BRPI0713559A2 - Composto ciclobuteno-1,2-dionas 3,4-di-substituídas, composição farmacêutica compreendendo o mesmo e usos do mesmo - Google Patents

Composto ciclobuteno-1,2-dionas 3,4-di-substituídas, composição farmacêutica compreendendo o mesmo e usos do mesmo Download PDF

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Publication number
BRPI0713559A2
BRPI0713559A2 BRPI0713559-9A BRPI0713559A BRPI0713559A2 BR PI0713559 A2 BRPI0713559 A2 BR PI0713559A2 BR PI0713559 A BRPI0713559 A BR PI0713559A BR PI0713559 A2 BRPI0713559 A2 BR PI0713559A2
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Brazil
Prior art keywords
same
cyclobutene
diones
pharmaceutical composition
moiety
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BRPI0713559-9A
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English (en)
Inventor
Chao Jianhua
F. Czarniecki Michael
He Zhenmin
Lai Gaifa
Robert Merritt James
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Schering Corporation
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Application filed by Schering Corporation filed Critical Schering Corporation
Publication of BRPI0713559A2 publication Critical patent/BRPI0713559A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
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  • Immunology (AREA)
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  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
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Abstract

COMPOSTO CICLOBUTENO-1,2-DIONAS 3,4-DI-SUBSTITUìDAS, COMPOSIçãO FARMACêUTICA COMPREENDENDO O MESMO E USOS DO MESMO. A presente invenção refere-se a novos compostos ciclobutenodiona compreendendo um anel de ciclobutenodiona, ou um anel fenila substituído, e uma porção -CH(C2H5)-furano. O anel fenila e a porção - CH(C2H5)-furano são cada um ligados ao anel ciclobutenodiona através de uma porção -NH-. São também descritos usos de compostos para a fabricação de um medicamento para tratamento de doenças mediadas por quimiocina (por exemplo, câncer, COPD, distúrbios inflamatórios agudos e crónicas, psoríase, fibrose cística e asma).
BRPI0713559-9A 2006-07-07 2007-07-05 Composto ciclobuteno-1,2-dionas 3,4-di-substituídas, composição farmacêutica compreendendo o mesmo e usos do mesmo BRPI0713559A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81954106P 2006-07-07 2006-07-07
US60/819,541 2006-07-07
PCT/US2007/015671 WO2008005570A1 (en) 2006-07-07 2007-07-05 3,4-di-substituted cyclobutene-1,2-diones as cxc-chemokine receptor ligands

Publications (1)

Publication Number Publication Date
BRPI0713559A2 true BRPI0713559A2 (pt) 2012-03-13

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ID=38654612

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0713559-9A BRPI0713559A2 (pt) 2006-07-07 2007-07-05 Composto ciclobuteno-1,2-dionas 3,4-di-substituídas, composição farmacêutica compreendendo o mesmo e usos do mesmo

Country Status (20)

Country Link
US (1) US20080045489A1 (pt)
EP (1) EP2041107A1 (pt)
JP (1) JP2009542700A (pt)
KR (1) KR20090028811A (pt)
CN (1) CN101511809A (pt)
AR (1) AR061829A1 (pt)
AU (1) AU2007269572A1 (pt)
BR (1) BRPI0713559A2 (pt)
CA (1) CA2657051A1 (pt)
CL (1) CL2007001969A1 (pt)
CO (1) CO6150138A2 (pt)
EC (1) ECSP099042A (pt)
IL (1) IL196335A0 (pt)
MX (1) MX2009000123A (pt)
NO (1) NO20090594L (pt)
PE (1) PE20080553A1 (pt)
RU (1) RU2009103999A (pt)
TW (1) TW200813033A (pt)
WO (1) WO2008005570A1 (pt)
ZA (1) ZA200900110B (pt)

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CA2692269A1 (en) * 2007-07-03 2009-01-08 Schering Corporation Process and intermediates for the synthesis of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds
CA2694268A1 (en) * 2007-07-05 2009-01-08 Schering Corporation Process for controlled crystal size in 1,2-substituted 3,4-dioxo-1-cyclobutene compounds
EP2252327A2 (en) * 2007-12-04 2010-11-24 Schering Corporation Methods of treating copd
UA103198C2 (en) 2008-08-04 2013-09-25 Новартис Аг Squaramide derivatives as cxcr2 antagonists
JP5603869B2 (ja) 2008-09-29 2014-10-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規化合物
WO2010063802A1 (en) * 2008-12-05 2010-06-10 Novartis Ag 3, 4-di-substituted cyclobutene- 1, 2 -diones as cxcr2 receptor antagonists
WO2011117381A1 (en) 2010-03-26 2011-09-29 Boehringer Ingelheim International Gmbh B-raf kinase inhibitors
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EP2760821B1 (en) 2011-09-02 2017-10-11 Novartis AG Choline salt of an anti-inflammatory substituted cyclobutenedione compound
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US8865723B2 (en) 2012-10-25 2014-10-21 Tetra Discovery Partners Llc Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury
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TWI734715B (zh) 2015-11-19 2021-08-01 美商卡默森屈有限公司 趨化因子受體調節劑
TWI724056B (zh) * 2015-11-19 2021-04-11 美商卡默森屈有限公司 Ｃｘｃｒ２抑制劑
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CN109879854A (zh) * 2019-03-25 2019-06-14 河南湾流生物科技有限公司 一种具有抗氧化作用的环丁烯酮类化合物及其制备方法
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CN111329857B (zh) * 2020-04-10 2022-10-11 青岛大学附属医院 一种氟苯甲酰胺衍生物注射液及其抗乳腺癌应用

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IL196335A0 (en) 2009-09-22
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TW200813033A (en) 2008-03-16
ECSP099042A (es) 2009-02-27
CA2657051A1 (en) 2008-01-10
PE20080553A1 (es) 2008-05-16
AU2007269572A1 (en) 2008-01-10
NO20090594L (no) 2009-03-30
CN101511809A (zh) 2009-08-19
CO6150138A2 (es) 2010-04-20
AR061829A1 (es) 2008-09-24
ZA200900110B (en) 2010-09-29
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JP2009542700A (ja) 2009-12-03

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