ECSP077846A - Tratamiento de eczemas - Google Patents

Tratamiento de eczemas

Info

Publication number
ECSP077846A
ECSP077846A EC2007007846A ECSP077846A ECSP077846A EC SP077846 A ECSP077846 A EC SP077846A EC 2007007846 A EC2007007846 A EC 2007007846A EC SP077846 A ECSP077846 A EC SP077846A EC SP077846 A ECSP077846 A EC SP077846A
Authority
EC
Ecuador
Prior art keywords
treatment
tyrosine kinase
eczem
kinase protein
dermatological diseases
Prior art date
Application number
EC2007007846A
Other languages
English (en)
Inventor
Morten Sloth Weidner
Original Assignee
Astion Pharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astion Pharma As filed Critical Astion Pharma As
Publication of ECSP077846A publication Critical patent/ECSP077846A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicinal Preparation (AREA)

Abstract

La invención se refiere a un principio novedoso para el tratamiento de enfermedades dermatológicas, que comprende inhibir varios pasos cruciales de la cascada inflamatoria, incluyendo por lo menos la inhibición de la proteína tirosina quinasa SYK, la proteína tirosina quinasa ZAP-70 y la fosfodiesterasa IV (PDE-IV). La invención proporciona medicamentos y métodos para el tratamiento de enfermedades dermatológicas inflamatorias, en particular, eczemas, que comprenden oxaprozina, un compuesto estrechamente relacionado o una sal de los mismos.
EC2007007846A 2005-03-30 2007-10-29 Tratamiento de eczemas ECSP077846A (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DKPA200500437 2005-03-30
DKPA200500438 2005-03-30
US69477405P 2005-06-27 2005-06-27
DKPA200500948 2005-06-27
DKPA200500949 2005-06-27
US69504005P 2005-06-28 2005-06-28

Publications (1)

Publication Number Publication Date
ECSP077846A true ECSP077846A (es) 2008-02-20

Family

ID=36215671

Family Applications (3)

Application Number Title Priority Date Filing Date
EC2007007843A ECSP077843A (es) 2005-03-30 2007-10-29 Tratamiento o prevención del prurito
EC2007007845A ECSP077845A (es) 2005-03-30 2007-10-29 Composiciones y sales dermatológicas para el tratamiento de enfermedades dermatológicas
EC2007007846A ECSP077846A (es) 2005-03-30 2007-10-29 Tratamiento de eczemas

Family Applications Before (2)

Application Number Title Priority Date Filing Date
EC2007007843A ECSP077843A (es) 2005-03-30 2007-10-29 Tratamiento o prevención del prurito
EC2007007845A ECSP077845A (es) 2005-03-30 2007-10-29 Composiciones y sales dermatológicas para el tratamiento de enfermedades dermatológicas

Country Status (12)

Country Link
EP (3) EP1707201A1 (es)
JP (3) JP2008534528A (es)
KR (3) KR20080005525A (es)
AU (3) AU2006228869A1 (es)
BR (3) BRPI0609535A2 (es)
CA (3) CA2603300A1 (es)
EA (3) EA200702026A1 (es)
EC (3) ECSP077843A (es)
IL (3) IL186020A0 (es)
MX (3) MX2007012052A (es)
NO (3) NO20075199L (es)
WO (3) WO2006102899A2 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0821537D0 (en) * 2008-11-25 2008-12-31 Union Life Sciences Ltd Therapeutic target
CA2997842A1 (en) * 2015-09-18 2017-03-23 Delivra Inc. Transdermal formulations for delivery of propionic and acetic acid nsaids, and their use in the treatment of nsaid-responsive diseases and conditions
US11406805B2 (en) 2016-08-08 2022-08-09 Avedro, Inc. Systems and methods for cross-linking treatments of an eye
US11229624B2 (en) 2016-10-25 2022-01-25 Ticure Ltd. FABP4 as a therapeutic target in skin diseases
KR20200097297A (ko) * 2017-12-07 2020-08-18 더마반트 사이언시즈 게엠베하 Pde-4 억제제의 국소 연고 제형 및 피부 병태 치료에서의 이의 용도
RU2685436C1 (ru) * 2018-06-22 2019-04-18 ЗАО "ФармФирма "Сотекс" Трансдермальный препарат для лечения и профилактики болезней суставов и мягких тканей
JP7514598B2 (ja) * 2018-12-20 2024-07-11 小林製薬株式会社 皮膚外用組成物

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE32084B1 (en) * 1967-06-07 1973-04-04 Wyeth John & Brother Ltd Thiazole derivatives
US3578671A (en) * 1967-11-06 1971-05-11 Wyeth John & Brother Ltd Oxazoles
IE52909B1 (en) * 1981-04-28 1988-04-13 Wyeth John & Brother Ltd Oxazole derivatives
US4659728A (en) * 1985-02-25 1987-04-21 American Home Products Corporation Hydroxy substituted 4,5-diphenyl-2-oxazole propanoic acid
EP0270316A3 (en) * 1986-12-04 1989-12-06 Pfizer Inc. Topical compositions comprising 1-substituted imidazoles and nsaids for treatment of acne
US6090834A (en) * 1993-05-21 2000-07-18 G.D. Searle & Co. Substituted oxazoles for the treatment of inflammation
US5380738A (en) 1993-05-21 1995-01-10 Monsanto Company 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents
PL314036A1 (en) 1993-10-20 1996-08-05 Boots Co Plc Pharmaceutical composition
JPH07316075A (ja) 1994-05-26 1995-12-05 Pola Chem Ind Inc 皮膚外用剤
GB9606429D0 (en) 1996-03-27 1996-06-05 Boots Co Plc Pharmaceutical compositions
AU718030B2 (en) * 1996-05-20 2000-04-06 G.D. Searle & Co. Potassium, sodium and tris oxaprozin salt pharmaceutical formulations
US5976566A (en) * 1997-08-29 1999-11-02 Macrochem Corporation Non-steroidal antiinflammtory drug formulations for topical application to the skin
IL142037A0 (en) * 2001-03-15 2002-03-10 Agis Ind 1983 Ltd Pharmaceutical compositions containing a non-steroidal anti-inflammatory drug
WO2005009342A2 (en) 2003-07-16 2005-02-03 Pharmacia Corporation Method for the treatment or prevention of dermatological disorders with a cyclooxygenase-2 inhibitor alone and in combination with a dermatological treatment agent and compositions therewith
US20050232957A1 (en) 2004-04-14 2005-10-20 Katz Kenneth A Compositions and methods for moisturizing skin

Also Published As

Publication number Publication date
EA200702023A1 (ru) 2008-04-28
MX2007012052A (es) 2008-02-22
EA200702027A1 (ru) 2008-02-28
JP2008534526A (ja) 2008-08-28
ECSP077843A (es) 2008-02-20
EA200702026A1 (ru) 2008-04-28
CA2603297A1 (en) 2006-10-05
AU2006228869A1 (en) 2006-10-05
NO20075227L (no) 2007-12-09
WO2006102899A2 (en) 2006-10-05
BRPI0607648A2 (pt) 2009-09-22
WO2006102898A2 (en) 2006-10-05
WO2006102899A3 (en) 2006-12-28
KR20080005525A (ko) 2008-01-14
WO2006102900A1 (en) 2006-10-05
BRPI0609535A2 (pt) 2010-04-13
IL186021A0 (en) 2008-02-09
EP1707201A1 (en) 2006-10-04
KR20080005526A (ko) 2008-01-14
AU2006228871A1 (en) 2006-10-05
ECSP077845A (es) 2008-02-20
IL186020A0 (en) 2008-01-20
NO20075218L (no) 2007-12-27
KR20080011280A (ko) 2008-02-01
MX2007012050A (es) 2008-03-11
MX2007012051A (es) 2008-02-22
EP1707200A1 (en) 2006-10-04
CA2605121A1 (en) 2006-10-05
JP2008534527A (ja) 2008-08-28
WO2006102898A3 (en) 2006-12-28
EP1707199A1 (en) 2006-10-04
BRPI0609653A2 (pt) 2010-04-20
JP2008534528A (ja) 2008-08-28
AU2006228870A1 (en) 2006-10-05
NO20075199L (no) 2008-01-02
IL186022A0 (en) 2008-02-09
CA2603300A1 (en) 2006-10-05

Similar Documents

Publication Publication Date Title
UY29449A1 (es) Tratamiento de enfermedades dermatólogicas y del prurito.
CY1119669T1 (el) Παραγωγα 1-φαινυλ-2-πυριδινυλ-αλκυλ-αλκοολων ως αναστολεις φωσφοδιεστερασης
UA85559C2 (en) Aminobenzophenone compounds
EA200802213A1 (ru) Способы лечения заболеваний крови
ECSP088561A (es) Derivados de pirimidinil-aril-urea que son inhibidores de fgf
EA201270535A1 (ru) Пуриновые производные, применимые в качестве ингибиторов hsp90
NO20092658L (no) New compounds
EA200900798A1 (ru) Производные индол-4-илпиримидинил-2-иламина и их применение в качестве ингибиторов циклинзависимой киназы
CL2011002300A1 (es) Compuestos derivados de 2,4-diamiropirimidinas 5-sustitudas inhibidoras de quinasa ptk2; preparaciones farmaceuticas; y su uso para el tratamiento y/o la prevencion de cancer, infecciones, enfermedades inflamatorias y autoinmunes.
CR9272A (es) Amino-imidazolonas para la inhibicion de b-secretasa
DK1853602T3 (da) Kemiske forbindelser
DK1853588T3 (da) Kemiske forbindelser
DK1631295T3 (da) Anvendelse af kondenserede heterocykliske forbindelser som SCCE-inhibitorer ved behandling af hudsygdomme
CL2008003472A1 (es) Compuestos derivados de 5-[3,3,3-trifluoro-2-hidroxi-1-arilpropil)amino]-1h-quinolin-2-ona, proceso para la preparacion de los mismos, compuestos intermediarios, composicion farmaceutica que comprende dicho compuesto; combinacion farmaceutica, y sus usos en el tratamiento de enfermedades inflamatorias.
ATE497961T1 (de) Als proteinkinaseinhibitoren geeignete verbindungen
CO6531429A2 (es) Inhibidores de la tirosina quinasa de bruton
EA201000329A1 (ru) Циклические депсипептиды
ECSP109964A (es) Pirimidinas bicíclicas fusionadas
NO20075227L (no) Treatment of eczemas
UA90698C2 (en) Triazole substituted aminobenzophenone compounds
NO20073276L (no) Metode for fremstilling av aminoetoksybenzylalkoholer
WO2006108680A3 (en) Substances and pharmaceutical compositions for the inhibition of glyoxalases and their use against protozoa and helminthes
ES2333026T3 (es) Derivados de ciclohexil-1,4-diamina sustituidos.
TW200639155A (en) Thiazolidinones, their production and use as pharmaceutical agents
DE602007008952D1 (de) Imidazolidinonylaminopyrimidinverbindungen zur behandlung von krebs