ECSP077230A - Moduladores delta-opioides triciclicos - Google Patents

Moduladores delta-opioides triciclicos

Info

Publication number
ECSP077230A
ECSP077230A EC2007007230A ECSP077230A ECSP077230A EC SP077230 A ECSP077230 A EC SP077230A EC 2007007230 A EC2007007230 A EC 2007007230A EC SP077230 A ECSP077230 A EC SP077230A EC SP077230 A ECSP077230 A EC SP077230A
Authority
EC
Ecuador
Prior art keywords
delta
tricycle
modulators
opioid
opioid modulators
Prior art date
Application number
EC2007007230A
Other languages
English (en)
Inventor
Li Liu
Scott L Dax
Bart Decorte
Mark Mcdonnell
James J Mcnally
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ECSP077230A publication Critical patent/ECSP077230A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención está dirigida a moduladores del receptor delta-opioide; más específicamente, la invención se refiere a moduladores d-opioides tricíclicos; también se describen composiciones farmacéuticas y veterinarias, y métodos de tratamiento del dolor leve a severo y de varias enfermedades usando los compuestos de la invención.
EC2007007230A 2004-08-05 2007-02-07 Moduladores delta-opioides triciclicos ECSP077230A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59913104P 2004-08-05 2004-08-05

Publications (1)

Publication Number Publication Date
ECSP077230A true ECSP077230A (es) 2007-04-26

Family

ID=37075386

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2007007230A ECSP077230A (es) 2004-08-05 2007-02-07 Moduladores delta-opioides triciclicos

Country Status (17)

Country Link
US (2) US7553850B2 (es)
EP (1) EP1910353A1 (es)
JP (1) JP2008529971A (es)
KR (1) KR20080027216A (es)
CN (1) CN101039940A (es)
AR (1) AR050198A1 (es)
AU (1) AU2005335481A1 (es)
BR (1) BRPI0513075A (es)
CA (1) CA2574768A1 (es)
EA (1) EA200700403A1 (es)
EC (1) ECSP077230A (es)
IL (1) IL181120A0 (es)
NI (1) NI200700030A (es)
NO (1) NO20071208L (es)
TW (1) TW200621767A (es)
WO (1) WO2007030089A1 (es)
ZA (1) ZA200701875B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
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UA86024C2 (ru) * 2003-06-27 2009-03-25 Янссен Фармацевтика Н.В. Трициклические дельта-опиоидные модуляторы
CA2574768A1 (en) 2004-08-05 2006-02-05 Janssen Pharmaceutica N.V. Tricyclic delta-opioid modulators
CA2591963A1 (en) * 2004-12-22 2006-06-29 Janssen Pharmaceutica N.V. Tricyclic o-opioid modulators
US20060135522A1 (en) * 2004-12-22 2006-06-22 Carson John R Tricyclic delta-opioid modulators
US7589104B2 (en) * 2004-12-22 2009-09-15 Janssen Pharmaceutica Nv Tricyclic-bridged piperidinyline derivatives as §-opioid modulators
JP2008526878A (ja) * 2005-01-06 2008-07-24 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 三環式δ−オピオイド調節剤
DE602006018604D1 (de) * 2005-06-16 2011-01-13 Janssen Pharmaceutica Nv Tricyclische opioidmodulatoren
WO2007014137A2 (en) 2005-07-21 2007-02-01 Rensselaer Polytechnic Institute 8-carboxamido-substituted-2 , 6-methano-3-benzazocines and 3 - carboxamido- substituted morphanes as opioid receptor binding agents
ES2638329T3 (es) 2011-06-29 2017-10-19 Alkermes, Inc. Compuestos opioides de acción periférica
EP3535243B1 (en) 2016-11-04 2021-12-15 Auckland Uniservices Limited Substituted 9h-xanthen-9-one, 9h-thioxanthen-9-one and acridin-9(10h)-one derivatives and related compounds csf-1r inhibitors for the treatment of cancer
CN112969965A (zh) 2018-07-19 2021-06-15 林特弗德有限公司 噻吨酮衍生物、包含其的组合物和包含所述组合物的图案形成方法

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JP2008526878A (ja) * 2005-01-06 2008-07-24 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 三環式δ−オピオイド調節剤
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Also Published As

Publication number Publication date
EA200700403A1 (ru) 2007-08-31
US7553850B2 (en) 2009-06-30
AU2005335481A1 (en) 2007-04-19
ZA200701875B (en) 2008-07-30
BRPI0513075A (pt) 2008-04-22
US20060030585A1 (en) 2006-02-09
AU2005335481A8 (en) 2008-12-11
TW200621767A (en) 2006-07-01
NI200700030A (es) 2008-02-04
JP2008529971A (ja) 2008-08-07
EP1910353A1 (en) 2008-04-16
NO20071208L (no) 2007-04-19
WO2007030089A8 (en) 2007-05-31
IL181120A0 (en) 2008-03-20
US20090291979A1 (en) 2009-11-26
CN101039940A (zh) 2007-09-19
KR20080027216A (ko) 2008-03-26
CA2574768A1 (en) 2006-02-05
WO2007030089A1 (en) 2007-03-15
AR050198A1 (es) 2006-10-04

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