ECSP077248A - Procedimiento para la preparación de dihidropteridinonas - Google Patents

Procedimiento para la preparación de dihidropteridinonas

Info

Publication number
ECSP077248A
ECSP077248A EC2007007248A ECSP077248A ECSP077248A EC SP077248 A ECSP077248 A EC SP077248A EC 2007007248 A EC2007007248 A EC 2007007248A EC SP077248 A ECSP077248 A EC SP077248A EC SP077248 A ECSP077248 A EC SP077248A
Authority
EC
Ecuador
Prior art keywords
dihydropteridinones
preparation
procedure
radicals
general formula
Prior art date
Application number
EC2007007248A
Other languages
English (en)
Inventor
Guenter Linz
Ludwig Gutschera
Gerd F Kraemer
Geert Asche
Original Assignee
Boehringer Ingelheim International Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35907775&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP077248(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim International Gmbh filed Critical Boehringer Ingelheim International Gmbh
Publication of ECSP077248A publication Critical patent/ECSP077248A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/54—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a un procedimiento para la preparación de dihidropteridinonas de la fórmula general (I) en la que los radicales L y R1- R5 tienen los significados mencionados en las reivindicaciones y en la descripción.
EC2007007248A 2004-08-14 2007-02-14 Procedimiento para la preparación de dihidropteridinonas ECSP077248A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04019365 2004-08-14
EP05001611 2005-01-27

Publications (1)

Publication Number Publication Date
ECSP077248A true ECSP077248A (es) 2007-03-29

Family

ID=35907775

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2007007248A ECSP077248A (es) 2004-08-14 2007-02-14 Procedimiento para la preparación de dihidropteridinonas

Country Status (30)

Country Link
US (3) US7759485B2 (es)
EP (1) EP1778668B1 (es)
JP (2) JP5094391B2 (es)
KR (1) KR101214394B1 (es)
CN (1) CN101023070B (es)
AR (1) AR054078A1 (es)
AU (1) AU2005274338B2 (es)
BR (1) BRPI0514361A8 (es)
CA (1) CA2576290C (es)
CL (1) CL2010000204A1 (es)
CY (1) CY1114564T1 (es)
DK (1) DK1778668T3 (es)
EA (1) EA013820B1 (es)
EC (1) ECSP077248A (es)
ES (1) ES2429873T3 (es)
HR (1) HRP20130890T1 (es)
IL (1) IL181303A (es)
ME (1) ME01599B (es)
MX (1) MX2007001852A (es)
MY (2) MY145652A (es)
NO (1) NO20070753L (es)
NZ (1) NZ553650A (es)
PE (2) PE20091582A1 (es)
PL (1) PL1778668T3 (es)
PT (1) PT1778668E (es)
RS (1) RS52917B (es)
SI (1) SI1778668T1 (es)
TW (1) TWI355383B (es)
UY (1) UY29061A1 (es)
WO (1) WO2006018220A2 (es)

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US20060035903A1 (en) * 2004-08-14 2006-02-16 Boehringer Ingelheim International Gmbh Storage stable perfusion solution for dihydropteridinones
EP1632493A1 (de) * 2004-08-25 2006-03-08 Boehringer Ingelheim Pharma GmbH & Co.KG Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
EP1630163A1 (de) * 2004-08-25 2006-03-01 Boehringer Ingelheim Pharma GmbH & Co.KG Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
DE102004058337A1 (de) * 2004-12-02 2006-06-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
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CN103180318B (zh) 2010-05-14 2017-05-10 达那-法伯癌症研究所 雄性避孕组合物以及使用方法
US8546566B2 (en) * 2010-10-12 2013-10-01 Boehringer Ingelheim International Gmbh Process for manufacturing dihydropteridinones and intermediates thereof
US9358233B2 (en) 2010-11-29 2016-06-07 Boehringer Ingelheim International Gmbh Method for treating acute myeloid leukemia
JP5931933B2 (ja) 2011-02-25 2016-06-08 武田薬品工業株式会社 Ｎ−置換オキサジノプテリジンおよびオキサジノプテリジノン
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Also Published As

Publication number Publication date
EA013820B1 (ru) 2010-08-30
UY29061A1 (es) 2006-03-31
JP5094391B2 (ja) 2012-12-12
KR101214394B1 (ko) 2012-12-21
WO2006018220A8 (de) 2006-06-15
HK1107821A1 (en) 2008-04-18
AU2005274338B2 (en) 2012-06-28
WO2006018220A2 (de) 2006-02-23
EP1778668B1 (de) 2013-07-03
JP2008509951A (ja) 2008-04-03
WO2006018220A3 (de) 2006-10-12
ES2429873T3 (es) 2013-11-18
JP2012232990A (ja) 2012-11-29
CA2576290C (en) 2013-07-16
KR20070050966A (ko) 2007-05-16
EA200700199A1 (ru) 2007-08-31
NZ553650A (en) 2010-12-24
CN101023070A (zh) 2007-08-22
PL1778668T3 (pl) 2013-11-29
US8138341B2 (en) 2012-03-20
AU2005274338A1 (en) 2006-02-23
US20100249458A1 (en) 2010-09-30
DK1778668T3 (da) 2013-09-30
MX2007001852A (es) 2007-03-28
US20100249412A1 (en) 2010-09-30
TW200621779A (en) 2006-07-01
EP1778668A2 (de) 2007-05-02
TWI355383B (en) 2012-01-01
CA2576290A1 (en) 2006-02-23
IL181303A (en) 2015-10-29
CN101023070B (zh) 2012-12-05
US8138373B2 (en) 2012-03-20
PT1778668E (pt) 2013-08-01
IL181303A0 (en) 2007-07-04
PE20091582A1 (es) 2009-11-07
CL2010000204A1 (es) 2010-12-03
MY150538A (en) 2014-01-30
ME01599B (me) 2014-09-20
US7759485B2 (en) 2010-07-20
HRP20130890T1 (hr) 2013-10-25
US20080177066A1 (en) 2008-07-24
CY1114564T1 (el) 2016-10-05
MY145652A (en) 2012-03-15
PE20060644A1 (es) 2006-07-24
AR054078A1 (es) 2007-06-06
NO20070753L (no) 2007-05-07
BRPI0514361A (pt) 2008-06-10
SI1778668T1 (sl) 2013-11-29
RS52917B (sr) 2014-02-28
BRPI0514361A8 (pt) 2018-04-17

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