ECSP099042A - Ciclobuten-1,2-dionas 3,4-di-sustituidas como ligandos de receptores de quimiocinas cxc - Google Patents

Ciclobuten-1,2-dionas 3,4-di-sustituidas como ligandos de receptores de quimiocinas cxc

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Publication number
ECSP099042A
ECSP099042A EC2009009042A ECSP099042A ECSP099042A EC SP099042 A ECSP099042 A EC SP099042A EC 2009009042 A EC2009009042 A EC 2009009042A EC SP099042 A ECSP099042 A EC SP099042A EC SP099042 A ECSP099042 A EC SP099042A
Authority
EC
Ecuador
Prior art keywords
substituted
ciclobuten
chemiokin
dionas
cxc
Prior art date
Application number
EC2009009042A
Other languages
English (en)
Inventor
Jianhua Chao
James Robert Merritt
Gaifa Lai
Zhenmin He
Michael F Czarniecki
Original Assignee
Schering Corp
Pharmacopeia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38654612&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP099042(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp, Pharmacopeia Inc filed Critical Schering Corp
Publication of ECSP099042A publication Critical patent/ECSP099042A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P31/14—Antivirals for RNA viruses
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • AIDS & HIV (AREA)

Abstract

Se revelan nuevos compuestos de ciclobutendiona 1 a 18 que comprenden un anillo de ciclobutendiona, un anillo fenilo sustituido y un resto -CH(C2H5)-furano. El anillo fenilo y el resto -CH(C2H5)-furano están ambos unidos al anillo de ciclobutendiona a través de un resto -NH-. También se revelaron usos de los compuestos 1 a 18 para la elaboración de un medicamento para tratar enfermedades mediadas por quimiocinas (p.ej., cáncer, EPOC, trastornos inflamatorios agudos y crónicos, psoriasis, fibrosis quística y asma).
EC2009009042A 2006-07-07 2009-01-08 Ciclobuten-1,2-dionas 3,4-di-sustituidas como ligandos de receptores de quimiocinas cxc ECSP099042A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81954106P 2006-07-07 2006-07-07

Publications (1)

Publication Number Publication Date
ECSP099042A true ECSP099042A (es) 2009-02-27

Family

ID=38654612

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2009009042A ECSP099042A (es) 2006-07-07 2009-01-08 Ciclobuten-1,2-dionas 3,4-di-sustituidas como ligandos de receptores de quimiocinas cxc

Country Status (20)

Country Link
US (1) US20080045489A1 (es)
EP (1) EP2041107A1 (es)
JP (1) JP2009542700A (es)
KR (1) KR20090028811A (es)
CN (1) CN101511809A (es)
AR (1) AR061829A1 (es)
AU (1) AU2007269572A1 (es)
BR (1) BRPI0713559A2 (es)
CA (1) CA2657051A1 (es)
CL (1) CL2007001969A1 (es)
CO (1) CO6150138A2 (es)
EC (1) ECSP099042A (es)
IL (1) IL196335A0 (es)
MX (1) MX2009000123A (es)
NO (1) NO20090594L (es)
PE (1) PE20080553A1 (es)
RU (1) RU2009103999A (es)
TW (1) TW200813033A (es)
WO (1) WO2008005570A1 (es)
ZA (1) ZA200900110B (es)

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US8865723B2 (en) 2012-10-25 2014-10-21 Tetra Discovery Partners Llc Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury
US9763992B2 (en) 2014-02-13 2017-09-19 Father Flanagan's Boys' Home Treatment of noise induced hearing loss
EP3305304A4 (en) * 2015-05-29 2019-01-23 Seikagaku Corporation COMPOSITION WITH GLUCOSAMINATE SCANDERIVATE AND CHEMOKIN RECEPTOR ACTIVITY CONTROLLER
TWI724056B (zh) * 2015-11-19 2021-04-11 美商卡默森屈有限公司 Ｃｘｃｒ２抑制劑
TWI734715B (zh) 2015-11-19 2021-08-01 美商卡默森屈有限公司 趨化因子受體調節劑
MA50424A (fr) 2018-01-08 2020-08-26 Chemocentryx Inc Méthodes de traitement du psoriasis pustuleux généralisé avec un antagoniste de ccr6 ou cxcr2
PE20211070A1 (es) 2018-09-21 2021-06-09 Pfizer Dioxociclobutenilamino-3-hidroxi-picolinamidas n-sustituidas utiles como inhibidores de ccr6
CN109879854A (zh) * 2019-03-25 2019-06-14 河南湾流生物科技有限公司 一种具有抗氧化作用的环丁烯酮类化合物及其制备方法
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CN111329857B (zh) * 2020-04-10 2022-10-11 青岛大学附属医院 一种氟苯甲酰胺衍生物注射液及其抗乳腺癌应用

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MX2009000123A (es) 2009-03-25
BRPI0713559A2 (pt) 2012-03-13
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PE20080553A1 (es) 2008-05-16
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CL2007001969A1 (es) 2008-01-18
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US20080045489A1 (en) 2008-02-21
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