ECSP10010675A - Moduladores de diamino-piridina, pirimidina, y piridazina del receptor h4 de histamina - Google Patents

Moduladores de diamino-piridina, pirimidina, y piridazina del receptor h4 de histamina

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Publication number
ECSP10010675A
ECSP10010675A EC2010010675A ECSP10010675A ECSP10010675A EC SP10010675 A ECSP10010675 A EC SP10010675A EC 2010010675 A EC2010010675 A EC 2010010675A EC SP10010675 A ECSP10010675 A EC SP10010675A EC SP10010675 A ECSP10010675 A EC SP10010675A
Authority
EC
Ecuador
Prior art keywords
diamino
modulators
pyrimidine
pyridine
pyridazine
Prior art date
Application number
EC2010010675A
Other languages
English (en)
Inventor
Brad M Savall
Kevin L Tays
Jianmei Wei
Ronald L Wolin
Frank Chavez
Hui Cai
Robin L Thurmond
Paul J Dunford
Andrew J Greenspan
Steven P Meduna
Jorge A Quiroz
Xiaohu Zhang
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41417123&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP10010675(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ECSP10010675A publication Critical patent/ECSP10010675A/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Abstract

Compuestos de diamino-piridina, pirimidina y piridazina que se pueden usar como moduladores del receptor H4, y en composiciones farmacéuticas y métodos para el tratamiento de estados de enfermedad, trastornos, y afecciones mediadas por la actividad del receptor H4, tales como alergia, asma, enfermedades autoinmunes, y prurito.
EC2010010675A 2008-06-12 2010-12-10 Moduladores de diamino-piridina, pirimidina, y piridazina del receptor h4 de histamina ECSP10010675A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6103908P 2008-06-12 2008-06-12
US11442508P 2008-11-13 2008-11-13
US11441608P 2008-11-13 2008-11-13

Publications (1)

Publication Number Publication Date
ECSP10010675A true ECSP10010675A (es) 2011-01-31

Family

ID=41417123

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2010010675A ECSP10010675A (es) 2008-06-12 2010-12-10 Moduladores de diamino-piridina, pirimidina, y piridazina del receptor h4 de histamina

Country Status (20)

Country Link
US (3) US8841287B2 (es)
EP (1) EP2315521B1 (es)
JP (1) JP5658662B2 (es)
KR (1) KR101600278B1 (es)
CN (1) CN102118969B (es)
AU (1) AU2009257434B2 (es)
BR (1) BRPI0915720A2 (es)
CA (1) CA2727684C (es)
CO (1) CO6321192A2 (es)
CR (1) CR20110029A (es)
EA (1) EA018198B1 (es)
EC (1) ECSP10010675A (es)
IL (1) IL209593A (es)
MX (1) MX2010013726A (es)
MY (1) MY158927A (es)
NI (1) NI201000214A (es)
NZ (1) NZ589532A (es)
PE (1) PE20110061A1 (es)
WO (1) WO2009152325A1 (es)
ZA (1) ZA201100298B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE478067T1 (de) 2006-03-31 2010-09-15 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyridine und pyrazine als modulatoren des histamin-h4-rezeptors
UA100567C2 (ru) * 2008-06-12 2013-01-10 Янссен Фармацевтика Нв Использование антагонистов н4-гистаминовых рецепторов для лечения послеоперационных спаек
KR101600278B1 (ko) 2008-06-12 2016-03-08 얀센 파마슈티카 엔.브이. 히스타민 ｈ4 수용체의 다이아미노-피리딘, 피리미딘, 및 피리다진 조절제
US9371311B2 (en) 2008-06-30 2016-06-21 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine derivatives
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WO2011078143A1 (ja) * 2009-12-22 2011-06-30 塩野義製薬株式会社 ピリミジン誘導体およびそれらを含有する医薬組成物
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