ECSP067080A - DIFENILIMIDAZOPIRIMIDINA Y AMINAS IMIDAZOL COMO INHIBIDORES DE ß-SECRETASA - Google Patents

DIFENILIMIDAZOPIRIMIDINA Y AMINAS IMIDAZOL COMO INHIBIDORES DE ß-SECRETASA

Info

Publication number
ECSP067080A
ECSP067080A EC2006007080A ECSP067080A ECSP067080A EC SP067080 A ECSP067080 A EC SP067080A EC 2006007080 A EC2006007080 A EC 2006007080A EC SP067080 A ECSP067080 A EC SP067080A EC SP067080 A ECSP067080 A EC SP067080A
Authority
EC
Ecuador
Prior art keywords
difenylimidazopirimidine
secretase
imidazol
amines
inhibitors
Prior art date
Application number
EC2006007080A
Other languages
English (en)
Inventor
Michael Sotirios Malamas
Iwan Gunawan
James Joseph Erdei
Keith Douglas Barnes
Matthew Robert Johnson
Yu Hui
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ECSP067080A publication Critical patent/ECSP067080A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención suministra un compuesto de fórmula I y el uso de este para el tratamiento, prevención o mejoramiento terapéutico de una enfermedad o trastorno caracterizado por depósitos b-amiloides o niveles b-amiloides elevados en un paciente.
EC2006007080A 2004-06-16 2006-12-13 DIFENILIMIDAZOPIRIMIDINA Y AMINAS IMIDAZOL COMO INHIBIDORES DE ß-SECRETASA ECSP067080A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58018704P 2004-06-16 2004-06-16

Publications (1)

Publication Number Publication Date
ECSP067080A true ECSP067080A (es) 2007-05-30

Family

ID=34982285

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2006007080A ECSP067080A (es) 2004-06-16 2006-12-13 DIFENILIMIDAZOPIRIMIDINA Y AMINAS IMIDAZOL COMO INHIBIDORES DE ß-SECRETASA

Country Status (24)

Country Link
US (2) US7456186B2 (es)
EP (1) EP1758907B1 (es)
JP (1) JP2008503460A (es)
KR (1) KR20070026811A (es)
CN (1) CN1997646A (es)
AR (1) AR049399A1 (es)
AT (1) ATE423121T1 (es)
AU (1) AU2005264917A1 (es)
BR (1) BRPI0512220A (es)
CA (1) CA2578600A1 (es)
DE (1) DE602005012825D1 (es)
EC (1) ECSP067080A (es)
ES (1) ES2321853T3 (es)
GT (1) GT200500157A (es)
IL (1) IL180018A0 (es)
MX (1) MXPA06014792A (es)
NO (1) NO20065847L (es)
PA (1) PA8637201A1 (es)
PE (1) PE20060299A1 (es)
RU (1) RU2006144075A (es)
SV (1) SV2007002146A (es)
TW (1) TW200602048A (es)
WO (1) WO2006009655A1 (es)
ZA (1) ZA200610593B (es)

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ATE482214T1 (de) * 2005-06-14 2010-10-15 Schering Corp Aspartylproteasehemmer
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US7759353B2 (en) * 2005-06-14 2010-07-20 Schering Corporation Substituted spiro iminopyrimidinones as aspartyl protease inhibitors, compositions, and methods of treatment
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CN101346357B (zh) 2005-10-25 2014-04-02 盐野义制药株式会社 氨基二氢噻嗪衍生物
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TW200815449A (en) * 2006-06-14 2008-04-01 Astrazeneca Ab Novel compounds II
TW200808796A (en) * 2006-06-14 2008-02-16 Astrazeneca Ab New compounds III
TW200815443A (en) * 2006-06-14 2008-04-01 Astrazeneca Ab Novel compounds I
TW200815447A (en) * 2006-06-14 2008-04-01 Astrazeneca Ab Novel compounds IV
TW200815349A (en) * 2006-06-22 2008-04-01 Astrazeneca Ab New compounds
US7700606B2 (en) * 2006-08-17 2010-04-20 Wyeth Llc Imidazole amines as inhibitors of β-secretase
TW200817406A (en) * 2006-08-17 2008-04-16 Wyeth Corp Imidazole amines as inhibitors of β-secretase
MX2009003102A (es) * 2006-09-21 2009-04-01 Wyeth Corp INDOLILALQUILPIRIDIN-2-AMINAS PARA LA INHIBICION DE ß-SECRETASA.
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Also Published As

Publication number Publication date
EP1758907B1 (en) 2009-02-18
RU2006144075A (ru) 2008-07-27
AR049399A1 (es) 2006-07-26
ES2321853T3 (es) 2009-06-12
PA8637201A1 (es) 2006-06-02
US20050282826A1 (en) 2005-12-22
IL180018A0 (en) 2007-05-15
SV2007002146A (es) 2007-03-20
EP1758907A1 (en) 2007-03-07
BRPI0512220A (pt) 2008-02-19
PE20060299A1 (es) 2006-05-18
TW200602048A (en) 2006-01-16
MXPA06014792A (es) 2007-02-16
ZA200610593B (en) 2009-09-30
NO20065847L (no) 2006-12-18
CN1997646A (zh) 2007-07-11
US20090042912A1 (en) 2009-02-12
JP2008503460A (ja) 2008-02-07
DE602005012825D1 (de) 2009-04-02
CA2578600A1 (en) 2006-01-26
GT200500157A (es) 2006-11-07
ATE423121T1 (de) 2009-03-15
US7456186B2 (en) 2008-11-25
AU2005264917A1 (en) 2006-01-26
WO2006009655A1 (en) 2006-01-26
KR20070026811A (ko) 2007-03-08

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