ECSP099324A - Nuevos derivados de aminopirimidina como inhibidores de plk1 - Google Patents

Nuevos derivados de aminopirimidina como inhibidores de plk1

Info

Publication number
ECSP099324A
ECSP099324A EC2009009324A ECSP099324A ECSP099324A EC SP099324 A ECSP099324 A EC SP099324A EC 2009009324 A EC2009009324 A EC 2009009324A EC SP099324 A ECSP099324 A EC SP099324A EC SP099324 A ECSP099324 A EC SP099324A
Authority
EC
Ecuador
Prior art keywords
lower alkyl
alkyl group
group
substituted
aminopirimidine
Prior art date
Application number
EC2009009324A
Other languages
English (en)
Inventor
Morihiro Mitsuya
Takashi Hashihayata
Mikako Kawamura
Yoshiyuki Sato
Original Assignee
Banyu Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd
Publication of ECSP099324A publication Critical patent/ECSP099324A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a un compuesto representado por la Fórmula [I]; o una sal farmacéuticamente aceptable o éster del mismo, donde cada uno de R1 y R2, que pueden ser iguales o diferentes, es un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo inferior que puede estar sustituido, o un grupo ciclopropilo; cada uno de R3 y R4, que pueden ser iguales o diferentes, es un átomo de hidrógeno, un grupo alquilo inferior sustituido con NRaRb, un grupo heterocíclico alifático de 4 a 6 miembros, un grupo alquilo inferior sustituido con un grupo heterocíclico alifático de 4 a 6 miembros, un grupo heterocíclico aromático de 5 ó 6 miembros, o un grupo alquilo inferior sustituido con un grupo heterocíclico aromático de 5 ó 6 miembros; y R5 es un átomo de hidrógeno, un grupo ciano, un átomo de halógeno, o un grupo alquilo inferior.
EC2009009324A 2006-12-28 2009-05-12 Nuevos derivados de aminopirimidina como inhibidores de plk1 ECSP099324A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006356575 2006-12-28
JP2007265783 2007-10-11

Publications (1)

Publication Number Publication Date
ECSP099324A true ECSP099324A (es) 2009-06-30

Family

ID=39588592

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2009009324A ECSP099324A (es) 2006-12-28 2009-05-12 Nuevos derivados de aminopirimidina como inhibidores de plk1

Country Status (24)

Country Link
US (1) US7977336B2 (es)
EP (2) EP2116543A4 (es)
JP (1) JPWO2008081914A1 (es)
KR (1) KR101481388B1 (es)
CN (1) CN101573361B (es)
AR (1) AR064619A1 (es)
AU (1) AU2007340530B2 (es)
BR (1) BRPI0718966B8 (es)
CA (1) CA2668738A1 (es)
CL (1) CL2007003758A1 (es)
CO (1) CO6190523A2 (es)
CR (1) CR10784A (es)
EC (1) ECSP099324A (es)
GT (1) GT200900124A (es)
IL (1) IL198675A0 (es)
MA (1) MA31109B1 (es)
MX (1) MX2009004920A (es)
NO (1) NO20092770L (es)
NZ (1) NZ577273A (es)
PE (1) PE20081845A1 (es)
RU (1) RU2458062C2 (es)
SV (1) SV2009003258A (es)
TW (1) TW200835485A (es)
WO (2) WO2008081914A1 (es)

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JP6559228B2 (ja) 2014-09-17 2019-08-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 肥満症及び糖尿病の治療に有用なテトラヒドロイソキノリン誘導体及び医薬組成物
WO2018191171A1 (en) * 2017-04-10 2018-10-18 City Of Hope P38 gamma inhibitors and method of use thereof
US12398132B2 (en) * 2019-07-10 2025-08-26 Aucentra Therapeutics Pty Ltd Derivatives of 4-(imidazo[1,2-a]pyridin-3-yl)-n-(pyridinyl)pyrimidin-2-amine as therapeutic agents
BR112022001158A2 (pt) * 2019-07-24 2022-05-17 Merck Patent Gmbh Derivados de 4-(imidazo[1,2-a]piridin-3-il)-pirimidina
CN112592318B (zh) * 2020-12-12 2022-05-03 贵州医科大学 2-(4-甲氨酰基)苯胺基-4-氨基嘧啶衍生物及应用
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Also Published As

Publication number Publication date
EP2114942A4 (en) 2010-09-08
EP2114942A1 (en) 2009-11-11
NO20092770L (no) 2009-09-25
MA31109B1 (fr) 2010-01-04
SV2009003258A (es) 2010-08-23
CN101573361B (zh) 2012-05-30
WO2008081910A1 (en) 2008-07-10
KR101481388B1 (ko) 2015-01-12
BRPI0718966A2 (pt) 2014-01-07
PE20081845A1 (es) 2008-12-27
AR064619A1 (es) 2009-04-15
NZ577273A (en) 2011-03-31
BRPI0718966B8 (pt) 2021-05-25
EP2116543A4 (en) 2010-09-08
GT200900124A (es) 2010-11-03
CA2668738A1 (en) 2008-07-10
AU2007340530A1 (en) 2008-07-10
AU2007340530B2 (en) 2012-09-13
KR20090092822A (ko) 2009-09-01
BRPI0718966B1 (pt) 2020-11-17
CR10784A (es) 2009-09-16
EP2116543A1 (en) 2009-11-11
CN101573361A (zh) 2009-11-04
RU2458062C2 (ru) 2012-08-10
MX2009004920A (es) 2009-05-21
CL2007003758A1 (es) 2008-07-04
EP2114942B1 (en) 2012-10-31
IL198675A0 (en) 2010-02-17
US7977336B2 (en) 2011-07-12
TW200835485A (en) 2008-09-01
US20080305081A1 (en) 2008-12-11
CO6190523A2 (es) 2010-08-19
JPWO2008081914A1 (ja) 2010-04-30
WO2008081914A1 (ja) 2008-07-10
RU2009128966A (ru) 2011-02-10

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