ECSP11010946A - Nuevos compuestos heterocíclicos nitrogenados, preparación de los mismos y utilización de los mismos como medicamentos antibacterianos - Google Patents

Nuevos compuestos heterocíclicos nitrogenados, preparación de los mismos y utilización de los mismos como medicamentos antibacterianos

Info

Publication number
ECSP11010946A
ECSP11010946A EC2011010946A ECSP11010946A ECSP11010946A EC SP11010946 A ECSP11010946 A EC SP11010946A EC 2011010946 A EC2011010946 A EC 2011010946A EC SP11010946 A ECSP11010946 A EC SP11010946A EC SP11010946 A ECSP11010946 A EC SP11010946A
Authority
EC
Ecuador
Prior art keywords
same
equal
amino
nitrogen
group
Prior art date
Application number
EC2011010946A
Other languages
English (en)
Inventor
Maxime Lampilas
David Alan Rowlands
Benoit Ledoussal
Marie-Edith Gourdel
Emilie Renaud
Camille Pierres
Adel Kebsi
Original Assignee
Novexel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40548019&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP11010946(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novexel filed Critical Novexel
Publication of ECSP11010946A publication Critical patent/ECSP11010946A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención se refiere a compuestos heterocíclicos nitrogenados de fórmula general (I)en la cual:R1 representa un radical (CH2)n-NH2, siendo n igual a 1 o 2;R2 representa un átomo de hidrógeno;R3 y R4 forman juntos un heterociclo nitrogenado de carácter aromático de 5 vértices que contiene 1, 2 o 3 átomos de nitrógeno, sustituido en este átomo de nitrógeno o en uno de estos átomos de nitrógeno por un grupo (CH2)m-(C(O))p-R5, siendo m igual a 0, 1, 2 o 3, siendo p igual a 0 o 1 y R5 representa un grupo hidroxi, en cuyo caso p es igual a 1, o un grupo amino, alquilo(C1-C6) o dialquilo(C1-C6) amino, o un heterociclo nitrogenado de carácter aromático de 5 o 6 vértices que contiene 1 o 2 átomos de nitrógeno y, eventualmente, 1 átomo de oxígeno o de azufre; siendo evidente que, cuando el sub-grupo (C(O))p-R5 forma un grupo carboxi, amino, alquilo(C1-C6) o dialquilo(C1-C6) amino, m es diferente de 0 o 1; en forma libre y en forma de zwitteriones y de sales con bases y ácidos minerales u orgánicos farmacéuticamente aceptables, a la preparación y utilización de los mismos como medicamentos antibacterianos.
EC2011010946A 2008-10-03 2011-04-01 Nuevos compuestos heterocíclicos nitrogenados, preparación de los mismos y utilización de los mismos como medicamentos antibacterianos ECSP11010946A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0805472A FR2936798B1 (fr) 2008-10-03 2008-10-03 Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens.

Publications (1)

Publication Number Publication Date
ECSP11010946A true ECSP11010946A (es) 2011-05-31

Family

ID=40548019

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2011010946A ECSP11010946A (es) 2008-10-03 2011-04-01 Nuevos compuestos heterocíclicos nitrogenados, preparación de los mismos y utilización de los mismos como medicamentos antibacterianos

Country Status (18)

Country Link
US (1) US8067435B2 (es)
EP (2) EP2845855A1 (es)
JP (1) JP5555240B2 (es)
KR (1) KR20110067137A (es)
CN (1) CN102203094B (es)
AU (1) AU2009299511A1 (es)
BR (1) BRPI0919810A8 (es)
CA (1) CA2739503A1 (es)
CL (1) CL2011000729A1 (es)
CO (1) CO6361957A2 (es)
EA (1) EA021799B1 (es)
EC (1) ECSP11010946A (es)
FR (1) FR2936798B1 (es)
IL (1) IL212059A0 (es)
MX (1) MX2011003573A (es)
PE (1) PE20110845A1 (es)
WO (1) WO2010038115A1 (es)
ZA (1) ZA201102429B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8772490B2 (en) 2010-12-22 2014-07-08 Meiji Seika Pharma Co., Ltd. Optically active diazabicyclooctane derivatives and process for preparing the same
MX340533B (es) * 2011-08-30 2016-07-13 Wockhardt Ltd Derivados de 1,6- diazabiciclo [3,2,1] octan-7-ona y su uso en el tratamiento de infecciones bacterianas.
EP3052497B1 (en) * 2011-09-13 2017-06-28 Wockhardt Limited Nitrogen containing compounds and their use
KR20150003777A (ko) * 2012-03-30 2015-01-09 큐비스트 파마슈티컬즈 인코포레이티드 이속사졸 β-락타마제 억제제
AR090539A1 (es) * 2012-04-02 2014-11-19 Astrazeneca Ab COMPUESTOS INHIBIDORES DE b LACTAMASA
RU2693898C2 (ru) 2012-05-30 2019-07-05 Мейдзи Сейка Фарма Ко., Лтд. НОВЫЙ ИНГИБИТОР бета-ЛАКТАМАЗЫ И СПОСОБ ЕГО ПОЛУЧЕНИЯ
BR112015003592B1 (pt) * 2012-08-25 2020-04-14 Wockhardt Ltd derivados de 1,6-diazabiciclo[3,2,1]octan-7-ona e seu uso no tratamento de infecções bacterianas
DK3050883T3 (da) 2013-09-24 2020-05-25 Meiji Seika Pharma Co Ltd Fremgangsmåde til fremstilling af diazabicyclooctanderivater og mellemprodukter
EP3613740A1 (en) 2013-10-08 2020-02-26 Meiji Seika Pharma Co., Ltd. Preparation of a diazabicyclooctane derivative
US9434728B1 (en) * 2013-10-11 2016-09-06 Wockhardt Limited Nitrogen containing compounds and their use
KR102542392B1 (ko) 2014-11-17 2023-06-09 엔타시스 테라퓨틱스 리미티드 내성 박테리아 감염의 치료를 위한 배합물 치료제
RU2732129C2 (ru) 2014-12-05 2020-09-11 Мейдзи Сейка Фарма Ко., Лтд. Способ производства кристаллов производного диазабициклооктана и стабильного лиофилизированного препарата
EP3075733A1 (en) * 2015-03-31 2016-10-05 Mutabilis Novel heterocyclic compounds and their use in preventing or treating bacterial infections
BR112017020796A2 (pt) * 2015-03-31 2018-06-26 Mutabilis compostos, composição farmacêutica e kit
CN107438614B (zh) * 2015-04-03 2020-01-31 拜欧蒂姆公司 杂环化合物及它们在预防或治疗细菌感染中的应用
CA3000087A1 (en) 2015-10-02 2017-04-06 Legochem Biosciences, Inc. Compositions and methods for inhibiting beta-lactamase
CN114591223B (zh) 2016-09-16 2025-01-24 恩塔西斯治疗有限公司 β-内酰胺酶抑制剂化合物
NZ758200A (en) 2017-05-08 2025-12-19 Entasis Therapeutics Inc Compounds and methods for treating bacterial infections
EP3604315A1 (en) * 2018-07-30 2020-02-05 Mutabilis Heterocyclic compounds and their use in preventing or treating bacterial infections
WO2025031214A1 (zh) * 2023-08-08 2025-02-13 成都四面体药物研究有限公司 一种含脲三环的β-内酰胺酶抑制剂、其制备方法及其用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK286420B6 (sk) * 1997-09-15 2008-09-05 The Procter & Gamble Company Zlúčenina so štruktúrou chinolónu, farmaceutický prostriedok s jej obsahom a jej použitie
US6387928B1 (en) * 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
FR2812635B1 (fr) 2000-08-01 2002-10-11 Aventis Pharma Sa Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
HUP0303457A3 (en) * 2000-12-14 2008-05-28 Procter & Gamble Antimicrobial 2-pyridones, compositions containing them and their use
ATE304539T1 (de) * 2000-12-14 2005-09-15 Procter & Gamble Antimikrobielle chinolone
FR2825705B1 (fr) * 2001-06-08 2005-05-20 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens
FR2833596B1 (fr) * 2001-12-14 2005-02-18 Aventis Pharma Sa Procede de preparation de derives d'echinocandine
FR2835186B1 (fr) * 2002-01-28 2006-10-20 Aventis Pharma Sa Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
US6900224B2 (en) * 2002-07-31 2005-05-31 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
FR2844273B1 (fr) 2002-09-05 2008-04-04 Aventis Pharma Sa Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens.
FR2844270B1 (fr) * 2002-09-11 2006-05-19 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur procede et intermediaires de preparation et les compositions qui les contiennent
FR2844268B1 (fr) * 2002-09-11 2004-10-22 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent
FR2848210B1 (fr) * 2002-12-06 2007-10-19 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens et inhibiteurs de beta-lactamases
US7439253B2 (en) * 2002-12-06 2008-10-21 Novexel Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
US7232833B2 (en) * 2003-03-28 2007-06-19 Novexel 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them
US7449481B2 (en) * 2004-04-13 2008-11-11 Cephalon, Inc. Thio-substituted biaryl-methanesulfinyl derivatives
FR2914923B1 (fr) * 2007-04-12 2013-06-14 Novexel Nouveaux composes heterocycliques azotes,leur preparation et leur utilisation comme medicaments antibacteriens.
FR2937034B1 (fr) * 2008-10-10 2012-11-23 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens

Also Published As

Publication number Publication date
CL2011000729A1 (es) 2012-07-06
CO6361957A2 (es) 2012-01-20
BRPI0919810A2 (pt) 2017-10-31
AU2009299511A1 (en) 2010-04-08
KR20110067137A (ko) 2011-06-21
IL212059A0 (en) 2011-06-30
FR2936798A1 (fr) 2010-04-09
CA2739503A1 (fr) 2010-04-08
MX2011003573A (es) 2011-08-12
JP2012504593A (ja) 2012-02-23
FR2936798B1 (fr) 2012-09-28
EP2845855A1 (fr) 2015-03-11
EA201170522A1 (ru) 2011-12-30
PE20110845A1 (es) 2011-11-17
ZA201102429B (en) 2012-05-30
WO2010038115A1 (fr) 2010-04-08
EA021799B1 (ru) 2015-09-30
CN102203094A (zh) 2011-09-28
CN102203094B (zh) 2014-04-02
BRPI0919810A8 (pt) 2017-12-12
EP2344499A1 (fr) 2011-07-20
US20100087648A1 (en) 2010-04-08
US8067435B2 (en) 2011-11-29
JP5555240B2 (ja) 2014-07-23

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