ECSP067091A - Procesos para preparacion de antagonistas de receptor de hormona que libera gonadotropina - Google Patents

Procesos para preparacion de antagonistas de receptor de hormona que libera gonadotropina

Info

Publication number
ECSP067091A
ECSP067091A EC2006007091A ECSP067091A ECSP067091A EC SP067091 A ECSP067091 A EC SP067091A EC 2006007091 A EC2006007091 A EC 2006007091A EC SP067091 A ECSP067091 A EC SP067091A EC SP067091 A ECSP067091 A EC SP067091A
Authority
EC
Ecuador
Prior art keywords
receptor antagonists
gonadotropine
processes
preparation
free
Prior art date
Application number
EC2006007091A
Other languages
English (en)
Inventor
Alexander V Gontcharov
Gulnaz Khafizova
John R Potoski
Donna Mary Huryn
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ECSP067091A publication Critical patent/ECSP067091A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08Radicals containing only hydrogen and carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se relaciona a métodos de producción de antagonistas de receptor de Hormona que Libera Gonadotropina ("GnRH") (también conocida como Hormona que Libera Hormona de Luteinización).
EC2006007091A 2004-06-17 2006-12-18 Procesos para preparacion de antagonistas de receptor de hormona que libera gonadotropina ECSP067091A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58066504P 2004-06-17 2004-06-17

Publications (1)

Publication Number Publication Date
ECSP067091A true ECSP067091A (es) 2007-01-26

Family

ID=34972567

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2006007091A ECSP067091A (es) 2004-06-17 2006-12-18 Procesos para preparacion de antagonistas de receptor de hormona que libera gonadotropina

Country Status (16)

Country Link
US (1) US7714130B2 (es)
EP (1) EP1756093A1 (es)
JP (1) JP2008503470A (es)
CN (1) CN1968948A (es)
AU (1) AU2005264998A1 (es)
BR (1) BRPI0512239A (es)
CA (1) CA2570693A1 (es)
CR (1) CR8786A (es)
EC (1) ECSP067091A (es)
IL (1) IL179993A0 (es)
MX (1) MXPA06014797A (es)
NO (1) NO20070248L (es)
NZ (1) NZ552093A (es)
RU (1) RU2007101509A (es)
WO (1) WO2006009736A1 (es)
ZA (1) ZA200610594B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1758895A1 (en) * 2004-06-17 2007-03-07 Wyeth a Corporation of the State of Delaware Gonadotropin releasing hormone receptor antagonists
CA2570693A1 (en) 2004-06-17 2006-01-26 Wyeth Processes for preparing gonadotropin releasing hormone receptor antagonists
MX2007005765A (es) * 2004-11-23 2007-07-19 Wyeth Corp Antagonistas del receptor de la hormona que libera gonadotropina.
US7534796B2 (en) * 2005-02-18 2009-05-19 Wyeth Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor
US7582634B2 (en) * 2005-02-18 2009-09-01 Wyeth 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US7538113B2 (en) * 2005-02-18 2009-05-26 Wyeth 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US20060189619A1 (en) * 2005-02-24 2006-08-24 Wyeth 3-({4-[2-(4-Tert-butylphenyl)-1h-benzimidazol-4-yl]piperazin-1-yl}methyl)pyrido[2,3-b]]pyrazi ne compounds
US20060211699A1 (en) * 2005-03-07 2006-09-21 Wyeth Quinoxaline dihydrohalide dihydrates and synthetic methods therefor
US7531542B2 (en) * 2005-05-18 2009-05-12 Wyeth Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor
US7582636B2 (en) * 2005-05-26 2009-09-01 Wyeth Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor
WO2016061190A1 (en) 2014-10-14 2016-04-21 The Board Of Trustees Of The Leland Stanford Junior University Method for treating neurodegenerative diseases
CN105879033B (zh) * 2015-04-01 2019-03-26 北京大学人民医院 GnRH Ⅱ型拮抗剂在抑制孕激素耐药子宫内膜癌细胞增殖中的应用
KR20180094989A (ko) * 2015-12-15 2018-08-24 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 주니어 유니버시티 노화 관련 인지장애 및 신경염증의 예방 및/또는 치료 방법
BR112021002165A2 (pt) 2018-08-06 2021-05-04 The Board Of Trustees Of The Leland Stanford Junior University composto, composição farmacêutica, e, métodos para tratar uma doença neurodegenerativa e deficiência cognitiva associada ao envelhecimento e neuroinflamação

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL281104A (es) 1961-07-18 1900-01-01
GB1049330A (en) 1962-08-13 1966-11-23 Merck & Co Inc Benzamidines and the preparation of 2-aryl benzimidazoles
NL135043C (es) 1963-10-11
IL22369A (en) 1963-11-19 1968-10-24 Merck & Co Inc 2-heteroaryl-5 and/or 6-substituted benzazoles
US3996233A (en) 1975-02-10 1976-12-07 E. R. Squibb & Sons, Inc. Amino derivatives of imidazo[4,5-b]pyridines
CH653021A5 (fr) * 1981-04-24 1985-12-13 Delalande Sa Derives piperidino, piperazino et homopiperazino, n-substitues par un groupe heterocyclique aromatique, leur procede de preparation et composition therapeutique les contenant.
NZ209876A (en) 1983-10-17 1988-03-30 Duphar Int Res Piperazines and pharmaceutical compositions
DE3586794T2 (de) 1984-12-21 1993-05-27 Duphar Int Res Arzneimittel mit psychotroper wirkung.
US5057517A (en) 1987-07-20 1991-10-15 Merck & Co., Inc. Piperazinyl derivatives of purines and isosteres thereof as hypoglycemic agents
IL87149A (en) 1987-07-20 1994-05-30 Merck & Co Inc 6-Piperazinyl derivatives of purine and its 3- and 9-deaza isosteres, their preparation and pharmaceutical compositions containing them
IL94390A (en) 1989-05-30 1996-03-31 Merck & Co Inc The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them
DE3926770A1 (de) 1989-08-12 1991-02-14 Basf Ag (1,2,4)triazolo(1,5-a)pyridine
US5716964A (en) 1989-12-04 1998-02-10 G.D. Searle & Co. Tetrazolyl substituted imidazo 1,2-a!pyridinylalkyl compounds for treatment of neurotoxic injury
EP0434038A1 (en) 1989-12-22 1991-06-26 Takeda Chemical Industries, Ltd. Fused imidazole derivatives, their production and use
EP0471236B1 (en) 1990-07-30 1995-03-15 Takeda Chemical Industries, Ltd. Imidazopyridine derivatives and their use
JPH08502721A (ja) 1992-04-03 1996-03-26 ジ・アップジョン・カンパニー 医薬的に活性な二環式‐複素環アミン
US5502187A (en) 1992-04-03 1996-03-26 The Upjohn Company Pharmaceutically active bicyclic-heterocyclic amines
US5338740A (en) 1993-07-13 1994-08-16 Pfizer Inc. Angiotensin II receptor antagonists
US5470847A (en) 1993-12-10 1995-11-28 Board Of Regents, The University Of Texas System Ovulation control by regulating nitric oxide levels with arginine derivatives
US5576460A (en) 1994-07-27 1996-11-19 Massachusetts Institute Of Technology Preparation of arylamines
AUPN449295A0 (en) 1995-07-28 1995-08-24 Inner And Eastern Health Care Network, The Radioprotectors
US6720472B2 (en) 1996-07-12 2004-04-13 University Of Medicine And Dentistry Of New Jersey HMGI proteins in cancer and obesity
US6187778B1 (en) 1997-08-05 2001-02-13 Pfizer Inc. 4-aminopyrrole (3, 2-D) pyrimidines as neuropeptide Y receptor antagonists
CA2303830A1 (en) 1997-09-26 1999-04-08 Merck & Co., Inc. Novel angiogenesis inhibitors
IT1298727B1 (it) 1998-03-12 2000-02-02 Silvia Anna Barbesti Procedimento per la determinazione della frazione cellulare vitale in un campione biologico e tipizzazione delle cellule in esame
AU3667899A (en) 1998-04-29 1999-11-16 American Home Products Corporation Antipsychotic indolyl derivatives
US6310066B1 (en) 1998-04-29 2001-10-30 American Home Products Corp. Antipsychotic indolyl derivatives
US6399629B1 (en) 1998-06-01 2002-06-04 Microcide Pharmaceuticals, Inc. Efflux pump inhibitors
IL139811A0 (en) 1998-06-04 2002-02-10 Abbott Lab Cell adhesion-inhibiting antinflammatory compounds
US6232320B1 (en) 1998-06-04 2001-05-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
US6307087B1 (en) 1998-07-10 2001-10-23 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
ES2257864T3 (es) 1998-07-10 2006-08-01 Massachusetts Institute Of Technology Ligandos para metales y procesos mejorados catalizados por metales basados en los mismos.
BR9912937A (pt) 1998-08-10 2001-05-08 Partnership Of Michael E Garst Pró-drogas de inibidores de bomba de prótons
US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
CA2341409A1 (en) 1998-08-31 2000-03-09 Merck And Co., Inc. Novel angiogenesis inhibitors
EP1147083B1 (en) 1999-01-07 2004-06-16 Wyeth Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression
US6313126B1 (en) 1999-01-07 2001-11-06 American Home Products Corp Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression
US6306859B1 (en) 1999-03-02 2001-10-23 American Home Products Corporation N-substituted imide derivatives with serotonergic activity
PE20010306A1 (es) 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
NZ516260A (en) 1999-07-02 2004-08-27 Eisai Co Ltd Fused imidazole compounds and remedies for diabetes mellitus
US20020147197A1 (en) 1999-10-08 2002-10-10 Newman Michael J. Methods and compositions for enhancing pharmaceutical treatments
US6787302B2 (en) 1999-10-25 2004-09-07 Genprime, Inc. Method and apparatus for prokaryotic and eukaryotic cell quantitation
US6620529B1 (en) 1999-10-27 2003-09-16 Fuji Photo Film Co., Ltd. Materials for light emitting devices and light emitting devices using the same
DE19963234A1 (de) 1999-12-27 2002-01-24 Boehringer Ingelheim Pharma Substituierte Piperazinderivate, ihre Herstellung und ihre Verwendung als Arzneimittel
EP1136483A1 (en) 2000-03-23 2001-09-26 Sanofi-Synthelabo 2-[Piperazinyl]pyrimidone derivatives
RU2182708C2 (ru) 2000-04-17 2002-05-20 Институт молекулярной биологии им. В.А. Энгельгардта РАН Способ множественного параллельного скрининга специфичности связывания биологически активных соединений с нуклеиновыми кислотами с использованием биочипа (варианты)
DE10030376A1 (de) 2000-06-21 2002-01-24 Bayer Ag Neues Verfahren zum Auffinden neuer Wirkstoffe
US6951947B2 (en) 2000-07-13 2005-10-04 The Scripps Research Institute Labeled peptides, proteins and antibodies and processes and intermediates useful for their preparation
JP4745547B2 (ja) 2000-07-14 2011-08-10 富山化学工業株式会社 新規ベンズイミダゾール誘導体またはその塩
US20030028018A1 (en) 2000-09-11 2003-02-06 Chiron Coporation Quinolinone derivatives
FR2815345B1 (fr) 2000-10-12 2002-12-13 Servier Lab Nouveaux derives de cyclobutene-dione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US20040102502A1 (en) 2000-10-25 2004-05-27 Toshifumi Watanabe Preventing/remedies for portal hypertension
JP2002161084A (ja) 2000-11-28 2002-06-04 Sumitomo Pharmaceut Co Ltd 複素環誘導体
ATE416784T1 (de) 2000-12-01 2008-12-15 Takeda Pharmaceutical Verfahren zur herstellung einer zubereitung mit einer bioaktiven substanz
KR100394086B1 (ko) 2000-12-04 2003-08-06 한국과학기술연구원 도파민 d3 및 d4 수용체의 선택적 활성을 지닌 신규이소옥사졸릴알킬피페라진 유도체와, 이의 제조방법
US20020072053A1 (en) 2000-12-08 2002-06-13 Mcnally Alan J. Immunoassay based on DNA replication using labeled primer
GB2370270A (en) 2000-12-20 2002-06-26 Lilly Co Eli Pharmaceutical compounds
JP2002212101A (ja) 2001-01-19 2002-07-31 Takeda Chem Ind Ltd 歯肉肥厚抑制剤
FR2821428B1 (fr) 2001-02-23 2004-08-06 Abx Sa Reactif et procede pour l'identification et le comptage de cellules biologiques
DE10110750A1 (de) 2001-03-07 2002-09-12 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
WO2002074340A1 (fr) 2001-03-16 2002-09-26 Takeda Chemical Industries, Ltd. Procede de fabrication d'une preparation a liberation continue
US6689391B2 (en) 2001-03-30 2004-02-10 Council Of Scientific & Industrial Research Natural non-polar fluorescent dye from a non-bioluminescent marine invertebrate, compositions containing the said dye and its uses
US6376141B1 (en) 2001-04-13 2002-04-23 Xerox Corporation Photoreceptor with layered charge generation section
AR035543A1 (es) 2001-06-26 2004-06-16 Japan Tobacco Inc Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con
US6855714B2 (en) 2001-07-06 2005-02-15 Schering Aktiengesellschaft 1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
US6492517B1 (en) 2001-07-19 2002-12-10 Air Products And Chemicals, Inc. Method for preparing halomethyl heterocyclic compounds
JP2003040890A (ja) 2001-07-31 2003-02-13 Fuji Photo Film Co Ltd ハロゲン化3H−ピロロ[2,3−b]ピリジン類及びその製造方法
CA2456034A1 (en) 2001-08-03 2003-02-20 Takeda Chemical Industries, Ltd. Sustained-release medicines
JP2003083968A (ja) 2001-09-14 2003-03-19 Jsr Corp Dnaチップおよびアッセイ方法
FR2831536A1 (fr) 2001-10-26 2003-05-02 Aventis Pharma Sa Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de kdr
EP1460067A4 (en) 2001-11-26 2005-12-07 Takeda Pharmaceutical BICYCLIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE
AU2002349705A1 (en) 2001-12-03 2003-06-17 Japan Tobacco Inc. Azole compound and medicinal use thereof
JP2003231687A (ja) 2002-02-04 2003-08-19 Japan Tobacco Inc ピラゾリル縮合環化合物及びその医薬用途
US6818420B2 (en) 2002-02-27 2004-11-16 Biosource International, Inc. Methods of using FET labeled oligonucleotides that include a 3′-5′ exonuclease resistant quencher domain and compositions for practicing the same
SE0202462D0 (sv) 2002-08-14 2002-08-14 Astrazeneca Ab Novel use
GB0219457D0 (en) 2002-08-21 2002-09-25 Amersham Biosciences Uk Ltd Fluorescence reference plate
US7582761B2 (en) * 2002-10-17 2009-09-01 Amgen Inc. Vanilloid receptor ligands and their use in treatments
JP4231321B2 (ja) * 2003-04-08 2009-02-25 ソフトバンクBb株式会社 Pcカード
CA2570693A1 (en) 2004-06-17 2006-01-26 Wyeth Processes for preparing gonadotropin releasing hormone receptor antagonists
EP1758895A1 (en) 2004-06-17 2007-03-07 Wyeth a Corporation of the State of Delaware Gonadotropin releasing hormone receptor antagonists
MX2007005765A (es) 2004-11-23 2007-07-19 Wyeth Corp Antagonistas del receptor de la hormona que libera gonadotropina.
US7534796B2 (en) 2005-02-18 2009-05-19 Wyeth Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor
US7582634B2 (en) 2005-02-18 2009-09-01 Wyeth 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US7538113B2 (en) 2005-02-18 2009-05-26 Wyeth 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US20060189619A1 (en) 2005-02-24 2006-08-24 Wyeth 3-({4-[2-(4-Tert-butylphenyl)-1h-benzimidazol-4-yl]piperazin-1-yl}methyl)pyrido[2,3-b]]pyrazi ne compounds
US7531542B2 (en) 2005-05-18 2009-05-12 Wyeth Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor
US7582636B2 (en) 2005-05-26 2009-09-01 Wyeth Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor

Also Published As

Publication number Publication date
BRPI0512239A (pt) 2008-02-19
ZA200610594B (en) 2008-07-30
IL179993A0 (en) 2007-05-15
CA2570693A1 (en) 2006-01-26
JP2008503470A (ja) 2008-02-07
RU2007101509A (ru) 2008-07-27
MXPA06014797A (es) 2007-02-16
CR8786A (es) 2007-08-28
NO20070248L (no) 2007-01-15
NZ552093A (en) 2009-06-26
CN1968948A (zh) 2007-05-23
WO2006009736A1 (en) 2006-01-26
US7714130B2 (en) 2010-05-11
US20050282820A1 (en) 2005-12-22
AU2005264998A1 (en) 2006-01-26
EP1756093A1 (en) 2007-02-28

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