ECSP077848A - Compuestos espiroheterocíclicos y sus usos como agentes terapéuticos - Google Patents

Compuestos espiroheterocíclicos y sus usos como agentes terapéuticos

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Publication number
ECSP077848A
ECSP077848A EC2007007848A ECSP077848A ECSP077848A EC SP077848 A ECSP077848 A EC SP077848A EC 2007007848 A EC2007007848 A EC 2007007848A EC SP077848 A ECSP077848 A EC SP077848A EC SP077848 A ECSP077848 A EC SP077848A
Authority
EC
Ecuador
Prior art keywords
compounds
therapeutic agents
spiroheterocyclic
spiroheterocyclic compounds
tautomer
Prior art date
Application number
EC2007007848A
Other languages
English (en)
Inventor
Serguei Sviridov
Shifeng Liu
Rajender Kamboj
Mikhail Chafeev
Sultan Chowdhury
Robert Fraser
Jianmin Fu
Mehran Seid Bagherzadeh
Jianyu Sun
Original Assignee
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc filed Critical Xenon Pharmaceuticals Inc
Publication of ECSP077848A publication Critical patent/ECSP077848A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Child & Adolescent Psychology (AREA)

Abstract

Compuestos espiroheterocíclicos de fórmula (I): en donde , k, j, p, Q, R1, R3a, R3b, R3c, y R3d tienen los valores que se definen, un estereoisómero, enantiómero, tautómero de los mismos o mezclas de los mismos, o una sal farmacéuticamente aceptable, solvato o prodroga de los mismos, que son útiles para el tratamiento y/o prevención, de enfermedades o condiciones mediadas por los canales de sodio, tales como el dolor. Composiciones farmacéuticas que comprenden los compuestos y métodos para preparar y usar los compuestos.
EC2007007848A 2005-04-11 2007-10-30 Compuestos espiroheterocíclicos y sus usos como agentes terapéuticos ECSP077848A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US67096205P 2005-04-11 2005-04-11

Publications (1)

Publication Number Publication Date
ECSP077848A true ECSP077848A (es) 2008-01-23

Family

ID=36694990

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2007007848A ECSP077848A (es) 2005-04-11 2007-10-30 Compuestos espiroheterocíclicos y sus usos como agentes terapéuticos

Country Status (27)

Country Link
US (2) US7799798B2 (es)
EP (1) EP1888592B1 (es)
JP (1) JP2008535916A (es)
KR (1) KR20080007250A (es)
CN (2) CN101967150A (es)
AR (1) AR053710A1 (es)
AT (1) ATE504587T1 (es)
AU (1) AU2006235329B2 (es)
BR (1) BRPI0608995A2 (es)
CA (1) CA2604010A1 (es)
DE (1) DE602006021169D1 (es)
EC (1) ECSP077848A (es)
ES (1) ES2362908T3 (es)
HR (1) HRP20070499A2 (es)
IL (1) IL186615A0 (es)
MA (1) MA29685B1 (es)
MX (1) MX2007012637A (es)
MY (1) MY145694A (es)
NO (1) NO20074620L (es)
NZ (1) NZ561204A (es)
PL (1) PL1888592T3 (es)
RU (1) RU2428424C2 (es)
SG (1) SG161264A1 (es)
TN (1) TNSN07384A1 (es)
TW (1) TW200720278A (es)
WO (1) WO2006110654A1 (es)
ZA (1) ZA200709004B (es)

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AR056968A1 (es) * 2005-04-11 2007-11-07 Xenon Pharmaceuticals Inc Compuestos espiro-oxindol y composiciones farmacéuticas
MY145694A (en) 2005-04-11 2012-03-30 Xenon Pharmaceuticals Inc Spiroheterocyclic compounds and their uses as therapeutic agents
AR053713A1 (es) * 2005-04-20 2007-05-16 Xenon Pharmaceuticals Inc Compuestos heterociclicos y sus usos como agentes terapeuticos
JP2010522690A (ja) * 2006-10-12 2010-07-08 ゼノン・ファーマシューティカルズ・インコーポレイテッド 三環式スピロオキシインドール誘導体および治療薬としてのその使用
RU2009117605A (ru) * 2006-10-12 2010-11-20 Ксенон Фармасьютикалз Инк. (Ca) ПРОИЗВОДНЫЕ СПИРО-(ФУРО[3,2-c]ПИРИДИН-3-3'-ИНДОЛ)-2'(1'H)-ОНА И РОДСТВЕННЫЕ ИМ СОЕДИНЕНИЯ ДЛЯ ЛЕЧЕНИЯ ОПОСРЕДОВАННЫХ НАТРИЕВЫМИ КАНАЛАМИ ЗАБОЛЕВАНИЙ, ТАКИХ КАК БОЛЬ
TW200833698A (en) * 2006-10-12 2008-08-16 Xenon Pharmaceuticals Inc Spiroheterocyclic compounds and their uses as therapeutic agents
WO2008046082A2 (en) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Use of heterocyclic compounds as therapeutic agents
WO2008046087A2 (en) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Spiro compounds and their uses as therapeutic agents
WO2008060789A2 (en) * 2006-10-12 2008-05-22 Xenon Pharmaceuticals Inc. Use of spiro-oxindole compounds as therapeutic agents
CN101641090B (zh) * 2006-12-19 2012-12-05 亚勒斯有限公司 莫达非尼在制备治疗多动腿综合征的药物中的应用
US7795228B2 (en) * 2006-12-28 2010-09-14 Theracos, Inc. Spiroheterocyclic glycosides and methods of use
CA2685942A1 (en) * 2007-05-16 2008-11-27 Merck & Co., Inc. Spiroindalones
US20100204247A1 (en) * 2007-10-04 2010-08-12 Duffy Joseph L N-substituted oxindoline derivatives as calcium channel blockers
EP2209373B1 (en) * 2007-10-04 2012-05-23 Merck Sharp & Dohme Corp. N-substituted oxindoline derivatives as calcium channel blockers
UA101004C2 (en) 2007-12-13 2013-02-25 Теракос, Инк. Derivatives of benzylphenylcyclohexane and use thereof
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