ECSP099772A - Sales novedosas de piperazina como antagonistas d3/d2 - Google Patents

Sales novedosas de piperazina como antagonistas d3/d2

Info

Publication number
ECSP099772A
ECSP099772A EC2009009772A ECSP099772A ECSP099772A EC SP099772 A ECSP099772 A EC SP099772A EC 2009009772 A EC2009009772 A EC 2009009772A EC SP099772 A ECSP099772 A EC SP099772A EC SP099772 A ECSP099772 A EC SP099772A
Authority
EC
Ecuador
Prior art keywords
salts
noveled
piperazine
antagonists
solvates
Prior art date
Application number
EC2009009772A
Other languages
English (en)
Inventor
Csongor Eva Againe
Gyoergy Domany
Laszlo Czibula
Ferenc Seboek
Istvan Greiner
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Publication of ECSP099772A publication Critical patent/ECSP099772A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Otolaryngology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)

Abstract

La presente invención se refiere a sales novedosas monohidrocloruro, dihidrocloruro, monohidrobromuro, maleato y metanosulfonato de trans 4-{2-[4-(2,3-diclorofenil)-piperazin-1-il]-etil}-N,N-dimetilcarbamoil-ciclohexilamina, y/o sus hidratos y/o solvatos. Además, la invención se refiere al proceso de preparación de sales y sus hidratos y/o solvatos, a su uso en el tratamiento y/o prevención de trastornos que requieren la modulación de receptores de dopamina y a composiciones farmacéuticas que las contienen.
EC2009009772A 2007-05-11 2009-11-30 Sales novedosas de piperazina como antagonistas d3/d2 ECSP099772A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0700339A HU230748B1 (hu) 2007-05-11 2007-05-11 Új piperazin só és előállítási eljárása

Publications (1)

Publication Number Publication Date
ECSP099772A true ECSP099772A (es) 2009-12-28

Family

ID=89987512

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2009009772A ECSP099772A (es) 2007-05-11 2009-11-30 Sales novedosas de piperazina como antagonistas d3/d2

Country Status (33)

Country Link
US (1) US7943621B2 (es)
EP (1) EP2155696B1 (es)
JP (1) JP2010526861A (es)
KR (2) KR20100018493A (es)
CN (1) CN101679315B (es)
AP (1) AP2009005012A0 (es)
AU (1) AU2008249772B2 (es)
CA (1) CA2684404C (es)
CO (1) CO6241112A2 (es)
CY (1) CY1119076T1 (es)
DK (1) DK2155696T3 (es)
EA (1) EA017270B1 (es)
EC (1) ECSP099772A (es)
ES (1) ES2628025T3 (es)
GE (1) GEP20125522B (es)
HR (1) HRP20170918T1 (es)
HU (2) HU230748B1 (es)
IL (1) IL201533A0 (es)
LT (1) LT2155696T (es)
MA (1) MA31434B1 (es)
MX (1) MX2009012182A (es)
MY (1) MY148078A (es)
NI (1) NI200900203A (es)
NZ (1) NZ580642A (es)
PL (1) PL2155696T3 (es)
PT (1) PT2155696T (es)
RS (1) RS56036B1 (es)
SI (1) SI2155696T1 (es)
TN (1) TN2009000458A1 (es)
TW (1) TWI424846B (es)
UA (1) UA102225C2 (es)
WO (1) WO2008139235A2 (es)
ZA (1) ZA200907511B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008251520B2 (en) * 2007-05-11 2014-03-06 Richter Gedeon Nyrt. Novel solvate and crystalline forms of carbamoyl-cyclohexane derivatives
HUP0700353A2 (en) * 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
HUP0700369A2 (en) 2007-05-24 2009-04-28 Richter Gedeon Nyrt Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment in the manufacture of a medicament for the treatment of schizophrenia
HUE036004T2 (hu) * 2007-08-03 2018-06-28 Richter Gedeon Nyrt Dopamin receptor ligandumokat tartalmazó gyógyszerkészítmények és kezelési eljárások dopamin receptor ligandumok alkalmazásával
US7875610B2 (en) * 2007-12-03 2011-01-25 Richter Gedeon Nyrt. Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
KR20130115393A (ko) * 2008-02-21 2013-10-21 미쓰비시 타나베 파마 코퍼레이션 경구 투여용 고형 제제
AP2975A (en) 2008-07-16 2014-09-30 Richter Gedeon Nyrt Pharmaceutical formulations containing dopamine receptor ligands
HU230067B1 (hu) * 2008-12-17 2015-06-29 Richter Gedeon Nyrt Új piperazin só és eljárás előállítására
HUP0800766A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Vegyeszet Process for the preparation of piperazine derivatives
HUP0800765A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Nyrt A new process for the preparation of piperazine derivatives and their hydrochloric salts
US8912197B2 (en) 2012-08-20 2014-12-16 Forest Laboratories Holdings Ltd. Crystalline form of carbamoyl-cyclohexane derivatives
HU231227B1 (hu) 2012-11-29 2022-03-28 Richter Gedeon Nyrt. Transz-4-{2-[4-(2,3-diklórfenil)-piperazin-1-il]-etil}N,N-dimetilkarbamoil-ciklohexilamin skizofrénia negatív tüneteinek kezelésére
CN105218484B (zh) * 2015-09-14 2018-02-23 安徽省逸欣铭医药科技有限公司 酒石酸卡利拉嗪及其制备方法和医药用途
CN106543105B (zh) * 2015-09-22 2019-10-11 江苏恩华药业股份有限公司 一种盐酸卡利拉嗪晶型ⅳ及其制备方法
US11274087B2 (en) 2016-07-08 2022-03-15 Richter Gedeon Nyrt. Industrial process for the preparation of cariprazine
WO2018229794A1 (en) 2017-06-13 2018-12-20 Cipla Limited Amorphous form of cariprazine
WO2019016828A1 (en) * 2017-07-15 2019-01-24 Msn Laboratories Private Limited, R&D Center NOVEL PROCESSES FOR THE PREPARATION OF TRANS-N- {4- [2- [4- (2,3-DICHLOROPHENYL) PIPERAZIN-1-YL] ETHYL] CYCLOHEXYL} -N ', N'-DIMETHYLUMED HYDROCHLORIDE AND POLYMORPHS THIS ONE
WO2020056929A1 (zh) * 2018-09-21 2020-03-26 上海诚妙医药科技有限公司 卡利拉嗪盐酸盐的新晶型及其制备方法及其用途
US11547707B2 (en) 2019-04-10 2023-01-10 Richter Gedeon Nyrt. Carbamoyl cyclohexane derivatives for treating autism spectrum disorder
HU231500B1 (hu) 2019-04-10 2024-04-28 Richter Gedeon Nyrt Karbamoil-ciklohexán származékok autizmus spektrum betegség kezelésére
CN116139080B (zh) * 2020-08-26 2025-07-29 上海云晟研新生物科技有限公司 卡利拉嗪药物组合物、制备方法及应用
IL312456A (en) * 2021-10-28 2024-06-01 Richter Gedeon Nyrt Treatment of major depressive disorder
CN120698949A (zh) 2022-02-22 2025-09-26 上海云晟研新生物科技有限公司 卡利拉嗪药用盐及其晶型、药物组合物、制备方法和用途
AU2023353560A1 (en) * 2022-09-30 2025-04-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Dopamine d3/d2 receptor partial agonists for the treatment of neuropsychiatric disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU227543B1 (en) * 2001-09-28 2011-08-29 Richter Gedeon Nyrt N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them
HU227534B1 (en) * 2003-08-04 2011-08-29 Richter Gedeon Nyrt (thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them
HUP0500170A3 (en) * 2005-02-03 2007-11-28 Richter Gedeon Nyrt Piperazine derivatives, process for producing them and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
US7943621B2 (en) 2011-05-17
ZA200907511B (en) 2010-07-28
TWI424846B (zh) 2014-02-01
WO2008139235A2 (en) 2008-11-20
ES2628025T3 (es) 2017-08-01
LT2155696T (lt) 2017-06-12
TW201002323A (en) 2010-01-16
PT2155696T (pt) 2017-06-02
HUE034796T2 (en) 2018-03-28
GEP20125522B (en) 2012-05-25
TN2009000458A1 (en) 2011-03-31
EA017270B1 (ru) 2012-11-30
KR20150090264A (ko) 2015-08-05
KR101668973B1 (ko) 2016-10-24
JP2010526861A (ja) 2010-08-05
CO6241112A2 (es) 2011-01-20
HK1140473A1 (en) 2010-10-15
KR20100018493A (ko) 2010-02-17
CN101679315B (zh) 2013-06-12
AU2008249772B2 (en) 2013-09-05
MY148078A (en) 2013-02-28
US20090023750A1 (en) 2009-01-22
AU2008249772A1 (en) 2008-11-20
EP2155696A2 (en) 2010-02-24
NZ580642A (en) 2012-02-24
CY1119076T1 (el) 2018-01-10
HRP20170918T1 (hr) 2017-09-22
CA2684404C (en) 2013-02-05
EA200971046A1 (ru) 2010-04-30
HU0700339D0 (en) 2007-07-30
BRPI0811199A2 (pt) 2014-10-29
AP2009005012A0 (en) 2009-10-31
WO2008139235A8 (en) 2009-12-03
HU230748B1 (hu) 2018-02-28
HUP0700339A2 (en) 2009-04-28
WO2008139235A3 (en) 2009-03-12
PL2155696T3 (pl) 2017-10-31
EP2155696B1 (en) 2017-03-22
NI200900203A (es) 2010-03-11
MX2009012182A (es) 2009-12-09
CN101679315A (zh) 2010-03-24
UA102225C2 (ru) 2013-06-25
HUP0700339A3 (en) 2010-01-28
CA2684404A1 (en) 2008-11-20
MA31434B1 (fr) 2010-06-01
IL201533A0 (en) 2010-05-31
SI2155696T1 (sl) 2017-08-31
DK2155696T3 (en) 2017-07-10
RS56036B1 (sr) 2017-09-29

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