ECSP099405A - Procedimiento para la preparación de derivados benzimida piperacinilo y diazepanilo - Google Patents

Procedimiento para la preparación de derivados benzimida piperacinilo y diazepanilo

Info

Publication number
ECSP099405A
ECSP099405A EC2009009405A ECSP099405A ECSP099405A EC SP099405 A ECSP099405 A EC SP099405A EC 2009009405 A EC2009009405 A EC 2009009405A EC SP099405 A ECSP099405 A EC SP099405A EC SP099405 A ECSP099405 A EC SP099405A
Authority
EC
Ecuador
Prior art keywords
preparation
derivatives
piperacinilo
diazepanilo
benzimida
Prior art date
Application number
EC2009009405A
Other languages
English (en)
Inventor
Kirk Leonard Sorgi
David C Palmer
Jing Liu
Anusuya Choudhury
Jeffrey S Grimm
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ECSP099405A publication Critical patent/ECSP099405A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La presente invención está dirigida a nuevos procedimientos para la preparación de derivados benzamida diazepanilo y piperacinilo, útiles para el tratamiento de trastornos y condiciones mediante un receptor histamine, preferiblemente e receptor H3.
EC2009009405A 2006-12-14 2009-06-11 Procedimiento para la preparación de derivados benzimida piperacinilo y diazepanilo ECSP099405A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87000306P 2006-12-14 2006-12-14

Publications (1)

Publication Number Publication Date
ECSP099405A true ECSP099405A (es) 2009-07-31

Family

ID=39387172

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2009009405A ECSP099405A (es) 2006-12-14 2009-06-11 Procedimiento para la preparación de derivados benzimida piperacinilo y diazepanilo

Country Status (33)

Country Link
US (2) US7893257B2 (es)
EP (1) EP2121636B1 (es)
JP (2) JP5385150B2 (es)
KR (1) KR101462891B1 (es)
CN (1) CN101605767A (es)
AR (1) AR064358A1 (es)
BR (1) BRPI0721088B8 (es)
CA (2) CA2880932A1 (es)
CL (1) CL2007003637A1 (es)
CO (1) CO6210827A2 (es)
CR (1) CR10928A (es)
CY (1) CY1118814T1 (es)
DK (1) DK2121636T3 (es)
EA (1) EA200970583A1 (es)
EC (1) ECSP099405A (es)
ES (1) ES2620818T3 (es)
HR (1) HRP20170621T1 (es)
HU (1) HUE032761T2 (es)
IL (2) IL199309A0 (es)
LT (1) LT2121636T (es)
MX (1) MX2009006472A (es)
MY (1) MY147320A (es)
NO (1) NO344305B1 (es)
NZ (1) NZ577603A (es)
PH (1) PH12012502236B1 (es)
PL (1) PL2121636T3 (es)
PT (1) PT2121636T (es)
RS (1) RS55866B1 (es)
SG (1) SG177207A1 (es)
SI (1) SI2121636T1 (es)
TW (1) TW200846004A (es)
WO (1) WO2008076685A2 (es)
ZA (1) ZA200904894B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0324159D0 (en) 2003-10-15 2003-11-19 Glaxo Group Ltd Novel compounds
LT1976828T (lt) 2005-12-29 2017-04-25 Celtaxsys, Inc. Diamino dariniai, kaip leukotrieno a4 hidrolazės inhibitoriai
SI2121636T1 (sl) * 2006-12-14 2017-06-30 Janssen Pharmaceutica N.V. Postopek za pripravo derivatov piperazinila in diazepanil benzamida
US8288389B2 (en) 2007-09-06 2012-10-16 Glaxo Group Limited Piperazine derivative having affinity for the histamine H3 receptor
CL2008003651A1 (es) 2007-12-10 2009-06-19 Novartis Ag Compuestos derivados de 3,5-diamino-6-cloropirazinamida sustituida; composicion farmaceutica; combinacion farmaceutica; y uso en el tratamiento de una condición inflamatoria o alergica, en particular una enfermedad inflamatoria u obstructiva de las vias respiratorias.
US8383657B2 (en) 2007-12-21 2013-02-26 Abbott Laboratories Thiazolylidine urea and amide derivatives and methods of use thereof
AU2014249168B2 (en) 2013-03-12 2018-07-12 Celltaxis, Llc Methods of inhibiting leukotriene A4 hydrolase
WO2014152536A2 (en) 2013-03-14 2014-09-25 Celtaxsys, Inc. Inhibitors of leukotriene a4 hydrolase
CA2906035A1 (en) 2013-03-14 2014-09-25 Celtaxsys, Inc. Inhibitors of leukotriene a4 hydrolase
BR112015022864A8 (pt) 2013-03-14 2019-11-26 Celtaxsys Inc composto, composição farmacêutica e uso dos mesmos
CN108341792B (zh) * 2018-04-28 2021-09-17 苏州莱克施德药业有限公司 一种Volasertib中间体1-环丙基甲基哌嗪的制备方法
ES3014615T3 (en) 2018-05-31 2025-04-23 Celltaxis Llc Method of reducing pulmonary exacerbations in respiratory disease patients
CN113372245B (zh) * 2021-06-17 2023-01-13 仪征市海帆化工有限公司 一种n-苯甲酰基-o,o-对甲苯磺酰基-二乙醇胺的合成方法
CN119462566A (zh) * 2023-10-30 2025-02-18 安徽皓元药业有限公司 一种1-环丙基哌嗪的制备方法
KR102815002B1 (ko) 2023-12-06 2025-05-30 주식회사 삼현 모터 일체형 중공형 감속기의 냉각구조

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2525223A (en) * 1948-05-25 1950-10-10 American Cyanamid Co Preparation of n-substituted piperazines
DE818805C (de) 1948-08-02 1951-10-29 Rhone Poulenc Sa Verfahren zur Herstellung von am Stickstoff durch eine Alkylgruppe monosubstituierten Piperazinen
US3342816A (en) * 1965-06-01 1967-09-19 Lilly Co Eli Cyclopropylpiperazinoalkyl-phenothiazines
DE3542002A1 (de) * 1985-11-28 1987-06-04 Bayer Ag 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3605005A1 (de) * 1986-02-18 1987-08-20 Basf Ag Verfahren zur herstellung von n-methylpiperazin
US6011029A (en) 1996-02-26 2000-01-04 Bristol-Myers Squibb Company Inhibitors of farnesyl protein transferase
CA2235642C (en) * 1998-05-15 2007-11-13 Torcan Chemical Ltd. Processes for preparing sildenafil
WO2002020500A2 (en) 2000-09-01 2002-03-14 Icos Corporation Materials and methods to potentiate cancer treatment
US6642226B2 (en) 2001-02-06 2003-11-04 Hoffman-La Roche Inc. Substituted phenyl-piperidine methanone compounds
DE10201240A1 (de) * 2002-01-15 2003-07-24 Bayer Ag Substituierte Alkyluracile und ihre Verwendung
EP1558595B1 (en) * 2002-10-23 2009-11-25 Janssen Pharmaceutica N.V. Piperazinyl and diazapanyl benzamides and benzthioamides
WO2005035534A1 (ja) * 2003-10-08 2005-04-21 Ono Pharmaceutical Co., Ltd. 複素ビシクロ環および複素トリシクロ環化合物およびその医薬
GB0324159D0 (en) * 2003-10-15 2003-11-19 Glaxo Group Ltd Novel compounds
WO2006042103A2 (en) 2004-10-05 2006-04-20 Axys Pharmaceuticals, Inc. Reversible inhibitors of cathepsin b
US7906645B2 (en) 2004-12-24 2011-03-15 Astrazeneca Ab Heterocyclic compounds as ccr2b antagonists
FR2885616B1 (fr) * 2005-05-12 2007-06-22 Servier Lab Nouveaux derives de phenylpyridinylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
SI1948607T1 (sl) * 2005-09-16 2010-07-30 Janssen Pharmaceutica Nv Ciklopropil amini kot modulatorji histaminskega H3 receptorja
US7795426B2 (en) * 2005-10-31 2010-09-14 Janssen Pharmaceutica Nv Processes for the preparation of cyclopropyl-amide derivatives
EP2404911A1 (en) * 2005-10-31 2012-01-11 Janssen Pharmaceutica NV Novel processes for the preparation of piperazinyl and diazapanyl benzamide derivatives
SI2121636T1 (sl) * 2006-12-14 2017-06-30 Janssen Pharmaceutica N.V. Postopek za pripravo derivatov piperazinila in diazepanil benzamida

Also Published As

Publication number Publication date
KR101462891B1 (ko) 2014-11-19
CA2880932A1 (en) 2008-06-26
AR064358A1 (es) 2009-04-01
DK2121636T3 (en) 2017-04-24
US8680273B2 (en) 2014-03-25
MX2009006472A (es) 2009-06-26
KR20090092319A (ko) 2009-08-31
NO20092634L (no) 2009-09-08
WO2008076685A3 (en) 2008-12-24
BRPI0721088A2 (pt) 2014-02-25
CA2672661C (en) 2015-04-28
PT2121636T (pt) 2017-04-26
BRPI0721088B1 (pt) 2020-11-10
IL234893A (en) 2015-09-24
PH12012502236A1 (en) 2015-02-23
ZA200904894B (en) 2010-09-29
TW200846004A (en) 2008-12-01
CA2672661A1 (en) 2008-06-26
JP2010513295A (ja) 2010-04-30
PH12012502236B1 (en) 2015-02-23
JP2013241453A (ja) 2013-12-05
PL2121636T3 (pl) 2017-09-29
CR10928A (es) 2009-11-17
EA200970583A1 (ru) 2009-12-30
LT2121636T (lt) 2017-05-10
AU2007334111A1 (en) 2008-06-26
CO6210827A2 (es) 2010-10-20
ES2620818T3 (es) 2017-06-29
NZ577603A (en) 2012-04-27
MY147320A (en) 2012-11-30
CY1118814T1 (el) 2018-01-10
HUE032761T2 (en) 2017-10-30
US7893257B2 (en) 2011-02-22
US20110105752A1 (en) 2011-05-05
CL2007003637A1 (es) 2008-07-18
RS55866B1 (sr) 2017-08-31
US20080171870A1 (en) 2008-07-17
IL199309A0 (en) 2010-03-28
WO2008076685A2 (en) 2008-06-26
EP2121636B1 (en) 2017-01-25
JP5385150B2 (ja) 2014-01-08
SI2121636T1 (sl) 2017-06-30
EP2121636A2 (en) 2009-11-25
CN101605767A (zh) 2009-12-16
SG177207A1 (en) 2012-01-30
NO344305B1 (no) 2019-10-28
BRPI0721088B8 (pt) 2021-05-25
HRP20170621T1 (hr) 2017-07-28

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