ECSP088189A - Derivados de 3-sulfonilindazol sustituido comoligandos de 5-hidroxitriptamina-6 - Google Patents
Derivados de 3-sulfonilindazol sustituido comoligandos de 5-hidroxitriptamina-6Info
- Publication number
- ECSP088189A ECSP088189A EC2008008189A ECSP088189A ECSP088189A EC SP088189 A ECSP088189 A EC SP088189A EC 2008008189 A EC2008008189 A EC 2008008189A EC SP088189 A ECSP088189 A EC SP088189A EC SP088189 A ECSP088189 A EC SP088189A
- Authority
- EC
- Ecuador
- Prior art keywords
- optionally substituted
- aryl
- alkyl
- heteroaryl group
- cycloalkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
La presente invención suministra un compuesto 3-sulfonilindazol de fórmula Ien dondeX es O, S, NR, CH2, CH2Y, CH2Z, CO, CONR o NRCO;Y es O, S o NR;Z es CO;n es 0 o un entero de 1, 2, 3, 4, 5 o 6 cuando X es CH2; n es un entero de 1, 2, 3, 4, 5 o 6 cuando X es CH2Z, CO o NRCO;n es un entero de 2, 3, 4, 5 o 6 cuando X es O, S, NR, CH2Y o CONR;R es H o un grupo alquilo opcionalmente sustituido;R1 es H o un grupo alquilo, cicloalquilo, arilo o heteroarilo cada uno opcionalmente sustituido;R2 es un grupo alquilo, cicloalquilo, arilo o heteroarilo opcionalmente sustituidos un sistema de anillo bicíclico o tricíclico de 8- a 13- miembros opcionalmente sustituido que tiene un átomo N en el cabezal del puente y opcionalmente contiene 1, 2 o 3 heteroátomos seleccionados entre N, O o S;R3 y R4 son cada uno independientemente H, o un grupo alquilo opcionalmente sustituido;R5 y R6 son cada uno independientemente H, o un grupo alquilo, alquenilo, alquinilo, cicloalquilo, cicloheteroalquilo, arilo o heteroarilo cada uno opcionalmente sustituido, o R5 y R6 pueden ser tomados juntos con el átomo al cual ellos están ligados para formar un anillo de 3- a 7- miembros opcionalmente sustituido que contiene opcionalmente un heteroátomo adicional seleccionado entre O, N o S;R7 es H, halógeno, CN, OR8, CO2R9, CONR10R11, o un grupo alquilo, alquenilo, alquinilo, cicloalquilo, cicloheteroalquilo, arilo o heteroarilo cada uno opcionalmente sustituido;m es un entero de 1, 2 o 3;R8 es H, COR12 o un grupo alquilo, alquenilo, alquinilo, arilo o heteroarilo cada uno opcionalmente sustituido;R9 es H o un alquilo C1-C6, o un grupo arilo o heteroarilo cada uno opcionalmente sustituido;R10 y R11 son cada uno independientemente H o un grupo alquilo opcionalmente sustituido; yR12 es un grupo alquilo C1-C6, cicloalquilo, cicloheteroalquilo, arilo o heteroarilo; oun estereoisómero del mismo o una sal farmacéuticamente aceptable del mismo. La presente invención también suministra métodos y composiciones útiles para el tratamiento terapéutico de trastornos del sistema nervioso central relacionados con o afectados por el receptor 5-HT6.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70831505P | 2005-08-15 | 2005-08-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP088189A true ECSP088189A (es) | 2008-04-28 |
Family
ID=37668440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2008008189A ECSP088189A (es) | 2005-08-15 | 2008-02-15 | Derivados de 3-sulfonilindazol sustituido comoligandos de 5-hidroxitriptamina-6 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7723329B2 (es) |
| EP (1) | EP1931640A2 (es) |
| JP (1) | JP5146766B2 (es) |
| KR (1) | KR20080039994A (es) |
| CN (1) | CN101282938A (es) |
| AR (1) | AR057756A1 (es) |
| AU (1) | AU2006280091A1 (es) |
| BR (1) | BRPI0614343A2 (es) |
| CA (1) | CA2619010C (es) |
| CR (1) | CR9734A (es) |
| EC (1) | ECSP088189A (es) |
| GT (1) | GT200600376A (es) |
| IL (1) | IL189476A0 (es) |
| NO (1) | NO20080937L (es) |
| NZ (1) | NZ565872A (es) |
| PE (1) | PE20070354A1 (es) |
| RU (1) | RU2429231C2 (es) |
| SA (1) | SA06270314B1 (es) |
| TW (1) | TW200740766A (es) |
| UA (1) | UA94053C2 (es) |
| WO (1) | WO2007021711A2 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20071143A1 (es) * | 2006-01-13 | 2008-01-20 | Wyeth Corp | Composicion farmaceutica que comprende un inhibidor de acetilcolinesterasa y un antagonista 5-hidroxitriptamina-6 |
| US7645752B2 (en) * | 2006-01-13 | 2010-01-12 | Wyeth Llc | Sulfonyl substituted 1H-indoles as ligands for the 5-hydroxytryptamine receptors |
| MX2008013053A (es) * | 2006-04-12 | 2008-10-17 | Wyeth Corp | Derivados de dihidri[1,4]oxazino[2,3,4-hi]indazol-sustituidos como ligandos de 5-hidroxitriptamina-6. |
| WO2007120596A1 (en) * | 2006-04-12 | 2007-10-25 | Wyeth | DIHYDRO[1,4]DIOXINO[2,3-e]INDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS |
| WO2007120599A2 (en) * | 2006-04-12 | 2007-10-25 | Wyeth | Dihydro[1,4]oxazino[2,3,4-hi]indazole derivatives as 5-hydroxytryptamine-6 ligands |
| US20090012308A1 (en) * | 2007-06-13 | 2009-01-08 | Wyeth | Process for the manufacture of benzylsulfonylarenes |
| CN103102348B (zh) * | 2011-11-14 | 2016-06-08 | 上海交通大学 | 噁二唑类化合物及其制备方法、药物组合物及其用途 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL135900A0 (en) * | 1997-11-04 | 2001-05-20 | Pfizer Prod Inc | Indazole bioisostere replacement of catechol in therapeuticaly active compounds |
| WO2001005758A2 (en) * | 1999-07-15 | 2001-01-25 | Nps Allelix Corp. | Indoles and indazoles for the treatment of migraine |
| JP4184077B2 (ja) * | 2000-11-02 | 2008-11-19 | ワイス | ５−ヒドロキシトリプトアミン−６リガンドとしての１−アリールまたは１−アルキルスルホニル−ヘテロシクリルベンザゾール |
| ATE327232T1 (de) * | 2000-12-22 | 2006-06-15 | Wyeth Corp | Heterozyklylalkylindole oder -azaindole als 5- hydroxytryptamine-6 liganden |
| WO2002051837A2 (en) * | 2000-12-22 | 2002-07-04 | Wyeth | Heterocyclindazole and azaindazole compounds as 5-hydroxytryptamine-6 ligands |
| TW593278B (en) * | 2001-01-23 | 2004-06-21 | Wyeth Corp | 1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands |
| CN1293073C (zh) * | 2001-04-20 | 2007-01-03 | 惠氏公司 | 作为5－羟色胺－6配体的杂环基烷氧基－、－烷硫基－和－烷基氨基吲哚衍生物 |
| CN1293072C (zh) * | 2001-04-20 | 2007-01-03 | 惠氏公司 | 作为5－羟色胺－6配体的杂环基氧基－、－硫代－和－氨基吲哚衍生物 |
| BR0210929A (pt) * | 2001-06-07 | 2004-06-08 | Hoffmann La Roche | Derivados de indol com afinidade para o receptor 5-ht6 |
| WO2002100833A1 (en) * | 2001-06-12 | 2002-12-19 | Sumitomo Pharmaceuticals Company, Limited | Rho KINASE INHIBITORS |
| US20050113283A1 (en) * | 2002-01-18 | 2005-05-26 | David Solow-Cordero | Methods of treating conditions associated with an EDG-4 receptor |
| TW200400177A (en) * | 2002-06-04 | 2004-01-01 | Wyeth Corp | 1-(Aminoalkyl)-3-sulfonylindole and-indazole derivatives as 5-hydroxytryptamine-6 ligands |
| JP4754821B2 (ja) * | 2002-06-20 | 2011-08-24 | プロキシマゲン・リミテッド | 肥満症、ｉｉ型糖尿病およびｃｎｓ障害の治療に有用な新規化合物 |
| TW200401641A (en) * | 2002-07-18 | 2004-02-01 | Wyeth Corp | 1-Heterocyclylalkyl-3-sulfonylindole or-indazole derivatives as 5-hydroxytryptamine-6 ligands |
| TW200403243A (en) * | 2002-07-18 | 2004-03-01 | Wyeth Corp | 1-Heterocyclylalkyl-3-sulfonylazaindole or-azaindazole derivatives as 5-hydroxytryptamine-6 ligands |
| RU2324693C2 (ru) * | 2002-10-18 | 2008-05-20 | Ф.Хоффманн-Ля Рош Аг | 4-пиперазинилбензолсульфонилиндолы, характеризующиеся сродством к рецептору 5-нт6 |
| WO2004050085A1 (en) * | 2002-12-03 | 2004-06-17 | F. Hoffmann-La Roche Ag | Aminoalkoxyindoles as 5-ht6-receptor ligands for the treatment of cns-disorders |
| EP1592683A2 (en) * | 2003-02-14 | 2005-11-09 | Wyeth | Heterocyclyl-3-sulfonylindazoles as 5-hydroxytryptamine-6 ligands |
| WO2004074286A1 (en) * | 2003-02-14 | 2004-09-02 | Wyeth | Heterocyclyl-3-sulfonylazaindole or -azaindazole derivatives as 5-hydroxytryptamine-6 ligands |
| RU2006134022A (ru) * | 2004-02-27 | 2008-04-10 | Ф.Хоффманн-Ля Рош Аг (Ch) | Производные индазола и содержащие их фармацевтические композиции |
| RU2008103700A (ru) * | 2005-08-15 | 2009-09-27 | Вайет (Us) | Производные азинил-3-сульфонилиндазола в качестве лиганд 5ов 5-гидрокситриптамина-6 |
-
2006
- 2006-08-08 RU RU2008105807/04A patent/RU2429231C2/ru not_active IP Right Cessation
- 2006-08-08 UA UAA200801842A patent/UA94053C2/ru unknown
- 2006-08-08 EP EP06801007A patent/EP1931640A2/en not_active Withdrawn
- 2006-08-08 CN CNA2006800374446A patent/CN101282938A/zh active Pending
- 2006-08-08 CA CA2619010A patent/CA2619010C/en not_active Expired - Fee Related
- 2006-08-08 AU AU2006280091A patent/AU2006280091A1/en not_active Abandoned
- 2006-08-08 NZ NZ565872A patent/NZ565872A/en unknown
- 2006-08-08 WO PCT/US2006/030965 patent/WO2007021711A2/en not_active Ceased
- 2006-08-08 JP JP2008526995A patent/JP5146766B2/ja not_active Expired - Fee Related
- 2006-08-08 BR BRPI0614343-1A patent/BRPI0614343A2/pt not_active IP Right Cessation
- 2006-08-08 KR KR1020087006267A patent/KR20080039994A/ko not_active Ceased
- 2006-08-14 PE PE2006000984A patent/PE20070354A1/es not_active Application Discontinuation
- 2006-08-14 TW TW095129795A patent/TW200740766A/zh unknown
- 2006-08-14 AR ARP060103549A patent/AR057756A1/es unknown
- 2006-08-14 GT GT200600376A patent/GT200600376A/es unknown
- 2006-08-14 US US11/504,350 patent/US7723329B2/en not_active Expired - Fee Related
- 2006-09-09 SA SA6270314A patent/SA06270314B1/ar unknown
-
2008
- 2008-02-12 IL IL189476A patent/IL189476A0/en unknown
- 2008-02-15 EC EC2008008189A patent/ECSP088189A/es unknown
- 2008-02-15 CR CR9734A patent/CR9734A/es not_active Application Discontinuation
- 2008-02-25 NO NO20080937A patent/NO20080937L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP5146766B2 (ja) | 2013-02-20 |
| RU2008105807A (ru) | 2009-09-27 |
| KR20080039994A (ko) | 2008-05-07 |
| SA06270314B1 (ar) | 2011-07-20 |
| RU2429231C2 (ru) | 2011-09-20 |
| NZ565872A (en) | 2011-06-30 |
| CR9734A (es) | 2008-04-03 |
| WO2007021711A2 (en) | 2007-02-22 |
| WO2007021711A3 (en) | 2007-05-03 |
| NO20080937L (no) | 2008-04-30 |
| AU2006280091A1 (en) | 2007-02-22 |
| JP2009504739A (ja) | 2009-02-05 |
| GT200600376A (es) | 2007-03-29 |
| US7723329B2 (en) | 2010-05-25 |
| EP1931640A2 (en) | 2008-06-18 |
| TW200740766A (en) | 2007-11-01 |
| PE20070354A1 (es) | 2007-04-04 |
| CN101282938A (zh) | 2008-10-08 |
| US20070037802A1 (en) | 2007-02-15 |
| CA2619010C (en) | 2013-10-01 |
| BRPI0614343A2 (pt) | 2011-03-22 |
| IL189476A0 (en) | 2008-08-07 |
| AR057756A1 (es) | 2007-12-19 |
| CA2619010A1 (en) | 2007-02-22 |
| UA94053C2 (ru) | 2011-04-11 |
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