ECSP078051A - Nuevos derivados de la 2-azetidinona como inhibidores de la absorción del colesterol para el tratamiento de condiciones hiperlipidémicas - Google Patents

Nuevos derivados de la 2-azetidinona como inhibidores de la absorción del colesterol para el tratamiento de condiciones hiperlipidémicas

Info

Publication number
ECSP078051A
ECSP078051A EC2007008051A ECSP078051A ECSP078051A EC SP078051 A ECSP078051 A EC SP078051A EC 2007008051 A EC2007008051 A EC 2007008051A EC SP078051 A ECSP078051 A EC SP078051A EC SP078051 A ECSP078051 A EC SP078051A
Authority
EC
Ecuador
Prior art keywords
treatment
inhibitors
cholesterol absorption
azetidinone
new derivatives
Prior art date
Application number
EC2007008051A
Other languages
English (en)
Inventor
Susanne Alenfalk
Mikael Dahlstroem
Fana Hunegnaw
Staffan Karlsson
Ingemar Starke
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37570735&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP078051(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of ECSP078051A publication Critical patent/ECSP078051A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compuestos de fórmula (I) (donde los grupos variables son como los definidos aquí), sales farmacéuticamente aceptables, solvatos, solvatos de tales sales o profármacos de los mismos y su uso como inhibidores de la absorción del colesterol para el tratamiento de la hiperlipidemia son descritos. Los procesos para su fabricación y las composiciones farmacéuticas que los contienen también son descritos.
EC2007008051A 2005-06-22 2007-12-26 Nuevos derivados de la 2-azetidinona como inhibidores de la absorción del colesterol para el tratamiento de condiciones hiperlipidémicas ECSP078051A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0501464 2005-06-22

Publications (1)

Publication Number Publication Date
ECSP078051A true ECSP078051A (es) 2008-01-23

Family

ID=37570735

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2007008051A ECSP078051A (es) 2005-06-22 2007-12-26 Nuevos derivados de la 2-azetidinona como inhibidores de la absorción del colesterol para el tratamiento de condiciones hiperlipidémicas

Country Status (20)

Country Link
US (1) US7906502B2 (es)
EP (1) EP1896459A4 (es)
JP (1) JP2008546774A (es)
KR (1) KR20080017475A (es)
CN (1) CN101243076A (es)
AR (1) AR057072A1 (es)
AU (1) AU2006259898B2 (es)
BR (1) BRPI0612109A2 (es)
CA (1) CA2610036A1 (es)
EC (1) ECSP078051A (es)
IL (1) IL187741A0 (es)
MX (1) MX2007016398A (es)
MY (1) MY148538A (es)
NO (1) NO20076138L (es)
RU (1) RU2409572C2 (es)
SA (1) SA06270197B1 (es)
TW (1) TW200728302A (es)
UY (1) UY29613A1 (es)
WO (1) WO2006137797A1 (es)
ZA (1) ZA200710604B (es)

Families Citing this family (21)

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SA06270191B1 (ar) 2005-06-22 2010-03-29 استرازينيكا ايه بي مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
AR060623A1 (es) 2006-04-27 2008-07-02 Astrazeneca Ab Compuestos derivados de 2-azetidinona y un metodo de preparacion
JP2010500300A (ja) 2006-08-08 2010-01-07 サノフィ−アベンティス アリールアミノアリール−アルキル−置換イミダゾリジン−２，４−ジオン、それらの製造法、それらの化合物を含有する薬剤、およびそれらの使用
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WO2012120055A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683704B1 (de) 2011-03-08 2014-12-17 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120054A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2766349B1 (de) 2011-03-08 2016-06-01 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012120056A1 (de) 2011-03-08 2012-09-13 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
BR112021002207A2 (pt) 2018-08-10 2021-05-04 Diapin Therapeutics, Llc tri-peptídeos e tratamento de distúrbios metabólicos, cardiovasculares e inflamatórios

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Also Published As

Publication number Publication date
MX2007016398A (es) 2008-03-05
AR057072A1 (es) 2007-11-14
UY29613A1 (es) 2007-01-31
ZA200710604B (en) 2008-12-31
AU2006259898A1 (en) 2006-12-28
RU2007147340A (ru) 2009-07-27
CN101243076A (zh) 2008-08-13
CA2610036A1 (en) 2006-12-28
KR20080017475A (ko) 2008-02-26
MY148538A (en) 2013-04-30
AU2006259898B2 (en) 2010-08-05
US20100168039A1 (en) 2010-07-01
IL187741A0 (en) 2008-03-20
RU2409572C2 (ru) 2011-01-20
EP1896459A1 (en) 2008-03-12
TW200728302A (en) 2007-08-01
BRPI0612109A2 (pt) 2016-09-06
JP2008546774A (ja) 2008-12-25
NO20076138L (no) 2008-02-27
WO2006137797A1 (en) 2006-12-28
EP1896459A4 (en) 2010-03-10
SA06270197B1 (ar) 2010-06-20
US7906502B2 (en) 2011-03-15

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