ECSP077846A - Tratamiento de eczemas - Google Patents

Tratamiento de eczemas

Info

Publication number
ECSP077846A
ECSP077846A EC2007007846A ECSP077846A ECSP077846A EC SP077846 A ECSP077846 A EC SP077846A EC 2007007846 A EC2007007846 A EC 2007007846A EC SP077846 A ECSP077846 A EC SP077846A EC SP077846 A ECSP077846 A EC SP077846A
Authority
EC
Ecuador
Prior art keywords
treatment
tyrosine kinase
eczem
kinase protein
dermatological diseases
Prior art date
Application number
EC2007007846A
Other languages
English (en)
Inventor
Morten Sloth Weidner
Original Assignee
Astion Pharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astion Pharma As filed Critical Astion Pharma As
Publication of ECSP077846A publication Critical patent/ECSP077846A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicinal Preparation (AREA)

Abstract

La invención se refiere a un principio novedoso para el tratamiento de enfermedades dermatológicas, que comprende inhibir varios pasos cruciales de la cascada inflamatoria, incluyendo por lo menos la inhibición de la proteína tirosina quinasa SYK, la proteína tirosina quinasa ZAP-70 y la fosfodiesterasa IV (PDE-IV). La invención proporciona medicamentos y métodos para el tratamiento de enfermedades dermatológicas inflamatorias, en particular, eczemas, que comprenden oxaprozina, un compuesto estrechamente relacionado o una sal de los mismos.
EC2007007846A 2005-03-30 2007-10-29 Tratamiento de eczemas ECSP077846A (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DKPA200500438 2005-03-30
DKPA200500437 2005-03-30
US69477405P 2005-06-27 2005-06-27
DKPA200500949 2005-06-27
DKPA200500948 2005-06-27
US69504005P 2005-06-28 2005-06-28

Publications (1)

Publication Number Publication Date
ECSP077846A true ECSP077846A (es) 2008-02-20

Family

ID=36215671

Family Applications (3)

Application Number Title Priority Date Filing Date
EC2007007845A ECSP077845A (es) 2005-03-30 2007-10-29 Composiciones y sales dermatológicas para el tratamiento de enfermedades dermatológicas
EC2007007846A ECSP077846A (es) 2005-03-30 2007-10-29 Tratamiento de eczemas
EC2007007843A ECSP077843A (es) 2005-03-30 2007-10-29 Tratamiento o prevención del prurito

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EC2007007845A ECSP077845A (es) 2005-03-30 2007-10-29 Composiciones y sales dermatológicas para el tratamiento de enfermedades dermatológicas

Family Applications After (1)

Application Number Title Priority Date Filing Date
EC2007007843A ECSP077843A (es) 2005-03-30 2007-10-29 Tratamiento o prevención del prurito

Country Status (12)

Country Link
EP (3) EP1707199A1 (es)
JP (3) JP2008534528A (es)
KR (3) KR20080005525A (es)
AU (3) AU2006228869A1 (es)
BR (3) BRPI0607648A2 (es)
CA (3) CA2605121A1 (es)
EA (3) EA200702026A1 (es)
EC (3) ECSP077845A (es)
IL (3) IL186020A0 (es)
MX (3) MX2007012051A (es)
NO (3) NO20075199L (es)
WO (3) WO2006102900A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0821537D0 (en) * 2008-11-25 2008-12-31 Union Life Sciences Ltd Therapeutic target
CA2997842A1 (en) * 2015-09-18 2017-03-23 Delivra Inc. Transdermal formulations for delivery of propionic and acetic acid nsaids, and their use in the treatment of nsaid-responsive diseases and conditions
EP3496681A4 (en) 2016-08-08 2020-07-22 Avedro, Inc. Systems and methods for cross-linking treatments of an eye
EP3532049A1 (en) 2016-10-25 2019-09-04 Ticure Ltd. Fabp4 as a therapeutic target in skin diseases
EP3720411A4 (en) * 2017-12-07 2021-11-24 Dermavant Sciences GmbH TOPICAL Ointment FORMULATIONS BY PDE-4 INHIBITORS AND THEIR USE FOR TREATMENT OF SKIN DISEASES
RU2685436C1 (ru) * 2018-06-22 2019-04-18 ЗАО "ФармФирма "Сотекс" Трансдермальный препарат для лечения и профилактики болезней суставов и мягких тканей
JP7514598B2 (ja) * 2018-12-20 2024-07-11 小林製薬株式会社 皮膚外用組成物

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE32084B1 (en) 1967-06-07 1973-04-04 Wyeth John & Brother Ltd Thiazole derivatives
US3578671A (en) 1967-11-06 1971-05-11 Wyeth John & Brother Ltd Oxazoles
IE52909B1 (en) * 1981-04-28 1988-04-13 Wyeth John & Brother Ltd Oxazole derivatives
US4659728A (en) * 1985-02-25 1987-04-21 American Home Products Corporation Hydroxy substituted 4,5-diphenyl-2-oxazole propanoic acid
EP0270316A3 (en) * 1986-12-04 1989-12-06 Pfizer Inc. Topical compositions comprising 1-substituted imidazoles and nsaids for treatment of acne
US5380738A (en) 1993-05-21 1995-01-10 Monsanto Company 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents
US6090834A (en) * 1993-05-21 2000-07-18 G.D. Searle & Co. Substituted oxazoles for the treatment of inflammation
WO1995011017A1 (en) 1993-10-20 1995-04-27 The Boots Company Plc Ibuprofen and flurbiprofen as anti-pruritic agents
JPH07316075A (ja) 1994-05-26 1995-12-05 Pola Chem Ind Inc 皮膚外用剤
GB9606429D0 (en) 1996-03-27 1996-06-05 Boots Co Plc Pharmaceutical compositions
DE69733752T2 (de) * 1996-05-20 2006-06-01 G.D. Searle Llc, Chicago Arzneimittel enthaltend oxaprozin-natriumsalz,-kaliumsalz, oder-tris(hydroxymethyl)aminomethansalz
US5976566A (en) * 1997-08-29 1999-11-02 Macrochem Corporation Non-steroidal antiinflammtory drug formulations for topical application to the skin
IL142037A0 (en) * 2001-03-15 2002-03-10 Agis Ind 1983 Ltd Pharmaceutical compositions containing a non-steroidal anti-inflammatory drug
WO2005009342A2 (en) 2003-07-16 2005-02-03 Pharmacia Corporation Method for the treatment or prevention of dermatological disorders with a cyclooxygenase-2 inhibitor alone and in combination with a dermatological treatment agent and compositions therewith
US20050232957A1 (en) 2004-04-14 2005-10-20 Katz Kenneth A Compositions and methods for moisturizing skin

Also Published As

Publication number Publication date
IL186020A0 (en) 2008-01-20
MX2007012051A (es) 2008-02-22
BRPI0609653A2 (pt) 2010-04-20
MX2007012050A (es) 2008-03-11
EP1707201A1 (en) 2006-10-04
EP1707200A1 (en) 2006-10-04
WO2006102900A1 (en) 2006-10-05
WO2006102899A2 (en) 2006-10-05
EA200702023A1 (ru) 2008-04-28
AU2006228871A1 (en) 2006-10-05
WO2006102898A2 (en) 2006-10-05
NO20075227L (no) 2007-12-09
KR20080011280A (ko) 2008-02-01
EP1707199A1 (en) 2006-10-04
EA200702026A1 (ru) 2008-04-28
WO2006102899A3 (en) 2006-12-28
AU2006228870A1 (en) 2006-10-05
MX2007012052A (es) 2008-02-22
JP2008534527A (ja) 2008-08-28
IL186022A0 (en) 2008-02-09
IL186021A0 (en) 2008-02-09
NO20075199L (no) 2008-01-02
CA2603300A1 (en) 2006-10-05
CA2603297A1 (en) 2006-10-05
ECSP077845A (es) 2008-02-20
WO2006102898A3 (en) 2006-12-28
NO20075218L (no) 2007-12-27
BRPI0609535A2 (pt) 2010-04-13
JP2008534528A (ja) 2008-08-28
BRPI0607648A2 (pt) 2009-09-22
CA2605121A1 (en) 2006-10-05
EA200702027A1 (ru) 2008-02-28
KR20080005525A (ko) 2008-01-14
ECSP077843A (es) 2008-02-20
JP2008534526A (ja) 2008-08-28
AU2006228869A1 (en) 2006-10-05
KR20080005526A (ko) 2008-01-14

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