PL2121636T3 - Sposób wytwarzania piperazynylowych i diazepanylowych pochodnych benzamidu - Google Patents

Sposób wytwarzania piperazynylowych i diazepanylowych pochodnych benzamidu

Info

Publication number: PL2121636T3
Authority: PL; Poland
Prior art keywords: piperazinyl; preparation; benzamide derivatives; diazepanyl benzamide; diazepanyl
Prior art date: 2006-12-14

Application number

PL07855037T

Other languages

English (en)

Inventor

Anusuya Choudhury

Jeffrey S. Grimm

Kirk L. Sorgi

David Palmer

Jing Liu

Original Assignee

Janssen Pharmaceutica N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-12-14

Filing date

2007-12-10

Publication date

2017-09-29

2007-12-10 Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.

2017-09-29 Publication of PL2121636T3 publication Critical patent/PL2121636T3/pl

Links

MCBOTNKJOSKNFJ-UHFFFAOYSA-N n-(diazepan-1-yl)benzamide Chemical class C=1C=CC=CC=1C(=O)NN1CCCCCN1 MCBOTNKJOSKNFJ-UHFFFAOYSA-N 0.000 title 1
125000004193 piperazinyl group Chemical group 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

PL07855037T 2006-12-14 2007-12-10 Sposób wytwarzania piperazynylowych i diazepanylowych pochodnych benzamidu PL2121636T3 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US87000306P	2006-12-14	2006-12-14

Publications (1)

Publication Number	Publication Date
PL2121636T3 true PL2121636T3 (pl)	2017-09-29

Family

ID=39387172

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL07855037T PL2121636T3 (pl)	2006-12-14	2007-12-10	Sposób wytwarzania piperazynylowych i diazepanylowych pochodnych benzamidu

Country Status (33)

Country	Link
US (2)	US7893257B2 (pl)
EP (1)	EP2121636B1 (pl)
JP (2)	JP5385150B2 (pl)
KR (1)	KR101462891B1 (pl)
CN (1)	CN101605767A (pl)
AR (1)	AR064358A1 (pl)
BR (1)	BRPI0721088B8 (pl)
CA (2)	CA2672661C (pl)
CL (1)	CL2007003637A1 (pl)
CO (1)	CO6210827A2 (pl)
CR (1)	CR10928A (pl)
CY (1)	CY1118814T1 (pl)
DK (1)	DK2121636T3 (pl)
EA (1)	EA200970583A1 (pl)
EC (1)	ECSP099405A (pl)
ES (1)	ES2620818T3 (pl)
HR (1)	HRP20170621T1 (pl)
HU (1)	HUE032761T2 (pl)
IL (2)	IL199309A0 (pl)
LT (1)	LT2121636T (pl)
MX (1)	MX2009006472A (pl)
MY (1)	MY147320A (pl)
NO (1)	NO344305B1 (pl)
NZ (1)	NZ577603A (pl)
PH (1)	PH12012502236A1 (pl)
PL (1)	PL2121636T3 (pl)
PT (1)	PT2121636T (pl)
RS (1)	RS55866B1 (pl)
SG (1)	SG177207A1 (pl)
SI (1)	SI2121636T1 (pl)
TW (1)	TW200846004A (pl)
WO (1)	WO2008076685A2 (pl)
ZA (1)	ZA200904894B (pl)

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GB0324159D0 (en)	2003-10-15	2003-11-19	Glaxo Group Ltd	Novel compounds
WO2007079078A1 (en)	2005-12-29	2007-07-12	Bayer Schering Pharma Aktiengesellschaft	Diamine derivatives as inhibitors of leukotriene a4 hydrolase
HRP20170621T1 (hr) *	2006-12-14	2017-07-28	Janssen Pharmaceutica N.V.	Postupak za pripremanje derivata piperazinil i diazepanil benzamida
TW200918527A (en)	2007-09-06	2009-05-01	Glaxo Group Ltd	Piperazine derivative having affinity for the histamine H3 receptor
MX2010006421A (es)	2007-12-10	2010-06-25	Novartis Ag	Compuestos organicos.
US8383657B2 (en)	2007-12-21	2013-02-26	Abbott Laboratories	Thiazolylidine urea and amide derivatives and methods of use thereof
ES2864862T3 (es)	2013-03-12	2021-10-14	Celltaxis Llc	Métodos de inhibición de la leucotrieno A4 hidrolasa
WO2014152536A2 (en)	2013-03-14	2014-09-25	Celtaxsys, Inc.	Inhibitors of leukotriene a4 hydrolase
MX2015011677A (es)	2013-03-14	2016-07-08	Celtaxsys Inc	Inhibidores de leucotrieno a4 hidrolasa.
RU2678196C2 (ru)	2013-03-14	2019-01-24	Селтакссис, Инк.	Производные 2-фениламино-3-цианопиразоло[1,5-а]пиримидина, полезные в качестве ингибитора лейкотриен-a4-гидролазы
CN108341792B (zh) *	2018-04-28	2021-09-17	苏州莱克施德药业有限公司	一种Volasertib中间体1-环丙基甲基哌嗪的制备方法
EP3801559B1 (en)	2018-05-31	2025-01-01	Celltaxis, LLC	Method of reducing pulmonary exacerbations in respiratory disease patients
CN113372245B (zh) *	2021-06-17	2023-01-13	仪征市海帆化工有限公司	一种n-苯甲酰基-o,o-对甲苯磺酰基-二乙醇胺的合成方法
CN119462566A (zh) *	2023-10-30	2025-02-18	安徽皓元药业有限公司	一种1-环丙基哌嗪的制备方法
KR102815002B1 (ko)	2023-12-06	2025-05-30	주식회사 삼현	모터 일체형 중공형 감속기의 냉각구조

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US2525223A (en) *	1948-05-25	1950-10-10	American Cyanamid Co	Preparation of n-substituted piperazines
DE818805C (de) *	1948-08-02	1951-10-29	Rhone Poulenc Sa	Verfahren zur Herstellung von am Stickstoff durch eine Alkylgruppe monosubstituierten Piperazinen
US3342816A (en) *	1965-06-01	1967-09-19	Lilly Co Eli	Cyclopropylpiperazinoalkyl-phenothiazines
DE3542002A1 (de) *	1985-11-28	1987-06-04	Bayer Ag	1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3605005A1 (de) *	1986-02-18	1987-08-20	Basf Ag	Verfahren zur herstellung von n-methylpiperazin
US6011029A (en)	1996-02-26	2000-01-04	Bristol-Myers Squibb Company	Inhibitors of farnesyl protein transferase
CA2235642C (en) *	1998-05-15	2007-11-13	Torcan Chemical Ltd.	Processes for preparing sildenafil
WO2002020500A2 (en)	2000-09-01	2002-03-14	Icos Corporation	Materials and methods to potentiate cancer treatment
US6642226B2 (en)	2001-02-06	2003-11-04	Hoffman-La Roche Inc.	Substituted phenyl-piperidine methanone compounds
DE10201240A1 (de)	2002-01-15	2003-07-24	Bayer Ag	Substituierte Alkyluracile und ihre Verwendung
SI1558595T1 (sl) *	2002-10-23	2010-03-31	Janssen Pharmaceutica Nv	Piperazinilni in diazapanilni benzamidi in benztioamidi
WO2005035534A1 (ja) *	2003-10-08	2005-04-21	Ono Pharmaceutical Co., Ltd.	複素ビシクロ環および複素トリシクロ環化合物およびその医薬
GB0324159D0 (en) *	2003-10-15	2003-11-19	Glaxo Group Ltd	Novel compounds
WO2006042103A2 (en)	2004-10-05	2006-04-20	Axys Pharmaceuticals, Inc.	Reversible inhibitors of cathepsin b
AU2005317928B2 (en)	2004-12-24	2010-06-10	Astrazeneca Ab	Heterocyclic compounds as CCR2b antagonists
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KR101336106B1 (ko) *	2005-09-16	2013-12-05	얀센 파마슈티카 엔.브이.	히스타민 ｈ3 수용체의 조절제로서 사이클로프로필 아민
US7795426B2 (en) *	2005-10-31	2010-09-14	Janssen Pharmaceutica Nv	Processes for the preparation of cyclopropyl-amide derivatives
US7728129B2 (en) *	2005-10-31	2010-06-01	Janssen Pharmaceutica Nv	Processes for the preparation of piperazinyl and diazapanyl benzamide derivatives
HRP20170621T1 (hr) *	2006-12-14	2017-07-28	Janssen Pharmaceutica N.V.	Postupak za pripremanje derivata piperazinil i diazepanil benzamida

2007
- 2007-12-10 HR HRP20170621TT patent/HRP20170621T1/hr unknown
- 2007-12-10 MY MYPI20092444A patent/MY147320A/en unknown
- 2007-12-10 RS RS20170402A patent/RS55866B1/sr unknown
- 2007-12-10 CN CNA2007800512756A patent/CN101605767A/zh active Pending
- 2007-12-10 US US11/953,262 patent/US7893257B2/en not_active Expired - Fee Related
- 2007-12-10 PT PT78550373T patent/PT2121636T/pt unknown
- 2007-12-10 JP JP2009541499A patent/JP5385150B2/ja not_active Expired - Fee Related
- 2007-12-10 KR KR1020097014605A patent/KR101462891B1/ko not_active Expired - Fee Related
- 2007-12-10 MX MX2009006472A patent/MX2009006472A/es active IP Right Grant
- 2007-12-10 EA EA200970583A patent/EA200970583A1/ru unknown
- 2007-12-10 PL PL07855037T patent/PL2121636T3/pl unknown
- 2007-12-10 LT LTEP07855037.3T patent/LT2121636T/lt unknown
- 2007-12-10 NZ NZ577603A patent/NZ577603A/en not_active IP Right Cessation
- 2007-12-10 SI SI200731919A patent/SI2121636T1/sl unknown
- 2007-12-10 HU HUE07855037A patent/HUE032761T2/en unknown
- 2007-12-10 ES ES07855037.3T patent/ES2620818T3/es active Active
- 2007-12-10 EP EP07855037.3A patent/EP2121636B1/en active Active
- 2007-12-10 BR BRPI0721088A patent/BRPI0721088B8/pt not_active IP Right Cessation
- 2007-12-10 WO PCT/US2007/086936 patent/WO2008076685A2/en not_active Ceased
- 2007-12-10 CA CA2672661A patent/CA2672661C/en active Active
- 2007-12-10 CA CA2880932A patent/CA2880932A1/en not_active Abandoned
- 2007-12-10 SG SG2011092046A patent/SG177207A1/en unknown
- 2007-12-10 DK DK07855037.3T patent/DK2121636T3/en active
- 2007-12-13 TW TW096147556A patent/TW200846004A/zh unknown
- 2007-12-14 AR ARP070105628A patent/AR064358A1/es active IP Right Grant
- 2007-12-14 CL CL200703637A patent/CL2007003637A1/es unknown
2009
- 2009-06-11 IL IL199309A patent/IL199309A0/en active IP Right Grant
- 2009-06-11 EC EC2009009405A patent/ECSP099405A/es unknown
- 2009-06-12 CO CO09061632A patent/CO6210827A2/es not_active Application Discontinuation
- 2009-07-10 NO NO20092634A patent/NO344305B1/no not_active IP Right Cessation
- 2009-07-13 ZA ZA200904894A patent/ZA200904894B/xx unknown
- 2009-07-14 CR CR10928A patent/CR10928A/es unknown
2011
- 2011-01-10 US US12/987,370 patent/US8680273B2/en not_active Expired - Fee Related
2012
- 2012-11-13 PH PH12012502236A patent/PH12012502236A1/en unknown
2013
- 2013-08-05 JP JP2013162225A patent/JP2013241453A/ja active Pending
2014
- 2014-09-30 IL IL234893A patent/IL234893A/en active IP Right Grant
2017
- 2017-04-07 CY CY20171100420T patent/CY1118814T1/el unknown

Also Published As

Publication number	Publication date
EP2121636B1 (en)	2017-01-25
EP2121636A2 (en)	2009-11-25
US8680273B2 (en)	2014-03-25
DK2121636T3 (en)	2017-04-24
BRPI0721088B1 (pt)	2020-11-10
LT2121636T (lt)	2017-05-10
AR064358A1 (es)	2009-04-01
CA2672661A1 (en)	2008-06-26
US20110105752A1 (en)	2011-05-05
IL234893A (en)	2015-09-24
PH12012502236B1 (en)	2015-02-23
ECSP099405A (es)	2009-07-31
JP5385150B2 (ja)	2014-01-08
EA200970583A1 (ru)	2009-12-30
JP2013241453A (ja)	2013-12-05
ES2620818T3 (es)	2017-06-29
BRPI0721088A2 (pt)	2014-02-25
US20080171870A1 (en)	2008-07-17
CN101605767A (zh)	2009-12-16
CR10928A (es)	2009-11-17
CL2007003637A1 (es)	2008-07-18
NO344305B1 (no)	2019-10-28
NZ577603A (en)	2012-04-27
KR101462891B1 (ko)	2014-11-19
HRP20170621T1 (hr)	2017-07-28
CO6210827A2 (es)	2010-10-20
HUE032761T2 (en)	2017-10-30
ZA200904894B (en)	2010-09-29
CA2672661C (en)	2015-04-28
WO2008076685A2 (en)	2008-06-26
KR20090092319A (ko)	2009-08-31
JP2010513295A (ja)	2010-04-30
PT2121636T (pt)	2017-04-26
MX2009006472A (es)	2009-06-26
RS55866B1 (sr)	2017-08-31
SG177207A1 (en)	2012-01-30
SI2121636T1 (sl)	2017-06-30
TW200846004A (en)	2008-12-01
CY1118814T1 (el)	2018-01-10
PH12012502236A1 (en)	2015-02-23
NO20092634L (no)	2009-09-08
AU2007334111A1 (en)	2008-06-26
BRPI0721088B8 (pt)	2021-05-25
WO2008076685A3 (en)	2008-12-24
MY147320A (en)	2012-11-30
CA2880932A1 (en)	2008-06-26
IL199309A0 (en)	2010-03-28
US7893257B2 (en)	2011-02-22

Publication	Publication Date	Title
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ZA200706203B (en)	2009-12-30	Processes and compounds for the preparation of substituted naphthylindole derivatives
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