ECSP099435A - Compuestos agonistas de receptores esfingosina-1-fosfato y compuestos antagonistas - Google Patents

Compuestos agonistas de receptores esfingosina-1-fosfato y compuestos antagonistas

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Publication number
ECSP099435A
ECSP099435A EC2009009435A ECSP099435A ECSP099435A EC SP099435 A ECSP099435 A EC SP099435A EC 2009009435 A EC2009009435 A EC 2009009435A EC SP099435 A ECSP099435 A EC SP099435A EC SP099435 A ECSP099435 A EC SP099435A
Authority
EC
Ecuador
Prior art keywords
compounds
receptors
agingist
sphingosine
phosphate
Prior art date
Application number
EC2009009435A
Other languages
English (en)
Inventor
Grier A Wallace
Shannon R Fix-Stenzel
Martin E Hayes
Eric C Breinlinger
Thomas D Gordon
Graham K Ansell
Kevin P Cusak
Adrian D Hobson
Pintipa Grongsaard
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39562856&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP099435(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of ECSP099435A publication Critical patent/ECSP099435A/es

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    • C07D231/08—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen or sulfur atoms directly attached to ring carbon atoms
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    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings
    • C—CHEMISTRY; METALLURGY
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
    • C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
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Abstract

La presente invención esta dirigida a agentes nuevos, potentes y selectivos, los cuales son agonistas o antagonistas de uno o más de los receptores individuales de la familia de receptores S1P. Los compuestos de la invención son usados como terapia en el tratamiento de condiciones médicas asociadas con el agonismo o antagonismo de los receptores individuales de la familia de receptores S1P.
EC2009009435A 2006-12-21 2009-06-15 Compuestos agonistas de receptores esfingosina-1-fosfato y compuestos antagonistas ECSP099435A (es)

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US87628806P 2006-12-21 2006-12-21
US87631806P 2006-12-21 2006-12-21
PCT/US2007/026263 WO2008079382A1 (en) 2006-12-21 2007-12-21 Sphingosine-1 -phosphate receptor agonist and antagonist compounds

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ECSP099435A true ECSP099435A (es) 2009-07-31

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KR20090095659A (ko) 2009-09-09
AU2007338700A1 (en) 2008-07-03
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TW200838497A (en) 2008-10-01
BRPI0720478A2 (pt) 2014-01-14
RU2009128062A (ru) 2011-01-27
EP2120575A1 (en) 2009-11-25
NO20092376L (no) 2009-06-22
MX2009006751A (es) 2009-06-30
DOP2009000149A (es) 2010-05-15
PE20081561A1 (es) 2008-10-30
JP2010513532A (ja) 2010-04-30
CL2007003784A1 (es) 2008-06-27
CA2672727A1 (en) 2008-07-03
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