ECSP11010973A - Nuevas combinaciones de compuestos heterocíclicos nitrogenados antibacterianos con otros compuestos antibacterianos y su utilización como medicamentos - Google Patents
Nuevas combinaciones de compuestos heterocíclicos nitrogenados antibacterianos con otros compuestos antibacterianos y su utilización como medicamentosInfo
- Publication number
- ECSP11010973A ECSP11010973A EC2011010973A ECSP11010973A ECSP11010973A EC SP11010973 A ECSP11010973 A EC SP11010973A EC 2011010973 A EC2011010973 A EC 2011010973A EC SP11010973 A ECSP11010973 A EC SP11010973A EC SP11010973 A ECSP11010973 A EC SP11010973A
- Authority
- EC
- Ecuador
- Prior art keywords
- antibacterial
- compounds
- heterocyclic compounds
- beta
- chosen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La invención se refiere a la combinación de compuestos heterocíclicos nitrogenados antibacterianos de fórmula (I) con otros compuestos antibacterianos y su utilización como medicamentos.Los compuestos heterocíclicos nitrogenados responden a la fórmula general (I)en la que R1 representa un radical (CH2)n NH2 o (CH2)n-NHR, siendo R un alquilo (C1-C6) y siendo n igual a 1 ó 2;R2 representa un átomo de hidrógeno;R3 y R4 forman juntos un heterociclo nitrogenado de carácter aromático con 5 vértices que contienen 1, 2 ó 3 átomos de nitrógeno eventualmente sustituido por uno o varios agrupamientos R', siendo R' elegido del grupo constituido por un átomo de hidrógeno y los radicales alquilo contienen de 1 a 6 átomos de carbono, en forma libre, de zwitteriones, y en forma de sales con las bases y los ácidos minerales u orgánicos farmacéuticamente aceptables.Los demás agentes antibacterianos se eligen del grupo constituido por los betalactámicos, los monobactamos, las penicilinas, llegado el caso combinados con un inhibidor de betalactamasas, los aminoglucósidos, las glicilciclinas, las tetraciclinas, las quinolonas, los glucopéptidos, los lipopéptidos, los macrólidos, les quetólidos, las lincosamidas, las estreptograminas, las oxazolidinonas, las polimixinas y los demás compuestos conocidos dotados de una actividad terapéutica sobre Pseudomonas aeruginosa y Enterobacteriaceae.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0805618A FR2936951B1 (fr) | 2008-10-10 | 2008-10-10 | Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP11010973A true ECSP11010973A (es) | 2011-06-30 |
Family
ID=40591054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2011010973A ECSP11010973A (es) | 2008-10-10 | 2011-04-11 | Nuevas combinaciones de compuestos heterocíclicos nitrogenados antibacterianos con otros compuestos antibacterianos y su utilización como medicamentos |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20100092443A1 (es) |
| EP (1) | EP2344500A1 (es) |
| JP (1) | JP2012505196A (es) |
| KR (1) | KR20110067148A (es) |
| CN (1) | CN102216301B (es) |
| AR (1) | AR073771A1 (es) |
| AU (1) | AU2009302153A1 (es) |
| BR (1) | BRPI0919812A8 (es) |
| CA (1) | CA2740035A1 (es) |
| CL (1) | CL2011000783A1 (es) |
| CO (1) | CO6361930A2 (es) |
| EA (1) | EA201170532A1 (es) |
| EC (1) | ECSP11010973A (es) |
| FR (1) | FR2936951B1 (es) |
| IL (1) | IL212180A0 (es) |
| MX (1) | MX2011003812A (es) |
| NZ (1) | NZ592165A (es) |
| PA (1) | PA8845401A1 (es) |
| PE (1) | PE20110392A1 (es) |
| TW (1) | TW201026697A (es) |
| UY (1) | UY32168A (es) |
| WO (1) | WO2010041112A1 (es) |
| ZA (1) | ZA201102498B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX375266B (es) | 2010-11-25 | 2025-03-06 | Allecra Therapeutics Gmbh | Compuestos y su uso. |
| US8796257B2 (en) | 2011-12-02 | 2014-08-05 | Naeja Pharmaceutical Inc. | Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors |
| US9505761B2 (en) | 2011-12-02 | 2016-11-29 | Fedora Pharmaceuticals Inc. | Bicyclic compounds and their use as antibacterial agents and beta-lactamase inhibitors |
| AR090539A1 (es) | 2012-04-02 | 2014-11-19 | Astrazeneca Ab | COMPUESTOS INHIBIDORES DE b LACTAMASA |
| UA111925C2 (uk) | 2012-12-11 | 2016-06-24 | Федора Фармасьютікалз Інк. | БІЦИКЛІЧНІ СПОЛУКИ ТА ЇХ ВИКОРИСТАННЯ ЯК АНТИБАКТЕРІАЛЬНИХ АГЕНТІВ ТА ІНГІБІТОРІВ β-ЛАКТАМАЗИ |
| GB201305277D0 (en) * | 2013-03-22 | 2013-05-01 | Helperby Therapeutics Ltd | Novel combination and use |
| US9434728B1 (en) | 2013-10-11 | 2016-09-06 | Wockhardt Limited | Nitrogen containing compounds and their use |
| KR102542392B1 (ko) * | 2014-11-17 | 2023-06-09 | 엔타시스 테라퓨틱스 리미티드 | 내성 박테리아 감염의 치료를 위한 배합물 치료제 |
| CN114591223B (zh) | 2016-09-16 | 2025-01-24 | 恩塔西斯治疗有限公司 | β-内酰胺酶抑制剂化合物 |
| JOP20190061A1 (ar) | 2016-09-28 | 2019-03-26 | Novartis Ag | مثبطات بيتا-لاكتاماز |
| MX390529B (es) | 2017-01-09 | 2025-03-20 | Rempex Pharmaceuticals Inc | Metodos para tratar infecciones bacterianas |
| NZ758200A (en) | 2017-05-08 | 2025-12-19 | Entasis Therapeutics Inc | Compounds and methods for treating bacterial infections |
| EP4146650B1 (en) | 2020-09-01 | 2026-01-21 | Ningxia Academy of Agriculture and Forestry Sciences | Beta-lactamase inhibitors and their preparation |
| US12410166B2 (en) | 2021-05-07 | 2025-09-09 | Ningxia Academy Of Agriculture And Forestry Sciences | Sulfonylamidine substituted compounds and their use as beta-lactamase inhibitors |
| GB202213753D0 (en) * | 2022-09-20 | 2022-11-02 | Helperby Therapeutics Ltd | Antimicrobial combinations |
| WO2025031214A1 (zh) * | 2023-08-08 | 2025-02-13 | 成都四面体药物研究有限公司 | 一种含脲三环的β-内酰胺酶抑制剂、其制备方法及其用途 |
| CN121021489B (zh) * | 2025-10-29 | 2026-01-23 | 潍坊学院 | 卡枯醇叔胺衍生物、制备方法及在制备植物源杀菌剂中的应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK286420B6 (sk) * | 1997-09-15 | 2008-09-05 | The Procter & Gamble Company | Zlúčenina so štruktúrou chinolónu, farmaceutický prostriedok s jej obsahom a jej použitie |
| US6387928B1 (en) * | 1997-09-15 | 2002-05-14 | The Procter & Gamble Co. | Antimicrobial quinolones, their compositions and uses |
| WO2001077115A1 (en) * | 2000-04-12 | 2001-10-18 | Pharma Mar, S.A. | Antitumoral ecteinascidin derivatives |
| HUP0303457A3 (en) * | 2000-12-14 | 2008-05-28 | Procter & Gamble | Antimicrobial 2-pyridones, compositions containing them and their use |
| ATE304539T1 (de) * | 2000-12-14 | 2005-09-15 | Procter & Gamble | Antimikrobielle chinolone |
| FR2833596B1 (fr) * | 2001-12-14 | 2005-02-18 | Aventis Pharma Sa | Procede de preparation de derives d'echinocandine |
| FR2835186B1 (fr) * | 2002-01-28 | 2006-10-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases |
| US6900224B2 (en) * | 2002-07-31 | 2005-05-31 | The Procter & Gamble Company | Antimicrobial quinolones, their compositions and uses |
| FR2844268B1 (fr) * | 2002-09-11 | 2004-10-22 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent |
| FR2844270B1 (fr) * | 2002-09-11 | 2006-05-19 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leur procede et intermediaires de preparation et les compositions qui les contiennent |
| FR2848210B1 (fr) * | 2002-12-06 | 2007-10-19 | Aventis Pharma Sa | Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens et inhibiteurs de beta-lactamases |
| US7439253B2 (en) * | 2002-12-06 | 2008-10-21 | Novexel | Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors |
| US7232833B2 (en) * | 2003-03-28 | 2007-06-19 | Novexel | 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them |
| CA2528587A1 (en) * | 2003-06-10 | 2005-01-20 | Fulcrum Pharmaceuticals, Inc. | .beta.-lactamase inhibitors and methods of use thereof |
| US7449481B2 (en) * | 2004-04-13 | 2008-11-11 | Cephalon, Inc. | Thio-substituted biaryl-methanesulfinyl derivatives |
| CN101129383B (zh) * | 2006-08-25 | 2014-04-02 | 天津和美生物技术有限公司 | 含氨基糖苷类抗生素的抗生素复方 |
| EP1958630A1 (en) * | 2007-02-13 | 2008-08-20 | LEK Pharmaceuticals d.d. | Antibacterial combination of a tricyclic carbapenem and an antibiotic |
-
2008
- 2008-10-10 FR FR0805618A patent/FR2936951B1/fr not_active Expired - Fee Related
-
2009
- 2009-08-05 US US12/535,865 patent/US20100092443A1/en not_active Abandoned
- 2009-09-29 AU AU2009302153A patent/AU2009302153A1/en not_active Abandoned
- 2009-09-29 EA EA201170532A patent/EA201170532A1/ru unknown
- 2009-09-29 KR KR1020117010169A patent/KR20110067148A/ko not_active Ceased
- 2009-09-29 MX MX2011003812A patent/MX2011003812A/es active IP Right Grant
- 2009-09-29 NZ NZ592165A patent/NZ592165A/xx not_active IP Right Cessation
- 2009-09-29 PE PE2011000865A patent/PE20110392A1/es not_active Application Discontinuation
- 2009-09-29 BR BRPI0919812A patent/BRPI0919812A8/pt not_active IP Right Cessation
- 2009-09-29 CN CN200980146340.2A patent/CN102216301B/zh not_active Expired - Fee Related
- 2009-09-29 WO PCT/IB2009/006992 patent/WO2010041112A1/fr not_active Ceased
- 2009-09-29 JP JP2011530584A patent/JP2012505196A/ja not_active Ceased
- 2009-09-29 CA CA2740035A patent/CA2740035A1/fr not_active Abandoned
- 2009-09-29 EP EP09786281A patent/EP2344500A1/fr not_active Withdrawn
- 2009-10-05 AR ARP090103834A patent/AR073771A1/es not_active Application Discontinuation
- 2009-10-07 TW TW098133951A patent/TW201026697A/zh unknown
- 2009-10-08 UY UY0001032168A patent/UY32168A/es not_active Application Discontinuation
- 2009-10-09 PA PA20098845401A patent/PA8845401A1/es unknown
-
2011
- 2011-04-05 ZA ZA2011/02498A patent/ZA201102498B/en unknown
- 2011-04-06 IL IL212180A patent/IL212180A0/en unknown
- 2011-04-08 CO CO11043791A patent/CO6361930A2/es not_active Application Discontinuation
- 2011-04-08 CL CL2011000783A patent/CL2011000783A1/es unknown
- 2011-04-11 EC EC2011010973A patent/ECSP11010973A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR073771A1 (es) | 2010-12-01 |
| FR2936951B1 (fr) | 2010-12-03 |
| AU2009302153A1 (en) | 2010-04-15 |
| EP2344500A1 (fr) | 2011-07-20 |
| TW201026697A (en) | 2010-07-16 |
| BRPI0919812A2 (pt) | 2015-12-22 |
| IL212180A0 (en) | 2011-06-30 |
| JP2012505196A (ja) | 2012-03-01 |
| KR20110067148A (ko) | 2011-06-21 |
| UY32168A (es) | 2010-04-30 |
| PE20110392A1 (es) | 2011-06-11 |
| FR2936951A1 (fr) | 2010-04-16 |
| PA8845401A1 (es) | 2010-05-26 |
| CO6361930A2 (es) | 2012-01-20 |
| NZ592165A (en) | 2012-12-21 |
| ZA201102498B (en) | 2013-07-25 |
| BRPI0919812A8 (pt) | 2016-11-01 |
| CN102216301B (zh) | 2014-12-10 |
| WO2010041112A1 (fr) | 2010-04-15 |
| EA201170532A1 (ru) | 2011-12-30 |
| MX2011003812A (es) | 2011-07-29 |
| CA2740035A1 (fr) | 2010-04-15 |
| US20100092443A1 (en) | 2010-04-15 |
| CL2011000783A1 (es) | 2012-07-06 |
| CN102216301A (zh) | 2011-10-12 |
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