2009-12-23	2013-05-23	Michael R. Bristow	Methods and compositions for cardiovascular diseases and conditions
FR2977252B1 (fr) *	2011-06-30	2013-08-02	Seppic Sa	Nouveaux esters de derives n-acyles d'acides amines et d'isosorbide, procede pour leur preparation, et utilisation en cosmetique et comme medicament.
JP6021938B2 (ja)	2011-12-16	2016-11-09	スリーエムイノベイティブプロパティズカンパニー	メルカプト含有ビスアンヒドロヘキシトール誘導体及びその使用
CA2902009A1 (en) *	2013-03-05	2014-09-12	Archer Daniels Midland Company	Isohexide monotriflates and process for synthesis thereof
CN116173012A (zh) *	2022-12-05	2023-05-30	温州医科大学	白当归脑在制备缺血性脑卒中神经保护用药物中的应用

Family Cites Families (14)

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Publication number	Priority date	Publication date	Assignee	Title
US3886186A (en)	1971-04-29	1975-05-27	American Home Prod	Mononitrate esters of 1,4:3,6-dianhydro-d-glucitol
GB1356374A (en) *	1971-04-29	1974-06-12	American Home Prod	Mononitrate esters of 1,3 3,6-dianhydro-d-glucitol
DE3102947A1 (de)	1981-01-29	1982-09-02	Heinrich Mack Nachf., 7918 Illertissen	Verfahren zur herstellung von isosorbid-5-nitrat
IT1204571B (it) *	1987-05-08	1989-03-10	Chiesi Farma Spa	Esteri di 1,4:3,6-dianidrosorbitolo-2-mononitrato e 5-mononitrato,loro procedimento di preparazione e loro composizioni farmaceutiche
US4891373A (en) *	1988-11-23	1990-01-02	Pfizer Inc.	Aminopropanol derivatives of 1,4:3,6-dianhydrohexitol nitrates, processes for their preparation and their use as medicaments
FR2680173A1 (fr) *	1991-08-07	1993-02-12	Hoechst Lab	Nitrates organiques, leurs procedes de preparation et leur utilisation dans le traitement de maladies cardiovasculaires .
ES2125342T3 (es) *	1992-07-30	1999-03-01	Cal Int Ltd	Esteres y combinaciones de un nitrato organico y de un salicilato.
DE4410997A1 (de) *	1994-03-30	1995-10-26	Isis Pharma Gmbh	Pharmazeutische Zubereitungen und Arzneistoffe zur Prävention und Behandlung endothelialer Dysfunktionen
IL120531A (en) *	1997-03-26	2006-12-31	Yissum Res Dev Co	Nitric oxide donors and pharmaceutical compositions containing them
ES2142773B1 (es) *	1998-10-07	2001-01-01	Lacer Sa	Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia desminuida.
US20020013483A1 (en) *	2000-07-13	2002-01-31	Consortium Fur Elektrochemische Industrie Gmbh	Process for the preparation of dianhydrohexitol bisacylates
JP2004521083A (ja) *	2000-10-27	2004-07-15	ニトロメッド，インク．	酸化窒素不足によって特徴づけられる血管疾患の治療方法
UA63467A (en)	2003-04-22	2004-01-15		Pharmaceutical composition of organic nitrates, dosage form based on pharmaceutical composition of organic nitrates and method of manufacture
ES2258365B1 (es) *	2003-10-03	2007-12-01	Lacer, S.A.	Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos.

2003
- 2003-10-03 ES ES200302368A patent/ES2258365B1/es not_active Expired - Fee Related
2004
- 2004-09-29 CA CA2540500A patent/CA2540500C/en not_active Expired - Fee Related
- 2004-09-29 SI SI200431109T patent/SI1668017T1/sl unknown
- 2004-09-29 AP AP2006003605A patent/AP1976A/xx active
- 2004-09-29 EA EA200600694A patent/EA008942B1/ru not_active IP Right Cessation
- 2004-09-29 WO PCT/EP2004/010882 patent/WO2005037842A1/en not_active Ceased
- 2004-09-29 RS YUP-2006/0241A patent/RS20060241A/sr unknown
- 2004-09-29 EP EP04765682A patent/EP1668017B1/en not_active Expired - Lifetime
- 2004-09-29 GE GEAP20049372A patent/GEP20084490B/en unknown
- 2004-09-29 DE DE602004019666T patent/DE602004019666D1/de not_active Expired - Lifetime
- 2004-09-29 PL PL04765682T patent/PL1668017T3/pl unknown
- 2004-09-29 DE DE112004001860T patent/DE112004001860T5/de not_active Withdrawn
- 2004-09-29 DK DK04765682T patent/DK1668017T3/da active
- 2004-09-29 JP JP2006530042A patent/JP4809769B2/ja not_active Expired - Fee Related
- 2004-09-29 PT PT04765682T patent/PT1668017E/pt unknown
- 2004-09-29 KR KR1020067006283A patent/KR101141683B1/ko not_active Expired - Fee Related
- 2004-09-29 HR HR20090152T patent/HRP20090152T3/xx unknown
- 2004-09-29 CN CN2004800289355A patent/CN1863805B/zh not_active Expired - Fee Related
- 2004-09-29 ES ES04765682T patent/ES2322468T3/es not_active Expired - Lifetime
- 2004-09-29 GB GB0605574A patent/GB2421241B/en not_active Expired - Fee Related
- 2004-09-29 AU AU2004281916A patent/AU2004281916B2/en not_active Ceased
- 2004-09-29 AT AT04765682T patent/ATE423781T1/de not_active IP Right Cessation
- 2004-09-29 NZ NZ546043A patent/NZ546043A/en unknown
- 2004-09-29 BR BRPI0415020-1A patent/BRPI0415020A/pt not_active IP Right Cessation
- 2004-09-29 MX MXPA06003610A patent/MXPA06003610A/es active IP Right Grant
- 2004-09-29 US US10/544,237 patent/US7521571B2/en not_active Expired - Fee Related
- 2004-09-30 PE PE2004000957A patent/PE20050436A1/es not_active Application Discontinuation
- 2004-10-01 AR ARP040103576A patent/AR045962A1/es unknown
- 2004-10-01 UY UY28547A patent/UY28547A1/es not_active Application Discontinuation
- 2004-10-01 GT GT200400200A patent/GT200400200A/es unknown
- 2004-10-01 PA PA20048614201A patent/PA8614201A1/es unknown
2006
- 2006-03-16 IL IL174371A patent/IL174371A0/en unknown
- 2006-04-27 NO NO20061872A patent/NO20061872L/no not_active Application Discontinuation
- 2006-05-02 ZA ZA200603475A patent/ZA200603475B/xx unknown
- 2006-05-03 EC EC2006006542A patent/ECSP066542A/es unknown
- 2006-05-03 IS IS8436A patent/IS8436A/is unknown
2009
- 2009-03-09 US US12/400,394 patent/US7777058B2/en not_active Expired - Fee Related
2010
- 2010-04-06 US US12/755,103 patent/US8541607B2/en not_active Expired - Fee Related
- 2010-10-08 JP JP2010228789A patent/JP2011012081A/ja active Pending

Also Published As

Publication number	Publication date
DK1668017T3 (da)	2009-05-11
ES2322468T3 (es)	2009-06-22
GB2421241A (en)	2006-06-21
HRP20090152T3 (en)	2009-05-31
UY28547A1 (es)	2005-04-29
GB0605574D0 (en)	2006-04-26
PL1668017T3 (pl)	2009-07-31
SI1668017T1 (sl)	2009-08-31
EP1668017A1 (en)	2006-06-14
AU2004281916A1 (en)	2005-04-28
AP2006003605A0 (en)	2006-04-30
PE20050436A1 (es)	2005-06-23
WO2005037842A1 (en)	2005-04-28
ES2258365B1 (es)	2007-12-01
CN1863805A (zh)	2006-11-15
US8541607B2 (en)	2013-09-24
CA2540500C (en)	2012-08-28
IL174371A0 (en)	2006-08-01
KR101141683B1 (ko)	2012-05-07
JP4809769B2 (ja)	2011-11-09
PA8614201A1 (es)	2005-05-24
MXPA06003610A (es)	2006-06-05
EA200600694A1 (ru)	2006-10-27
RS20060241A (sr)	2008-06-05
JP2007507451A (ja)	2007-03-29
CN1863805B (zh)	2010-06-16
KR20060066743A (ko)	2006-06-16
US7521571B2 (en)	2009-04-21
DE112004001860T5 (de)	2006-07-27
JP2011012081A (ja)	2011-01-20
EA008942B1 (ru)	2007-10-26
AR045962A1 (es)	2005-11-16
ZA200603475B (en)	2007-09-26
HK1092807A1 (en)	2007-02-16
NZ546043A (en)	2009-02-28
DE602004019666D1 (de)	2009-04-09
US20090169560A1 (en)	2009-07-02
ATE423781T1 (de)	2009-03-15
GEP20084490B (en)	2008-09-25
GT200400200A (es)	2005-05-23
US20060235052A1 (en)	2006-10-19
CA2540500A1 (en)	2005-04-28
BRPI0415020A (pt)	2006-11-07
GB2421241B (en)	2008-04-16
EP1668017B1 (en)	2009-02-25
AP1976A (en)	2009-03-16
ES2258365A1 (es)	2006-08-16
NO20061872L (no)	2006-06-30
AU2004281916B2 (en)	2010-10-21
US20100196387A1 (en)	2010-08-05
PT1668017E (pt)	2009-03-09
US7777058B2 (en)	2010-08-17
IS8436A (is)	2006-05-03

Publication	Publication Date	Title
ECSP066542A (es)	2006-10-17	Derivados de disulfuro, sulfuro, sulfóxido, y sulfota de azúcares cíclicos y sus usos
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UY30498A1 (es)	2008-02-29	Nueva clase de compuestos de benzimidazolilo, sus sales, composiciones farmacéuticas conteniéndolos y aplicaciones
ECSP066541A (es)	2006-12-20	Nuevos derivados de piridazin-3(2h)-ona
UY28122A1 (es)	2004-07-30	Nuevos derivados de fluoroglicósidos heterocíclicos, medicamentos que contienen estos compuestos, y el uso de los mismos.
ECSP067025A (es)	2006-12-29	DERIVADOS DE TETRAAZABENZO [e] AZULENO Y SUS ANÁLOGOS
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ECSP066667A (es)	2006-10-25	Derivados de ciclohexano espirociclicos
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SV1999000118A (es)	2000-05-02	Nuevos derivados de pirazol substituidos ref. lea 33188-sv
ECSP066701A (es)	2006-10-31	Derivados de sulfonamida para el tratamiento de enfermedades
UY30856A1 (es)	2008-09-02	Nuevos derivados de 2,4 dianilinopirimidinas, su preparacion, como medicamentos, composiciones farmacéuticas y principalmente como inhibidores de ikk
NI201000134A (es)	2014-02-11	Nuevos derivados dihidroindolonas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
DOP2006000243A (es)	2007-05-31	Derivados de pirazina
UY28848A1 (es)	2005-11-30	Antagonistas de cgrp seleccionados, procedimientos para su preparación, y su empleo como medicamentos
UY28861A1 (es)	2005-11-30	Nuevas combinaciones farmacologicas para el tratamiento de enfermedades de las vias respiratorias
PA8768301A1 (es)	2008-11-19	Nuevos derivados tricíclicos, su procedimiento de preparación y las composiciones farmacéuticas que lo contienen
PA8589801A1 (es)	2004-11-26	Aminoalcoxiindoles
UY26566A1 (es)	2001-08-27	Nuevos moduladores alostéricos positivos de receptores de ampa (paarm), procedimientos para su preparación y su utilización como medicamentos.
ECSP099080A (es)	2009-02-27	Combinaciones farmacológicas para el tratamiento de enfermedades de las vías aéreas
PA8653801A1 (es)	2006-06-02	Derivados de octahidropirrolo [3,4-c] pirrol
UY29394A1 (es)	2006-10-02	Derivados sustituidos de n-(5-(2-propilamino.1.hidroxietil)-2-hdroxifenil) metano sulfonamida, composiciones farmacéuticas que lo contienen y aplicaciónes.
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