ECSP088712A - Compuestos de n-formil-hidroxilamina - Google Patents
Compuestos de n-formil-hidroxilaminaInfo
- Publication number
- ECSP088712A ECSP088712A EC2008008712A ECSP088712A ECSP088712A EC SP088712 A ECSP088712 A EC SP088712A EC 2008008712 A EC2008008712 A EC 2008008712A EC SP088712 A ECSP088712 A EC SP088712A EC SP088712 A ECSP088712 A EC SP088712A
- Authority
- EC
- Ecuador
- Prior art keywords
- compounds
- formil
- hydroxylamine compounds
- disclosed
- formyl hydroxylamine
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 4
- KDGKTJGPFXIBEB-UHFFFAOYSA-N n-hydroxyformamide Chemical compound ONC=O KDGKTJGPFXIBEB-UHFFFAOYSA-N 0.000 abstract 2
- 125000001151 peptidyl group Chemical group 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000002274 Matrix Metalloproteinases Human genes 0.000 abstract 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 abstract 1
- 102000005741 Metalloproteases Human genes 0.000 abstract 1
- 108010006035 Metalloproteases Proteins 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se dan a conocer novedosos compuestos de N-formil-hidroxilamina y sus derivados. Estos compuestos de N-formil-hidroxilamina inhiben la peptidil-desformilasa (PDF), una enzima presente en los procariotes. Los compuestos son útiles como antimicrobianos y antibióticos. Los compuestos de la invención exhiben una inhibición selectiva de la peptidil-desformilasa contra otras metaloproteinasas, tales como MMPs. También se dan a conocer métodos de preparación y uso de los compuestos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77937706P | 2006-03-03 | 2006-03-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP088712A true ECSP088712A (es) | 2008-10-31 |
Family
ID=38510154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2008008712A ECSP088712A (es) | 2006-03-03 | 2008-09-02 | Compuestos de n-formil-hidroxilamina |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20090062537A1 (es) |
| EP (1) | EP1994027A2 (es) |
| JP (1) | JP2009529008A (es) |
| KR (1) | KR20080095895A (es) |
| CN (1) | CN101395148A (es) |
| AU (1) | AU2007226715A1 (es) |
| BR (1) | BRPI0708524A2 (es) |
| CA (1) | CA2643267A1 (es) |
| CR (1) | CR10251A (es) |
| EC (1) | ECSP088712A (es) |
| GT (1) | GT200800170A (es) |
| IL (1) | IL193524A0 (es) |
| MA (1) | MA30285B1 (es) |
| MX (1) | MX2008011128A (es) |
| NO (1) | NO20084069L (es) |
| RU (1) | RU2008139192A (es) |
| TN (1) | TNSN08344A1 (es) |
| WO (1) | WO2007106670A2 (es) |
| ZA (1) | ZA200807054B (es) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101584694B (zh) * | 2009-06-15 | 2011-01-12 | 华东师范大学 | 含2,5-二氢吡咯的肽脱甲酰基酶抑制剂及合成方法 |
| CN101869563B (zh) * | 2010-07-02 | 2011-11-16 | 华东师范大学 | 含4-亚甲基吡咯烷的肽脱甲酰基酶抑制剂 |
| AR085698A1 (es) * | 2011-03-09 | 2013-10-23 | Glaxosmithkline Llc | Inhibidores de la peptido desformilasa |
| CN103159660B (zh) * | 2011-12-08 | 2016-07-06 | 天津市国际生物医药联合研究院 | (2r)-1-(2-甲基-3-(甲氧基(甲基)氨基)-丙酰基)吡咯烷-2-羧酸及其应用 |
| WO2013106646A2 (en) * | 2012-01-12 | 2013-07-18 | Yale University | Compounds and methods for the inhibition of vcb e3 ubiquitin ligase |
| RU2666530C2 (ru) * | 2012-01-12 | 2018-09-11 | Йейл Юниверсити | Соединения и способы усиления деградации белков-мишеней и других полипептидов с помощью е3 убиквитин лигазы |
| BR112014015582A8 (pt) | 2012-02-24 | 2017-07-04 | Hoffmann La Roche | compostos antivirais |
| GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
| GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| PL3102568T3 (pl) * | 2014-02-06 | 2019-01-31 | Heptares Therapeutics Limited | Bicykliczne związki aza w postaci agonistów receptorów muskarynowych m1 |
| US20180228907A1 (en) | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| US10071164B2 (en) | 2014-08-11 | 2018-09-11 | Yale University | Estrogen-related receptor alpha based protac compounds and associated methods of use |
| US12312316B2 (en) | 2015-01-20 | 2025-05-27 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
| MX390189B (es) | 2015-01-20 | 2025-03-20 | Arvinas Operations Inc | COMPUESTOS Y METODOS PARA LA DEGRADACION DIRIGIDA DE RECEPTOR DE ANDROGENOs. |
| AU2016232705C1 (en) | 2015-03-18 | 2021-06-17 | Arvinas, Inc. | Compounds and methods for the enhanced degradation of targeted proteins |
| WO2016197114A1 (en) | 2015-06-05 | 2016-12-08 | Arvinas, Inc. | Tank-binding kinase-1 protacs and associated methods of use |
| WO2017030814A1 (en) | 2015-08-19 | 2017-02-23 | Arvinas, Inc. | Compounds and methods for the targeted degradation of bromodomain-containing proteins |
| RU2018120330A (ru) | 2015-11-02 | 2019-12-04 | Йейл Юниверсити | Химерные соединения, осуществляющие нацеливание для протеолиза, и способы их получения и применения |
| US20170281784A1 (en) | 2016-04-05 | 2017-10-05 | Arvinas, Inc. | Protein-protein interaction inducing technology |
| US20180072711A1 (en) | 2016-09-15 | 2018-03-15 | Arvinas, Inc. | Indole derivatives as estrogen receptor degraders |
| IL318681A (en) | 2016-10-11 | 2025-03-01 | Arvinas Operations Inc | Compounds and methods for targeted reduction of androgen receptor |
| AU2017367872B2 (en) | 2016-11-01 | 2022-03-31 | Arvinas, Inc. | Tau-protein targeting protacs and associated methods of use |
| CN118834201A (zh) | 2016-12-01 | 2024-10-25 | 阿尔维纳斯运营股份有限公司 | 作为雌激素受体降解剂的四氢萘和四氢异喹啉衍生物 |
| WO2018118598A1 (en) | 2016-12-23 | 2018-06-28 | Arvinas, Inc. | Compounds and methods for the targeted degradation of fetal liver kinase polypeptides |
| KR102839545B1 (ko) | 2016-12-23 | 2025-07-29 | 아비나스 오퍼레이션스, 인코포레이티드 | 급속 진행성 섬유육종 폴리펩티드의 표적화 분해를 위한 화합물 및 방법 |
| KR20190101406A (ko) | 2016-12-23 | 2019-08-30 | 아비나스 오퍼레이션스, 인코포레이티드 | Egfr 단백질분해 표적화 키메라 분자 및 관련 사용 방법 |
| US11173211B2 (en) | 2016-12-23 | 2021-11-16 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of rapidly accelerated Fibrosarcoma polypeptides |
| US11191741B2 (en) | 2016-12-24 | 2021-12-07 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide |
| CA3049912A1 (en) | 2017-01-26 | 2018-08-02 | Arvinas Operations, Inc. | Modulators of estrogen receptor proteolysis and associated methods of use |
| JP2020506922A (ja) | 2017-01-31 | 2020-03-05 | アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． | セレブロンリガンド、およびセレブロンリガンドを含有する二官能性化合物 |
| US11065231B2 (en) | 2017-11-17 | 2021-07-20 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides |
| WO2019148055A1 (en) | 2018-01-26 | 2019-08-01 | Yale University | Imide-based modulators of proteolysis and methods of use |
| US12539292B2 (en) | 2018-04-01 | 2026-02-03 | Arvinas Operations, Inc. | BRM targeting compounds and associated methods of use |
| BR112020020307A2 (pt) | 2018-04-04 | 2021-01-12 | Arvinas Operations, Inc. | Moduladores de proteólise e métodos de uso associados |
| JP7297053B2 (ja) | 2018-08-20 | 2023-06-23 | アルビナス・オペレーションズ・インコーポレイテッド | 神経変性疾患を治療するためのｅ３ユビキチンリガーゼ結合活性を有するキメラ（ｐｒｏｔａｃ）化合物を標的とし、アルファ－シヌクレインタンパク質を標的とするタンパク質分解 |
| CN114867727B (zh) | 2019-07-17 | 2025-02-21 | 阿尔维纳斯运营股份有限公司 | Tau蛋白靶向化合物及相关使用方法 |
| IL290789B2 (en) | 2019-08-26 | 2025-09-01 | Arvinas Operations Inc | Methods for treating breast cancer with a history of tetrahydronaphthalene as estrogen receptor-disrupting agents |
| CN119019369A (zh) | 2019-10-17 | 2024-11-26 | 阿尔维纳斯运营股份有限公司 | 含有与bcl6靶向部分连接的e3泛素连接酶结合部分的双官能分子 |
| PE20221582A1 (es) | 2019-12-19 | 2022-10-06 | Arvinas Operations Inc | Compuestos y metodos para la degradacion dirigida de receptor de androgenos |
| TW202208345A (zh) | 2020-05-09 | 2022-03-01 | 美商亞文納營運公司 | 雙官能性化合物的製造方法、該雙官能性化合物的超純形式、及含彼之劑型 |
| US12180193B2 (en) | 2020-08-28 | 2024-12-31 | Arvinas Operations, Inc. | Accelerating fibrosarcoma protein degrading compounds and associated methods of use |
| KR20230069144A (ko) | 2020-09-14 | 2023-05-18 | 아비나스 오퍼레이션스, 인코포레이티드 | 에스트로겐 수용체의 표적화된 분해를 위한 화합물의 결정질 형태 |
| CN118388454A (zh) | 2021-04-16 | 2024-07-26 | 阿尔维纳斯运营股份有限公司 | Bcl6蛋白水解的调节剂和其相关使用方法 |
| EP4584258A1 (en) | 2022-09-07 | 2025-07-16 | Arvinas Operations, Inc. | Rapidly accelerated fibrosarcoma (raf) degrading compounds and associated methods of use |
| AU2024212035A1 (en) | 2023-01-26 | 2025-08-14 | Arvinas Operations, Inc. | Cereblon-based kras degrading protacs ans uses related thereto |
| US12496301B2 (en) | 2023-12-08 | 2025-12-16 | Arvinas Operations, Inc. | Use of androgen receptor degrader for the treatment of spinal and bulbar muscular atrophy |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR036053A1 (es) * | 2001-06-15 | 2004-08-04 | Versicor Inc | Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas |
| AU2004216178B2 (en) * | 2003-02-21 | 2008-07-03 | Novartis Ag | Chemical process for the preparation of intermediates to obtain N-formyl hydroxylamine compounds |
-
2007
- 2007-03-02 MX MX2008011128A patent/MX2008011128A/es not_active Application Discontinuation
- 2007-03-02 AU AU2007226715A patent/AU2007226715A1/en not_active Abandoned
- 2007-03-02 KR KR1020087021464A patent/KR20080095895A/ko not_active Ceased
- 2007-03-02 JP JP2008557514A patent/JP2009529008A/ja active Pending
- 2007-03-02 BR BRPI0708524-9A patent/BRPI0708524A2/pt not_active IP Right Cessation
- 2007-03-02 US US12/280,896 patent/US20090062537A1/en not_active Abandoned
- 2007-03-02 CA CA002643267A patent/CA2643267A1/en not_active Abandoned
- 2007-03-02 WO PCT/US2007/063167 patent/WO2007106670A2/en not_active Ceased
- 2007-03-02 RU RU2008139192/04A patent/RU2008139192A/ru not_active Application Discontinuation
- 2007-03-02 EP EP07757788A patent/EP1994027A2/en not_active Withdrawn
- 2007-03-02 CN CNA2007800077069A patent/CN101395148A/zh active Pending
-
2008
- 2008-08-15 ZA ZA200807054A patent/ZA200807054B/xx unknown
- 2008-08-18 IL IL193524A patent/IL193524A0/en unknown
- 2008-08-26 CR CR10251A patent/CR10251A/es unknown
- 2008-09-02 EC EC2008008712A patent/ECSP088712A/es unknown
- 2008-09-02 TN TNP2008000344A patent/TNSN08344A1/en unknown
- 2008-09-02 GT GT200800170A patent/GT200800170A/es unknown
- 2008-09-17 MA MA31247A patent/MA30285B1/fr unknown
- 2008-09-24 NO NO20084069A patent/NO20084069L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MX2008011128A (es) | 2008-09-08 |
| JP2009529008A (ja) | 2009-08-13 |
| US20090062537A1 (en) | 2009-03-05 |
| CN101395148A (zh) | 2009-03-25 |
| RU2008139192A (ru) | 2010-04-10 |
| KR20080095895A (ko) | 2008-10-29 |
| TNSN08344A1 (en) | 2009-12-29 |
| WO2007106670A2 (en) | 2007-09-20 |
| CA2643267A1 (en) | 2007-09-20 |
| AU2007226715A1 (en) | 2007-09-20 |
| CR10251A (es) | 2008-10-27 |
| ZA200807054B (en) | 2009-10-28 |
| WO2007106670A3 (en) | 2008-01-24 |
| BRPI0708524A2 (pt) | 2011-05-31 |
| GT200800170A (es) | 2008-10-29 |
| IL193524A0 (en) | 2009-08-03 |
| NO20084069L (no) | 2008-12-03 |
| MA30285B1 (fr) | 2009-03-02 |
| EP1994027A2 (en) | 2008-11-26 |
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