ECSP10010427A - DERIVADOS DE IMIDAZO-[1,2-b]-PIRIDAZINA PARA EL TRATAMIENTO DE ENFERMEDAD MEDIADA POR CINASA DE TIROSINA C-MET - Google Patents
DERIVADOS DE IMIDAZO-[1,2-b]-PIRIDAZINA PARA EL TRATAMIENTO DE ENFERMEDAD MEDIADA POR CINASA DE TIROSINA C-METInfo
- Publication number
- ECSP10010427A ECSP10010427A EC2010010427A ECSP10010427A ECSP10010427A EC SP10010427 A ECSP10010427 A EC SP10010427A EC 2010010427 A EC2010010427 A EC 2010010427A EC SP10010427 A ECSP10010427 A EC SP10010427A EC SP10010427 A ECSP10010427 A EC SP10010427A
- Authority
- EC
- Ecuador
- Prior art keywords
- treatment
- met
- formula
- piridazine
- compound
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 2
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La invención se refiere a los compuestos de la fórmula (I) y sales de los mismos; en donde los sustituyentes son como se definen en la memoria descriptiva, a la aplicación de un compuesto de la fórmula (I) en un proceso para el tratamiento del cuerpo humano o animal, en particular con respecto una enfermedad mediada por la cinasa de tirosina c-Met; al uso de un compuesto de la fórmula (I) para la fabricación de un medicamento para el tratamiento de estas enfermedades; a composiciones farmacéuticas que comprenden un compuesto de la fórmula (I), opcionalmente en la presencia de un componente de combinación; y a procesos para la preparación de un compuesto de la fórmula (I).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08152068 | 2008-02-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP10010427A true ECSP10010427A (es) | 2010-09-30 |
Family
ID=39672115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2010010427A ECSP10010427A (es) | 2008-02-28 | 2010-08-27 | DERIVADOS DE IMIDAZO-[1,2-b]-PIRIDAZINA PARA EL TRATAMIENTO DE ENFERMEDAD MEDIADA POR CINASA DE TIROSINA C-MET |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US8822468B2 (es) |
| EP (1) | EP2265614A1 (es) |
| JP (1) | JP5576802B2 (es) |
| KR (1) | KR20100128305A (es) |
| CN (1) | CN102015716B (es) |
| AR (1) | AR070487A1 (es) |
| AU (1) | AU2009218459A1 (es) |
| BR (1) | BRPI0908504A2 (es) |
| CA (1) | CA2717034A1 (es) |
| CL (1) | CL2009000443A1 (es) |
| CO (1) | CO6300957A2 (es) |
| CR (1) | CR11620A (es) |
| DO (1) | DOP2010000263A (es) |
| EA (1) | EA201001365A1 (es) |
| EC (1) | ECSP10010427A (es) |
| IL (1) | IL207434A0 (es) |
| MA (1) | MA32167B1 (es) |
| MX (1) | MX2010009414A (es) |
| NI (1) | NI201000145A (es) |
| PE (1) | PE20091468A1 (es) |
| SM (1) | SMAP201000112A (es) |
| TW (1) | TW200940545A (es) |
| UY (1) | UY31676A1 (es) |
| WO (1) | WO2009106577A1 (es) |
| ZA (1) | ZA201005602B (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY32049A (es) | 2008-08-14 | 2010-03-26 | Takeda Pharmaceutical | Inhibidores de cmet |
| US20110053968A1 (en) | 2009-06-09 | 2011-03-03 | Auspex Pharmaceuticals, Inc. | Aminopyrimidine inhibitors of tyrosine kinase |
| US8389526B2 (en) * | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
| CA2770873A1 (en) | 2009-08-12 | 2011-02-17 | Novartis Ag | Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation |
| CA2771432A1 (en) | 2009-08-20 | 2011-02-24 | Novartis Ag | Heterocyclic oxime compounds |
| HUE025504T2 (en) * | 2009-12-31 | 2016-02-29 | Hutchison Medipharma Ltd | Certain triazolopyrazines, compositions thereof and methods of use therefor |
| US20110195066A1 (en) * | 2010-02-05 | 2011-08-11 | Auspex Pharmaceuticals, Inc. | Quinoline inhibitors of tyrosine kinase |
| EP2588107A1 (en) * | 2010-07-01 | 2013-05-08 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
| AR085183A1 (es) | 2010-07-30 | 2013-09-18 | Lilly Co Eli | Compuesto 6-(1-metil-1h-pirazol-4-il)-3-(2-metil-2h-indazol-5-iltio)-[1,2,4]triazol[4,3-b]piridazina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar cancer |
| UY33597A (es) | 2010-09-09 | 2012-04-30 | Irm Llc | Compuestos y composiciones como inhibidores de la trk |
| US9284319B2 (en) * | 2011-06-22 | 2016-03-15 | Bayer Intellectual Property Gmbh | Heterocyclyl aminoimidazopyridazines |
| CN103958509B (zh) * | 2011-09-15 | 2015-12-23 | 诺华股份有限公司 | 作为酪氨酸激酶抑制剂的6-取代的3-(喹啉-6-基硫代)-[1,2,4]三唑并[4,3-a]吡啶化合物 |
| AU2012310168B2 (en) | 2011-09-15 | 2015-07-16 | Novartis Ag | 6 - substituted 3 - (quinolin- 6 - ylthio) - [1,2,4] triazolo [4, 3 -a] pyradines as tyrosine kinase |
| CN103122000B (zh) * | 2012-09-03 | 2013-12-25 | 中美冠科生物技术(太仓)有限公司 | 用作抗肿瘤药物的高选择性的c-Met激酶抑制剂 |
| WO2014078802A1 (en) | 2012-11-19 | 2014-05-22 | Irm Llc | Compounds and compositions for the treatment of parasitic diseases |
| JP2016510764A (ja) | 2013-03-07 | 2016-04-11 | カリフィア バイオ, インク.Califia Bio, Inc. | 混合系キナーゼ阻害剤および治療法 |
| AR097543A1 (es) * | 2013-09-06 | 2016-03-23 | Lexicon Pharmaceuticals Inc | COMPUESTOS BASADOS EN IMIDAZO[1,2-b]PIRIDAZINA, COMPOSICIONES QUE LOS COMPRENDEN Y SUS MÉTODOS DE USO |
| CN105326793A (zh) * | 2014-08-06 | 2016-02-17 | 中美冠科生物技术(太仓)有限公司 | 一种包含c-Met激酶抑制剂的固体分散体及其制备方法和用途 |
| JP6586463B2 (ja) * | 2014-12-19 | 2019-10-02 | ヤンセン ファーマシューティカ エヌ.ベー. | PI3Kβ阻害剤としての複素環連結イミダゾピリダジン誘導体 |
| EA029789B1 (ru) * | 2014-12-19 | 2018-05-31 | Янссен Фармацевтика Нв | ПРОИЗВОДНЫЕ ИМИДАЗОПИРИДАЗИНА В КАЧЕСТВЕ ИНГИБИТОРОВ PI3Kβ |
| CA3032210A1 (en) | 2016-09-16 | 2018-03-22 | Helmholtz Zentrum Muenchen - Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (Gmbh) | Traf 6 inhibitors |
| WO2018115319A2 (en) * | 2016-12-23 | 2018-06-28 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Inhibitors of cytochrome p450 family 7 subfamily b member 1 (cyp7b1) for use in treating diseases |
| WO2018138050A1 (de) | 2017-01-26 | 2018-08-02 | Bayer Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
| WO2018237349A1 (en) * | 2017-06-23 | 2018-12-27 | University Of Washington | Inhibitors of typed 1 methionyl-trna synthetase and methods of using them |
| JP7296992B2 (ja) * | 2018-05-28 | 2023-06-23 | エフ. ホフマン-ラ ロシュ アーゲー | 細菌感染症の処置および予防のための新規オキソキノリジン化合物 |
| WO2021126779A1 (en) * | 2019-12-18 | 2021-06-24 | The Regents Of The University Of California | Inhibitors of lin28 and methods of use thereof |
| CN119081395B (zh) * | 2024-09-07 | 2025-03-18 | 广东环塑众创实业有限公司 | 一种耐高温尼龙工程塑料及其制备方法 |
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| US3489755A (en) | 1966-08-03 | 1970-01-13 | Pfizer & Co C | Imidazo (1,2-b) pyridazines |
| GB8719368D0 (en) * | 1987-08-15 | 1987-09-23 | Wellcome Found | Heterocyclic compounds |
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| CA2057089A1 (en) | 1990-12-07 | 1992-06-08 | Eric E. Allen | Substituted pyrazolopyrimidines and imidazopyridazines as angiotensin ii antagonists |
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| WO2004058749A1 (en) | 2002-12-18 | 2004-07-15 | Vertex Pharmaceuticals Incorporated | Benzisoxazole derivatives useful as inhibitors of protein kinases |
| AU2004255200A1 (en) | 2003-06-30 | 2005-01-20 | Merck & Co., Inc. | 17-acetamido-4-azasteroid derivatives as androgen receptor modulators |
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| CN1871008A (zh) | 2003-10-21 | 2006-11-29 | 默克公司 | 用于治疗神经病变性疼痛的三唑并-哒嗪化合物和它们的衍生物 |
| CN1905873A (zh) | 2003-11-19 | 2007-01-31 | 阵列生物制药公司 | Mek的杂环抑制剂及其使用方法 |
| WO2005073224A2 (en) | 2004-01-23 | 2005-08-11 | Amgen Inc | Quinoline quinazoline pyridine and pyrimidine counds and their use in the treatment of inflammation angiogenesis and cancer |
| WO2005080355A1 (en) | 2004-02-12 | 2005-09-01 | Neurogen Corporation | Imidazo-pyridazines, triazolo-pyridazines and related benzodiazepine receptor ligands |
| US7456289B2 (en) | 2004-12-31 | 2008-11-25 | National Health Research Institutes | Anti-tumor compounds |
| ATE460417T1 (de) | 2005-03-23 | 2010-03-15 | Hoffmann La Roche | Acetylenylpyrazolopyrimidinderivate als mglur2- antagonsten |
| AU2006247833A1 (en) | 2005-05-12 | 2006-11-23 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| EP1910369A1 (en) * | 2005-07-29 | 2008-04-16 | Astellas Pharma Inc. | Fused heterocycles as lck inhibitors |
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| PT1966214T (pt) | 2005-12-21 | 2017-02-03 | Janssen Pharmaceutica Nv | Triazolpiridazinas como moduladores de tirosina quinase |
| NL2000613C2 (nl) | 2006-05-11 | 2007-11-20 | Pfizer Prod Inc | Triazoolpyrazinederivaten. |
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| WO2008030744A2 (en) | 2006-09-05 | 2008-03-13 | Board Of Regents, The University Of Texas System | Inhibitors of c-met and uses thereof |
| CA2663091A1 (en) | 2006-09-07 | 2008-03-13 | Biogen Idec Ma Inc. | Modulators of interleukin-1 receptor-associated kinase |
| PL2081937T3 (pl) | 2006-10-23 | 2013-01-31 | Sgx Pharmaceuticals Inc | Triazolopirydazynowe modulatory kinaz białkowych |
| KR101532256B1 (ko) | 2006-11-22 | 2015-06-29 | 인사이트 코포레이션 | 키나제 억제제로서의 이미다조트리아진 및 이미다조피리미딘 |
| AR064420A1 (es) | 2006-12-21 | 2009-04-01 | Alcon Mfg Ltd | Composiciones farmaceuticas oftalmicas que comprenden una cantidad efectiva de analogos de 6-aminoimidazo[1,2b]piridazinas, utiles para el tratamiento del glaucoma y/o controlar la presion intraocular normal o elevada(iop). |
| WO2009011954A2 (en) | 2007-04-27 | 2009-01-22 | Alaka'i Consulting & Engineering, Inc. | Laser spectroscopy system |
| EP2170894A1 (en) | 2007-06-21 | 2010-04-07 | Janssen Pharmaceutica N.V. | Polymorphic and hydrate forms, salts and process for preparing 6-{difluoro[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}quinoline |
| WO2009060197A1 (en) * | 2007-11-08 | 2009-05-14 | Centro Nacional De Investigaciones Oncologicas (Cnio) | Imidazopyridazines for use as protein kinase inhibitors |
| WO2009088955A2 (en) | 2007-12-31 | 2009-07-16 | Energenox, Inc. | Boundary layer effect turbine |
| JP2009227599A (ja) | 2008-03-21 | 2009-10-08 | Daiichi Sankyo Co Ltd | イミダゾピリダジン誘導体 |
-
2009
- 2009-02-26 UY UY031676A patent/UY31676A1/es not_active Application Discontinuation
- 2009-02-26 BR BRPI0908504-1A patent/BRPI0908504A2/pt not_active IP Right Cessation
- 2009-02-26 PE PE2009000287A patent/PE20091468A1/es not_active Application Discontinuation
- 2009-02-26 EP EP09714429A patent/EP2265614A1/en not_active Withdrawn
- 2009-02-26 KR KR1020107021426A patent/KR20100128305A/ko not_active Ceased
- 2009-02-26 EA EA201001365A patent/EA201001365A1/ru unknown
- 2009-02-26 CA CA2717034A patent/CA2717034A1/en not_active Abandoned
- 2009-02-26 WO PCT/EP2009/052302 patent/WO2009106577A1/en not_active Ceased
- 2009-02-26 CN CN200980114928.XA patent/CN102015716B/zh not_active Expired - Fee Related
- 2009-02-26 JP JP2010548110A patent/JP5576802B2/ja not_active Expired - Fee Related
- 2009-02-26 AU AU2009218459A patent/AU2009218459A1/en not_active Abandoned
- 2009-02-26 MX MX2010009414A patent/MX2010009414A/es not_active Application Discontinuation
- 2009-02-26 AR ARP090100659A patent/AR070487A1/es unknown
- 2009-02-27 TW TW098106564A patent/TW200940545A/zh unknown
- 2009-02-27 CL CL2009000443A patent/CL2009000443A1/es unknown
- 2009-03-02 US US12/396,137 patent/US8822468B2/en not_active Expired - Fee Related
-
2010
- 2010-08-05 IL IL207434A patent/IL207434A0/en unknown
- 2010-08-05 ZA ZA2010/05602A patent/ZA201005602B/en unknown
- 2010-08-06 CR CR11620A patent/CR11620A/es not_active Application Discontinuation
- 2010-08-27 DO DO2010000263A patent/DOP2010000263A/es unknown
- 2010-08-27 NI NI201000145A patent/NI201000145A/es unknown
- 2010-08-27 EC EC2010010427A patent/ECSP10010427A/es unknown
- 2010-08-27 CO CO10106017A patent/CO6300957A2/es not_active Application Discontinuation
- 2010-09-24 MA MA33198A patent/MA32167B1/fr unknown
- 2010-09-28 SM SM201000112T patent/SMAP201000112A/it unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW200940545A (en) | 2009-10-01 |
| CR11620A (es) | 2010-10-08 |
| IL207434A0 (en) | 2010-12-30 |
| ZA201005602B (en) | 2011-04-28 |
| CL2009000443A1 (es) | 2010-09-10 |
| PE20091468A1 (es) | 2009-10-22 |
| AU2009218459A1 (en) | 2009-09-03 |
| SMAP201000112A (it) | 2010-11-12 |
| EA201001365A1 (ru) | 2011-04-29 |
| BRPI0908504A2 (pt) | 2015-08-11 |
| US8822468B2 (en) | 2014-09-02 |
| CA2717034A1 (en) | 2009-09-03 |
| US20090264406A1 (en) | 2009-10-22 |
| NI201000145A (es) | 2011-03-02 |
| EP2265614A1 (en) | 2010-12-29 |
| AR070487A1 (es) | 2010-04-07 |
| JP2011513279A (ja) | 2011-04-28 |
| CN102015716B (zh) | 2014-09-17 |
| KR20100128305A (ko) | 2010-12-07 |
| CN102015716A (zh) | 2011-04-13 |
| MA32167B1 (fr) | 2011-03-01 |
| MX2010009414A (es) | 2010-09-24 |
| UY31676A1 (es) | 2009-09-30 |
| WO2009106577A1 (en) | 2009-09-03 |
| CO6300957A2 (es) | 2011-07-21 |
| JP5576802B2 (ja) | 2014-08-20 |
| DOP2010000263A (es) | 2010-09-30 |
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