MA30285B1 - Composes de n-formyle hydroxylamine - Google Patents

Composes de n-formyle hydroxylamine

Info

Publication number
MA30285B1
MA30285B1 MA31247A MA31247A MA30285B1 MA 30285 B1 MA30285 B1 MA 30285B1 MA 31247 A MA31247 A MA 31247A MA 31247 A MA31247 A MA 31247A MA 30285 B1 MA30285 B1 MA 30285B1
Authority
MA
Morocco
Prior art keywords
compounds
formyl hydroxylamine
hydroxylamine compounds
present
relates
Prior art date
Application number
MA31247A
Other languages
English (en)
Inventor
Kwangho Lee
Jennifer Leeds
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA30285B1 publication Critical patent/MA30285B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne de nouveaux composés de N-formyle hydroxylamine et leurs dérivés. Lesdits composés de N-formyle hydroxylamine inhibent la peptidyl-déformylase (PDF), une enzyme présente chez les procaryotes. Ces composés servent d'antimicrobiens et d'antibiotiques. Les composés de ladite invention démontrent une inhibition sélective de la peptidyl-déformylase par rapport à d'autres métalloprotéinases telles que les MMP. L'invention porte également sur des méthodes de préparation et d'utilisation desdits composés.
MA31247A 2006-03-03 2008-09-17 Composes de n-formyle hydroxylamine MA30285B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77937706P 2006-03-03 2006-03-03

Publications (1)

Publication Number Publication Date
MA30285B1 true MA30285B1 (fr) 2009-03-02

Family

ID=38510154

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31247A MA30285B1 (fr) 2006-03-03 2008-09-17 Composes de n-formyle hydroxylamine

Country Status (19)

Country Link
US (1) US20090062537A1 (fr)
EP (1) EP1994027A2 (fr)
JP (1) JP2009529008A (fr)
KR (1) KR20080095895A (fr)
CN (1) CN101395148A (fr)
AU (1) AU2007226715A1 (fr)
BR (1) BRPI0708524A2 (fr)
CA (1) CA2643267A1 (fr)
CR (1) CR10251A (fr)
EC (1) ECSP088712A (fr)
GT (1) GT200800170A (fr)
IL (1) IL193524A0 (fr)
MA (1) MA30285B1 (fr)
MX (1) MX2008011128A (fr)
NO (1) NO20084069L (fr)
RU (1) RU2008139192A (fr)
TN (1) TNSN08344A1 (fr)
WO (1) WO2007106670A2 (fr)
ZA (1) ZA200807054B (fr)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101584694B (zh) * 2009-06-15 2011-01-12 华东师范大学 含2,5-二氢吡咯的肽脱甲酰基酶抑制剂及合成方法
CN101869563B (zh) * 2010-07-02 2011-11-16 华东师范大学 含4-亚甲基吡咯烷的肽脱甲酰基酶抑制剂
AR085698A1 (es) * 2011-03-09 2013-10-23 Glaxosmithkline Llc Inhibidores de la peptido desformilasa
CN103159660B (zh) * 2011-12-08 2016-07-06 天津市国际生物医药联合研究院 (2r)-1-(2-甲基-3-(甲氧基(甲基)氨基)-丙酰基)吡咯烷-2-羧酸及其应用
WO2013106646A2 (fr) * 2012-01-12 2013-07-18 Yale University Composés et procédés pour l'inhibition de l'ubiquitine ligase vcb e3
RU2666530C2 (ru) * 2012-01-12 2018-09-11 Йейл Юниверсити Соединения и способы усиления деградации белков-мишеней и других полипептидов с помощью е3 убиквитин лигазы
BR112014015582A8 (pt) 2012-02-24 2017-07-04 Hoffmann La Roche compostos antivirais
GB201311891D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compound
GB201311888D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compounds
PL3102568T3 (pl) * 2014-02-06 2019-01-31 Heptares Therapeutics Limited Bicykliczne związki aza w postaci agonistów receptorów muskarynowych m1
US20180228907A1 (en) 2014-04-14 2018-08-16 Arvinas, Inc. Cereblon ligands and bifunctional compounds comprising the same
US10071164B2 (en) 2014-08-11 2018-09-11 Yale University Estrogen-related receptor alpha based protac compounds and associated methods of use
US12312316B2 (en) 2015-01-20 2025-05-27 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of androgen receptor
MX390189B (es) 2015-01-20 2025-03-20 Arvinas Operations Inc COMPUESTOS Y METODOS PARA LA DEGRADACION DIRIGIDA DE RECEPTOR DE ANDROGENOs.
AU2016232705C1 (en) 2015-03-18 2021-06-17 Arvinas, Inc. Compounds and methods for the enhanced degradation of targeted proteins
WO2016197114A1 (fr) 2015-06-05 2016-12-08 Arvinas, Inc. Tank-binding kinase-1 protacs et procédés d'utilisation associés
WO2017030814A1 (fr) 2015-08-19 2017-02-23 Arvinas, Inc. Composés et procédés pour la dégradation ciblée de protéines contenant un bromodomaine
RU2018120330A (ru) 2015-11-02 2019-12-04 Йейл Юниверсити Химерные соединения, осуществляющие нацеливание для протеолиза, и способы их получения и применения
US20170281784A1 (en) 2016-04-05 2017-10-05 Arvinas, Inc. Protein-protein interaction inducing technology
US20180072711A1 (en) 2016-09-15 2018-03-15 Arvinas, Inc. Indole derivatives as estrogen receptor degraders
IL318681A (en) 2016-10-11 2025-03-01 Arvinas Operations Inc Compounds and methods for targeted reduction of androgen receptor
AU2017367872B2 (en) 2016-11-01 2022-03-31 Arvinas, Inc. Tau-protein targeting protacs and associated methods of use
CN118834201A (zh) 2016-12-01 2024-10-25 阿尔维纳斯运营股份有限公司 作为雌激素受体降解剂的四氢萘和四氢异喹啉衍生物
WO2018118598A1 (fr) 2016-12-23 2018-06-28 Arvinas, Inc. Composés et procédés pour la dégradation ciblée de polypeptides de kinase du foie fœtal
KR102839545B1 (ko) 2016-12-23 2025-07-29 아비나스 오퍼레이션스, 인코포레이티드 급속 진행성 섬유육종 폴리펩티드의 표적화 분해를 위한 화합물 및 방법
KR20190101406A (ko) 2016-12-23 2019-08-30 아비나스 오퍼레이션스, 인코포레이티드 Egfr 단백질분해 표적화 키메라 분자 및 관련 사용 방법
US11173211B2 (en) 2016-12-23 2021-11-16 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of rapidly accelerated Fibrosarcoma polypeptides
US11191741B2 (en) 2016-12-24 2021-12-07 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide
CA3049912A1 (fr) 2017-01-26 2018-08-02 Arvinas Operations, Inc. Modulateurs du recepteur des ƒstrogenes de proteolyse et procedes d'utilisation associes
JP2020506922A (ja) 2017-01-31 2020-03-05 アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． セレブロンリガンド、およびセレブロンリガンドを含有する二官能性化合物
US11065231B2 (en) 2017-11-17 2021-07-20 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides
WO2019148055A1 (fr) 2018-01-26 2019-08-01 Yale University Modulateurs de protéolyse à base d'imide et procédés d'utilisation associés
US12539292B2 (en) 2018-04-01 2026-02-03 Arvinas Operations, Inc. BRM targeting compounds and associated methods of use
BR112020020307A2 (pt) 2018-04-04 2021-01-12 Arvinas Operations, Inc. Moduladores de proteólise e métodos de uso associados
JP7297053B2 (ja) 2018-08-20 2023-06-23 アルビナス・オペレーションズ・インコーポレイテッド 神経変性疾患を治療するためのｅ３ユビキチンリガーゼ結合活性を有するキメラ（ｐｒｏｔａｃ）化合物を標的とし、アルファ－シヌクレインタンパク質を標的とするタンパク質分解
CN114867727B (zh) 2019-07-17 2025-02-21 阿尔维纳斯运营股份有限公司 Tau蛋白靶向化合物及相关使用方法
IL290789B2 (en) 2019-08-26 2025-09-01 Arvinas Operations Inc Methods for treating breast cancer with a history of tetrahydronaphthalene as estrogen receptor-disrupting agents
CN119019369A (zh) 2019-10-17 2024-11-26 阿尔维纳斯运营股份有限公司 含有与bcl6靶向部分连接的e3泛素连接酶结合部分的双官能分子
PE20221582A1 (es) 2019-12-19 2022-10-06 Arvinas Operations Inc Compuestos y metodos para la degradacion dirigida de receptor de androgenos
TW202208345A (zh) 2020-05-09 2022-03-01 美商亞文納營運公司 雙官能性化合物的製造方法、該雙官能性化合物的超純形式、及含彼之劑型
US12180193B2 (en) 2020-08-28 2024-12-31 Arvinas Operations, Inc. Accelerating fibrosarcoma protein degrading compounds and associated methods of use
KR20230069144A (ko) 2020-09-14 2023-05-18 아비나스 오퍼레이션스, 인코포레이티드 에스트로겐 수용체의 표적화된 분해를 위한 화합물의 결정질 형태
CN118388454A (zh) 2021-04-16 2024-07-26 阿尔维纳斯运营股份有限公司 Bcl6蛋白水解的调节剂和其相关使用方法
EP4584258A1 (fr) 2022-09-07 2025-07-16 Arvinas Operations, Inc. Composés de dégradation de fibrosarcome rapidement accéléré (raf) et procédés d'utilisation associés
AU2024212035A1 (en) 2023-01-26 2025-08-14 Arvinas Operations, Inc. Cereblon-based kras degrading protacs ans uses related thereto
US12496301B2 (en) 2023-12-08 2025-12-16 Arvinas Operations, Inc. Use of androgen receptor degrader for the treatment of spinal and bulbar muscular atrophy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR036053A1 (es) * 2001-06-15 2004-08-04 Versicor Inc Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas
AU2004216178B2 (en) * 2003-02-21 2008-07-03 Novartis Ag Chemical process for the preparation of intermediates to obtain N-formyl hydroxylamine compounds

Also Published As

Publication number Publication date
MX2008011128A (es) 2008-09-08
JP2009529008A (ja) 2009-08-13
US20090062537A1 (en) 2009-03-05
CN101395148A (zh) 2009-03-25
RU2008139192A (ru) 2010-04-10
KR20080095895A (ko) 2008-10-29
TNSN08344A1 (en) 2009-12-29
WO2007106670A2 (fr) 2007-09-20
CA2643267A1 (fr) 2007-09-20
AU2007226715A1 (en) 2007-09-20
CR10251A (es) 2008-10-27
ZA200807054B (en) 2009-10-28
WO2007106670A3 (fr) 2008-01-24
BRPI0708524A2 (pt) 2011-05-31
ECSP088712A (es) 2008-10-31
GT200800170A (es) 2008-10-29
IL193524A0 (en) 2009-08-03
NO20084069L (no) 2008-12-03
EP1994027A2 (fr) 2008-11-26

Similar Documents

Publication Publication Date Title
MA30285B1 (fr) Composes de n-formyle hydroxylamine
WO2004033632A3 (fr) Derives d'hydantoine en tant qu'inhibiteurs de metalloproteinases matricielles et/ou de l'enzyme de conversion de tnf-alpha (tace)
EA200702470A1 (ru) Производные пиррола в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторов
WO2004032846A3 (fr) Derives de la triazolone et de la triazolethione, inhibiteurs des metalloproteinases de matrices et/ou de l'enzyme de conversion du tnf$g(a)
MA29393B1 (fr) Derives d'azole sous forme d'inhibiteurs de lipase et de phospholipase
MA29856B1 (fr) Derives de diacylindazole en tant qu'inhibiteurs de lipases et de phospholipases
DK1751108T3 (da) Adamantyl-acetamidderivater som inhibitorer for 11-beta-hydroxysteroid-dehydrogenase-type 1-enzymet
MA30784B1 (fr) Derives phenyliques et utilisation de ceux-ci en tant qu'immunomodulateurs.
MA29909B1 (fr) Derives de pyridazine
NO20075298L (no) Novel thiophene derivatives as sphingosine-1-phosphate-1 receptor agonists
CY1110425T1 (el) Συνεργεια των gos και της πολυφρουκτοζης
BRPI0609121B8 (pt) 1h-benzimidazol-4-carboxamidas substituídas com um carbono quaternário na posição 2
WO2005123703A8 (fr) Nouveauc derives alkynyl servant de modulateurs de recepteurs de glutamate metabotropiques
MA30717B1 (fr) Derives de pyridin-3-yle en tant qu'agents immunomodulateurs
MA30718B1 (fr) Derives de pyridin-4-yle en tant qu'agents immunomodulateurs.
NO20082509L (no) Pyridopyrazinderivater og deres anvendelse
MA30988B1 (fr) Composes destines a inhiber la progression mitotique
NO20083462L (no) Nye tiofenderivater som S1P1/EDG1-reseptoragonister
ATE244241T1 (de) Hemmung der menschlichen telomerase durch g- quadruplex interaktionverbindung
MX2007014405A (es) Novedosos derivados de oxadiazol y su uso como moduladores aloestericos positivos de los receptores de glutamato metabotropicos.
EP2251011A4 (fr) Préparation solide pour administration orale
BRPI0414864A (pt) composição farmacêutica multiparticulada compreendendo ácido micofenólico ou micofenolato de sódio e combinação com rapamicida
NO20092691L (no) 4-hydroksy-2-okso-2,3-dihydro-1,3-benzotiazol-7yl-forbindelser for modulering av B2-adrenoreseptoraktivitet
WO2006123255A3 (fr) Derives oxadiazole substitues convenant comme modulateurs allosteriques positifs de recepteurs metabotropiques du glutamate
BR0307071A (pt) ésteres hidroxamato do ácido n-(fenil 4-substituìdo)-antranìlico